Mib2 | mindbomb E3 ubiquitin protein ligase 2

GeneMGI:2679684Synonyms: 2210008I11Rik, Zzank1

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Nervous system Vision/eye Behavior/neurological

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased grip strength2 supporting datasetsMib2tm1a(EUCOMM)WtsihomozygoteEarly adult8.49x10-6 
abnormal retina morphology4 supporting datasetsMib2tm1a(EUCOMM)WtsihomozygoteEarly adult1.03x10-5 
decreased lean body mass1 supporting datasetMib2tm1a(EUCOMM)WtsihomozygoteEarly adult7.06x10-5 
abnormal eye morphology1 supporting datasetMib2tm1a(EUCOMM)WtsihomozygoteEarly adult5.87x10-5 
decreased blood urea nitrogen level1 supporting datasetMib2tm1a(EUCOMM)WtsihomozygoteEarly adult8.47x10-5 
decreased prepulse inhibition1 supporting datasetMib2tm1a(EUCOMM)WtsihomozygoteEarly adult1.63x10-5 
abnormal tail movements1 supporting datasetMib2tm1a(EUCOMM)WtsihomozygoteEarly adult7.06x10-7 
decreased circulating amylase level1 supporting datasetMib2tm1a(EUCOMM)WtsihomozygoteEarly adult3.47x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mib2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Mib2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Mib2tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Mib2tm44581(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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