Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
dynein axonemal intermediate chain 2
Synonyms:
C030015H18Rik,  Dnaic2,  b2b3405Clo

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dnai2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dnai2 by orthology or direct annotation.

The table below shows human diseases predicted to be associated to Dnai2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Ciliary Dyskinesia, Primary, 7
Dextrocardia, Ciliary dyskinesia, Bronchiectasis, Situs inversus totalis, Reduced FEV1/FVC ratio,... OMIM:611884
Ciliary Dyskinesia, Primary, 3
Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Situs inversus totalis, Recurr... OMIM:608644
Ciliary Dyskinesia, Primary, 25
Dextrocardia, Sinusitis, Chronic pulmonary obstruction, Ciliary dyskinesia, Bronchiectasis, Situs... OMIM:615482
Ciliary Dyskinesia, Primary, 23
Productive cough, Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Situs invers... OMIM:615451
Ciliary Dyskinesia, Primary, 20
Dextrocardia, Ciliary dyskinesia, Bronchiectasis, Situs inversus totalis, Respiratory insufficien... OMIM:615067
Ciliary Dyskinesia, Primary, 9
Ciliary dyskinesia, Pneumonia, Bronchiectasis, Situs inversus totalis, Chronic rhinitis, Cough, R... OMIM:612444
Ciliary Dyskinesia, Primary, 16
Ciliary dyskinesia, Bronchiectasis, Situs inversus totalis, Chronic rhinitis, Chronic sinusitis, ... OMIM:614017
Laterality Defects, Autosomal Dominant
Situs inversus totalis, Heterotaxy OMIM:601086
Ciliary Dyskinesia, Primary, 36, X-Linked
Neonatal respiratory distress, Bronchiectasis, Situs inversus totalis, Cough, Recurrent sinusitis OMIM:300991
Ciliary Dyskinesia, Primary, 10
Situs inversus totalis, Chronic sinusitis, Recurrent sinusitis, Ciliary dyskinesia OMIM:612518
Ciliary Dyskinesia, Primary, 28
Sinusitis, Ciliary dyskinesia, Bronchiectasis, Rhinitis, Situs inversus totalis, Respiratory insu... OMIM:615505
Ciliary Dyskinesia, Primary, 18
Respiratory insufficiency, Ciliary dyskinesia, Rhinitis, Situs inversus totalis, Respiratory insu... OMIM:614874
Ciliary Dyskinesia, Primary, 40
Abnormal heart morphology, Situs inversus totalis, Rhinitis, Cough OMIM:618300
Ciliary Dyskinesia, Primary, 17
Dextrocardia, Ciliary dyskinesia, Bronchiectasis, Situs inversus totalis, Chronic rhinitis, Chron... OMIM:614679
Ciliary Dyskinesia, Primary, 26
Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Rhinitis, Situs inversus total... OMIM:615500
Ciliary Dyskinesia, Primary, 30
Dextrocardia, Respiratory insufficiency, Ciliary dyskinesia, Bronchiectasis, Situs inversus total... OMIM:616037
Porencephaly, Cerebellar Hypoplasia, And Internal Malformations
Situs inversus totalis, Atrial septal defect, Tetralogy of Fallot OMIM:601322
Heterotaxy, Visceral, 10, Autosomal, With Male Infertility
Dextrocardia, Abdominal situs inversus, Situs inversus totalis, Chronic sinusitis, Cough, Decreas... OMIM:619607
Ciliary Dyskinesia, Primary, 13
Sinusitis, Situs inversus totalis, Ciliary dyskinesia, Bronchiectasis OMIM:613193
Ciliary Dyskinesia, Primary, 2
Dextrocardia, Sinusitis, Ciliary dyskinesia, Bronchiectasis, Situs inversus totalis, Respiratory ... OMIM:606763
Congenital Pseudoarthrosis Of The Clavicle
Dextrocardia, Situs inversus totalis ORPHA:66630
Ciliary Dyskinesia, Primary, 14
Wheezing, Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Situs inversus total... OMIM:613807
