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Gene: Gfy MGI:2685427

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
golgi-associated olfactory signaling regulator
Synonyms:
Gm581,  Goofy

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gfy mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gfy by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Leber Congenital Amaurosis 10
Hyposmia OMIM:611755
Anosmia For Isobutyric Acid
Partial anosmia OMIM:207000
Anosmia For Butyl Mercaptan
Anosmia OMIM:270350
Isovaleric Acid, Inability To Smell
Anosmia OMIM:243450
Anosmia, Isolated Congenital, X-Linked
Anosmia OMIM:301700
Anosmia, Isolated Congenital
Anosmia OMIM:107200
Hypogonadotropic Hypogonadism 17 With Or Without Anosmia
Hyposmia OMIM:615266
Musk, Inability To Smell
Anosmia OMIM:254150
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia
Hyposmia OMIM:615271
Thumb Agenesis, Short Stature, And Immunodeficiency
Anosmia OMIM:274190
Aural Atresia, Congenital
Hyposmia OMIM:607842
Apnea, Obstructive Sleep
Anosmia OMIM:107650
Hypogonadotropic Hypogonadism 20 With Or Without Anosmia
Anosmia OMIM:615270
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Anosmia OMIM:614858
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Choanal atresia, Aplasia/Hypoplasia involving the nose, Abnormality of the sense of smell ORPHA:1135
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Abnormality of the sense of smell OMIM:146110
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Anosmia OMIM:612370
Hypogonadotropic Hypogonadism 18 With Or Without Anosmia
Anosmia OMIM:615267
Chondrodysplasia Punctata 1, X-Linked Recessive
Depressed nasal bridge, Anosmia, Short nasal septum, Short nose OMIM:302950
Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Bifid nose, Anosmia, Hyposmia OMIM:614838
Asthma, Nasal Polyps, And Aspirin Intolerance
Nasal polyposis OMIM:208550
Hypogonadotropic Hypogonadism 27 Without Anosmia
Anosmia OMIM:619755
Leukoencephalopathy With Dystonia And Motor Neuropathy
Azoospermia, Hyposmia OMIM:613724
Body Mass Index Quantitative Trait Locus 19
Anosmia, Hyposmia OMIM:617885
Ciliary Dyskinesia With Defective Radial Spokes
Nasal polyposis, Immotile cilia, Chronic rhinitis, Absent respiratory ciliary axoneme radial spok... OMIM:242670
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
Anosmia, Hyposmia OMIM:612702
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Anosmia, Hyposmia OMIM:610628
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia
Azoospermia, Abnormality of the sense of smell OMIM:229070
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Anosmia OMIM:614839
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Anosmia OMIM:614842
Peroxisome Biogenesis Disorder 9B
Anosmia, Total anosmia OMIM:614879
Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Anosmia OMIM:614880
Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Anosmia, Hyposmia OMIM:244200
Hypogonadotropic Hypogonadism 25 With Anosmia
Anosmia OMIM:618841
Ciliary Dyskinesia, Primary, 19
Nasal polyposis, Immotile cilia, Recurrent sinusitis, Absent inner and outer dynein arms, Respira... OMIM:614935
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia
Anosmia, Azoospermia, Hyposmia OMIM:614897
Blepharophimosis-Ptosis-Esotropia-Syndactyly-Short Stature Syndrome
Anosmia ORPHA:2057
Hyperostosis Cranialis Interna
Anosmia, Hyposmia OMIM:144755
Blepharophimosis With Ptosis, Syndactyly, And Short Stature
Wide nasal bridge, Anosmia OMIM:210745
Ciliary Dyskinesia, Primary, 49, Without Situs Inversus
Nasal polyposis, Recurrent sinusitis, Ciliary dyskinesia, Short sperm flagella, Coiled sperm flag... OMIM:620197
Indifference To Pain, Congenital, Autosomal Recessive
Anosmia, Hyposmia OMIM:243000
Ciliary Dyskinesia, Primary, 1
Anosmia, Nasal polyposis, Immotile cilia, Chronic rhinitis, Absent outer dynein arms, Ciliary dys... OMIM:244400
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia
Choanal atresia, Anosmia, Hyposmia OMIM:147950
Ciliary Dyskinesia, Primary, 42
Nasal polyposis, Recurrent sinusitis, Chronic rhinitis OMIM:618695
Bardet-Biedl Syndrome 19
Hyposmia OMIM:615996
Solitary Median Maxillary Central Incisor
Choanal atresia, Anosmia, Midnasal stenosis, Abnormal nasopharynx morphology, Pyriform aperture s... OMIM:147250
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Anosmia, Abnormal nostril morphology, Short nose ORPHA:1295
Parkinson Disease 8, Autosomal Dominant
Hyposmia OMIM:607060
Marcus-Gunn Syndrome
Choanal atresia, Abnormality of the sense of smell ORPHA:91412
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia
Anosmia OMIM:616030
Ciliary Dyskinesia, Primary, 30
Nasal polyposis, Nasal congestion, Respiratory insufficiency due to defective ciliary clearance, ... OMIM:616037
Ventricular Extrasystoles With Syncopal Episodes-Perodactyly-Robin Sequence Syndrome
Abnormality of the sense of smell ORPHA:3201
Ciliary Dyskinesia, Primary, 22
