Sh3tc1 | SH3 domain and tetratricopeptide repeats 1
GeneMGI:2678949
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Muscle Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
11 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
increased neutrophil cell number | 2 supporting datasets | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.58x10-8 | ||
decreased grip strength | 4 supporting datasets | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.62x10-6 | ||
increased circulating bilirubin level | 1 supporting dataset | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.14x10-7 | ||
increased monocyte cell number | 2 supporting datasets | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.34x10-8 | ||
abnormal vitreous body morphology | 1 supporting dataset | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.34x10-5 | ||
decreased circulating triglyceride level | 1 supporting dataset | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.88x10-6 | ||
prolonged QT interval | 1 supporting dataset | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.76x10-5 | ||
prolonged ST segment | 1 supporting dataset | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.85x10-5 | ||
decreased cardiac muscle contractility | 1 supporting dataset | Sh3tc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.09x10-5 |
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External links
No external links available for Sh3tc1.
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Sh3tc1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Sh3tc1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Sh3tc1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |