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Gene: Paqr3 MGI:2679683

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
progestin and adipoQ receptor family member III
Synonyms:
6330415A20Rik,  RKTG

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Paqr3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Paqr3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Colorectal Cancer, Susceptibility To, 12
Carcinoma OMIM:615083
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Recurrent cutaneous abscess formation, Perifolliculitis, Squamous cell carcinoma, Chronic furuncu... OMIM:613736
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Myofibromatosis, Infantile, 1
Fibroma, Myofibromatosis OMIM:228550
Tumor Predisposition Syndrome 4
Glioma, Meningioma, Breast carcinoma, Sarcoma OMIM:609265
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Melanoma-Pancreatic Cancer Syndrome
Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcinoma, Squamous cell carcinoma, Melano... OMIM:606719
Acquired Ichthyosis
Recurrent skin infections, Pruritus, Lymphoma, Hyperkeratosis, Neoplasm, Palmoplantar keratoderma... ORPHA:454
Hyperkeratosis Lenticularis Perstans
Pruritus, Basal cell carcinoma, Hyperkeratosis lenticularis perstans, Squamous cell carcinoma ORPHA:409
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Pilomatrixoma
Pilomatrixoma OMIM:132600
Disseminated Superficial Actinic Porokeratosis
Pruritus, Squamous cell carcinoma ORPHA:79152
Nut Midline Carcinoma
Oropharyngeal squamous cell carcinoma, Pancreatoblastoma, Squamous cell carcinoma, Neoplasm, Panc... ORPHA:443167
Epidermodysplasia Verruciformis, Susceptibility To, 3
Basal cell carcinoma, Verrucae, Squamous cell carcinoma OMIM:618267
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Pilomatrixoma
Pruritus, Pilomatrixoma, Neoplasm of head and neck ORPHA:91414
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Palmoplantar keratoderma, Squamous cell carcinoma of the skin ORPHA:85112
Palmoplantar Carcinoma, Multiple Self-Healing
Parakeratosis, Carcinoma, Squamous cell carcinoma, Palmoplantar keratoderma, Follicular hyperkera... OMIM:615225
Cheilitis Glandularis
Neoplasm, Squamous cell carcinoma ORPHA:1221
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Ichthyosis, Hystrix-Like, With Deafness
Palmoplantar hyperkeratosis, Squamous cell carcinoma, Hyperkeratosis, Cobblestone-like hyperkerat... OMIM:602540
Li-Fraumeni Syndrome
Neoplasm of the pancreas, Adrenocortical carcinoma, Soft tissue sarcoma, Breast carcinoma, Acute ... OMIM:151623
Cutaneous Neuroendocrine Carcinoma
Brain neoplasm, Lymphoid leukemia, Neoplasm of the outer ear, Basal cell carcinoma, Squamous cell... ORPHA:79140
Punctate Palmoplantar Keratoderma Type 1
Pancreatic adenocarcinoma, Brain neoplasm, Neoplasm of the skeletal system, Breast carcinoma, Eso... ORPHA:79501
Huriez Syndrome
Congenital palmoplantar hyperkeratosis, Squamous cell carcinoma of the skin OMIM:181600
Familial Adenomatous Polyposis 1
Astrocytoma, Adrenocortical carcinoma, Fibroadenoma of the breast, Medulloblastoma, Desmoid tumor... OMIM:175100
Schƶpf-Schulz-Passarge Syndrome
Ovarian neoplasm, Basal cell carcinoma, Palmoplantar keratoderma, Squamous cell carcinoma ORPHA:50944
Epidermodysplasia Verruciformis, Susceptibility To, 5
Squamous cell carcinoma of the skin, Verrucae OMIM:618309
Schopf-Schulz-Passarge Syndrome
Poroma, Squamous cell carcinoma, Hyperkeratosis, Basal cell carcinoma, Palmoplantar keratoderma, ... OMIM:224750
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Pituitary adenoma, Carcinoma, Parathyroid adenoma, Renal angiomyolipo... OMIM:610755
Familial Multinodular Goiter
Alveolar rhabdomyosarcoma, Pleuropulmonary blastoma, Pilomatrixoma, Ovarian neoplasm, Basal cell ... ORPHA:276399
Maffucci Syndrome
Neoplasm of the adrenal cortex, Chondrosarcoma, Astrocytoma, Hemangiomatosis, Neoplasm of the par... ORPHA:163634
Apc-Related Attenuated Familial Adenomatous Polyposis
Neoplasm of the pancreas, Astrocytoma, Adrenocortical carcinoma, Pilomatrixoma, Medulloblastoma, ... ORPHA:247806
Large Congenital Melanocytic Nevus
Rhabdomyosarcoma, Pruritus, Neoplasm, Neoplasm of the skin, Cutaneous melanoma, Sarcoma ORPHA:626
Epidermodysplasia Verruciformis
Recurrent skin infections, Seborrheic dermatitis, Pustule, Squamous cell carcinoma, Verrucae ORPHA:302
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Endometrial carcinoma, Pancreatic adenocarcinoma, Seborrheic keratosis, Breast carcinoma, Squamou... ORPHA:454840
Mosaic Variegated Aneuploidy Syndrome 7 With Inflammation And Tumor Predisposition
Pilomatrixoma, Embryonal rhabdomyosarcoma, Hyperkeratosis, Multiple enchondromatosis, Adenocarcin... OMIM:620189
Paraneoplastic Pemphigus
B-cell lymphoma, Thymoma, Sarcoma ORPHA:63455
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Orthokeratotic hyperkeratosis, Palmoplantar keratoderma, Laryngeal carcinoma, Carcinoma OMIM:610644
Oncogenic Osteomalacia
Neoplasm of the skeletal system, Neoplasm of head and neck, Neurofibroma, Carcinoma, Giant cell t... ORPHA:352540
Xeroderma Pigmentosum Variant
Melanoma, Basal cell carcinoma, Squamous cell carcinoma ORPHA:90342
Gardner Syndrome
Neoplasm of the pancreas, Brain neoplasm, Astrocytoma, Adrenocortical carcinoma, Pilomatrixoma, M... ORPHA:79665
Junctional Epidermolysis Bullosa Inversa
Basal cell carcinoma, Palmoplantar keratoderma, Cutaneous melanoma, Squamous cell carcinoma ORPHA:79405
Cowden Syndrome 1
Fibroadenoma of the breast, Palmoplantar hyperkeratosis, Breast carcinoma, Hamartomatous polyposi... OMIM:158350
Combined Immunodeficiency Due To Dock8 Deficiency
Recurrent bacterial skin infections, Atopic dermatitis, Squamous cell carcinoma, Squamous cell ca... ORPHA:217390
Late-Onset Junctional Epidermolysis Bullosa
Basal cell carcinoma, Palmoplantar keratoderma, Cutaneous melanoma, Squamous cell carcinoma ORPHA:79406
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Acute myeloid leukemia, B-cell lymphoma, Myelodysplasia, Hematological neoplasm, T-cell lymphoma,... ORPHA:158057
Self-Improving Dystrophic Epidermolysis Bullosa
Basal cell carcinoma, Palmoplantar keratoderma, Cutaneous melanoma, Squamous cell carcinoma ORPHA:79411
Oculocutaneous Albinism Type 1A
Hyperkeratosis, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Xeroderma Pigmentosum, Complementation Group E
Melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin OMIM:278740
Localized Dystrophic Epidermolysis Bullosa, Pretibial Form
Pruritus, Squamous cell carcinoma, Basal cell carcinoma, Palmoplantar keratoderma, Cutaneous mela... ORPHA:79410
Turcot Syndrome With Polyposis
Glioblastoma multiforme, Brain neoplasm, Astrocytoma, Soft tissue neoplasm, Glioma, Pilomatrixoma... ORPHA:99818
Necrobiosis Lipoidica
Inflammatory abnormality of the skin, Squamous cell carcinoma ORPHA:542592
Papillon-LefĆØvre Syndrome
Recurrent cutaneous abscess formation, Recurrent skin infections, Pustule, Palmoplantar hyperkera... ORPHA:678
Xeroderma Pigmentosum, Complementation Group C
Actinic keratosis, Basal cell carcinoma, Squamous cell carcinoma of the skin, Cutaneous melanoma OMIM:278720
Chromomycosis
Pruritus, Hyperparakeratosis, Squamous cell carcinoma, Hyperkeratosis, Multiple cutaneous maligna... ORPHA:182
Oculocutaneous Albinism Type 1B
Melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79434
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 7
Squamous cell carcinoma of the skin, Myelodysplasia OMIM:620365
Xeroderma Pigmentosum, Complementation Group B
Basal cell carcinoma, Neoplasm, Squamous cell carcinoma of the skin, Cutaneous melanoma OMIM:610651
Werner Syndrome
Renal neoplasm, Acral lentiginous melanoma, Breast carcinoma, Squamous cell carcinoma, Neoplasm o... ORPHA:902
Recessive Dystrophic Epidermolysis Bullosa Inversa
Basal cell carcinoma, Palmoplantar keratoderma, Cutaneous melanoma, Squamous cell carcinoma ORPHA:79409
Hyper-Ige Syndrome 2, Autosomal Recessive, With Recurrent Infections
Disseminated molluscum contagiosum, Atopic dermatitis, Eczema, Squamous cell carcinoma OMIM:243700
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Skin rash, Melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:220295
Xeroderma Pigmentosum, Variant Type
Basal cell carcinoma, Cutaneous melanoma, Squamous cell carcinoma OMIM:278750
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Palmoplantar keratoderma, Squamous cell carcinoma OMIM:618373
Aicardi Syndrome
Teratoma, Carcinoma, Lipoma, Hepatoblastoma, Metastatic angiosarcoma, Hemangioma OMIM:304050
Xeroderma Pigmentosum, Complementation Group A
Melanoma, Squamous cell carcinoma of the skin OMIM:278700
Dyskeratosis Congenita, Digenic
Melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin OMIM:620040
Dyskeratosis Congenita, X-Linked
Acute myeloid leukemia, Oropharyngeal squamous cell carcinoma, Myelodysplasia, Hodgkin lymphoma, ... OMIM:305000
Retinoblastoma
Lymphoma, Retinoblastoma, Leukemia, Ewing sarcoma, Pinealoma, Osteosarcoma OMIM:180200
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Dominant
Hyperkeratosis, Recurrent bacterial skin infections, Squamous cell carcinoma OMIM:148210
Oculocutaneous Albinism Type 2
Basal cell carcinoma, Squamous cell carcinoma of the skin, Cutaneous melanoma ORPHA:79432
Hermansky-Pudlak Syndrome
Hyperkeratosis, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79430
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Recurrent skin infections, Palmoplantar keratoderma, Squamous cell carcinoma of the skin ORPHA:79396
Lmna-Related Cardiocutaneous Progeria Syndrome
Papillary renal cell carcinoma, Basal cell carcinoma, Squamous cell carcinoma of the skin, Pulmon... ORPHA:363618
Dyskeratosis Congenita, Autosomal Dominant 1
Squamous cell carcinoma of the skin, Myelodysplasia OMIM:127550
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Pilomatrixoma, Neoplasm, Spinal cord tumor, Meningioma ORPHA:353281
Tetrasomy 9P
Pilomatrixoma ORPHA:3310
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Pilomatrixoma, Meningioma ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Pilomatrixoma, Meningioma ORPHA:353277

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Paqr3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Paqr3.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9. Metabolism: clinical and experimental (March 2019) Paqr3tm1c(KOMP)Wtsi Paqr3tm1a(KOMP)Wtsi 30831144
Hepatic PPARĪ± function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. Hepatology (Baltimore, Md.) (April 2018) Paqr3tm1a(KOMP)Wtsi PMC6055728

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MGI Allele Allele Type Produced
Paqr3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Paqr3tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Paqr3tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Paqr3tm42465(L1L2_Pgk_PM) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Paqr3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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