Satb2 | special AT-rich sequence binding protein 2
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Vision/eye Hematopoietic system Mortality/aging Craniofacial
12 No significant impact
5 Not tested
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:42Adult tissues
0Embryo tissues
increased circulating alkaline phosphatase level | 1 supporting dataset | Satb2em3(IMPC)Tcp | heterozygote | Early adult | 2.65x10-10 | ||
enlarged lymph nodes | 2 supporting datasets | Satb2tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
preweaning lethality, complete penetrance | 3 supporting datasets | Satb2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
abnormal retina morphology | 1 supporting dataset | Satb2em3(IMPC)Tcp | heterozygote | Early adult | 3.84x10-9 | ||
abnormal craniofacial morphology | 1 supporting dataset | Satb2em3(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
increased mean corpuscular volume | 1 supporting dataset | Satb2em3(IMPC)Tcp | heterozygote | Early adult | 2.23x10-5 | ||
preweaning lethality, complete penetrance | 3 supporting datasets | Satb2em3(IMPC)Tcp | homozygote | Early adult | N/A * | ||
abnormal uterus morphology | 1 supporting dataset | Satb2tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * |
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adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
epididymis | heterozygote | n/a | 100% (1/1) | 87.5% (21/24) |
esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
eye | heterozygote | n/a | 0% (0/2) | 0% (0/335) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Satb2.
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Satb2em2(IMPC)Mbp | Indel | | mouse |
Satb2em3(IMPC)Tcp | Indel | | mouse |
Satb2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Satb2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Satb2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
Satb2tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
Satb2tm41799(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
Satb2tm41799(L1L2_gt1_Del_LacZ) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |