Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
G protein-coupled receptor 55
Synonyms:
LOC227326,  CTFL

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gpr55 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr55 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neutropenia-Monocytopenia-Deafness Syndrome
Abnormality of neutrophils, Abnormal macrophage morphology ORPHA:2690
Papular Xanthoma
Histiocytosis ORPHA:158008
Histiocytosis, Familial Lipochrome
Increased circulating antibody level, Histiocytosis OMIM:235900
Hemophagocytic Lymphohistiocytosis, Familial, 3
Hepatosplenomegaly, Granulocytopenia, Reduced natural killer cell activity, Hemophagocytosis, Anemia OMIM:608898
Eiken Syndrome
Abnormal trabecular bone morphology, Abnormal bone ossification, Limited elbow flexion, Thin bony... ORPHA:79106
Florid Cemento-Osseous Dysplasia
Abnormal bone structure, Mandibular osteomyelitis, Multiple bony cystic lesions, Abnormal trabecu... ORPHA:83451
Sea-Blue Histiocyte Disease
Sea-blue histiocytosis, Splenomegaly, Thrombocytopenia OMIM:269600
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Sparse bone trabeculae, Generalized bone demineralization, Thin bony cortex, Delayed epiphyseal o... OMIM:600785
Angioosteohypotrophic Syndrome
Thin bony cortex, Abnormal trabecular bone morphology ORPHA:75508
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Recurrent fractures, Sparse bone trabeculae, Thin bony cortex, Delayed epiphyseal ossification, R... OMIM:600081
Hypophosphatemic Rickets, X-Linked Recessive
Recurrent fractures, Sparse bone trabeculae, Hypophosphatemic rickets, Osteomalacia, Thin bony co... OMIM:300554
Osteopetrosis, Autosomal Recessive 7
Decreased circulating IgG level, Decreased circulating total IgM, Abnormal trabecular bone morpho... OMIM:612301
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Recurrent fractures, Sparse bone trabeculae, Hypophosphatemic rickets, Thin bony cortex, Delayed ... OMIM:241530
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Recurrent fractures, Sparse bone trabeculae, Thin bony cortex, Delayed epiphyseal ossification, R... OMIM:264700
Autosomal Recessive Hypophosphatemic Rickets
Pseudo-fractures, Craniosynostosis, Increased bone mineral density, Abnormal trabecular bone morp... ORPHA:289176
Dent Disease 1
Recurrent fractures, Sparse bone trabeculae, Osteomalacia, Thin bony cortex, Delayed epiphyseal o... OMIM:300009
Vitamin D-Dependent Rickets, Type 2A
Recurrent fractures, Sparse bone trabeculae, Thin bony cortex, Delayed epiphyseal ossification, R... OMIM:277440
Hypocalcemic Vitamin D-Dependent Rickets
Sparse bone trabeculae, Increased susceptibility to fractures, Osteomalacia, Thin bony cortex, De... ORPHA:289157
Rothmund-Thomson Syndrome
Osteopenia, Abnormal trabecular bone morphology, Leukemia, Increased susceptibility to fractures,... ORPHA:2909
Rothmund-Thomson Syndrome Type 2
Finger symphalangism, Osteopenia, Abnormal trabecular bone morphology, Leukemia, Neutropenia, Ane... ORPHA:221016
Rothmund-Thomson Syndrome Type 1
Finger symphalangism, Osteopenia, Abnormal trabecular bone morphology, Leukemia, Neutropenia, Ane... ORPHA:221008
Dent Disease
Recurrent fractures, Sparse bone trabeculae, Osteomalacia, Thin bony cortex, Delayed epiphyseal o... ORPHA:1652

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr55

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr55.

No publications found that use IMPC mice or data for Gpr55.

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MGI Allele Allele Type Produced
Gpr55tm368899(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Gpr55em1(IMPC)Mbp Intra-exon deletion Mice
Gpr55tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Gpr55tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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