Genes Phenotypes

Gene: Ric8b

Name
RIC8 guanine nucleotide exchange factor B
MGI ID
MGI:2682307
Synonyms
Ric-8 Ric-8b
Viability
Homozygous - Lethal
Other links
MGI   Ensembl  
Significant phenotypes (5) All measurements (272) Expression & images (67) Disease models (0) Order (4)
View data by physiological system
Significant
Not Significant
Not tested
Body weight
Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Ric8btm1b(EUCOMM)Hmgu HET postnatal 2.80×10-08
decreased lean body mass Ric8btm1b(EUCOMM)Hmgu HET postnatal 5.08×10-08
decreased bone mineral content Ric8btm1b(EUCOMM)Hmgu HET postnatal 5.79×10-08
increased leukocyte cell number Ric8btm1b(EUCOMM)Hmgu HET postnatal 1.76×10-06
preweaning lethality, complete penetrance Ric8btm1b(EUCOMM)Hmgu HOM n/a 0.00

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (1/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
adipose tissue (1)
Brown adipose tissue expression
MA:0000057
cardiovascular system (3)
Aorta expression
Heart expression
Vascular System expression
MA:0000062
MA:0000072
MA:0002718
digestive system (4)
Gall Bladder expression
MA:0000356
endocrine system (1)
Adrenal gland expression
MA:0000116
exocrine system (2)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (2)
Lymph Node expression
MA:0000139
integumental system (1)
Mammary gland expression
MA:0000145
musculoskeletal system (1)
Cartilage tissue expression
Bone expression
Vascular System expression
MA:0000104
MA:0001459
MA:0002718
nervous system (4)
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Brain expression
MA:0000185
MA:0000891
MA:0000191
MA:0000168
postnatal mouse (22)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
sensory organ (1)
Eye no expression
MA:0000261
set of connective tissues (2)
Brown adipose tissue expression
MA:0000057
trunk (13)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (3/4) N/A
Ear 2  (1/485)  (2/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (3/4) N/A
Foot 2  (1/485)  (2/4) N/A
Forebrain 2  (1/485)  (3/4) N/A
Forelimb 2  (1/485)  (3/4) N/A
Hand 2  (1/485)  (2/4) N/A
Head 2  (5/485)  (3/4) N/A
Heart 2  (1/485)  (2/4) N/A
Hindbrain 2  (6/485)  (3/4) N/A
Hindlimb 2  (1/485)  (3/4) N/A
Liver 2  (1/485)  (2/4) N/A
Lung 2  (1/485)  (2/4) N/A
Mandibular process 2  (1/485)  (2/4) N/A
Maxillary process 2  (1/485)  (2/4) N/A
Midbrain 2  (1/485)  (3/4) N/A
Oral cavity 2  (1/485)  (2/4) N/A
Skin 2  (1/485)  (2/4) N/A
Tail 2  (1/485)  (3/4) N/A
Tail somite 2  (1/485)  (3/4) N/A

 Associated Images

Echo: M-Mode Images
28 Images
X-ray: XRay Images Lateral Orientation
10 Images
Adult LacZ: LacZ Images Wholemount
22 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
Embryo LacZ: LacZ images wholemount
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Dorso Ventral
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Ric8btm1c(EUCOMM)Hmgu Wild type floxed exon (post-Flp) Mice
Ric8btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ric8btm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Ric8btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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