Ciliary Dyskinesia, Primary, 32
Immotile cilia, Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis OMIM:616481
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility
Dextrocardia, Situs inversus totalis OMIM:618948
Ciliary Dyskinesia, Primary, 38
Dextrocardia, Neonatal respiratory distress, Bronchiectasis, Rhinitis, Situs inversus totalis, Ch... OMIM:618063
Ciliary Dyskinesia, Primary, 19
Ciliary dyskinesia, Bronchiectasis, Rhinitis, Situs inversus totalis, Respiratory insufficiency d... OMIM:614935
Ciliary Dyskinesia, Primary, 35
Bronchiectasis, Situs inversus totalis, Chronic rhinitis, Chronic sinusitis, Cough OMIM:617092
Ciliary Dyskinesia, Primary, 21
Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Chronic sinusitis, Recurrent p... OMIM:615294
Ciliary Dyskinesia, Primary, 37
Dextrocardia, Wheezing, Bronchiectasis, Situs inversus totalis, Chronic rhinitis, Rhinorrhea OMIM:617577
Ciliary Dyskinesia, Primary, 15
Wheezing, Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Situs inversus total... OMIM:613808
Ciliary Dyskinesia, Primary, 22
Sinusitis, Ciliary dyskinesia, Bronchiectasis, Rhinitis, Situs inversus totalis, Respiratory insu... OMIM:615444
Ciliary Dyskinesia, Primary, 29
Decreased nasal nitric oxide, Ciliary dyskinesia, Atelectasis, Bronchiectasis OMIM:615872
Nephronophthisis 14
Situs inversus totalis OMIM:614844
Ciliary Dyskinesia, Primary, 46
Reduced forced expiratory volume in one second, Ciliary dyskinesia, Bronchiectasis, Recurrent pne... OMIM:619436
Ciliary Dyskinesia, Primary, 11
Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Chronic rhinitis, Abnormal cil... OMIM:612649
Heterotaxy, Visceral, 2, Autosomal
Dextrocardia, Abdominal situs inversus, Atrioventricular canal defect, Situs inversus totalis, Do... OMIM:605376
Ciliary Dyskinesia, Primary, 27
Sinusitis, Ciliary dyskinesia, Bronchiectasis, Rhinitis, Respiratory insufficiency due to defecti... OMIM:615504
Ciliary Dyskinesia, Primary, 6
Sinusitis, Recurrent sinusitis, Abnormal ciliary motility, Ciliary dyskinesia OMIM:610852
Ciliary Dyskinesia, Primary, 33
Ciliary dyskinesia, Bronchiectasis, Chronic rhinitis, Cough, Recurrent pneumonia, Atelectasis OMIM:616726
Ciliary Dyskinesia, Primary, 24
Sinusitis, Ciliary dyskinesia, Bronchiectasis, Rhinitis, Recurrent sinusitis OMIM:615481
Heterotaxy, Visceral, 11, Autosomal, With Male Infertility
Primum atrial septal defect, Partial atrioventricular canal defect, Situs inversus totalis, Chron... OMIM:619608
Ciliary Dyskinesia With Excessively Long Cilia
Sinusitis, Ciliary dyskinesia, Chronic rhinitis, Immotile cilia, Airway obstruction OMIM:242680
Bardet-Biedl Syndrome 8
Situs inversus totalis OMIM:615985
Hypoglossia With Situs Inversus
Situs inversus totalis, Respiratory distress, Upper airway obstruction OMIM:612776
Ciliary Dyskinesia, Primary, 34
Neonatal respiratory distress, Bronchiectasis, Chronic rhinitis, Decreased nasal nitric oxide, Re... OMIM:617091
Nephronophthisis 16
Hypertrophic cardiomyopathy, Situs inversus totalis, Aortic valve stenosis, Pulmonic stenosis OMIM:615382
Ciliary Dyskinesia With Defective Radial Spokes
Sinusitis, Abnormal respiratory system physiology, Ciliary dyskinesia, Chronic rhinitis, Immotile... OMIM:242670
Ciliary Dyskinesia, Primary, 45
Immotile cilia, Chronic rhinitis, Bronchiectasis OMIM:618801
Retinitis Pigmentosa 82 With Or Without Situs Inversus