Nasal polyposis, Immotile cilia, Recurrent sinusitis, Absent inner and outer dynein arms, Respira... OMIM:615444
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Anosmia, Azoospermia OMIM:614837
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Anosmia OMIM:614841
Huntington Disease
Abnormality of the sense of smell ORPHA:399
Ciliary Dyskinesia, Primary, 2
Immotile cilia, Nasal polyposis, Ciliary dyskinesia, Absent inner and outer dynein arms OMIM:606763
Johnson Neuroectodermal Syndrome
Choanal atresia, Anosmia, Bulbous nose ORPHA:2316
Neuropathy, Hereditary Sensory And Autonomic, Type Viii
Hyposmia OMIM:616488
Polyendocrine-Polyneuropathy Syndrome
Abnormality of the sense of smell OMIM:616113
Ciliary Dyskinesia, Primary, 5
Nasal polyposis, Recurrent sinusitis, Chronic rhinitis, Respiratory insufficiency due to defectiv... OMIM:608647
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Anosmia, Azoospermia, Hyposmia OMIM:308700
Kleine-Levin Syndrome
Parosmia ORPHA:33543
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Azoospermia, Abnormality of the sense of smell OMIM:228300
Bardet-Biedl Syndrome 17
Anosmia, Hyposmia OMIM:615994
Kallmann Syndrome With Spastic Paraplegia
Anosmia OMIM:308750
Refsum Disease, Classic
Anosmia OMIM:266500
Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy
Anosmia OMIM:601152
Hydrolethalus
Abnormality of the sense of smell ORPHA:2189
Kufor-Rakeb Syndrome
Anosmia, Hyposmia OMIM:606693
Ciliary Dyskinesia, Primary, 15
Abnormal axonemal organization of respiratory motile cilia, Nasal polyposis, Ciliary dyskinesia OMIM:613808
Ciliary Dyskinesia, Primary, 35
Nasal polyposis, Chronic rhinitis OMIM:617092
8Q21.11 Microdeletion Syndrome
Underdeveloped nasal alae, Abnormality of the sense of smell, Wide nose ORPHA:284160
Cleft, Median, Of Upper Lip With Polyps Of Facial Skin And Nasal Mucosa
Nasal polyposis OMIM:155145
Immunodeficiency 13
Recurrent upper respiratory tract infections, Nasal polyposis, Recurrent sinusitis OMIM:615518
Pai Syndrome
Depressed nasal bridge, Nasal polyposis, Midline defect of the nose ORPHA:1993
Refsum Disease
Anosmia ORPHA:773
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Anosmia, Absent nares, Single naris, Hyposmia ORPHA:2250
Mhc Class I Deficiency 1
Nasal polyposis OMIM:604571
Acro-Renal-Mandibular Syndrome
Abnormality of the sense of smell ORPHA:958
Campomelic Dysplasia
Depressed nasal bridge, Abnormality of the sense of smell ORPHA:140
Septo-Optic Dysplasia Spectrum
Anosmia ORPHA:3157
Young-Onset Parkinson Disease
Hyposmia ORPHA:2828
Kallmann Syndrome-Heart Disease Syndrome
Partial anosmia, Total anosmia ORPHA:2326
Waardenburg Syndrome, Type 4C
Anosmia OMIM:613266
Hypogonadotropic Hypogonadism 26 With Or Without Anosmia
Anosmia OMIM:619718
Kallmann Syndrome
Anosmia, Hyposmia ORPHA:478
8P11.2 Deletion Syndrome
Depressed nasal bridge, Anosmia, Azoospermia ORPHA:251066
Gorlin Syndrome
Wide nasal bridge, Abnormality of the sense of smell ORPHA:377
Holoprosencephaly
Choanal atresia, Depressed nasal ridge, Anosmia, Aplasia/Hypoplasia involving the nose, Depressed... ORPHA:2162
Moebius Syndrome
Abnormality of the sense of smell ORPHA:570
Hereditary Late-Onset Parkinson Disease
Hyposmia ORPHA:411602
Waardenburg Syndrome, Type 2E
Anosmia OMIM:611584
Bosma Arhinia Microphthalmia Syndrome
Choanal atresia, Aplasia of the nose, Anosmia OMIM:603457
Superficial Siderosis
Anosmia, Partial anosmia ORPHA:247245
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Anosmia OMIM:609136
Lipoid Proteinosis
Nasal polyposis ORPHA:530
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Hyposmia OMIM:618653
Leopard Syndrome 1
Depressed nasal ridge, Hyposmia OMIM:151100
Peutz-Jeghers Syndrome
Neoplasm of the nose, Nasal polyposis, Abnormality of the nose ORPHA:2869
Meningioma
Abnormality of the sense of smell ORPHA:2495
Occipital Horn Syndrome
Abnormality of the sense of smell ORPHA:198
Amoebiasis Due To Free-Living Amoebae
Hyposmia ORPHA:68
Bardet-Biedl Syndrome
Depressed nasal bridge, Rhinitis, Prominent nasal bridge, Abnormality of the sense of smell ORPHA:110
Primary Ciliary Dyskinesia
Chronic rhinitis, Nasal polyposis, Nasal congestion ORPHA:244
Wilson Disease
Hyposmia OMIM:277900
Charge Syndrome
Depressed nasal bridge, Choanal atresia, Anosmia ORPHA:138
Benign Schwannoma
Nasal polyposis ORPHA:252164
Lacrimoauriculodentodigital Syndrome
Choanal atresia, Anosmia ORPHA:2363
Eosinophilic Granulomatosis With Polyangiitis
Nasal polyposis ORPHA:183
Granulomatosis With Polyangiitis
Concave nasal ridge, Nasal mucosa vasculitis OMIM:608710
Peutz-Jeghers Syndrome
Nasal polyposis OMIM:175200
Charge Syndrome
Choanal atresia, Anosmia OMIM:214800
Cystic Fibrosis
Nasal polyposis OMIM:219700
Cystic Fibrosis
Nasal polyposis ORPHA:586
Sarcoidosis
Abnormal nasal mucosa morphology ORPHA:797

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gfy

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gfy.

No publications found that use IMPC mice or data for Gfy.

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