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Gene: Hcrtr2 MGI:2680765

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
hypocretin (orexin) receptor 2
Synonyms:
mOX2aR,  mOX2bR,  OX2r,  mOXR2

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Hcrtr2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Hcrtr2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Narcolepsy 3
Narcolepsy, Paroxysmal drowsiness, Abnormal rapid eye movement sleep, Excessive daytime somnolence OMIM:609039
Narcolepsy 1
Excessive daytime somnolence, Narcolepsy, Paroxysmal drowsiness, Abnormal rapid eye movement slee... OMIM:161400
Narcolepsy 7
Narcolepsy, Sleep paralysis, Obstructive sleep apnea, Excessive daytime somnolence OMIM:614250
Idiopathic Hypersomnia
Sleep abnormality, Excessive daytime somnolence, Hypersomnia ORPHA:33208
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy, Sleep paralysis, Abnormal rapid eye movement sleep, Excessive daytime somnolence OMIM:604121
Hypoglycemia, Leucine-Induced
Drowsiness, Irritability, Spasticity, Coma OMIM:240800
Infantile Spasms-Psychomotor Retardation-Progressive Brain Atrophy-Basal Ganglia Disease Syndrome
Drowsiness, Spastic tetraplegia, Irritability, Loss of consciousness, Dystonia, Infantile muscula... ORPHA:263410
Epilepsy, Hot Water, 1
Drowsiness, Hypotonia, Generalized hypotonia OMIM:613339
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy, Spasticity, Depression ORPHA:314404
Kleine-Levin Hibernation Syndrome
Episodic hypersomnia OMIM:148840
Spinocerebellar Ataxia, Autosomal Recessive 23
Generalized hypotonia, Hypersomnia OMIM:616949
Benign Paroxysmal Torticollis Of Infancy
Drowsiness, Irritability, Torticollis ORPHA:71518
Niemann-Pick Disease Type C
Axial dystonia, Lower limb spasticity, Dystonia, Sleep abnormality, Narcolepsy, Hypotonia, Depres... ORPHA:646
Thyroid Hemiagenesis
Hypotonia, Hypersomnia ORPHA:95719
Athyreosis
Hypotonia, Hypersomnia ORPHA:95713
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Obstructive sleep apnea, Narcolepsy, Depression, Generalized hypotonia, Emotional lability ORPHA:293987
African Trypanosomiasis
Coma, Excessive daytime somnolence, Sleep abnormality, Narcolepsy, Abnormal rapid eye movement sl... ORPHA:3385
Migraine, Familial Hemiplegic, 1
Drowsiness, Coma OMIM:141500
Inherited Creutzfeldt-Jakob Disease
Spastic hemiparesis, Hypersomnia, Depression, Spastic dysarthria, Irritability, Progressive extra... ORPHA:282166
Kleine-Levin Syndrome
Hypnagogic hallucination, Depression, Irritability, Sleep paralysis, Episodic hypersomnia ORPHA:33543
Valinemia
Drowsiness OMIM:277100
Sandhoff Disease, Juvenile Form
Insomnia, Hypersomnia ORPHA:309162
Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency
Axial hypotonia, Oculogyric crisis, Rigidity, Sleep abnormality, Drowsiness, Dystonia, Limb hyper... ORPHA:70594
Postpoliomyelitis Syndrome
Sleep abnormality, Hypersomnia ORPHA:2942
Congenital Hypothyroidism Due To Transplacental Passage Of Tsh-Binding Inhibitory Antibodies
Neonatal hypotonia, Hypersomnia ORPHA:95715
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Neonatal hypotonia, Hypersomnia ORPHA:226313
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Oculogyric crisis, Rigidity, Drowsiness, Hypotonia, Opisthotonus, Depression, Hypertonia, Dystonia ORPHA:13
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Coma, Drowsiness, Infantile muscular hypotonia, Emotional lability, Insomnia, Loss of consciousness ORPHA:927
Leukoencephalopathy, Acute Reversible, With Increased Urinary Alpha-Ketoglutarate
Drowsiness, Generalized hypotonia OMIM:618384
Genetic Transient Congenital Hypothyroidism
Hypotonia, Hypersomnia ORPHA:226316
Hyperinsulinism Due To Hnf1A Deficiency
Neonatal hypotonia, Drowsiness, Hypoglycemic coma, Loss of consciousness ORPHA:324575
Acute Disseminated Encephalomyelitis
Irritability, Coma, Hypersomnia ORPHA:83597
Postencephalitic Parkinsonism
Oculogyric crisis, Rigidity, Drowsiness, Cogwheel rigidity, Depression, Abnormal aggressive, impu... ORPHA:97349
Thyroid Ectopia
Hypotonia, Hypersomnia ORPHA:95712
Fructose-1,6-Bisphosphatase Deficiency
Coma, Excessive daytime somnolence, Drowsiness, Hypotonia, Irritability, Reduced consciousness ORPHA:348
Citrullinemia Type Ii
Coma, Drowsiness, Sleep abnormality, Fluctuations in consciousness, Irritability, Sleep terror, M... ORPHA:247585
Acquired Methemoglobinemia
Drowsiness, Coma, Loss of consciousness ORPHA:464453
Steinert Myotonic Dystrophy
Obstructive sleep apnea, Excessive daytime somnolence, Hypersomnia, Depression, Abnormal rapid ey... ORPHA:273
Bickerstaff Brainstem Encephalitis
Drowsiness, Coma, Hypersomnia ORPHA:79138
Complete Atrioventricular Septal Defect
Hypersomnia ORPHA:1329
Somatomammotropinoma
Sleep apnea, Hypersomnia, Depression ORPHA:314769
Acromegaly
Sleep apnea, Hypersomnia, Depression ORPHA:963
Mitochondrial Complex I Deficiency, Nuclear Type 2
Drowsiness, Hypotonia, Dystonia OMIM:618222
Neuroocular Syndrome
Sleep onset insomnia, Axial hypotonia, Obstructive sleep apnea, Hypersomnia OMIM:619539

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hcrtr2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hcrtr2.

No publications found that use IMPC mice or data for Hcrtr2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Hcrtr2tm1e(KOMP)Wtsi Targeted, non-conditional allele Mice, ES Cells
Hcrtr2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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