Pigl | phosphatidylinositol glycan anchor biosynthesis, class L

GeneMGI:2681271Synonyms: LOC327942

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Integument Mortality/aging

16 No significant impact

6 Not tested

Gene metrics:3Significant phenotypes
3Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

prenatal lethality prior to heart atrial septation1 supporting datasetPigltm1b(KOMP)WtsihomozygoteE15.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetPigltm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal vibrissa morphology1 supporting datasetPigltm1b(KOMP)WtsiheterozygoteEarly adult6.98x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/an/a0.19% (1/533)
blood vesselheterozygoten/a0% (0/2)0% (0/173)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
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Histopathology

IMPC related publications

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Pigltm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Pigltm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Pigltm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Pigltm1e(KOMP)MbpTargeted, non-conditional alleleES Cell
Pigltm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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