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Gene: Cspp1 MGI:2681832

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Gene Summary

Name:
centrosome and spindle pole associated protein 1
Synonyms:
4930413O22Rik,  2310020J12Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral content Cspp1em1(IMPC)J HOM   Early adult 3.99×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

3 Images

View images
PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

View images

Human diseases caused by Cspp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cspp1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Early ossification of capital femoral epiphyses ORPHA:397715
Meckel Syndrome
ORPHA:564
Joubert Syndrome
ORPHA:475
Joubert Syndrome 21
OMIM:615636

The table below shows human diseases predicted to be associated to Cspp1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Distal Osteosclerosis
Hyperostosis, Craniofacial osteosclerosis, Diaphyseal sclerosis OMIM:126250
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Early ossification of capital femoral epiphyses ORPHA:397715
Meckel Syndrome
ORPHA:564
Joubert Syndrome
ORPHA:475
Joubert Syndrome 21
OMIM:615636

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cspp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cspp1.

No publications found that use IMPC mice or data for Cspp1.

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MGI Allele Allele Type Produced
Cspp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cspp1em1(IMPC)J Exon Deletion Mice

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