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Gene: Mir185 MGI:2676849

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

microRNA 185

Synonyms:

mmu-mir-185, Mirn185

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mir185 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Mir185 (0 diseases)
Human diseases predicted to be associated with Mir185 (264 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mir185 by phenotypic similarity.

Disease	Matching phenotypes	Source
Superior Transverse Scapular Ligament, Calcification Of, Familial	Ectopic ossification in ligament tissue	OMIM:601708
Osteomesopyknosis	Increased bone mineral density	OMIM:166450
Osteosclerotic Metaphyseal Dysplasia	Elevated circulating alkaline phosphatase concentration, Increased bone mineral density, Clavicul...	OMIM:615198
Metaphyseal Modeling Abnormality, Skin Lesions, And Spastic Paraplegia	Increased bone mineral density	OMIM:250500
12q14 microdeletion syndrome	Osteopoikilosis	DECIPHER:76
Pyknoachondrogenesis	Increased bone mineral density	OMIM:265880
Buschke-Ollendorff Syndrome	Osteopoikilosis, Flexion contracture, Joint stiffness	OMIM:166700
Osteosclerosis-Ichthyosis-Premature Ovarian Failure Syndrome	Increased bone mineral density	ORPHA:75325
Paget Disease Of Bone 4	Elevated circulating alkaline phosphatase concentration, Osteolysis	OMIM:606263
Van Buchem Disease	Elevated circulating alkaline phosphatase concentration, Increased bone mineral density, Cranial ...	OMIM:239100
Ossification Of The Posterior Longitudinal Ligament Of Spine	Ectopic ossification, Increased bone mineral density	OMIM:602475
Dentin Dysplasia	Increased bone mineral density	ORPHA:1653
Melorheostosis With Osteopoikilosis	Osteopoikilosis, Abnormal cortical bone morphology	ORPHA:1879
Osteomesopyknosis	Increased bone mineral density, Abnormal cortical bone morphology	ORPHA:2777
Osteopoikilosis And Dacryocystitis	Osteopoikilosis	OMIM:166705
Hyperostosis Corticalis Generalisata	Generalized osteosclerosis, Abnormal cortical bone morphology, Cranial hyperostosis	ORPHA:3416
Melorheostosis, Isolated	Hyperostosis, Increased bone mineral density	OMIM:155950
Dacryocystitis-Osteopoikilosis Syndrome	Increased bone mineral density, Osteopoikilosis	ORPHA:1562
Trichodentoosseous Syndrome	Increased bone mineral density	OMIM:190320
Ribbing Disease	Diaphyseal sclerosis	OMIM:601477
Spastic Paraplegia-Paget Disease Of Bone Syndrome	Elevated circulating alkaline phosphatase concentration, Increased spinal bone density, Recurrent...	ORPHA:329475
Osteosclerosis-Developmental Delay-Craniosynostosis Syndrome	Increased bone mineral density, Craniosynostosis	ORPHA:178377
Endosteal Hyperostosis, Worth Type	Craniofacial hyperostosis, Clavicular sclerosis, Abnormal cortical bone morphology, Generalized o...	ORPHA:2790
Familial Expansile Osteolysis	Pathologic fracture, Elevated circulating alkaline phosphatase concentration, Osteolysis, Thin bo...	OMIM:174810
Osteopenia And Sparse Hair	Osteopenia, Joint laxity	OMIM:259690
Osteochondrosis Of The Metatarsal Bone	Arthritis, Thickened cortex of bones, Sclerosis of foot bone, Joint stiffness	ORPHA:564003
Melorheostosis	Increased bone mineral density, Joint stiffness, Hyperostosis, Arthritis, Ectopic ossification in...	ORPHA:2485
Sclerosteosis	Craniofacial hyperostosis, Increased bone mineral density, Abnormal cortical bone morphology	ORPHA:3152
Paget Disease Of Bone 3	Fractures of the long bones, Elevated circulating alkaline phosphatase concentration, Osteolysis,...	OMIM:167250
Hypophosphatemic Rickets, Autosomal Recessive, 1	Hypophosphatemic rickets, Increased bone mineral density, Rickets, Craniosynostosis	OMIM:241520
Dentin Dysplasia With Sclerotic Bones	Cortical sclerosis	OMIM:125440
Flynn-Aird Syndrome	Increased bone mineral density, Osteoporosis, Increased bone density with cystic changes, Joint s...	OMIM:136300
Craniodiaphyseal Dysplasia, Autosomal Dominant	Craniofacial hyperostosis, Cortical sclerosis, Craniofacial osteosclerosis, Diaphyseal sclerosis,...	OMIM:122860
Body Mass Index Quantitative Trait Locus 20	Increased bone mineral density	OMIM:618406
Osteosclerosis With Ichthyosis And Fractures	Cortical thickening of long bone diaphyses, Increased bone mineral density, Recurrent fractures	OMIM:166740
Mueller-Weiss Syndrome	Limitation of movement at ankles, Sclerosis of foot bone, Joint stiffness, Knee osteoarthritis, A...	ORPHA:566943
Isolated Osteopoikilosis	Abnormally ossified vertebrae, Increased bone mineral density, Sclerosis of foot bone, Sclerotic ...	ORPHA:166119
Dysplastic Cortical Hyperostosis, Kozlowski-Tsuruta Type	Increased bone mineral density, Abnormal cortical bone morphology	ORPHA:2204
Osteopetrosis, Autosomal Recessive 9	Increased bone mineral density, Cortical sclerosis, Elevated circulating alkaline phosphatase con...	OMIM:620366
Osteopetrosis, Autosomal Recessive 6	Osteopetrosis	OMIM:611497
Osteosarcoma	Increased circulating lactate dehydrogenase concentration, Abnormal lactate dehydrogenase level, ...	ORPHA:668
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor	Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Elevated circulating alkaline p...	OMIM:600785
Osteopetrosis, Autosomal Dominant 1	Thickened cortex of long bones, Generalized osteosclerosis, Calvarial osteosclerosis, Osteopetrosis	OMIM:607634
Hypogonadotropic Hypogonadism 19 With Or Without Anosmia	Osteopenia, Osteoporosis	OMIM:615269
Hypophosphatasia, Adult	Recurrent fractures, Osteomalacia, Rickets, Low alkaline phosphatase, Increased susceptibility to...	OMIM:146300
Intermediate Osteopetrosis	Osteomyelitis, Recurrent fractures, Cortical sclerosis, Generalized osteosclerosis, Increased sus...	ORPHA:210110
Camurati-Engelmann Disease, Type 2	Osteopenia, Hip contracture, Knee flexion contracture, Hyperostosis, Elevated circulating alkalin...	OMIM:606631
Hypophosphatemic Rickets, Autosomal Dominant	Hypophosphatemic rickets, Elevated circulating alkaline phosphatase concentration, Rickets, Osteo...	OMIM:193100
Endosteal Hyperostosis, Autosomal Dominant	Hyperostosis, Metacarpal diaphyseal endosteal sclerosis, Clavicular sclerosis, Thickened cortex o...	OMIM:144750
Vitamin D-Dependent Rickets, Type 3	Osteopenia, Elevated circulating alkaline phosphatase concentration	OMIM:619073
Osteopetrosis, Autosomal Dominant 2	Recurrent fractures, Mandibular osteomyelitis, Fractures of the long bones, Generalized osteoscle...	OMIM:166600
Axial Osteomalacia	Increased bone mineral density, Osteomalacia	OMIM:109130
Gnathodiaphyseal Dysplasia	Osteopenia, Mandibular osteomyelitis, Recurrent fractures, Thickened cortex of long bones	ORPHA:53697
Epiphyseal Chondrodysplasia, Miura Type	Osteopenia, Elevated alkaline phosphatase of bone origin	OMIM:615923
Calvarial Doughnut Lesions With Bone Fragility	Osteopenia, Elevated circulating alkaline phosphatase concentration, Osteoporosis, Recurrent frac...	OMIM:126550
Osteoporosis	Osteoporosis	OMIM:166710
Ghosal Hematodiaphyseal Dysplasia	Myelofibrosis, Increased bone mineral density, Hyperostosis cranialis interna	OMIM:231095
Lethal Recessive Chondrodysplasia	Generalized osteosclerosis	ORPHA:1423
Hypercholanemia, Familial, 2	Osteopenia, Prolonged neonatal jaundice	OMIM:619256
Hip Dysplasia, Beukes Type	Abnormal ossification involving the femoral head and neck, Osteoarthritis, Abnormality of bone mi...	ORPHA:2114
Hypophosphatasia, Childhood	Low alkaline phosphatase, Craniosynostosis	OMIM:241510
Osteopetrosis, Autosomal Recessive 4	Osteopetrosis, Increased bone mineral density, Recurrent fractures	OMIM:611490
Eiken Syndrome	Abnormal trabecular bone morphology, Delayed epiphyseal ossification, Limited elbow flexion, Abno...	ORPHA:79106
Osteoporosis, Juvenile	Osteoporosis	OMIM:259750
Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 2	Elevated circulating alkaline phosphatase concentration, Paget disease of bone	OMIM:615422
Schnitzler Syndrome	Arthritis, Increased bone mineral density	ORPHA:37748
Osteopetrosis, Autosomal Recessive 1	Increased bone mineral density, Osteomyelitis, Increased circulating lactate dehydrogenase concen...	OMIM:259700
Chondrodysplasia, Blomstrand Type	Generalized osteosclerosis, Advanced ossification of carpal bones, Advanced tarsal ossification	OMIM:215045
Gnathodiaphyseal Dysplasia	Osteopenia, Osteomyelitis, Diaphyseal cortical sclerosis, Increased susceptibility to fractures	OMIM:166260
Metaphyseal Dysplasia, Braun-Tinschert Type	Osteopenia, Increased bone mineral density, Elevated alkaline phosphatase of bone origin, Scleros...	ORPHA:85188
Vitamin D Hydroxylation-Deficient Rickets, Type 1B	Recurrent fractures, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Elevated c...	OMIM:600081
