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Gene: Hcrtr2 MGI:2680765

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
hypocretin (orexin) receptor 2
Synonyms:
mOX2aR,  mOX2bR,  OX2r,  mOXR2

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Hcrtr2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Hcrtr2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Narcolepsy 3
Narcolepsy, Paroxysmal drowsiness, Abnormal rapid eye movement sleep, Excessive daytime somnolenc... OMIM:609039
Narcolepsy 1
Narcolepsy, Paroxysmal drowsiness, Abnormal rapid eye movement sleep, Hypnopompic hallucination, ... OMIM:161400
Narcolepsy 7
Obstructive sleep apnea, Narcolepsy, Excessive daytime somnolence, Sleep paralysis, Hypnagogic ha... OMIM:614250
Idiopathic Hypersomnia
Depression, Sleep abnormality, Hypersomnia, Hypnopompic hallucination, Excessive daytime somnolen... ORPHA:33208
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy, Abnormal rapid eye movement sleep, Excessive daytime somnolence, Sleep paralysis, Hyp... OMIM:604121
Hypoglycemia, Leucine-Induced
Coma, Spasticity, Drowsiness, Irritability OMIM:240800
Infantile Spasms-Psychomotor Retardation-Progressive Brain Atrophy-Basal Ganglia Disease Syndrome
Irritability, Loss of consciousness, Infantile muscular hypotonia, Drowsiness, Dystonia, Spastic ... ORPHA:263410
Epilepsy, Hot Water, 1
Hypotonia, Drowsiness, Generalized hypotonia OMIM:613339
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy, Spasticity, Depression ORPHA:314404
Kleine-Levin Hibernation Syndrome
Episodic hypersomnia OMIM:148840
Spinocerebellar Ataxia, Autosomal Recessive 23
Hypersomnia, Generalized hypotonia OMIM:616949
Benign Paroxysmal Torticollis Of Infancy
Torticollis, Drowsiness, Irritability ORPHA:71518
Niemann-Pick Disease Type C
Depression, Narcolepsy, Hypotonia, Limb dystonia, Low frustration tolerance, Axial dystonia, Lowe... ORPHA:646
Athyreosis
Hypotonia, Hypersomnia ORPHA:95713
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Depression, Obstructive sleep apnea, Generalized hypotonia, Narcolepsy, Emotional lability ORPHA:293987
African Trypanosomiasis
Insomnia, Reduced consciousness, Narcolepsy, Sleep-wake cycle disturbance, Abnormal rapid eye mov... ORPHA:3385
Inherited Creutzfeldt-Jakob Disease
Insomnia, Depression, Progressive extrapyramidal muscular rigidity, Spastic hemiparesis, Emotiona... ORPHA:282166
Kleine-Levin Syndrome
Depression, Irritability, Episodic hypersomnia, Sleep paralysis, Hypnagogic hallucination ORPHA:33543
Sandhoff Disease, Juvenile Form
Insomnia, Hypersomnia ORPHA:309162
Valinemia
Drowsiness OMIM:277100
Congenital Hypothyroidism Due To Transplacental Passage Of Tsh-Binding Inhibitory Antibodies
Neonatal hypotonia, Hypersomnia ORPHA:95715
Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency
Oculogyric crisis, Rigidity, Limb hypertonia, Drowsiness, Dystonia, Axial hypotonia, Sleep abnorm... ORPHA:70594
Postpoliomyelitis Syndrome
Hypersomnia, Sleep abnormality ORPHA:2942
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Neonatal hypotonia, Hypersomnia ORPHA:226313
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Depression, Oculogyric crisis, Hypotonia, Rigidity, Opisthotonus, Hypertonia, Drowsiness, Dystonia ORPHA:13
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Insomnia, Emotional lability, Loss of consciousness, Drowsiness, Infantile muscular hypotonia, Coma ORPHA:927
Leukoencephalopathy, Acute Reversible, With Increased Urinary Alpha-Ketoglutarate
Drowsiness, Generalized hypotonia OMIM:618384
Thyroid Hemiagenesis
Hypotonia, Hypersomnia ORPHA:95719
Genetic Transient Congenital Hypothyroidism
Hypotonia, Hypersomnia ORPHA:226316
Acute Disseminated Encephalomyelitis
Hypersomnia, Coma, Irritability ORPHA:83597
Postencephalitic Parkinsonism
Depression, Oculogyric crisis, Cogwheel rigidity, Rigidity, Drowsiness, Abnormal aggressive, impu... ORPHA:97349
Fructose-1,6-Bisphosphatase Deficiency
Reduced consciousness, Hypotonia, Irritability, Drowsiness, Excessive daytime somnolence, Coma ORPHA:348
Citrullinemia Type Ii
Insomnia, Sleep terror, Irritability, Fluctuations in consciousness, Drowsiness, Mania, Coma, Sle... ORPHA:247585
Thyroid Ectopia
Hypotonia, Hypersomnia ORPHA:95712
Steinert Myotonic Dystrophy
Depression, Obstructive sleep apnea, Neonatal hypotonia, Emotional lability, Abnormal rapid eye m... ORPHA:273
Bickerstaff Brainstem Encephalitis
Drowsiness, Hypersomnia, Coma ORPHA:79138
Complete Atrioventricular Septal Defect
Hypersomnia ORPHA:1329
Acromegaly
Depression, Hypersomnia, Sleep apnea ORPHA:963
Somatomammotropinoma
Depression, Hypersomnia, Sleep apnea ORPHA:314769
Neuroocular Syndrome 1
Obstructive sleep apnea, Sleep onset insomnia, Hypersomnia, Axial hypotonia OMIM:619539

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hcrtr2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hcrtr2.

No publications found that use IMPC mice or data for Hcrtr2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Hcrtr2tm1e(KOMP)Wtsi Targeted, non-conditional allele Mice, ES Cells
Hcrtr2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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