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Genes Phenotypes Help, News, Blog

Gene: Prss48 MGI:2685865

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Gene Summary

Name:
serine protease 48
Synonyms:
Gm1019,  Esspl

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal thymus morphology Prss48em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal spleen morphology Prss48em1(IMPC)Ccpcz HOM Early adult 0.00
decreased respiratory quotient Prss48em1(IMPC)Ccpcz HOM Early adult 8.11×10-07
abnormal digit morphology Prss48em1(IMPC)Ccpcz HOM Early adult 7.95×10-05
decreased lean body mass Prss48em1(IMPC)Ccpcz HOM Early adult 6.21×10-05
enlarged thymus Prss48em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal seminal vesicle morphology Prss48em1(IMPC)Ccpcz HOM Early adult 0.00
small seminal vesicle Prss48em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal eye morphology Prss48em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal kidney morphology Prss48em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal vertebral arch morphology Prss48em1(IMPC)Ccpcz HOM   Early adult 1.11×10-06
abnormal caudal vertebrae morphology Prss48em1(IMPC)Ccpcz HOM   Early adult 2.53×10-06
increased cardiac muscle contractility Prss48em1(IMPC)Ccpcz HOM   Early adult 1.10×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Hind Leg and Hip

30 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

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X-ray

XRay Images Whole Body Dorso Ventral

30 Images

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X-ray

XRay Images Whole Body Lateral Orientation

15 Images

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X-ray

XRay Images Skull Lateral Orientation

15 Images

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X-ray

XRay Images Forepaw

15 Images

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Human diseases caused by Prss48 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prss48

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prss48.

No publications found that use IMPC mice or data for Prss48.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Prss48tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Prss48em1(IMPC)Ccpcz Exon Deletion Mice
Prss48tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Prss48tm3e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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