Gene: Zyg11b MGI:2685277
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal behavior | Zyg11bem1(IMPC)J | HET | Early adult | 1.30×10-05 | ||
decreased thigmotaxis | Zyg11bem1(IMPC)J | HET | Early adult | 1.30×10-05 | ||
preweaning lethality, incomplete penetrance | Zyg11bem1(IMPC)J | HOM | Early adult | 0.00 | ||
hypoactivity | Zyg11bem1(IMPC)J | HET | Early adult | 2.76×10-07 | ||
decreased body length | Zyg11bem1(IMPC)J | HET | Early adult | 6.45×10-07 |
Human diseases caused by Zyg11b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Zyg11b by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Severe Primary Trimethylaminuria | Low self esteem, Aggressive behavior, Emotional lability, Negative affectivity, Anxiety, Depression | ORPHA:468726 | |
Obsessive-Compulsive Disorder | Skin-picking, Anxiety, Depression | OMIM:164230 | |
Myoclonus-Dystonia Syndrome | Dystonia, Writer's cramp, Torticollis, Personality disorder, Panic attack, Anxiety, Depression | ORPHA:36899 | |
Pandas | Abnormal fear/anxiety-related behavior, Agoraphobia, Claustrophobia, Irritability, Emotional labi... | ORPHA:66624 | |
Dystonia 26, Myoclonic | Torticollis, Laryngeal dystonia, Depression, Anxiety, Blepharospasm | OMIM:616398 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Zyg11btm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Zyg11btm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Zyg11bem1(IMPC)J | Exon Deletion | Mice |
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