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Gene: Muc19 MGI:2676278

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
mucin 19
Synonyms:
sld,  apomucin

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Muc19 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Muc19 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Salivary Gland Adenoma, Pleomorphic
Salivary gland neoplasm OMIM:181030
Pemphigus Vulgaris, Familial
Autoimmune antibody positivity, Autoimmunity, Oral mucosal blisters OMIM:169610
Autoimmune Disease
Autoimmune antibody positivity, Autoimmunity OMIM:109100
Parotid Salivary Glands, Polycystic Dysgenetic Disease Of
Enlargement of parotid gland OMIM:600343
Complement Component 4, Partial Deficiency Of
Systemic lupus erythematosus OMIM:120790
Cheilitis Glandularis
Abnormal salivary gland morphology, Thick lower lip vermilion ORPHA:1221
Hearing Loss-Familial Salivary Gland Insensitivity To Aldosterone Syndrome
Abnormal salivary gland morphology ORPHA:3225
Van Der Woude Syndrome
Lip pit, Cleft upper lip, Lower lip pit, Cleft palate, Hypodontia, Abnormal salivary gland morpho... ORPHA:888
Tn Polyagglutination Syndrome
Autoimmunity OMIM:300622
Hashimoto Thyroiditis
Autoimmune antibody positivity, Hashimoto thyroiditis OMIM:140300
Complement Component 8 Deficiency, Type I
Systemic lupus erythematosus OMIM:613790
Systemic Lupus Erythematosus 16
Antinuclear antibody positivity, Perinuclear antineutrophil antibody positivity, Anti-dsDNA antib... OMIM:614420
Mucous Membrane Pemphigoid
Autoimmunity, Gingivitis, Oral mucosal blisters ORPHA:46486
Masp2 Deficiency
Ulcerative colitis, Systemic lupus erythematosus OMIM:613791
Kimura Disease
Abnormal salivary gland morphology ORPHA:482
C1Q Deficiency 1
Autoimmunity, Systemic lupus erythematosus OMIM:613652
Complement Component C1S Deficiency
Hashimoto thyroiditis, Systemic lupus erythematosus OMIM:613783
Alopecia Areata 1
Autoimmunity OMIM:104000
Complement Component 2 Deficiency
Systemic lupus erythematosus OMIM:217000
Brooke-Spiegler Syndrome
Abnormality of the sublingual glands, Abnormality of the submandibular glands, Salivary gland neo... ORPHA:79493
Immunoglobulin A Deficiency 1
Autoimmunity, Malabsorption OMIM:137100
Linear Iga Dermatosis
Inflammation of the large intestine, Autoimmunity, Oral ulcer ORPHA:46488
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Autoimmune hemolytic anemia, Autoimmunity, Systemic lupus erythematosus, Autoimmune thrombocytopenia ORPHA:444463
Eosinophilopenia
Autoimmunity OMIM:131430
Diabetes Mellitus, Ketosis-Prone
Autoimmunity OMIM:612227
Complement Component C1R/C1S Deficiency
Autoimmunity OMIM:216950
Lupus Erythematosus Tumidus
Antinuclear antibody positivity, Autoimmune antibody positivity, Anti-La/SS-B antibody positivity... ORPHA:90283
Igg4-Related Thyroid Disease
Pancreatic fibrosis, Autoimmunity, Anti-thyroid peroxidase antibody positivity, Abnormal pituitar... ORPHA:64744
Variant Abeta2M Amyloidosis
Intestinal perforation, Abnormal salivary gland morphology, Abnormality of the tongue ORPHA:314652
Igg4-Related Submandibular Gland Disease
Autoimmunity, Xerostomia, Enlarged lacrimal glands, Abnormal pancreas morphology, Enlargement of ... ORPHA:449432
Pemphigus Erythematosus
Autoimmunity, Antinuclear antibody positivity, Anti-acetylcholine receptor antibody positivity, O... ORPHA:79480
Subacute Cutaneous Lupus Erythematosus
Antiphospholipid antibody positivity, Rheumatoid factor positive, Anti-histone antibody positivit... ORPHA:163525
Insulin Autoimmune Syndrome
Autoimmune antibody positivity, Autoimmunity, Systemic lupus erythematosus ORPHA:411593
Inclusion Body Myositis
Autoimmunity ORPHA:611
Sjogren Syndrome
Xerostomia, Autoimmunity, Rheumatoid arthritis OMIM:270150
Oxoglutaric Aciduria
Abnormal salivary gland morphology ORPHA:31
Immunoglobulin A Deficiency 2
Autoimmunity OMIM:609529
Autoimmune Disease, Multisystem, Infantile-Onset, 2
Colitis, Autoimmunity OMIM:617006
Igg4-Related Dacryoadenitis And Sialadenitis
