Pdzd8 | PDZ domain containing 8

GeneMGI:2677270Synonyms: A630041P07Rik, Pdzk8

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

7 Not tested

Gene metrics:12Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased circulating aspartate transaminase level1 supporting datasetPdzd8tm1b(EUCOMM)WtsihomozygoteEarly adult3.02x10-5 
increased blood urea nitrogen level1 supporting datasetPdzd8tm1b(EUCOMM)WtsiheterozygoteEarly adult1.32x10-5 
abnormal vibrissa morphology1 supporting datasetPdzd8tm1b(EUCOMM)WtsihomozygoteEarly adult1.59x10-5 
increased lean body mass1 supporting datasetPdzd8tm1b(EUCOMM)WtsihomozygoteEarly adult6.99x10-5 
increased large unstained cell number1 supporting datasetPdzd8tm1b(EUCOMM)WtsiheterozygoteEarly adult1.74x10-6 
increased circulating amylase level1 supporting datasetPdzd8tm1b(EUCOMM)WtsihomozygoteEarly adult3.08x10-6 
hyperactivity1 supporting datasetPdzd8tm1b(EUCOMM)WtsihomozygoteEarly adult4.82x10-6 
increased mean platelet volume1 supporting datasetPdzd8tm1b(EUCOMM)WtsiheterozygoteEarly adult2.55x10-5 
short tibia1 supporting datasetPdzd8tm1b(EUCOMM)WtsihomozygoteEarly adult4.34x10-5 
increased circulating triglyceride level1 supporting datasetPdzd8tm1b(EUCOMM)WtsihomozygoteEarly adult8.83x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pdzd8tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Pdzd8tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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