Gene: Dagla MGI:2677061

Log in to follow

Gene Summary

Name:
diacylglycerol lipase, alpha
Synonyms:
Nsddr

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased thigmotaxis Daglatm1a(EUCOMM)Wtsi HOM   Early adult 2.80×10-05
small thymus Daglatm1a(EUCOMM)Wtsi HOM Early adult 0.00
small lung Daglatm1a(EUCOMM)Wtsi HOM Early adult 0.00
small liver Daglatm1a(EUCOMM)Wtsi HOM Early adult 0.00
abnormal behavior Daglatm1a(EUCOMM)Wtsi HOM   Early adult 2.90×10-05
decreased brain size Daglatm1a(EUCOMM)Wtsi HOM Early adult 0.00
small stomach Daglatm1a(EUCOMM)Wtsi HOM Early adult 0.00
small spleen Daglatm1a(EUCOMM)Wtsi HOM Early adult 0.00
increased startle reflex Daglatm1a(EUCOMM)Wtsi HOM   Early adult 5.27×10-06
small heart Daglatm1a(EUCOMM)Wtsi HOM Early adult 0.00
decreased body length Daglatm1a(EUCOMM)Wtsi HOM Early adult 6.21×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dagla mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dagla by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Bronchogenic Cyst
ORPHA:2357
Nphp3-Related Meckel-Like Syndrome
ORPHA:3032
Tonne-Kalscheuer Syndrome
OMIM:300978
Renal-Hepatic-Pancreatic Dysplasia 2
OMIM:615415
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4
OMIM:615228
Serrated Polyposis Syndrome
ORPHA:157798
Intrinsic Factor And R Binder, Combined Congenital Deficiency Of
OMIM:243320
Microphthalmia, Syndromic 12
OMIM:615524
Lissencephaly Syndrome, Norman-Roberts Type
ORPHA:89844
Renal-Hepatic-Pancreatic Dysplasia 1
OMIM:208540
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
OMIM:619313
Intrinsic Factor Deficiency
OMIM:261000
Combined Oxidative Phosphorylation Deficiency 8
OMIM:614096
Pericardial And Diaphragmatic Defect
ORPHA:2847
Microphthalmia, Syndromic 9
OMIM:601186
Pallister-Hall-Like Syndrome
OMIM:241800
Pulmonary Hypoplasia, Primary
OMIM:265430
Renal Hypodysplasia/Aplasia 2
OMIM:615721
Chronic Intestinal Pseudoobstruction
ORPHA:2978
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
OMIM:263200
Polyposis of gastric fundus without polyposis coli
OMIM:175505
Pyloric Atresia
OMIM:265950
Mesomelic Dwarfism-Cleft Palate-Camptodactyly Syndrome
ORPHA:2631
Lethal Congenital Contracture Syndrome 11
OMIM:617194
Dubin-Johnson Syndrome
ORPHA:234
Ornithine Transcarbamylase Deficiency
ORPHA:664
Cardiac-Urogenital Syndrome
OMIM:618280
Scleroderma
ORPHA:801
Matthew-Wood Syndrome
ORPHA:2470
Microgastria-Limb Reduction Defects Association
OMIM:156810
Intellectual Developmental Disorder With Cardiac Defects And Dysmorphic Facies
OMIM:618316
Thymic Aplasia With Fetal Death
OMIM:274210
Chronic Granulomatous Disease
ORPHA:379
Lethal Congenital Contracture Syndrome 10
OMIM:617022
Congenital Tracheal Stenosis
ORPHA:141127
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
OMIM:601163
Stiff-Person Syndrome
OMIM:184850
Mirage Syndrome
OMIM:617053
Syndromic Recessive X-Linked Ichthyosis
ORPHA:281090
Hydrops Fetalis, Nonimmune, With Gracile Bones And Dysmorphism
OMIM:613124
Stiff Person Spectrum Disorder
ORPHA:3198
Renal Tubular Dysgenesis
ORPHA:3033
Acrocephalopolydactylous Dysplasia
OMIM:200995
Kagami-Ogata Syndrome
OMIM:608149
Hydrocephalus With Associated Malformations
OMIM:236640
Gm2 Gangliosidosis, Ab Variant
ORPHA:309246
Metachromatic Leukodystrophy
ORPHA:512
Autosomal Recessive Polycystic Kidney Disease
ORPHA:731
Microgastria-Limb Reduction Defect Syndrome
ORPHA:2538
Dyssegmental Dysplasia, Silverman-Handmaker Type
OMIM:224410
Pearson Syndrome
ORPHA:699
Mitochondrial Complex I Deficiency, Nuclear Type 35
OMIM:619003
Pentalogy Of Cantrell
ORPHA:1335
Oculogastrointestinal Muscular Dystrophy
ORPHA:1876
Esophageal Atresia
ORPHA:1199
Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome
ORPHA:3035
Gillessen-Kaesbach-Nishimura Syndrome
OMIM:263210
Ménétrier Disease
ORPHA:2494
Nk-Cell Enteropathy
ORPHA:263665
Meckel Syndrome, Type 6
OMIM:612284
Serkal Syndrome
ORPHA:139466
Coenzyme Q10 Deficiency, Primary, 8
OMIM:616733
Systemic Sclerosis
ORPHA:90291
Sandhoff Disease
OMIM:268800
Spinal Muscular Atrophy With Congenital Bone Fractures 2
OMIM:616867
1Q41Q42 Microdeletion Syndrome
ORPHA:250999
Marden-Walker Syndrome
OMIM:248700
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
OMIM:616897
Cutis Laxa, Autosomal Recessive, Type Ic
OMIM:613177
Chromosome 13Q33-Q34 Deletion Syndrome
OMIM:619148
Congenital Diaphragmatic Hernia
ORPHA:2140
Larsen-Like Syndrome, Lethal Type
OMIM:245650
Truncus Arteriosus
ORPHA:3384
Arthrogryposis Multiplex Congenita 1, Neurogenic, With Myelin Defect
OMIM:617468
Diaphragmatic Defect-Limb Deficiency-Skull Defect Syndrome
ORPHA:2141
Atelosteogenesis, Type Ii
OMIM:256050
Scimitar Syndrome
ORPHA:185
Fryns Syndrome
ORPHA:2059
Primary Pulmonary Hypoplasia
ORPHA:2257
Aphalangy With Hemivertebrae
OMIM:207620
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
ORPHA:438216
Thanatophoric Dysplasia
ORPHA:2655
Gracile Bone Dysplasia
OMIM:602361
Meier-Gorlin Syndrome 7
OMIM:617063
Reynolds Syndrome
ORPHA:779
Greenberg Dysplasia
OMIM:215140
Minicore Myopathy With External Ophthalmoplegia
OMIM:255320
Fetal Akinesia Deformation Sequence
ORPHA:994
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1
OMIM:614080
Opitz Gbbb Syndrome, Type Ii
OMIM:145410
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
OMIM:236500
Gm1 Gangliosidosis Type 1
ORPHA:79255
Multiple Acyl-Coa Dehydrogenase Deficiency
OMIM:231680
Atelosteogenesis Type I
ORPHA:1190
46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs
OMIM:611812
Caudal Regression Sequence
ORPHA:3027
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
OMIM:263520
Diaphanospondylodysostosis
OMIM:608022
Peroxisome Biogenesis Disorder 1A (Zellweger)
OMIM:214100
Multiple Pterygium Syndrome, X-Linked
OMIM:312150
Short-Rib Thoracic Dysplasia 12
OMIM:269860
Spondylospinal Thoracic Dysostosis
OMIM:601809
Tay-Sachs Disease
OMIM:272800
Short-Rib Thoracic Dysplasia 19 With Or Without Polydactyly
OMIM:617895
Aromatic L-Amino Acid Decarboxylase Deficiency
OMIM:608643
Multiple Pterygium Syndrome, Lethal Type
OMIM:253290
Czeizel-Losonci Syndrome
ORPHA:2437
Short-Rib Thoracic Dysplasia 20 With Polydactyly
OMIM:617925
Developmental And Epileptic Encephalopathy 8
OMIM:300607
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
OMIM:614091
Meckel Syndrome, Type 1
OMIM:249000
Hyperekplexia 3
OMIM:614618
Fryns Syndrome
OMIM:229850
Achondrogenesis Type 2
ORPHA:93296
Genitopatellar Syndrome
ORPHA:85201
Mosaic Trisomy 1
ORPHA:1692
Spinal Muscular Atrophy With Congenital Bone Fractures 1
OMIM:616866
Tetraamelia Syndrome 1
OMIM:273395
Short-Rib Thoracic Dysplasia 8 With Or Without Polydactyly
OMIM:615503
Tay-Sachs Disease
ORPHA:845
Platyspondylic Dysplasia, Torrance Type
ORPHA:85166
Lethal Congenital Contracture Syndrome Type 1
ORPHA:1486
Smith-Lemli-Opitz Syndrome
OMIM:270400
Hyperekplexia-Epilepsy Syndrome
ORPHA:163985
Lissencephaly Type Iii And Bone Dysplasia
OMIM:601160
Gm2-Gangliosidosis, Ab Variant
OMIM:272750
Dyssegmental Dysplasia, Silverman-Handmaker Type
ORPHA:1865
Odontochondrodysplasia 1
OMIM:184260
Glycine Encephalopathy With Normal Serum Glycine
OMIM:617301
Smith-Lemli-Opitz Syndrome
ORPHA:818
Pagod Syndrome
ORPHA:991
Tarp Syndrome
ORPHA:2886
Mosaic Trisomy 16
ORPHA:1708
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly
OMIM:208500
Nephronophthisis 2
OMIM:602088
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
ORPHA:83617
Hyperekplexia 2
OMIM:614619
Distal Tetrasomy 15Q
ORPHA:314588
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
OMIM:253800
Renal Agenesis, Bilateral
ORPHA:1848
Severe Congenital Nemaline Myopathy
ORPHA:171430
Autosomal Recessive Multiple Pterygium Syndrome
ORPHA:2990
Developmental And Epileptic Encephalopathy 68
OMIM:618201
Tetrasomy 5P
ORPHA:3309
Acro-Renal-Mandibular Syndrome
ORPHA:958
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
OMIM:618367
Abnormal Origin Of Right Or Left Pulmonary Artery From The Aorta
ORPHA:99050
Short-Rib Thoracic Dysplasia 13 With Or Without Polydactyly
OMIM:616300
Penile Agenesis
ORPHA:49
Otopalatodigital Syndrome Type 2
ORPHA:90652
Spastic Paraplegia, Optic Atrophy, And Neuropathy
OMIM:609541
Fraser Syndrome 1
OMIM:219000
Lethal Congenital Contracture Syndrome 1
OMIM:253310
Microcephaly-Micromelia Syndrome
OMIM:251230
Spastic Tetraplegia And Axial Hypotonia, Progressive
OMIM:618598
Stuve-Wiedemann Syndrome
OMIM:601559
Orofaciodigital Syndrome Type 4
ORPHA:2753
Congenital Total Pulmonary Venous Return Anomaly
ORPHA:99125
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
ORPHA:320406
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
OMIM:619351
Renal Agenesis
ORPHA:411709
Hyperekplexia 1
OMIM:149400
Maternal Uniparental Disomy Of Chromosome 2
ORPHA:96179
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
OMIM:617527
Vacterl With Hydrocephalus
ORPHA:3412
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
OMIM:308050
Tetrasomy 9P
ORPHA:3310
Schinzel-Giedion Syndrome
ORPHA:798
Thoracoabdominal Syndrome
OMIM:313850
Plaa-Associated Neurodevelopmental Disorder
ORPHA:521426
Raine Syndrome
OMIM:259775
Renal Hypodysplasia/Aplasia 1
OMIM:191830
Neu-Laxova Syndrome
ORPHA:2671
Short-Rib Thoracic Dysplasia 14 With Polydactyly
OMIM:616546
Atelosteogenesis Type Ii
ORPHA:56304
Asparagine Synthetase Deficiency
OMIM:615574
Fontaine Progeroid Syndrome
OMIM:612289
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
ORPHA:536467
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
ORPHA:438213
Fraser Syndrome
ORPHA:2052
Distal Monosomy 15Q
ORPHA:1596
Multiple Pterygium Syndrome, Escobar Variant
OMIM:265000
Myopathy, Congenital, With Diaphragmatic Defects, Respiratory Insufficiency, And Dysmorphic Facies
OMIM:618975
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
ORPHA:96334
Renal Tubular Dysgenesis
OMIM:267430
Mckusick-Kaufman Syndrome
OMIM:236700
Renal Dysplasia-Limb Defects Syndrome
OMIM:266910
Lissencephaly Type 3-Metacarpal Bone Dysplasia Syndrome
ORPHA:86822
Oligomeganephronia
ORPHA:2260
Blomstrand Lethal Chondrodysplasia
ORPHA:50945
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
ORPHA:93271
Hemifacial Microsomia
OMIM:164210
Genitopatellar Syndrome
OMIM:606170
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
OMIM:271520
Spondylodysplastic Ehlers-Danlos Syndrome
ORPHA:536471
Acrorenal-Mandibular Syndrome
OMIM:200980
Restrictive Dermopathy
ORPHA:1662
Osteogenesis Imperfecta
ORPHA:666
Lethal Congenital Contracture Syndrome 9
OMIM:616503
Neu-Laxova Syndrome 1
OMIM:256520
Joubert Syndrome 21
OMIM:615636
Microphthalmia, Syndromic 1
OMIM:309800
Fetal Akinesia Deformation Sequence 1
OMIM:208150
Pallister-Killian Syndrome
OMIM:601803
Aphalangy-Hemivertebrae-Urogenital-Intestinal Dysgenesis Syndrome
ORPHA:1112
Restrictive Dermopathy, Lethal
OMIM:275210
Ulbright-Hodes Syndrome
ORPHA:3404

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dagla

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dagla.

No publications found that use IMPC mice or data for Dagla.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Daglatm40176(L1L2_gt0) Targeting vectors
Daglatm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Daglatm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter