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Gene: Tmem150b MGI:2679718

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Gene Summary

Name:
transmembrane protein 150B
Synonyms:
Tmem224

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged kidney Tmem150bem1(IMPC)Ccpcz HOM Early adult 0.00
abnormal vibrissa morphology Tmem150bem1(IMPC)Ccpcz HOM Early adult 3.61×10-08
abnormal liver morphology Tmem150bem1(IMPC)Ccpcz HOM Early adult 0.00
abnormal kidney morphology Tmem150bem1(IMPC)Ccpcz HOM Early adult 0.00
increased freezing behavior Tmem150bem1(IMPC)Ccpcz HOM Early adult 0.00
absent vibrissae Tmem150bem1(IMPC)Ccpcz HOM Early adult 3.77×10-05
decreased memory-marker CD4-positive NK T cell number Tmem150bem1(IMPC)Ccpcz HOM Early adult 1.75×10-12
decreased eosinophil cell number Tmem150bem1(IMPC)Ccpcz HOM   Early adult 8.81×10-05
abnormal lens morphology Tmem150bem1(IMPC)Ccpcz HOM Early adult 8.59×10-06

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

16 Images

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X-ray

XRay Images Hind Leg and Hip

33 Images

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X-ray

XRay Images Whole Body Dorso Ventral

32 Images

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X-ray

XRay Images Forepaw

16 Images

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X-ray

XRay Images Skull Lateral Orientation

16 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

16 Images

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Human diseases caused by Tmem150b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tmem150b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neutropenia, Severe Congenital, 5, Autosomal Recessive
Leukopenia, Enlarged kidney, Anemia, Extramedullary hematopoiesis, Hepatomegaly, Thrombocytopenia... OMIM:615285
Hepatorenocardiac Degenerative Fibrosis
Hepatosplenomegaly, Renal interstitial fibrosis, Hepatocellular carcinoma, Jaundice, Enlarged kid... OMIM:619902
Polycystic Kidney Disease 5
Hepatosplenomegaly, Polycystic kidney dysplasia, Stage 5 chronic kidney disease, Enlarged kidney,... OMIM:617610
Immunodeficiency, Common Variable, 6
Hydronephrosis, Glomerulonephritis, Stage 5 chronic kidney disease, Enlarged kidney, Autoimmune t... OMIM:613496
Nephronophthisis 16
Polycystic kidney dysplasia, Stage 5 chronic kidney disease, Enlarged kidney, Cholestasis, Renal ... OMIM:615382
Congenital Megacalycosis
Recurrent urinary tract infections, Hydronephrosis, Abnormal renal physiology, Tubulointerstitial... ORPHA:93109
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Absence of renal corticomedullary differentiation, Polycystic kidney dysplasia, Hyperechogenic ki... OMIM:263200
Aa Amyloidosis
Proteinuria, Acute kidney injury, Abnormality of the kidney, Chronic kidney disease, Enlarged kid... ORPHA:85445
Renal-Hepatic-Pancreatic Dysplasia 1
Polycystic kidney dysplasia, Enlarged kidney, Asplenia, Cholestasis, Hepatomegaly, Polysplenia, H... OMIM:208540
Mucopolysaccharidosis-Plus Syndrome
Proteinuria, Long eyelashes, Renal tubular atrophy, Leukopenia, Enlarged kidney, Anemia, Synophry... OMIM:617303
Renal-Hepatic-Pancreatic Dysplasia 2
Asplenia, Enlarged kidney, Cholestasis, Hepatic fibrosis, Hepatomegaly, Cystic renal dysplasia, H... OMIM:615415
Nephronophthisis 2
Renal cortical microcysts, Chronic tubulointerstitial nephritis, Absence of renal corticomedullar... OMIM:602088
Renal Dysplasia
Enlarged kidney, Abnormal renal calyx morphology, Hydroureter, Abnormal nephron morphology, Multi... ORPHA:93108
Autosomal Dominant Polycystic Kidney Disease
Recurrent urinary tract infections, Stage 5 chronic kidney disease, Chronic kidney disease, Abnor... ORPHA:730
Acanthosis Nigricans-Insulin Resistance-Muscle Cramps-Acral Enlargement Syndrome
Enlarged polycystic ovaries, Hirsutism, Enlarged kidney ORPHA:90301
Meckel Syndrome, Type 8
Polycystic kidney dysplasia, Hyperechogenic kidneys, Enlarged kidney OMIM:613885
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Cataract, Polycystic kidney dysplasia, Hydronephrosis, Enlarged kidney, Elevated circulating aspa... OMIM:608836
Glycogen Storage Disease Ib
Hepatocellular carcinoma, Proteinuria, Enlarged kidney, Decreased glomerular filtration rate, Pan... OMIM:232220
Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor
Nephroblastoma, Enlarged kidney OMIM:618272
Autosomal Recessive Polycystic Kidney Disease
Polycystic kidney dysplasia, Enlarged kidney, Cholestasis, Recurrent urinary tract infections, He... ORPHA:731
Tyrosinemia, Type I
Acute hepatic failure, Hepatocellular carcinoma, Nephrocalcinosis, Enlarged kidney, Anemia, Renal... OMIM:276700
H Syndrome
Hepatosplenomegaly, Abnormality of the kidney, Micropenis, Enlarged kidney, Abnormal eyebrow morp... ORPHA:168569
Diaphanospondylodysostosis
Enlarged kidney, Horseshoe kidney, Nephroblastomatosis, Abnormal liver lobulation, Cystic renal d... OMIM:608022
Glycogen Storage Disease Ia
Hepatocellular carcinoma, Proteinuria, Enlarged kidney, Decreased glomerular filtration rate, Pan... OMIM:232200
Acrocephalopolydactylous Dysplasia
Enlarged kidney, Hepatic fibrosis, Hepatomegaly, Polysplenia, Pancreatic fibrosis, Cystic renal d... OMIM:200995
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Heparan sulfate excretion in urine, Hepatosplenomegaly, Proteinuria, Long eyelashes, Leukopenia, ... ORPHA:505248
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Abnormal myeloid leukocyte morphology, Hepatocellular carcinoma, Proteinuria, Stage 5 chronic kid... ORPHA:79259
Paternal Uniparental Disomy Of Chromosome 1
Episodic hemolytic anemia, Proteinuria, Enlarged kidney, Macroscopic hematuria, Membranoprolifera... ORPHA:251004
Kaposiform Lymphangiomatosis
Hepatosplenomegaly, Enlarged kidney, Abnormal spleen morphology, Anemia, Multiple renal cysts, Th... ORPHA:464329
Igg4-Related Kidney Disease
Enlarged kidney, Urethritis, Albuminuria, Abnormality of mesentery morphology, Decreased liver fu... ORPHA:449395
Tall Stature-Intellectual Disability-Renal Anomalies Syndrome
Cataract, Bifid ureter, Enlarged kidney, Chronic neutropenia, Astigmatism, Transient neutropenia,... ORPHA:500095
Alg9-Cdg
Hydronephrosis, Enlarged kidney, Hypoplasia of the bladder, Hypoplastic nipples, Abnormal renal a... ORPHA:79328
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Hydronephrosis, Urethral atresia, Enlarged kidney OMIM:314390
Exfoliation Syndrome
Cataract, Mydriasis, Phakodonesis, Abnormal lens morphology, Iris hypoperfusion, Anisocoria, Pigm... OMIM:177650
Lymphoid Interstitial Pneumonia
Keratoconjunctivitis sicca, Hepatomegaly, Enlarged kidney ORPHA:79128
Mucolipidosis Ii Alpha/Beta
Mucopolysacchariduria, Enlarged kidney, Megalocornea, Brittle hair, Hepatomegaly, Sparse eyebrow,... OMIM:252500
Denys-Drash Syndrome
Stage 5 chronic kidney disease, Diffuse mesangial sclerosis, Enlarged kidney, Nephropathy, Nephro... OMIM:194080
Hyperparathyroidism, Transient Neonatal
Unilateral renal agenesis, Splenic cyst, Enlarged kidney OMIM:618188
Beckwith-Wiedemann Syndrome
Renal cortical cysts, Nephrocalcinosis, Enlarged kidney, Hepatomegaly, Hepatoblastoma, Nephrolith... OMIM:130650
Chronic Myeloid Leukemia
Myeloproliferative disorder, Leukocytosis, Abnormal granulocyte morphology, Thrombocytopenia, Abn... ORPHA:521
Ogden Syndrome
Global glomerulosclerosis, Polycystic kidney dysplasia, Jaundice, Long eyelashes, Polycythemia, E... OMIM:300855
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly
Renal dysplasia, Polycystic kidney dysplasia, Micropenis, Enlarged kidney OMIM:613091
Beckwith-Wiedemann Syndrome
Polycythemia, Enlarged kidney, Congenital megaureter, Multiple renal cysts, Nephropathy, Hepatome... ORPHA:116
Helsmoortel-Van Der Aa Syndrome
Recurrent urinary tract infections, Enuresis nocturna, Enlarged kidney, Astigmatism, Anxiety, Irr... OMIM:615873
Endocrine-Cerebroosteodysplasia
Hyperechogenic kidneys, Microphallus, Enlarged kidney, Hypospadias OMIM:612651
Glycogen Storage Disease Of Heart, Lethal Congenital
Cataract, Cardiomegaly, Enlarged kidney OMIM:261740
Heterotaxy, Visceral, 1, X-Linked
Enlarged kidney, Asplenia, Horseshoe kidney, Hepatomegaly, Polysplenia, Biliary atresia, Cardiome... OMIM:306955
Meacham Syndrome
Horseshoe kidney, Accessory spleen, Enlarged kidney OMIM:608978
Leprechaunism
Facial hypertrichosis, Nephrocalcinosis, Enlarged kidney, Hypertrichosis, Hepatomegaly, Enlarged ... ORPHA:508
Hemihyperplasia-Multiple Lipomatosis Syndrome
Nephroblastoma, Enlarged kidney ORPHA:276280
Simpson-Golabi-Behmel Syndrome, Type 1
Hydronephrosis, Enlarged kidney, Renal cyst, Duplication of renal pelvis, Supernumerary nipple, P... OMIM:312870
Cardiac-Urogenital Syndrome
Penoscrotal hypospadias, Micropenis, Enlarged kidney, Patent urachus, Hepatopulmonary fusion, Acc... OMIM:618280

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tmem150b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tmem150b.

No publications found that use IMPC mice or data for Tmem150b.

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MGI Allele Allele Type Produced
Tmem150bem1(IMPC)Ccpcz Deletion Mice
Tmem150btm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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