Gene Summary

leucine zipper, putative tumor suppressor 1
F37,  PSD-Zip70,  FEZ1

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

DSS Histology


8 Images

Legacy Phenotype Associated Images

Human diseases caused by Lzts1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lzts1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Esophageal Cancer
Esophageal carcinoma OMIM:133239

The table below shows human diseases predicted to be associated to Lzts1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Rhabdoid Tumor Predisposition Syndrome 2
Carcinoma, Neoplasm of the central nervous system OMIM:613325
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Li-Fraumeni Syndrome 2
Sarcoma, Breast carcinoma, Meningioma, Stomach cancer, Glioma OMIM:609265
Tumor Predisposition Syndrome
Lung adenocarcinoma, Cutaneous melanoma, Meningioma, Uveal melanoma, Renal cell carcinoma OMIM:614327
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Myofibromatosis, Infantile, 1
Fibroma, Myofibromatosis OMIM:228550
Li-Fraumeni Syndrome
Prostate neoplasm, Adrenocortical carcinoma, Colon cancer, Breast carcinoma, Osteosarcoma, Lung a... OMIM:151623
Lung Cancer
Non-small cell lung carcinoma, Lung adenocarcinoma, Alveolar cell carcinoma OMIM:211980
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Cerebral Sarcoma
Fibrosarcoma, Neoplasm OMIM:117600
Melanoma-Pancreatic Cancer Syndrome
Squamous cell carcinoma, Sarcoma, Melanoma, Oropharyngeal squamous cell carcinoma, Pancreatic ade... OMIM:606719
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia
Carcinoma OMIM:603641
Muir-Torre Syndrome
Benign genitourinary tract neoplasm, Adenoma sebaceum, Carcinoma, Colon cancer, Breast carcinoma,... OMIM:158320
Multiple Fibroadenomas Of The Breast
Fibroadenoma of the breast OMIM:615554
Enchondromatosis, Multiple, Ollier Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:166000
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Desmoid Disease, Hereditary
Desmoid tumors, Colon cancer OMIM:135290
Colorectal Cancer, Susceptibility To, 10
Colorectal polyposis, Endometrial carcinoma, Carcinoma OMIM:612591
Undifferentiated Pleomorphic Sarcoma
Soft tissue sarcoma ORPHA:2023
Chondrosarcoma, Extraskeletal Myxoid
Chondrosarcoma OMIM:612237
Chondrosarcoma OMIM:215300
Nut Midline Carcinoma
Ewing sarcoma, Squamous cell carcinoma, Leukemia, Neuroblastoma, Neoplasm, Oropharyngeal squamous... ORPHA:443167
Epidermodysplasia Verruciformis, Susceptibility To, 3
Basal cell carcinoma, Squamous cell carcinoma OMIM:618267
Multiple Enchondromatosis, Maffucci Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:614569
Acquired Ichthyosis
Lymphoma, Sarcoma, Multiple myeloma, Neoplasm ORPHA:454
Bazex Syndrome
Liposarcoma, Lung adenocarcinoma, Neoplasm, Nail dystrophy, Yellow nails ORPHA:166113
Cheilitis Glandularis
Abnormal salivary gland morphology, Squamous cell carcinoma, Neoplasm ORPHA:1221
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Maffucci Syndrome
Multiple enchondromatosis, Sarcoma, Goiter, Neoplasm of the adrenal cortex, Chondrosarcoma, Heman... ORPHA:163634
Cheilitis Glandularis
Squamous cell carcinoma, Carcinoma OMIM:118330
Dermatofibrosarcoma Protuberans
Fibrosarcoma, Neoplasm of the skin ORPHA:31112
Ollier Disease
Visceral angiomatosis, Multiple enchondromatosis, Sarcoma, Lymphangioma, Chondrosarcoma, Neoplasm... ORPHA:296
Progressive Osseous Heteroplasia
Abnormality of the parathyroid gland, Sarcoma ORPHA:2762
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Non-Hodgkin lymphoma, Squamous cell carcinoma, Colon cancer, Breast carcinoma, Neoplasm of the re... ORPHA:454840
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Multinodular goiter, Squamous cell carcinoma, Alopecia, Nail dystrophy OMIM:618373
Fanconi Renotubular Syndrome 5
Emphysema, Lung adenocarcinoma, Pulmonary fibrosis OMIM:618913
Paraneoplastic Pemphigus
Sarcoma, B-cell lymphoma, Thymoma ORPHA:63455
Infantile Myofibromatosis
Sarcoma, Fibroma, Abnormal hair morphology, Gingival fibromatosis, Tracheoesophageal fistula, Ben... ORPHA:2591
Pancreatic Cancer, Susceptibility To, 5
Pancreatic adenocarcinoma, Melanoma OMIM:618680
Mast Cell Sarcoma
Hepatomegaly, Sarcoma ORPHA:66661
Sarcoma ORPHA:69078
Asbestos Intoxication
Pleural thickening, Lung adenocarcinoma, Interlobular septal thickening, Pulmonary fibrosis, Mali... ORPHA:2302
Large Congenital Melanocytic Nevus
Generalized hirsutism, Sarcoma, Rhabdomyosarcoma, Cutaneous melanoma, Neoplasm, Neoplasm of the skin ORPHA:626
Familial Adenomatous Polyposis 1
Multiple lipomas, Hepatoblastoma, Papillary thyroid carcinoma, Adrenocortical carcinoma, Colon ca... OMIM:175100
Multiple Endocrine Neoplasia, Type Iv
Renal angiomyolipoma, Carcinoma, Parathyroid adenoma, Pancreatic endocrine tumor, Elevated circul... OMIM:610755
Desmoplastic Small Round Cell Tumor
Ileus, Sarcoma, Testicular neoplasm, Hepatomegaly, Ovarian neoplasm, Neoplasm of the central nerv... ORPHA:83469
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Schöpf-Schulz-Passarge Syndrome
Squamous cell carcinoma, Aplasia/Hypoplasia of the eyebrow, Ovarian neoplasm, Basal cell carcinom... ORPHA:50944
Hyperkeratosis Lenticularis Perstans
Basal cell carcinoma, Squamous cell carcinoma ORPHA:409
Apc-Related Attenuated Familial Adenomatous Polyposis
Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomatous colonic polyp... ORPHA:247806
Hereditary Breast And Ovarian Cancer Syndrome
Primary peritoneal carcinoma, Melanoma, Breast carcinoma, Ovarian neoplasm, Prostate cancer, Neop... ORPHA:145
Schopf-Schulz-Passarge Syndrome
Squamous cell carcinoma, Apocrine hidrocystoma, Sparse hair, Basal cell carcinoma, Poroma OMIM:224750
Mismatch Repair Cancer Syndrome 1
Plexiform neurofibroma, Non-Hodgkin lymphoma, Neuroblastoma, Rhabdomyosarcoma, Leukemia, Lymphoma... OMIM:276300
Cowden Syndrome 7
Papillary thyroid carcinoma, Goiter, Papilloma, Breast carcinoma, Hemangioma, Trichilemmoma, Duct... OMIM:616858
Rhabdoid Tumor
Sarcoma, Renal neoplasm, Neoplasm of the liver, Neoplasm of the central nervous system ORPHA:69077
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Memory impairment, Inertia, Anxiety, Dementia, Motor deterioration, Inappropriate behavior, Apath... ORPHA:412066
Yellow Nail Syndrome
Renal neoplasm, Sarcoma, Biliary tract neoplasm, Neoplasm, Bronchiectasis, Recurrent respiratory ... ORPHA:662
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Gist-Plus Syndrome
Gastrointestinal stroma tumor, Intestinal polyposis, Intussusception OMIM:175510
Punctate Palmoplantar Keratoderma Type 1
Esophageal neoplasm, Squamous cell carcinoma, Melanoma, Brain neoplasm, Breast carcinoma, Adenoca... ORPHA:79501
Palmoplantar Carcinoma, Multiple Self-Healing
Nail dystrophy, Squamous cell carcinoma, Carcinoma OMIM:615225
Gastrointestinal Stromal Tumor
Gastrointestinal stroma tumor, Esophageal neoplasm, Neoplasm of the gastrointestinal tract, Abnor... ORPHA:44890
Polymerase Proofreading-Related Adenomatous Polyposis
Colorectal polyposis, Breast carcinoma, Brain neoplasm, Neoplasm of the rectum, Adenocarcinoma of... ORPHA:447877
Gastrointestinal Stromal Tumor
Gastrointestinal stroma tumor, Neurofibromas, Intestinal obstruction OMIM:606764
Exostoses, Multiple, Type Ii
Chondrosarcoma, Scapular exostoses, Multiple exostoses, Pelvic bone exostoses, Rib exostoses OMIM:133701
Exostoses, Multiple, Type I
Chondrosarcoma, Scapular exostoses, Multiple exostoses, Pelvic bone exostoses, Rib exostoses OMIM:133700
Gardner Syndrome
Hepatoblastoma, Adrenocortical carcinoma, Colon cancer, Osteoma, Lipoma, Pilomatrixoma, Adenomato... ORPHA:79665
Li-Fraumeni Syndrome
Central primitive neuroectodermal tumor, Neoplasm of the gastrointestinal tract, Adrenocortical c... ORPHA:524
Epidermodysplasia Verruciformis, X-Linked
Squamous cell carcinoma of the skin, Verrucae OMIM:305350
Pancreatic Cancer
Neoplasm of the pancreas OMIM:260350
Attenuated Familial Adenomatous Polyposis
Colorectal polyposis, Thyroid adenoma, Fibroma, Papilloma, Adenocarcinoma of the colon, Uterine l... ORPHA:220460
Adrenocortical Carcinoma
Lung adenocarcinoma, Hypertrichosis, Adrenocorticotropic hormone deficiency, Adrenocortical carci... ORPHA:1501
Legius Syndrome
Multiple lipomas, Ovarian neoplasm, Desmoid tumors, Non-small cell lung carcinoma, Acute monocyti... ORPHA:137605
Hereditary Mixed Polyposis Syndrome
Colorectal polyposis, Neoplasm of the gastrointestinal tract, Colon cancer, Intussusception, Juve... ORPHA:157794
Mutyh-Related Attenuated Familial Adenomatous Polyposis
Colorectal polyposis, Adenocarcinoma of the colon, Adenomatous colonic polyposis, Large intestina... ORPHA:247798
Paragangliomas 4
Gastrointestinal stroma tumor, Chemodectoma, Paraganglioma, Neuroblastoma, Paraganglioma of head ... OMIM:115310
Xeroderma Pigmentosum Variant
Basal cell carcinoma, Squamous cell carcinoma, Melanoma ORPHA:90342
Desmoid Tumor
Fibroma, Desmoid tumors, Neoplasm of the skin, Malabsorption, Intestinal polyposis, Intestinal ob... ORPHA:873
Acromesomelic Dysplasia, Grebe Type
Sarcoma ORPHA:2098
Pancreatic Cancer, Susceptibility To, 1
Pancreatic adenocarcinoma OMIM:606856
Ovarian Fibrothecoma
Abnormality of the ovary, Pleural effusion, Diffuse leiomyomatosis, Ovarian fibroma, Hirsutism, F... ORPHA:314478
Pancreatic Cancer, Susceptibility To, 2
Neoplasm of the pancreas OMIM:613347
Familial Adenomatous Polyposis
Hepatoblastoma, Neoplasm of the gastrointestinal tract, Colon cancer, Osteoma, Neoplasm of the ga... ORPHA:733
Opsoclonus-Myoclonus Syndrome
Neuroblastoma, Melanoma, Breast carcinoma, Neoplasm, Neoplasm of the lung, Small cell lung carcin... ORPHA:1183
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Hepatic failure, Squamous cell carcinoma, Multiple myeloma, Hematological neoplasm, Colon cancer,... ORPHA:158057
Ichthyosis, Hystrix-Like, With Deafness
Squamous cell carcinoma, Absent eyelashes, Scarring alopecia of scalp, Sparse eyebrow, Sparse eye... OMIM:602540
Oncogenic Osteomalacia
Giant cell tumor of bone, Carcinoma, Neurofibromas, Osteosarcoma, Neoplasm of head and neck, Neop... ORPHA:352540
Carney-Stratakis Syndrome
Gastrointestinal stroma tumor, Paraganglioma, Intestinal obstruction ORPHA:97286
Cowden Syndrome 1
High palate, Subcutaneous lipoma, Carcinoma, Breast carcinoma, Colonic diverticula, Ovarian carci... OMIM:158350
Werner Syndrome
Aplasia/Hypoplasia of the testes, Cutaneous melanoma, Meningioma, Neoplasm of the lung, Neoplasm ... ORPHA:902
Gastrointestinal stroma tumor, Lymphoma, Breast carcinoma, Lung adenocarcinoma, Neoplasm, Recurre... ORPHA:221
Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Sarcoma, Polycystic ovaries, Goiter, Neoplasm of the breast, Testicular neoplasm, Neoplasm of the... ORPHA:457059
Combined Immunodeficiency Due To Dock8 Deficiency
Squamous cell carcinoma, Pneumonia, Verrucae, Recurrent respiratory infections, Recurrent sinusit... ORPHA:217390
Cancer-Associated Retinopathy
Colon cancer, Thymoma, Neoplasm of the breast, Testicular neoplasm, Uterine neoplasm, Small cell ... ORPHA:71505
Oral Submucous Fibrosis
Oropharyngeal squamous cell carcinoma ORPHA:357154
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Decreased testicular size, Nail dystrophy, Laryngeal carcinoma, Carcinoma OMIM:610644
Ewing sarcoma, Leukemia, Lymphoma, Pinealoma, Osteosarcoma, Retinoblastoma, Cleft palate OMIM:180200
Terminal Osseous Dysplasia
Fibroma, Cleft palate OMIM:300244
Chronic leukemia, Hepatomegaly, Sarcoma, Acute leukemia ORPHA:98292
Milroy Disease
Angiosarcoma, Hydrocele testis, Neoplasm of the skin ORPHA:79452
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Epidermodysplasia Verruciformis
Squamous cell carcinoma, Verrucae ORPHA:302
Progressive Supranuclear Palsy
Cognitive impairment, Memory impairment, Dementia, Abnormal synaptic transmission, Depression, Im... ORPHA:683
Familial Multinodular Goiter
Colorectal polyposis, Medulloepithelioma, Sertoli cell neoplasm, Testicular seminoma, Ovarian neo... ORPHA:276399
Tuberous Sclerosis 2
Renal angiomyolipoma, Cortical tubers, Adenoma sebaceum, Cardiac rhabdomyoma, Pulmonary lymphangi... OMIM:613254
Lambert-Eaton Myasthenic Syndrome
Xerostomia, Small cell lung carcinoma ORPHA:43393
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma
Premature graying of hair, Histiocytoma, Osteosarcoma, Fibrosarcoma OMIM:112250
Xeroderma Pigmentosum, Variant Type
Basal cell carcinoma, Squamous cell carcinoma, Cutaneous melanoma OMIM:278750
Ewing sarcoma, Leukemia, Rhabdomyosarcoma, Melanoma, Lymphoma, Osteosarcoma, Leiomyosarcoma, Pine... ORPHA:790
Carney Triad
Gastrointestinal stroma tumor, Paraganglioma, Leiomyosarcoma, Pheochromocytoma, Adrenocortical ad... ORPHA:139411
Necrobiosis Lipoidica
Squamous cell carcinoma ORPHA:542592
Monosomy 22
High palate, Schwannoma, Sarcoma, Hepatosplenomegaly, Meningioma, Gonadal neoplasm, Synophrys, Ap... ORPHA:96123
Juvenile Polyposis Syndrome
Colon cancer, Intussusception, Rectal prolapse, Duodenal adenocarcinoma, Multiple gastric polyps,... OMIM:174900
Pleuropulmonary Blastoma
Rhabdomyosarcoma, Medulloblastoma, Pleuropulmonary blastoma OMIM:601200
Lymphedema-Distichiasis Syndrome
Patent ductus arteriosus, Distichiasis, Abnormality of the pulmonary vasculature, Fibrosarcoma, C... ORPHA:33001
Neurofibromatosis Type 1
Multiple lipomas, Plexiform neurofibroma, Neoplasm of the gastrointestinal tract, Leukemia, Sarco... ORPHA:636
Common Variable Immunodeficiency
Emphysema, Gastrointestinal stroma tumor, Abnormality of the liver, Pneumonia, Lymphoma, Anal atr... ORPHA:1572
Cowden Syndrome
Cavernous hemangioma, Meningioma, Lipoma, Macroglossia, Neoplasm of the skin, Endometrial carcino... ORPHA:201
Multiple Endocrine Neoplasia Type 4
Pituitary corticotropic cell adenoma, Pulmonary carcinoid tumor, Thymoma, Esophagitis, Neuroendoc... ORPHA:276152
Turcot Syndrome With Polyposis
Hepatoblastoma, Colon cancer, Lymphoma, Pilomatrixoma, Adenomatous colonic polyposis, Glioma, Pap... ORPHA:99818
Recurrent Respiratory Papillomatosis
Abnormal lung morphology, Recurrent pneumonia, Recurrent upper respiratory tract infections, Squa... ORPHA:60032
Meige Disease
Angiosarcoma, Pleural effusion ORPHA:90186
Aicardi Syndrome
Hiatus hernia, Hepatoblastoma, Teratoma, Recurrent pneumonia, Carcinoma, Sparse lateral eyebrow, ... OMIM:304050
Dyskeratosis Congenita, X-Linked
Oral leukoplakia, Premature graying of hair, Squamous cell carcinoma, Carcinoma, Cryptorchidism, ... OMIM:305000
Carney Complex
Testicular adrenal rest tumor, Neoplasm of the breast, Ovarian carcinoma, Leydig cell neoplasia, ... ORPHA:1359
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Aspiration pneumonia, Esophageal neoplasm, Fibroma, Vulvar neoplasm, Uterine neoplasm, Diffuse le... ORPHA:1018
Hyper-Ige Recurrent Infection Syndrome 2, Autosomal Recessive
Recurrent pneumonia, Squamous cell carcinoma, Bronchiectasis, Recurrent sinusitis, Eosinophilic i... OMIM:243700
Neuroendocrine Neoplasm Of Appendix
Intestinal carcinoid, Adrenocorticotropic hormone excess, Appendiceal mucinous neoplasm, Mechanic... ORPHA:100079
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Squamous cell carcinoma, Nail dystrophy, Esophageal stricture, Alopecia, Abnormal esophagus morph... OMIM:226600
Papillon-Lefèvre Syndrome
Generalized hirsutism, Squamous cell carcinoma, Hypertrichosis, Melanoma, Sparse body hair, Nail ... ORPHA:678
Fanconi Anemia, Complementation Group E
Cryptorchidism, Prolonged G2 phase of cell cycle, Leukemia OMIM:600901
Adenocarcinoma Of The Anal Canal
Anal stenosis, Neoplasm of the rectum, Neoplasm of the liver, Rectal prolapse, Neoplasm of the sk... ORPHA:424016
Fanconi Anemia, Complementation Group A
Cryptorchidism, Prolonged G2 phase of cell cycle, Leukemia OMIM:227650
Hyperparathyroidism-Jaw Tumor Syndrome
Renal hamartoma, Fibroma, Testicular neoplasm, Parathyroid adenoma, Primary hyperparathyroidism, ... ORPHA:99880
Pilomatrixoma OMIM:132600
Parathyroid Carcinoma