Hyperphosphatasia With Impaired Intellectual Development Syndrome 6	Osteopenia, Hip contracture, Elbow flexion contracture, Knee flexion contracture, Elevated circul...	OMIM:616809
Neurodevelopmental Delay-Seizures-Ophthalmic Anomalies-Osteopenia-Cerebellar Atrophy Syndrome	Osteopenia, Elevated circulating alkaline phosphatase concentration, Osteoporosis	ORPHA:529665
Otopalatodigital Syndrome Type 1	Increased bone mineral density, Abnormal vertebral segmentation and fusion, Limitation of joint m...	ORPHA:90650
Dysosteosclerosis	Craniofacial hyperostosis, Increased bone mineral density, Recurrent fractures, Coarse metaphysea...	ORPHA:1782
Fibrodysplasia Ossificans Progressiva	Progressive cervical vertebral spine fusion, Ectopic ossification in tendon tissue, Ectopic ossif...	OMIM:135100
Autosomal Dominant Hypophosphatemic Rickets	Elevated circulating alkaline phosphatase concentration, Rickets, Osteomalacia	ORPHA:89937
Paget Disease Of Bone 2, Early-Onset	Fractures of the long bones, Osteolysis, Increased susceptibility to fractures, Sclerosis of skul...	OMIM:602080
Beemer-Ertbruggen Syndrome	Increased bone mineral density	ORPHA:1237
Craniometaphyseal Dysplasia	Craniofacial hyperostosis, Osteopetrosis	ORPHA:1522
Florid Cemento-Osseous Dysplasia	Mandibular osteomyelitis, Abnormal trabecular bone morphology, Multiple bony cystic lesions, Abno...	ORPHA:83451
Angioosteohypotrophic Syndrome	Abnormal trabecular bone morphology, Thin bony cortex	ORPHA:75508
Osteosclerosis With Ichthyosis And Premature Ovarian Failure	Subperiosteal bone formation, Osteosclerosis of the base of the skull	OMIM:609993
Gorham-Stout Disease	Osteopenia, Osteomyelitis, Elevated alkaline phosphatase of bone origin, Osteolysis involving bon...	ORPHA:73
Tricho-Dento-Osseous Syndrome	Increased bone mineral density	ORPHA:3352
Osteopetrosis, Autosomal Recessive 8	Osteopetrosis	OMIM:615085
Hypophosphatemic Rickets With Hypercalciuria, Hereditary	Recurrent fractures, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Elevated c...	OMIM:241530
Bile Acid Conjugation Defect 1	Elevated circulating aspartate aminotransferase concentration, Jaundice, Elevated circulating ala...	OMIM:619232
Hypogonadotropic Hypogonadism 20 With Or Without Anosmia	Osteopenia, Osteoporosis	OMIM:615270
Craniometadiaphyseal Dysplasia, Wormian Bone Type	Osteopenia, Wide anterior fontanel, Increased bone mineral density, Thin bony cortex	ORPHA:85184
Osteogenesis Imperfecta, Type Xi	Osteopenia, Joint laxity, Recurrent fractures, Increased susceptibility to fractures, Elevated ci...	OMIM:610968
Congenital Bile Acid Synthesis Defect Type 2	Elevated hepatic transaminase, Giant cell hepatitis, Abnormal circulating enzyme concentration or...	ORPHA:79303
Albers-Schönberg Osteopetrosis	Osteomyelitis, Recurrent fractures, Mandibular osteomyelitis, Generalized osteosclerosis, Osteoar...	ORPHA:53
Paget Disease Of Bone 5, Juvenile-Onset	Osteopenia, Increased bone mineral density, Recurrent fractures, Ankylosis, Osteoporosis, Elevate...	OMIM:239000
Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness	Increased bone mineral density, Osteopetrosis	OMIM:617306
Spondyloepiphyseal Dysplasia-Craniosynostosis-Cleft Palate-Cataracts-Intellectual Disability Syndrome	Delayed patellar ossification, Increased bone mineral density, Wide anterior fontanel, Abnormal b...	ORPHA:163649
Hypophosphatemic Rickets, Autosomal Recessive, 2	Hypophosphatemic rickets, Elevated circulating alkaline phosphatase concentration	OMIM:613312
Osteopetrosis, Autosomal Recessive 2	Osteomyelitis, Recurrent fractures, Mandibular osteomyelitis, Cranial hyperostosis, Diaphyseal sc...	OMIM:259710
Diastrophic Dysplasia	Joint hyperflexibility, Increased bone mineral density, Camptodactyly of finger, Joint stiffness	ORPHA:628
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Osteolysis, Increased susceptibility to fractures, Elevated circulating alkaline phosphatase conc...	ORPHA:52430
Aplasia Cutis Congenita	Abnormality of bone mineral density	ORPHA:1114
Osteogenesis Imperfecta, Type Xiii	Increased bone mineral density, Recurrent fractures, Osteoporosis, Reduced bone mineral density, ...	OMIM:614856
Fanconi Renotubular Syndrome 1	Elevated circulating alkaline phosphatase concentration, Rickets, Osteomalacia	OMIM:134600
