Gene: Asxl1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased hemoglobin content Asxl1tm1a(EUCOMM)Wtsi HET Early adult 2.98×10-06
decreased mean corpuscular hemoglobin Asxl1tm1a(EUCOMM)Wtsi HET Early adult 1.58×10-05
vertebral fusion Asxl1tm1a(EUCOMM)Wtsi HET Early adult 3.72×10-05
increased bone mineral content Asxl1tm1a(EUCOMM)Wtsi HET Early adult 1.35×10-05
increased bone mineral density Asxl1tm1a(EUCOMM)Wtsi HET Early adult 1.72×10-05
increased lumbar vertebrae number Asxl1tm1a(EUCOMM)Wtsi HET Early adult 5.61×10-07
decreased circulating glucose level Asxl1tm1a(EUCOMM)Wtsi HET Early adult 1.08×10-05
decreased leukocyte cell number Asxl1tm1a(EUCOMM)Wtsi HET   Early adult 2.91×10-05
decreased sacral vertebrae number Asxl1tm1a(EUCOMM)Wtsi HET Early adult 1.17×10-07

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (4/584)  (4/4) N/A
Aorta 4 No  (1/584) N/A
Blood vessel 4 No  (2/4) N/A
Bone 4 No  (3/4) N/A
Brain 4 No  (4/584)  (4/4) N/A
Brainstem 4 No  (2/584) N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No  (1/584)  (4/4) N/A
Cerebellum 4 No  (3/584) N/A
Cerebral cortex 4 No  (2/584) N/A
Eye 4 No  (4/4) N/A
Gall bladder 4 No  (2/4) N/A
Heart 4 No  (2/584)  (4/4) N/A
Hippocampus 4 No  (3/584) N/A
Hypothalamus 4 No  (2/584) N/A
Kidney 4 No  (21/584)  (4/4) N/A
Large intestine 4 No  (10/584)  (4/4) N/A
Liver 4 No  (3/4) N/A
Lower urinary tract 4 No  (1/584)  (3/4) N/A
Lung 4 No  (2/584)  (4/4) N/A
Lymph node 4 No  (1/584)  (4/4) N/A
Mammary gland 4 No  (1/4) N/A
Esophagus 4 No  (4/4) N/A
Olfactory lobe 4 No  (2/584) N/A
Ovary 4 No  (1/584)  (2/4) N/A
Oviduct 4 No  (2/4) N/A
Pancreas 4 No  (5/584)  (3/4) N/A
Parathyroid gland 4 No  (1/562)  (3/4) N/A
Peripheral nervous system 4 No  (2/584)  (4/4) N/A
Peyer's patch 4 No  (1/176)  (4/4) N/A
Pituitary gland 4 No  (1/584)  (1/4) N/A
Prostate gland 4 No  (12/584)  (2/4) N/A
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 4 No  (1/584)  (4/4) N/A
Small intestine 4 No  (9/584)  (4/4) N/A
Spinal cord 4 No  (3/584)  (4/4) N/A
Spleen 4 No  (3/584)  (3/4) N/A
Stomach 4 No  (12/584)  (4/4) N/A
Striatum 4 No  (3/584) N/A
Testis 4 No  (6/584)  (2/4) N/A
Thymus 4 No  (1/584)  (4/4) N/A
Thyroid gland 4 No  (16/584)  (3/4) N/A
Trachea 4 No  (3/584)  (4/4) N/A
Uterus 4 No  (2/4) N/A
White adipose tissue 4 No  (1/4) N/A
LacZ Section Images

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No Embryo expression data was found for this gene.

 Associated Images

Histopathology
8 Images
Legacy Phenotype Associated Images

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 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - MPATH diagnostic term cataract Asxl1tm1a(EUCOMM)Wtsi HET Early adult
Eye with optic nerve - process of degenerative change Asxl1tm1a(EUCOMM)Wtsi HET Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Asxl1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Asxl1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele Mice
Asxl1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Asxl1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells