Bcl2l15 | BCLl2-like 15

GeneMGI:2685412Synonyms: LOC229672, Bfk

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased mean corpuscular hemoglobin1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adult1.25x10-9 
increased circulating total protein level1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adult2.42x10-5 
decreased hemoglobin content1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adult9.01x10-5 
enlarged heart1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased mean corpuscular hemoglobin concentration1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adult5.65x10-10 
abnormal liver morphology1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating bilirubin level1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adult7.13x10-5 
decreased exploration in new environment1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adult9.81x10-7 
increased startle reflex1 supporting datasetBcl2l15tm1b(EUCOMM)HmguhomozygoteEarly adult2.21x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Bcl2l15tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Bcl2l15tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Bcl2l15tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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