Autosomal Recessive Hypophosphatemic Rickets	Abnormal trabecular bone morphology, Increased bone mineral density, Elevated alkaline phosphatas...	ORPHA:289176
Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 1	Paget disease of bone, Elevated alkaline phosphatase of bone origin	OMIM:167320
Vitamin D Hydroxylation-Deficient Rickets, Type 1A	Recurrent fractures, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Elevated c...	OMIM:264700
Vitamin D-Dependent Rickets, Type 2A	Recurrent fractures, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Elevated c...	OMIM:277440
Immunoerythromyeloid Hypoplasia	Absent leukocyte alkaline phosphatase	OMIM:242880
Aggressive Systemic Mastocytosis	Portal hypertension, Osteoporosis, Osteolysis, Elevated circulating alkaline phosphatase concentr...	ORPHA:98850
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma	Osteopenia, Diaphyseal cortical sclerosis, Patchy osteosclerosis, Fractures of the long bones, Os...	OMIM:112250
Neutrophilia, Hereditary	Elevated leukocyte alkaline phosphatase	OMIM:162830
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Rickets	OMIM:616026
Paget Disease Of Bone 6	Elevated circulating alkaline phosphatase concentration, Osteoarthritis, Recurrent fractures	OMIM:616833
Osteopathia Striata-Cranial Sclerosis Syndrome	Increased bone mineral density, Osteopetrosis, Facial hyperostosis, Spina bifida occulta, Coarse ...	ORPHA:2780
Majeed Syndrome	Increased bone mineral density, Osteomyelitis, Flexion contracture, Synovitis, Increased suscepti...	ORPHA:77297
Hereditary Hypophosphatemic Rickets With Hypercalciuria	Elevated alkaline phosphatase of bone origin, Osteomalacia, Reduced bone mineral density, Hypopho...	ORPHA:157215
Congenital Disorder Of Glycosylation, Type Iip	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Decreased...	OMIM:616829
Craniometadiaphyseal Dysplasia	Osteopenia, Wide anterior fontanel, Sclerosis of skull base, Elevated circulating alkaline phosph...	OMIM:269300
Hypophosphatemic Rickets, X-Linked Dominant	Osteomalacia, Osteoarthritis, Rickets, Elevated circulating alkaline phosphatase concentration, H...	OMIM:307800
Spondyloepiphyseal Dysplasia Tarda	Increased bone mineral density, Osteoarthritis of the distal interphalangeal joint, Abnormally os...	ORPHA:93284
Autoimmune Hypoparathyroidism	Increased bone mineral density	ORPHA:36913
Fanconi-Bickel Syndrome	Osteopenia, Elevated circulating aspartate aminotransferase concentration, Elevated circulating a...	ORPHA:2088
Oncogenic Osteomalacia	Fibrous dysplasia of the bones, Elevated circulating alkaline phosphatase concentration, Patholog...	ORPHA:352540
Neurodevelopmental Disorder With Or Without Hypotonia, Seizures, And Cerebellar Atrophy	Elevated circulating alkaline phosphatase concentration	OMIM:616917
Gaucher Disease Type 1	Osteopenia, Increased bone mineral density, Osteoarthritis, Osteolysis, Pathologic fracture	ORPHA:77259
Leukocyte Adhesion Deficiency, Type Iii	Osteopetrosis	OMIM:612840
Camurati-Engelmann Disease	Sclerosis of skull base, Cortical thickening of long bone diaphyses, Increased bone mineral densi...	OMIM:131300
Hypopigmentation, Organomegaly, And Delayed Myelination And Development	Osteopetrosis	OMIM:618541
Metaphyseal Chondrodysplasia, Jansen Type	Osteopenia, Hip contracture, Knee flexion contracture, Elevated circulating alkaline phosphatase ...	OMIM:156400
Estrogen Resistance	Osteopenia, Elevated alkaline phosphatase of bone origin	OMIM:615363
Estrogen Resistance Syndrome	Osteopenia, Delayed epiphyseal ossification, Osteoporosis, Elevated tissue non-specific alkaline ...	ORPHA:785
Neurodevelopmental Disorder With Hypotonia And Cerebellar Atrophy, With Or Without Seizures	Low alkaline phosphatase	OMIM:618879
Hypophosphatemic Rickets, X-Linked Recessive	Recurrent fractures, Osteomalacia, Delayed epiphyseal ossification, Rickets, Sparse bone trabecul...	OMIM:300554
Pycnodysostosis	Increased bone mineral density, Osteolytic defects of the distal phalanges of the hand	OMIM:265800
Hypophosphatasia, Infantile	Craniosynostosis, Low alkaline phosphatase, Increased susceptibility to fractures, Decreased calv...	OMIM:241500
Cholestasis, Progressive Familial Intrahepatic, 7, With Or Without Hearing Loss	Elevated circulating alkaline phosphatase concentration, Jaundice, Elevated circulating alanine a...	OMIM:619658
Cystic Echinococcosis	Elevated hepatic transaminase, Eosinophilia, Jaundice, Bone cyst, Elevated circulating alkaline p...	ORPHA:400
Osteopetrosis, Autosomal Recessive 3	Osteopetrosis, Cranial hyperostosis, Diaphyseal sclerosis	OMIM:259730
Dysostosis, Stanescu Type	Massively thickened long bone cortices, Increased bone mineral density	ORPHA:1798
Fanconi-Bickel Syndrome	Elevated circulating aspartate aminotransferase concentration, Osteomalacia, Intrahepatic cholest...	OMIM:227810
Dysosteosclerosis	Osteopenia, Sclerosis of hand bone, Sclerotic scapulae, Increased susceptibility to fractures, Sc...	OMIM:224300
X-Linked Hypophosphatemia	Craniosynostosis, Generalized osteosclerosis, Limitation of joint mobility, Rickets, Enthesitis, ...	ORPHA:89936
Hypocalcemic Vitamin D-Dependent Rickets	Elevated alkaline phosphatase of bone origin, Osteomalacia, Delayed epiphyseal ossification, Rick...	ORPHA:289157
Pseudohypoparathyroidism Type 1B	Increased bone density with cystic changes, Increased bone mineral density, Diaphyseal sclerosis	ORPHA:94089
Fibrous Dysplasia Of Bone	Thin bony cortex, Cortical irregularity, Osteomalacia, Fibrous dysplasia of the bones, Rickets, O...	ORPHA:249
Glycosylphosphatidylinositol Biosynthesis Defect 25	Low alkaline phosphatase, Ankle flexion contracture	OMIM:619985
Osteopetrosis, Autosomal Recessive 5	Increased bone mineral density, Cranial hyperostosis, Decreased osteoclast count, Osteopetrosis, ...	OMIM:259720
Pycnodysostosis	Joint laxity, Increased bone mineral density, Generalized osteosclerosis, Increased susceptibilit...	ORPHA:763
Myeloproliferative Disease, Autosomal Recessive	Reduced leukocyte alkaline phosphatase	OMIM:254700
Congenital Hyperinsulinism Due To Hnf4A Deficiency	Hypophosphatemic rickets, Elevated circulating alkaline phosphatase concentration, Elevated hepat...	ORPHA:263455
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Elevated circulating alkaline phosphatase concentration	OMIM:174050
Spondyloepimetaphyseal Dysplasia, Krakow Type	Elbow contracture, Knee flexion contracture, Elevated circulating alkaline phosphatase concentrat...	OMIM:618162
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Osteopetrosis, Increased skull ossification, Craniofacial osteosclerosis, Diaphyseal sclerosis	OMIM:618476
Kenny-Caffey Syndrome, Type 2	Increased bone mineral density, Thickened cortex of long bones	OMIM:127000
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome	Osteopetrosis	ORPHA:3240
Eiken Syndrome	Delayed ossification of carpal bones, Delayed epiphyseal ossification, Delayed tarsal ossificatio...	OMIM:600002
Osteopetrosis, Autosomal Recessive 7	Abnormal trabecular bone morphology, Osteopetrosis	OMIM:612301
Werner Syndrome	Increased bone mineral density, Osteoporosis, Joint stiffness	ORPHA:902
Hyperparathyroidism, Transient Neonatal	Osteopenia, Recurrent fractures, Subperiosteal bone formation, Elevated circulating alkaline phos...	OMIM:618188
12Q14 Microdeletion Syndrome	Osteopoikilosis	ORPHA:94063
Raine Syndrome	Elevated circulating alkaline phosphatase concentration, Arthrogryposis multiplex congenita, Incr...	OMIM:259775
Primary Biliary Cholangitis	Portal hypertension, Jaundice, Osteoporosis, Hepatitis, Elevated circulating alkaline phosphatase...	ORPHA:186
Dent Disease 1	Recurrent fractures, Osteomalacia, Delayed epiphyseal ossification, Rickets, Sparse bone trabecul...	OMIM:300009
Cholestasis-Lymphedema Syndrome	Elevated hepatic transaminase, Jaundice, Elevated circulating alkaline phosphatase concentration	OMIM:214900
Desmosterolosis	Increased bone mineral density, Osteopetrosis	ORPHA:35107
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3	Osteopenia, Calvarial osteosclerosis, Metacarpal periosteal thickening	OMIM:617994
Hyperoxaluria, Primary, Type I	Pathologic fracture, Increased bone mineral density	OMIM:259900
Amyotrophic Lateral Sclerosis 20	Elevated circulating alkaline phosphatase concentration	OMIM:615426
Poems Syndrome	Sclerosis of hand bone, Sclerosis of skull base, Sclerosis of foot bone	ORPHA:2905
Onychodystrophy, Osteodystrophy, Impaired Intellectual Development, And Seizures Syndrome	Abnormality of alkaline phosphatase level	OMIM:619356
Cholestasis, Progressive Familial Intrahepatic, 6	Elevated hepatic transaminase, Intrahepatic cholestasis, Elevated circulating alkaline phosphatas...	OMIM:619484
Gaucher Disease Type 3	Increased bone mineral density, Osteolysis, Increased susceptibility to fractures	ORPHA:77261
Lenz-Majewski Hyperostotic Dwarfism	Increased bone mineral density, Cranial hyperostosis, Limitation of joint mobility, Joint hyperfl...	ORPHA:2658
Erdheim-Chester Disease	Increased bone mineral density, Osteomyelitis, Osteolysis	ORPHA:35687
Refractory Celiac Disease	Elevated hepatic transaminase, Osteoporosis, Elevated alkaline phosphatase of bone origin	ORPHA:398063
Otopalatodigital Syndrome Type 2	Increased bone mineral density, Camptodactyly of finger, Tarsal synostosis, Carpal synostosis, Ab...	ORPHA:90652
Specific Granule Deficiency 1	Low neutrophil alkaline phosphatase	OMIM:245480
Hyperphosphatasia With Impaired Intellectual Development Syndrome 2	Left unicoronal synostosis, Elevated circulating alkaline phosphatase concentration	OMIM:614749
Bile Acid Synthesis Defect, Congenital, 2	Elevated hepatic transaminase, Intrahepatic cholestasis, Jaundice, Elevated circulating alkaline ...	OMIM:235555
Congenital Disorder Of Glycosylation, Type Iij	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Hepatic f...	OMIM:613489
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Patchy osteosclerosis	OMIM:241410
Gaucher Disease	Osteopenia, Increased bone mineral density, Osteomyelitis, Recurrent fractures, Joint stiffness, ...	ORPHA:355
Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 3	Elevated circulating alkaline phosphatase concentration	OMIM:615424
Desmosterolosis	Generalized osteosclerosis, Joint contracture of the hand, Arthrogryposis multiplex congenita	OMIM:602398
Growth Retardation, Impaired Intellectual Development, Hypotonia, And Hepatopathy	Joint laxity, Elevated circulating aspartate aminotransferase concentration, Intrahepatic cholest...	OMIM:617093
Blomstrand Lethal Chondrodysplasia	Increased bone mineral density, Synostosis of joints	ORPHA:50945
Hyperphosphatasia With Impaired Intellectual Development Syndrome 1	Elevated circulating alkaline phosphatase concentration, Delayed ossification of carpal bones	OMIM:239300
Glycosylphosphatidylinositol Biosynthesis Defect 11	Elevated circulating alkaline phosphatase concentration	OMIM:616025
Primary Hyperoxaluria	Elevated hepatic transaminase, Generalized osteosclerosis, Recurrent fractures	ORPHA:416
Cholesteryl Ester Storage Disease	Acute hepatic failure, Elevated circulating aspartate aminotransferase concentration, Portal hype...	OMIM:278000
Cog4-Cdg	Elevated hepatic transaminase, Fatal liver failure in infancy, Elevated circulating alkaline phos...	ORPHA:263501
Congenital Bile Acid Synthesis Defect Type 3	Elevated circulating aspartate aminotransferase concentration, Jaundice, Elevated circulating ala...	ORPHA:79302
Vascular Malformation, Primary Intraosseous	Elevated circulating alkaline phosphatase concentration	OMIM:606893
Schwartz-Jampel Syndrome	Hip contracture, Increased bone mineral density, Abnormally ossified vertebrae, Shoulder flexion ...	ORPHA:800
Sanjad-Sakati Syndrome	Patchy osteosclerosis	ORPHA:2323
Pseudohypoparathyroidism Type 1C	Ectopic ossification, Increased bone mineral density	ORPHA:79444
Trichothiodystrophy	Osteopenia, Increased bone mineral density, Multiple joint contractures, Craniosynostosis	ORPHA:33364
Graft Versus Host Disease	Elevated hepatic transaminase, Dupuytren contracture, Acute hepatitis, Limited elbow movement, Ja...	ORPHA:39812
Pseudohypoparathyroidism Type 1A	Hyperostosis frontalis interna, Ectopic ossification, Increased bone mineral density, Reduced bon...	ORPHA:79443
Cholestasis, Benign Recurrent Intrahepatic, 2	Elevated circulating alkaline phosphatase concentration, Intrahepatic cholestasis, Jaundice	OMIM:605479
Peroxisome Biogenesis Disorder 5A (Zellweger)	Elevated circulating aspartate aminotransferase concentration, Wide anterior fontanel, Jaundice, ...	OMIM:614866
Bile Acid Synthesis Defect, Congenital, 3	Elevated circulating aspartate aminotransferase concentration, Intrahepatic cholestasis, Jaundice...	OMIM:613812
Lathosterolosis	Elevated hepatic transaminase, Intrahepatic cholestasis, Osteoporosis, Elevated circulating alkal...	OMIM:607330
Hyperphosphatasia With Impaired Intellectual Development Syndrome 4	Elevated circulating alkaline phosphatase concentration	OMIM:615716
Cholestasis, Progressive Familial Intrahepatic, 8	Elevated circulating aspartate aminotransferase concentration, Portal hypertension, Jaundice, Ele...	OMIM:619662
Congenital Disorder Of Glycosylation, Type Iio	Elevated hepatic transaminase, Hepatic failure, Elevated alkaline phosphatase of bone origin, Pro...	OMIM:616828
Dent Disease	Recurrent fractures, Osteomalacia, Delayed epiphyseal ossification, Rickets, Sparse bone trabecul...	ORPHA:1652
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome	Osteopenia, Craniosynostosis, Low alkaline phosphatase, Joint hypermobility	ORPHA:369837
Cleidocranial Dysplasia 1	Increased bone mineral density, Delayed pubic bone ossification, Increased susceptibility to frac...	OMIM:119600
Congenital Disorder Of Glycosylation, Type Iil	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Elevated ...	OMIM:614576
Sapho Syndrome	Osteomyelitis, Recurrent fractures, Craniofacial osteosclerosis, Osteolysis, Synovitis, Enthesiti...	ORPHA:793
Cholestasis, Progressive Familial Intrahepatic, 2	Intrahepatic cholestasis, Elevated circulating alkaline phosphatase concentration, Intermittent j...	OMIM:601847
Sclerosteosis 1	Facial palsy secondary to cranial hyperostosis, Cortically dense long tubular bones, Sclerotic sc...	OMIM:269500
Rothmund-Thomson Syndrome	Osteopenia, Increased susceptibility to fractures, Abnormal trabecular bone morphology, Reduced b...	ORPHA:2909
Congenital Disorder Of Glycosylation, Type Iiw	Elevated hepatic transaminase, Elevated circulating aspartate aminotransferase concentration, Ele...	OMIM:619525
Developmental And Epileptic Encephalopathy 95	Joint laxity, Multiple joint contractures, Low alkaline phosphatase, Elevated circulating alkalin...	OMIM:618143
Atypical Werner Syndrome	Sclerosis of hand bone, Increased bone mineral density, Limitation of joint mobility, Osteoporosi...	ORPHA:79474
Autosomal Recessive Malignant Osteopetrosis	Osteopetrosis, Recurrent fractures, Craniosynostosis, Reduced bone mineral density	ORPHA:667
Xq12-Q13.3 Duplication Syndrome	Low alkaline phosphatase	ORPHA:314389
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease	Elevated circulating alkaline phosphatase concentration, Elevated gamma-glutamyltransferase level...	OMIM:613095
Rothmund-Thomson Syndrome Type 2	Osteopenia, Abnormal trabecular bone morphology, Finger symphalangism, Synostosis involving bones...	ORPHA:221016
Gallbladder Disease 1	Elevated hepatic transaminase, Jaundice, Elevated circulating alkaline phosphatase concentration	OMIM:600803
Rothmund-Thomson Syndrome Type 1	Osteopenia, Abnormal trabecular bone morphology, Finger symphalangism	ORPHA:221008
Primordial Dwarfism-Immunodeficiency-Lipodystrophy Syndrome	Portal hypertension, Elevated circulating alkaline phosphatase concentration, Craniosynostosis, E...	OMIM:620005
Primary Sclerosing Cholangitis	Osteopenia, Acute hepatic failure, Elevated hepatic transaminase, Abnormal eosinophil morphology,...	ORPHA:171
Boudin-Mortier Syndrome	Joint laxity, Elevated alkaline phosphatase of bone origin	OMIM:619543
Osteopetrosis With Renal Tubular Acidosis	Osteopetrosis, Recurrent fractures, Abnormal circulating enzyme concentration or activity	ORPHA:2785
Wild Type Attr Amyloidosis	Elevated circulating alkaline phosphatase concentration	ORPHA:330001
Isolated Biliary Atresia	Elevated hepatic transaminase, Jaundice, Elevated circulating alkaline phosphatase concentration,...	ORPHA:30391
Intrahepatic Cholestasis Of Pregnancy	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Jaundice	ORPHA:69665
Parenteral Nutrition-Associated Cholestasis	Elevated hepatic transaminase, Portal hypertension, Jaundice, Elevated circulating alkaline phosp...	ORPHA:567983
Citrullinemia, Type Ii, Neonatal-Onset	Elevated circulating aspartate aminotransferase concentration, Intrahepatic cholestasis, Elevated...	OMIM:605814
Caroli Disease	Portal hypertension, Intrahepatic cholestasis, Jaundice, Elevated circulating alanine aminotransf...	ORPHA:53035
Trichohepatoneurodevelopmental Syndrome	Joint laxity, Elevated circulating alkaline phosphatase concentration, Distal arthrogryposis, Dec...	OMIM:618268
Developmental And Epileptic Encephalopathy 80	Elevated circulating alkaline phosphatase concentration	OMIM:618580