Parathyroid carcinoma, Renal hamartoma, Fibroma, Testicular neoplasm, Primary hyperparathyroidism... ORPHA:143
Cushing Syndrome Due To Ectopic Acth Secretion
Pulmonary carcinoid tumor, Medullary thyroid carcinoma, Atypical pulmonary carcinoid tumor, Spars... ORPHA:99889
Fanconi Anemia, Complementation Group P
Cryptorchidism, Squamous cell carcinoma OMIM:613951
Bloom Syndrome
Recurrent upper respiratory tract infections, Squamous cell carcinoma, Leukemia, Lymphoma, Crypto... OMIM:210900
Fanconi Anemia, Complementation Group C
Cryptorchidism, Prolonged G2 phase of cell cycle, Leukemia OMIM:227645
Fanconi Anemia, Complementation Group D2
Leukemia, Patent ductus arteriosus, Cryptorchidism, Tracheoesophageal fistula, Esophageal atresia... OMIM:227646
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Dominant
Oral leukoplakia, Squamous cell carcinoma, Trichiasis, Sparse eyebrow, Nail dystrophy, Furrowed t... OMIM:148210
Trichothiodystrophy 1, Photosensitive
Brittle hair, Squamous cell carcinoma, Pili torti, Fine hair, Trichorrhexis nodosa, Nail dystroph... OMIM:601675
Tuberous Sclerosis Complex
Renal angiomyolipoma, Cortical tubers, Cardiac rhabdomyoma, Retinal astrocytic hamartoma, Pulmona... ORPHA:805
Squamous cell carcinoma, Abnormal lung morphology, Multiple cutaneous malignancies ORPHA:182
Multiple Endocrine Neoplasia Type 1
Intestinal carcinoid, Pituitary corticotropic cell adenoma, Pulmonary carcinoid tumor, Adrenocort... ORPHA:652
17Q11 Microdeletion Syndrome
Gastrointestinal stroma tumor, Cerebellar glioma, Plexiform neurofibroma, Schwannoma, Leukemia, R... ORPHA:97685
Esophageal Cancer
Esophageal carcinoma OMIM:133239
Sotos Syndrome
Neuroblastoma, Pulmonary bleb, Patent ductus arteriosus, Sparse anterior scalp hair, Cryptorchidi... ORPHA:821
Rothmund-Thomson Syndrome, Type 2
Premature graying of hair, High palate, Squamous cell carcinoma, Cryptorchidism, Absent eyelashes... OMIM:268400
Rothmund-Thomson Syndrome Type 2
High palate, Squamous cell carcinoma, Leukemia, Melanoma, Lymphoma, Cryptorchidism, Aplasia/Hypop... ORPHA:221016
Rothmund-Thomson Syndrome Type 1
Squamous cell carcinoma, Leukemia, Melanoma, Cryptorchidism, Aplasia/Hypoplasia of the eyebrow, O... ORPHA:221008
Primary Sclerosing Cholangitis
Cholelithiasis, Adenocarcinoma of the large intestine, Portal hypertension, Hepatosplenomegaly, C... ORPHA:171
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion
High palate, Schwannoma, Subcutaneous neurofibromas, Neurofibrosarcoma, Spinal neurofibromas, Lis... ORPHA:363700
Kindler Epidermolysis Bullosa
Squamous cell carcinoma, Colitis, Neoplasm of the urethra, Inflammation of the large intestine, E... ORPHA:2908


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lzts1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lzts1.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Lzts1em1(IMPC)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Lzts1em1(IMPC)Wtsi PMC6671969

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MGI Allele Allele Type Produced
Lzts1em1(IMPC)Wtsi Deletion Mice
Lzts1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Lzts1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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