Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Megf10 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset | Abnormal motor nerve conduction velocity, Facial palsy | OMIM:614399 |
The table below shows human diseases predicted to be associated to Megf10 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Megf10.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Stroke subtype-dependent synapse elimination by reactive gliosis in mice. | Nature communications (November 2021) | Megf10tm1(KOMP)Vlcg | PMC8626497 |
Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact. | eLife (April 2018) | Megf10tm1a(KOMP)Jrs Megf10tm1b(KOMP)Jrs | PMC5931800 |
Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes. | The Journal of neuroscience : the official journal of the Society for Neuroscience (May 2016) | Megf10tm1(KOMP)Vlcg | PMC4863057 |
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. | Nature (November 2013) | Megf10tm1(KOMP)Vlcg | PMC3969024 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Megf10tm42779(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Megf10tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Megf10tm42779(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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