Hyperphosphatasia-Intellectual Disability Syndrome	Elevated circulating alkaline phosphatase concentration	ORPHA:247262
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Elevated circulating alkaline phosphatase concentration, Elevated gamma-glutamyltransferase level	ORPHA:247691
Spondyloepimetaphyseal Dysplasia, X-Linked	Joint laxity, Abnormality of alkaline phosphatase level, Limited elbow extension, Delayed ossific...	OMIM:300106
Schinzel-Giedion Midface Retraction Syndrome	Sclerosis of skull base, Increased density of long bones, Thickened cortex of long bones	OMIM:269150
Renal Cysts And Diabetes Syndrome	Abnormality of alkaline phosphatase level, Gout, Elevated hepatic transaminase	OMIM:137920
Hyperphosphatasia With Impaired Intellectual Development Syndrome 3	Elevated circulating alkaline phosphatase concentration	OMIM:614207
Williams Syndrome	Osteopenia, Joint laxity, Increased bone mineral density, Joint stiffness, Osteoporosis, Spina bi...	ORPHA:904
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Low alkaline phosphatase	OMIM:201100
Amoebiasis Due To Entamoeba Histolytica	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration	ORPHA:67
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 4	Wide anterior fontanel, Elevated circulating alkaline phosphatase concentration	OMIM:618548
Coloboma, Congenital Heart Disease, Ichthyosiform Dermatosis, Impaired Intellectual Development, And Ear Anomalies Syndrome	Elevated circulating aspartate aminotransferase concentration, Elevated circulating alanine amino...	OMIM:280000
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2	Hip contracture, Flexion contracture, Elbow flexion contracture, Knee flexion contracture, Elevat...	OMIM:300868
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Hepatic f...	OMIM:617156
Lysosomal Acid Lipase Deficiency	Elevated hepatic transaminase, Fatal liver failure in infancy, Jaundice, Elevated circulating alk...	ORPHA:275761
Mirizzi Syndrome	Elevated hepatic transaminase, Jaundice, Elevated circulating alkaline phosphatase concentration	ORPHA:521219
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome	Elevated hepatic transaminase, Interface hepatitis, Elevated circulating alkaline phosphatase con...	ORPHA:562639
Caroli Syndrome	Elevated hepatic transaminase, Portal hypertension, Intrahepatic cholestasis, Jaundice, Elevated ...	ORPHA:480520
Al Amyloidosis	Elevated circulating alkaline phosphatase concentration	ORPHA:85443
Neuroleptic Malignant Syndrome	Elevated hepatic transaminase, Increased circulating lactate dehydrogenase concentration, Elevate...	ORPHA:94093
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Elevated hepatic transaminase, Jaundice, Elevated circulating alkaline phosphatase concentration,...	ORPHA:247598
Biliary, Renal, Neurologic, And Skeletal Syndrome	Osteopenia, Elevated circulating aspartate aminotransferase concentration, Portal hypertension, J...	OMIM:619534
Senior-Boichis Syndrome	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Portal hy...	ORPHA:84081
Primary Hepatic Neuroendocrine Carcinoma	Elevated hepatic transaminase, Intrahepatic cholestasis with episodic jaundice, Intermittent jaun...	ORPHA:100085
Leukemia, Chronic Myeloid	Reduced leukocyte alkaline phosphatase	OMIM:608232
Mitochondrial Complex Iii Deficiency, Nuclear Type 1	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Elevated ...	OMIM:124000
Reynolds Syndrome	Elevated hepatic transaminase, Elevated circulating alkaline phosphatase concentration, Jaundice	OMIM:613471
Gallbladder Neuroendocrine Tumor	Elevated alkaline phosphatase of hepatic origin, Elevated gamma-glutamyltransferase level, Interm...	ORPHA:100086
Generalized Arterial Calcification Of Infancy	Elevated alkaline phosphatase of bone origin, Osteomalacia, Abnormal calcification of the carpal ...	ORPHA:51608
Juvenile Nephropathic Cystinosis	Elevated alkaline phosphatase of bone origin	ORPHA:411634

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mir185

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mir185.

No publications found that use IMPC mice or data for Mir185.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Mir185^{tm1(mirKO)Wtsi}	Reporter-tagged deletion allele (with selection cassette)	Targeting vectors, ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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