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Gene: Zyg11b MGI:2685277

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Gene Summary

Name:
zyg-ll family member B, cell cycle regulator
Synonyms:
LOC242610,  2810482G21Rik,  1110046I03Rik,  D4Mgi23

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased locomotor activity Zyg11bem1(IMPC)J HET   Early adult 2.59×10-07
abnormal behavior Zyg11bem1(IMPC)J HET   Early adult 4.04×10-05
preweaning lethality, incomplete penetrance Zyg11bem1(IMPC)J HOM   Early adult 0.00
decreased thigmotaxis Zyg11bem1(IMPC)J HET   Early adult 4.04×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

3 Images

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X-ray

XRay Images Whole Body Lateral Orientation

3 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

3 Images

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X-ray

XRay Images Skull Lateral Orientation

3 Images

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MicroCT E18.5

Embryo reconstruction

8 Images

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Electroretinography 3

Fundus file

11 Images

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Electrocardiogram (ECG)

Waveform Image

16 Images

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X-ray

XRay Images Whole Body Dorso Ventral

3 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

1 Images

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Human diseases caused by Zyg11b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zyg11b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Severe Primary Trimethylaminuria
Aggressive behavior, Anxiety, Emotional lability, Low self esteem, Depression, Negative affectivity ORPHA:468726
Obsessive-Compulsive Disorder
Skin-picking, Depression, Anxiety OMIM:164230

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zyg11b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zyg11b.

No publications found that use IMPC mice or data for Zyg11b.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Zyg11btm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zyg11btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zyg11bem1(IMPC)J Exon Deletion Mice

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