Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal skin morphology | Garem1em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
decreased body length | Garem1em1(IMPC)Mbp | HOM | Early adult | 2.48×10-05 | ||
abnormal spleen morphology | Garem1em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
small liver | Garem1em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
small spleen | Garem1em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
small kidney | Garem1em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
abnormal liver morphology | Garem1em1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
abnormal kidney morphology | Garem1em1(IMPC)Mbp | HOM | Early adult | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Garem1 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Lissencephaly Syndrome, Norman-Roberts Type | Hypoplastic spleen | ORPHA:89844 | |
Gracile Bone Dysplasia | Hypoplastic spleen, Asplenia, Micropenis | OMIM:602361 | |
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy | Hypoplasia of the thymus, B lymphocytopenia, T lymphocytopenia, Impaired lymphocyte transformatio... | OMIM:619313 | |
Pearson Syndrome | Exocrine pancreatic insufficiency, Hepatomegaly, Hepatic failure, Glycosuria, Proteinuria, Hypopl... | ORPHA:699 | |
Microphthalmia, Syndromic 9 | Multilobulated spleen, Renal hypoplasia, Horseshoe kidney, Hypoplastic spleen, Hydronephrosis, Pe... | OMIM:601186 | |
Mirage Syndrome | Lymphopenia, Hypospadias, Leukopenia, Hypoplastic spleen, Anemia, Thrombocytopenia, Microphallus | OMIM:617053 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Garem1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Garem1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Garem1em1(IMPC)Mbp | Exon Deletion | Mice |
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