The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|preweaning lethality, complete penetrance||Polr3aem2(IMPC)Tcp||HOM||Early adult||0.00|
|enlarged urinary bladder||Polr3aem2(IMPC)Tcp||HET||Early adult||0.00|
|enlarged lymph nodes||Polr3aem2(IMPC)Tcp||HET||Early adult||0.00|
|embryonic lethality prior to tooth bud stage||Polr3aem2(IMPC)Tcp||HOM||E12.5||0.00|
|increased mean platelet volume||Polr3aem2(IMPC)Tcp||HET||Early adult||4.27×10-07|
|embryonic lethality prior to organogenesis||Polr3aem2(IMPC)Tcp||HOM||E9.5||0.00|
|increased bone mineral content||Polr3aem2(IMPC)Tcp||HET||Early adult||1.83×10-05|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Polr3a by orthology or direct annotation.
|Hypomyelination-Hypogonadotropic Hypogonadism-Hypodontia Syndrome||
|Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism||
|Tremor-Ataxia-Central Hypomyelination Syndrome||
||Osteopenia, Hydronephrosis, Hypospadias, Dilatation of renal calices, Wide penis, Vesicoureteral ...||ORPHA:3455|
The table below shows human diseases predicted to be associated to Polr3a by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Polr3a
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|MGI Allele||Allele Type||Produced|
|Polr3aem2(IMPC)Tcp||Point Mutation||Mice, Tissue|
|Polr3atm119248(L1L2_Bact_P)||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors|
|Polr3atm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||ES Cells|