Situs inversus totalis OMIM:615434
Ciliary Dyskinesia With Transposition Of Ciliary Microtubules
Ciliary dyskinesia OMIM:215520
Spondylocostal Dysostosis 4, Autosomal Recessive
Dextrocardia, Situs inversus totalis, Restrictive ventilatory defect OMIM:613686
Ciliary Dyskinesia, Primary, 39
Dextrocardia, Bronchiectasis, Double outlet right ventricle, Rhinorrhea, Cough, Chronic lung dise... OMIM:618254
Ciliary Dyskinesia, Primary, 1
Pneumonia, Ciliary dyskinesia, Bronchiectasis, Situs inversus totalis, Chronic rhinitis, Chronic ... OMIM:244400
Right Atrial Isomerism
Dextrocardia, Complete atrioventricular canal defect, Ventricular septal defect, Abdominal situs ... OMIM:208530
Ciliary Dyskinesia, Primary, 5
Sinusitis, Ciliary dyskinesia, Bronchiectasis, Rhinitis, Respiratory insufficiency due to defecti... OMIM:608647
Ciliary Dyskinesia, Primary, 12
Chronic rhinitis, Chronic sinusitis, Ciliary dyskinesia, Bronchiectasis OMIM:612650
Retinitis Pigmentosa 6
Immotile cilia OMIM:312612
Heterotaxy, Visceral, 7, Autosomal
Dextrocardia, Hypoplasia of right ventricle, Abnormal aortic valve morphology, Situs inversus tot... OMIM:616749
Primary Ciliary Dyskinesia
Wheezing, Productive cough, Neonatal respiratory distress, Bronchiectasis, Situs inversus totalis... ORPHA:244
Agnathia-Otocephaly Complex
Situs inversus totalis, Tracheomalacia, Respiratory distress OMIM:202650
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Dextrocardia, Situs inversus totalis OMIM:613095
Heterotaxy, Visceral, 6, Autosomal
Dextrocardia, Transposition of the great arteries, Abdominal situs inversus OMIM:614779
Thiamine-Responsive Megaloblastic Anemia Syndrome
Situs inversus totalis, Ventricular septal defect, Atrial septal defect, Cardiomyopathy OMIM:249270
Renal-Hepatic-Pancreatic Dysplasia 2
Hypertrophic cardiomyopathy, Truncus arteriosus, Situs inversus totalis, Pulmonic stenosis, Aorti... OMIM:615415
Marfanoid Habitus With Situs Inversus
Situs inversus totalis, Mitral valve prolapse, Obstructive sleep apnea, Pulmonic stenosis OMIM:609008
Nephronophthisis 2
Respiratory failure, Situs inversus totalis, Respiratory insufficiency OMIM:602088
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Situs inversus totalis, Respiratory distress ORPHA:990
Bardet-Biedl Syndrome 17
Dextrocardia, Situs inversus totalis OMIM:615994
Joubert Syndrome
Situs inversus totalis, Apnea, Abnormal pattern of respiration, Episodic tachypnea ORPHA:475
Dextrocardia
Dextrocardia, Situs inversus totalis, Abnormality of abdominal situs, Abnormal heart morphology ORPHA:1666
Hypohidrotic Ectodermal Dysplasia-Hypothyroidism-Ciliary Dyskinesia Syndrome
Ciliary dyskinesia ORPHA:1882
Heterotaxy, Visceral, 4, Autosomal
Dextrocardia, Ventricular septal defect, Atrioventricular canal defect OMIM:613751
Ectodermal Dysplasia, Hypohidrotic, With Hypothyroidism And Ciliary Dyskinesia
Ciliary dyskinesia OMIM:225050
Heterotaxy, Visceral, 8, Autosomal
Ventricular septal defect, Abdominal situs inversus, Double outlet right ventricle, Atrial situs ... OMIM:617205
Partial Atrioventricular Septal Defect
Bicuspid aortic valve, Bacterial endocarditis, Partial atrioventricular canal defect, Double outl... ORPHA:1330
Aminopterin/Methotrexate Embryofetopathy
Situs inversus totalis, Ventricular septal defect, Tetralogy of Fallot ORPHA:1908
Atrioventricular Septal Defect, Susceptibility To, 2
Dextrocardia, Atrioventricular canal defect OMIM:606217
Meckel Syndrome, Type 7
Right ventricular hypertrophy, Situs inversus totalis, Aortic valve stenosis, Atrial septal defect OMIM:267010
Meacham Syndrome
Ventricular septal defect, Conotruncal defect, Situs inversus totalis, Transposition of the great... ORPHA:3097
Congenitally Corrected Transposition Of The Great Arteries
Single ventricle, Double outlet left ventricle, Abnormal left ventricular outflow tract morpholog... ORPHA:216694
Ellis Van Creveld Syndrome
Dextrocardia, Ventricular septal defect, Atrioventricular canal defect, Situs inversus totalis, A... ORPHA:289
Double Outlet Right Ventricle
Ventricular septal defect, Truncus arteriosus, Tachypnea, Double outlet right ventricle, Heterota... ORPHA:3426
Isolated Cleft Lip
Situs inversus totalis ORPHA:199302
Short Rib-Polydactyly Syndrome
Abnormal heart morphology, Situs inversus totalis, Respiratory failure, Transposition of the grea... ORPHA:1505
Renpenning Syndrome
Heterotaxy ORPHA:3242
Marden-Walker Syndrome
Abnormal anatomic location of the heart, Situs inversus totalis, Ventricular septal defect, Dextr... ORPHA:2461
Thoraco-Abdominal Enteric Duplication
Dextrocardia, Abnormal tricuspid valve morphology, Respiratory insufficiency ORPHA:1759
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Isomerism, Transposition of the great arteries, Atrioventricular canal defect OMIM:314390
Pagod Syndrome
Situs inversus totalis, Hypoplastic left heart ORPHA:991
Primary Pulmonary Hypoplasia
Dextrocardia, Abnormal breath sound, Hypoxemia, Neonatal respiratory distress, Tachypnea, Pneumot... ORPHA:2257
Renpenning Syndrome 1
Situs inversus totalis, Ventricular septal defect, Atrial septal defect, Tetralogy of Fallot OMIM:309500
Congenital Total Pulmonary Venous Return Anomaly
Paroxysmal dyspnea, Mitral atresia, Single ventricle, Exertional dyspnea, Supracardiac total anom... ORPHA:99125
Biliary, Renal, Neurologic, And Skeletal Syndrome
Dextrocardia, Primum atrial septal defect, Ventricular septal defect, Atrioventricular canal defe... OMIM:619534
Carpenter Syndrome 2
Dextrocardia, Situs inversus totalis, Atrial septal defect, Transposition of the great arteries OMIM:614976
Meckel Syndrome
Situs inversus totalis ORPHA:564
Heterotaxy, Visceral, 1, X-Linked
Dextrocardia, Ventricular septal defect, Abdominal situs inversus, Mitral atresia, Double outlet ... OMIM:306955
Ring Chromosome 7 Syndrome
Situs inversus totalis ORPHA:1449
Scimitar Syndrome
Dextrocardia, Ventricular septal defect, Truncus arteriosus, Tricuspid atresia, Mitral atresia, A... ORPHA:185
Johanson-Blizzard Syndrome
Dilated cardiomyopathy, Situs inversus totalis, Ventricular septal defect, Atrial septal defect OMIM:243800
Heterotaxy, Visceral, 5, Autosomal
Dextrocardia, Ventricular septal defect, Abdominal situs ambiguus, Abdominal situs inversus, Righ... OMIM:270100
Diets-Jongmans Syndrome
Ventricular septal defect, Heterotaxy OMIM:618846

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dnai2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dnai2.

No publications found that use IMPC mice or data for Dnai2.

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MGI Allele Allele Type Produced
Dnai2tm134(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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