Gene: Asxl1

Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Asxl1tm1a(EUCOMM)Wtsi HOM n/a 0.00
corneal opacity Asxl1tm1a(EUCOMM)Wtsi HET postnatal 2.40×10-05
abnormal cornea morphology Asxl1tm1a(EUCOMM)Wtsi HET postnatal 2.08×10-05
increased circulating iron level Asxl1tm1a(EUCOMM)Wtsi HET postnatal 2.86×10-06
vertebral fusion Asxl1tm1a(EUCOMM)Wtsi HET postnatal 1.23×10-05
increased mean corpuscular hemoglobin concentration Asxl1tm1a(EUCOMM)Wtsi HET postnatal 3.53×10-05
decreased hemoglobin content Asxl1tm1a(EUCOMM)Wtsi HET postnatal 5.92×10-07
impaired pupillary reflex Asxl1tm1a(EUCOMM)Wtsi HET postnatal 2.93×10-05
decreased circulating triglyceride level Asxl1tm1a(EUCOMM)Wtsi HET postnatal 6.69×10-05
increased blood uric acid level Asxl1tm1a(EUCOMM)Wtsi HET postnatal 3.37×10-06
decreased circulating glucose level Asxl1tm1a(EUCOMM)Wtsi HET postnatal 1.01×10-05
decreased circulating free fatty acid level Asxl1tm1a(EUCOMM)Wtsi HET postnatal 5.19×10-05
increased startle reflex Asxl1tm1a(EUCOMM)Wtsi HET postnatal 6.22×10-05
decreased B cell number Asxl1tm1a(EUCOMM)Wtsi HET postnatal 3.06×10-05
increased circulating alkaline phosphatase level Asxl1tm1a(EUCOMM)Wtsi HET postnatal 4.56×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584)  (4/4) N/A
Aorta 4 No N/A
Blood vessel 4 No  (2/4) N/A
Bone 4 No  (3/4) N/A
Brain 4 No  (4/4) N/A
Brainstem 4 No N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No  (4/4) N/A
Cerebellum 4 No N/A
Cerebral cortex 4 No N/A
Eye 4 No  (4/4) N/A
Gall bladder 4 No  (2/4) N/A
Heart 4 No  (4/4) N/A
Hippocampus 4 No N/A
Hypothalamus 4 No N/A
Kidney 4 No  (18/584)  (4/4) N/A
Large intestine 4 No  (10/584)  (4/4) N/A
Liver 4 No  (3/4) N/A
Lower urinary tract 4 No  (3/4) N/A
Lung 4 No  (4/4) N/A
Lymph node 4 No  (4/4) N/A
Mammary gland 4 No  (1/4) N/A
Esophagus 4 No  (4/4) N/A
Olfactory lobe 4 No N/A
Ovary 4 No  (1/584)  (2/4) N/A
Oviduct 4 No  (2/4) N/A
Pancreas 4 No  (5/584)  (3/4) N/A
Parathyroid gland 4 No  (3/4) N/A
Peripheral nervous system 4 No  (4/4) N/A
Peyer's patch 4 No  (4/4) N/A
Pituitary gland 4 No  (1/4) N/A
Prostate gland 4 No  (12/584)  (2/4) N/A
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 4 No  (4/4) N/A
Small intestine 4 No  (9/584)  (4/4) N/A
Spinal cord 4 No  (4/4) N/A
Spleen 4 No  (2/584)  (3/4) N/A
Stomach 4 No  (12/584)  (4/4) N/A
Striatum 4 No N/A
Testis 4 No  (2/584)  (2/4) N/A
Thymus 4 No  (4/4) N/A
Thyroid gland 4 No  (15/584)  (3/4) N/A
Trachea 4 No  (4/4) N/A
Uterus 4 No  (2/4) N/A
White adipose tissue 4 No  (1/4) N/A
LacZ Section Images

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View all 12 images

No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Asxl1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Asxl1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele Mice
Asxl1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Asxl1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells