Sh3tc1 | SH3 domain and tetratricopeptide repeats 1

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Muscle Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased neutrophil cell number2 supporting datasetsSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult1.58x10-8 
decreased grip strength4 supporting datasetsSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult1.62x10-6 
increased circulating bilirubin level1 supporting datasetSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult2.14x10-7 
increased monocyte cell number2 supporting datasetsSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult1.34x10-8 
abnormal vitreous body morphology1 supporting datasetSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult1.34x10-5 
decreased circulating triglyceride level1 supporting datasetSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult9.88x10-6 
prolonged QT interval1 supporting datasetSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult3.76x10-5 
prolonged ST segment1 supporting datasetSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult1.85x10-5 
decreased cardiac muscle contractility1 supporting datasetSh3tc1tm1b(EUCOMM)HmguhomozygoteEarly adult2.09x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sh3tc1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Sh3tc1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Sh3tc1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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