Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
PR domain containing 6
Synonyms:
LOC225518,  PRISM

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Prdm6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Prdm6 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Patent Ductus Arteriosus 3
Patent ductus arteriosus OMIM:617039

The table below shows human diseases predicted to be associated to Prdm6 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Congenital Heart Block
Hydrops fetalis, Patent foramen ovale, Pleural effusion, Pericardial effusion, Patent ductus arte... ORPHA:60041
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Peripheral Cone Dystrophy
Pallor OMIM:609021
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Hb Bart'S Hydrops Fetalis
Polyhydramnios, Hydrops fetalis, Pericarditis, Pallor, Oligohydramnios ORPHA:163596
Acute Peripheral Arterial Occlusion
Pallor, Limb muscle weakness ORPHA:90064
Benign Paroxysmal Torticollis Of Infancy
Pallor, Torticollis ORPHA:71518
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor, Hypertrophic cardiomyopathy OMIM:612989
Dermatitis, Atopic
Pallor, Facial erythema, Dry skin OMIM:603165
Breath-Holding Spells
Pallor OMIM:607578
Myopathic Ehlers-Danlos Syndrome
Ankle flexion contracture, Weakness of facial musculature, Foot joint contracture, Congenital mus... ORPHA:536516
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Ragged-red muscle fibers, Generalized amyotrophy, Pallor, Hypertrophic cardiomyopathy OMIM:613561
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Pallor ORPHA:2786
Primary Lateral Sclerosis, Juvenile
Pallor, Spasticity of facial muscles OMIM:606353
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Lymphatic Malformation 8
Stillbirth, Polyhydramnios, Pleural effusion, Generalized edema, Pericardial effusion, Nonimmune ... OMIM:618773
Optic Atrophy 1
Pallor OMIM:165500
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
American Trypanosomiasis
Myocarditis, Cardiomyopathy, Periorbital edema, Edema, Pallor ORPHA:3386
Thiamine-Responsive Megaloblastic Anemia Syndrome
Atrial septal defect, Ventricular septal defect, Pallor ORPHA:49827
Hemoglobin D Disease
Pallor ORPHA:90039
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Cyclic Vomiting Syndrome
Pallor, Cardiomyopathy OMIM:500007
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Rheumatic Fever
Myocarditis, Abnormal aortic valve morphology, Abnormal heart valve morphology, Abnormal mitral v... ORPHA:3099
Hyperinsulinism Due To Ucp2 Deficiency
Pallor, Hypertrophic cardiomyopathy ORPHA:276556
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor ORPHA:276608
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Pallor, Hypertrophic cardiomyopathy ORPHA:276575
Beta-Thalassemia
Pallor, Skin ulcer, Hypertrophic cardiomyopathy ORPHA:848
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema, Cerebral edema ORPHA:439218
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Pallor, Hypertrophic cardiomyopathy ORPHA:276580
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Retinitis Pigmentosa 51
Pallor OMIM:613464
Evans Syndrome
Petechiae, Pallor ORPHA:1959
Lymphatic Malformation 7
Pulmonary edema, Facial edema, Chylothorax, Lymphedema, Pleural effusion, Ascites, Increased nuch... OMIM:617300
Deafness-Lymphedema-Leukemia Syndrome
Pallor, Lymphedema ORPHA:3226
Hyperinsulinism Due To Hnf1A Deficiency
Pallor ORPHA:324575
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Ragged-red muscle fibers, Generalized limb muscle atrophy, Scapular winging, Pallor OMIM:600462
Anemia, Congenital Dyserythropoietic, Type Ib
Pallor OMIM:615631
Leishmaniasis
Pallor, Skin ulcer ORPHA:507
Irida Syndrome
Pallor ORPHA:209981
Primary Myelofibrosis
Petechiae, Purpura, Ecchymosis, Pallor ORPHA:824
Dravet Syndrome
Pallor ORPHA:33069
Pyruvate Kinase Deficiency Of Red Cells
Pallor, Nonimmune hydrops fetalis OMIM:266200
Fanconi Anemia, Complementation Group I
Atrial septal defect, Patent foramen ovale, Ventricular septal defect, Pallor OMIM:609053
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Idiopathic Pulmonary Hemosiderosis
Cardiomegaly, Pallor ORPHA:99931
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Pallor OMIM:611590
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Myelofibrosis
Purpura, Pallor OMIM:254450
Cold Agglutinin Disease
Pallor ORPHA:56425
Retinitis Pigmentosa 75
Pallor OMIM:617023
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Beta-Ketothiolase Deficiency
Edema, Pallor, Dehydration ORPHA:134
Waldenström Macroglobulinemia
Purpura, Pleural effusion, Periorbital edema, Pallor, Pedal edema ORPHA:33226
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
3-Hydroxy-3-Methylglutaric Aciduria
Edema, Dilated cardiomyopathy, Dehydration, Pallor ORPHA:20
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Edema, Anemic pallor ORPHA:329971
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Sepsis In Premature Infants
Petechiae, Purpura, Edema, Pallor ORPHA:90051
Hereditary Folate Malabsorption
Pallor, Skeletal muscle atrophy ORPHA:90045
Myopathy, Mitochondrial, And Ataxia
Increased variability in muscle fiber diameter, Distal amyotrophy, Pallor OMIM:617675
Anemia, Hypochromic Microcytic, With Iron Overload 2
Pallor OMIM:615234
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Elliptocytosis 1
Pallor OMIM:611804
Tay-Sachs Disease
Pallor OMIM:272800
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Pallor ORPHA:263455
Hereditary Spherocytosis
Pallor, Restrictive cardiomyopathy, Skin ulcer ORPHA:822
Fumarase Deficiency
Perimembranous ventricular septal defect, Polyhydramnios, Pallor, Ascites OMIM:606812
Refractory Anemia With Excess Blasts
Anemic pallor, Pedal edema ORPHA:86839
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor, Dehydration OMIM:246450
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Dominant Beta-Thalassemia
Hypoplasia of the musculature, Dilated cardiomyopathy, Skin ulcer, Pallor ORPHA:231226
Senior-Loken Syndrome 8
Pallor OMIM:616307
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Congenital Dyserythropoietic Anemia Type Iii
Pallor ORPHA:98870
Alternating Hemiplegia Of Childhood
Pallor, Dehydration, Cardiomyopathy, Facial hypotonia ORPHA:2131
Letterer-Siwe Disease
Pallor OMIM:246400
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Beta-Thalassemia Major
Hypoplasia of the musculature, Dilated cardiomyopathy, Skin ulcer, Pallor ORPHA:231214
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Pearson Marrow-Pancreas Syndrome
Pallor, Hydrops fetalis, Dehydration, Erythema OMIM:557000
Idiopathic Hypereosinophilic Syndrome
Myocardial eosinophilic infiltration, Pleural effusion, Angioedema, Pallor, Skeletal muscle atrop... ORPHA:3260
Von Hippel-Lindau Disease
Myocarditis, Distal lower limb muscle weakness, Cardiomyopathy, Upper limb muscle weakness, Pallo... ORPHA:892
Anemia, Sideroblastic, And Spinocerebellar Ataxia
Pallor OMIM:301310
Infection-Related Hemolytic Uremic Syndrome
Myocarditis, Pleural empyema, Generalized edema, Edema, Pallor ORPHA:544482
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor ORPHA:331206
Histiocytoid Cardiomyopathy
Cardiomegaly, Pulmonary edema, Pallor, Ventricular septal defect ORPHA:137675
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Pallor ORPHA:300298
Imerslund-Gräsbeck Syndrome
Pallor ORPHA:35858
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Adenohypophysitis
Pallor ORPHA:95512
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Aregenerative Anemia
Pallor ORPHA:101096
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Esophageal Atresia
Polyhydramnios, Pallor, Ventricular septal defect, Tetralogy of Fallot ORPHA:1199
Panhypophysitis
Pallor ORPHA:95513
Sheehan Syndrome
Pallor, Dry skin ORPHA:91355
Pituitary Apoplexy
Pallor ORPHA:95613
Hereditary Pheochromocytoma-Paraganglioma
Pallor ORPHA:29072
Degcags Syndrome
Polyhydramnios, Dysplastic pulmonary valve, Patent foramen ovale, Pulmonic stenosis, Pallor, Diap... OMIM:619488
Diamond-Blackfan Anemia
Abnormality of the thenar eminence, Pallor, Abnormal heart morphology, Nonimmune hydrops fetalis,... ORPHA:124
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor ORPHA:98849
Congenital Total Pulmonary Venous Return Anomaly
Infracardiac total anomalous pulmonary venous connection, Atrial situs ambiguous, Transposition o... ORPHA:99125
Prolactinoma
Pallor ORPHA:2965
Incontinentia Pigmenti
Pallor, Erythema OMIM:308300
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Pallor OMIM:277400
Diamond-Blackfan Anemia 1
Spina bifida occulta, Tricuspid stenosis, Pallor, Atrial septal defect, Ventricular septal defect... OMIM:105650
Fanconi Anemia, Complementation Group D2
Anemic pallor, Abnormal heart morphology, Patent ductus arteriosus OMIM:227646
Fanconi Anemia, Complementation Group E
Anemic pallor, Abnormal heart morphology OMIM:600901
Fanconi Anemia, Complementation Group A
Anemic pallor, Abnormal heart morphology OMIM:227650
Fanconi Anemia, Complementation Group C
Anemic pallor, Ventricular septal defect, Flexion contracture OMIM:227645
Tsh-Secreting Pituitary Adenoma
Pericardial effusion, Pallor ORPHA:91347
Neuroblastoma
Anemic pallor ORPHA:635
Multiple Endocrine Neoplasia Type 2
Pallor, Proximal amyotrophy ORPHA:653
Autosomal Recessive Malignant Osteopetrosis
Pallor, Abnormal pulmonary valve morphology ORPHA:667
Patent Ductus Arteriosus 3
Patent ductus arteriosus OMIM:617039
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Muscular dystrophy, Pallor OMIM:253280
Goodpasture Syndrome
Pallor OMIM:233450
Homozygous Familial Hypercholesterolemia
Myocardial steatosis, Tendon xanthomatosis, Abnormal tendon morphology ORPHA:391665

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prdm6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prdm6.

No publications found that use IMPC mice or data for Prdm6.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Prdm6tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Prdm6tm96457(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Prdm6tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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