The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|decreased locomotor activity||Zyg11bem1(IMPC)J||HET||Early adult||2.59×10-07|
|abnormal behavior||Zyg11bem1(IMPC)J||HET||Early adult||4.04×10-05|
|preweaning lethality, incomplete penetrance||Zyg11bem1(IMPC)J||HOM||Early adult||0.00|
|decreased thigmotaxis||Zyg11bem1(IMPC)J||HET||Early adult||4.04×10-05|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Human diseases caused by Zyg11b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Zyg11b by phenotypic similarity.
|Severe Primary Trimethylaminuria||
||Aggressive behavior, Anxiety, Emotional lability, Low self esteem, Depression, Negative affectivity||ORPHA:468726|
||Skin-picking, Depression, Anxiety||OMIM:164230|
Order Mouse and ES Cells
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|MGI Allele||Allele Type||Produced|
|Zyg11btm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|
|Zyg11btm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
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