Autoimmunity, Antinuclear antibody positivity, Cytoplasmic antineutrophil antibody positivity, Xe... ORPHA:79078
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Autoimmune thrombocytopenia, Antinuclear antibody positivity, Celiac disease, Anti-U1 ribonucleop... OMIM:619375
Darier-White Disease
Enlargement of parotid gland OMIM:124200
Febrile Infection-Related Epilepsy Syndrome
Autoimmunity ORPHA:163703
Muir-Torre Syndrome
Adenoma sebaceum, Colon cancer, Neoplasm of the stomach, Salivary gland neoplasm ORPHA:587
Secondary Non-Traumatic Avascular Necrosis
Autoimmunity, Rheumatoid arthritis, Systemic lupus erythematosus ORPHA:399180
Pemphigus Vulgaris
Autoimmunity, Abnormal oral cavity morphology ORPHA:704
Combined Immunodeficiency Due To Partial Rag1 Deficiency
Autoimmune hemolytic anemia, Neutropenia in presence of anti-neutropil antibodies, Autoimmunity ORPHA:231154
Idiopathic Non-Lupus Full-House Nephropathy
Autoimmunity, Anti-dsDNA antibody positivity, Oral ulcer ORPHA:567544
Insulin-Resistance Syndrome Type B
Enlarged ovaries, Autoimmunity, Antinuclear antibody positivity, Enlarged polycystic ovaries, Sys... ORPHA:2298
Subcorneal Pustular Dermatosis
Autoimmunity, Rheumatoid arthritis, Systemic lupus erythematosus ORPHA:48377
Autoimmune Disease, Multisystem, Infantile-Onset, 1
Autoimmune hemolytic anemia, Autoimmunity, Autoimmune thrombocytopenia, Celiac disease, Abnormali... OMIM:615952
Gamma-Heavy Chain Disease
Autoimmune hemolytic anemia, Autoimmunity, Autoimmune thrombocytopenia, Rheumatoid arthritis, Neo... ORPHA:100026
Acquired Ichthyosis
Autoimmunity ORPHA:454
Type 1 Diabetes Mellitus
Autoimmunity OMIM:222100
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Autoimmunity, Decreased response to growth hormone stimulation test, Pituitary adenoma, Adrenocor... ORPHA:91354
Al Amyloidosis
Macroglossia, Abnormal salivary gland morphology, Xerostomia ORPHA:85443
Acquired Partial Lipodystrophy
Autoimmunity ORPHA:79087
Mixed-Type Autoimmune Hemolytic Anemia
Autoimmune hemolytic anemia, Autoimmunity, Systemic lupus erythematosus ORPHA:90036
Unclassified Myelodysplastic Syndrome
Autoimmunity ORPHA:98827
Monosomy 18P
Autoimmunity, Carious teeth, Cleft palate, Downturned corners of mouth, Short philtrum, Hypodonti... ORPHA:1598
Melioidosis
Abnormal parotid gland morphology, Parotitis ORPHA:31202
Diffuse Alveolar Hemorrhage
Antiphospholipid antibody positivity, Rheumatoid factor positive, Autoimmunity, Antinuclear antib... ORPHA:90060
Autoimmune Lymphoproliferative Syndrome, Type Iii
Autoimmune hemolytic anemia, Autoimmunity, Anticardiolipin IgG antibody positivity, Autoimmune th... OMIM:615559
Anti-Glomerular Basement Membrane Disease
Autoimmunity, Persistence of primary teeth ORPHA:375
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Recurrent aphthous stomatitis, Juvenile rheumatoid arthritis, Autoimmunity, Hashimoto thyroiditis ORPHA:275
Preeclampsia
Autoimmunity, Polycystic ovaries ORPHA:275555
Brachydactylous Dwarfism, Mseleni Type
Autoimmunity ORPHA:2619
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Anti-thyroid peroxidase antibody positivity, Autoimmunity ORPHA:277
Treacher Collins Syndrome 1
Cleft soft palate, Cryptorchidism, Cleft palate, Wide mouth, Abnormal parotid gland morphology, N... OMIM:154500
Ehlers-Danlos Syndrome, Periodontal Type, 1
Alveolar bone loss around teeth, Autoimmunity, Hiatus hernia, Intestinal perforation, Periodontit... OMIM:130080
Neurofibroma
Enlargement of parotid gland, Multiple intestinal neurofibromatosis, Intestinal bleeding ORPHA:252183
Ras-Associated Autoimmune Leukoproliferative Disorder
Autoimmunity, Autoimmune thrombocytopenia OMIM:614470
Lacrimoauriculodentodigital Syndrome
Abnormal dental enamel morphology, Abnormality of the dentition, Carious teeth, Cryptorchidism, E... ORPHA:2363
Cernunnos-Xlf Deficiency
Autoimmunity ORPHA:169079
Syndromic Multisystem Autoimmune Disease Due To Itch Deficiency
Autoimmunity, Anti-thyroid peroxidase antibody positivity, Neutropenia in presence of anti-neutro... ORPHA:228426
Autoimmune Hemolytic Anemia, Warm Type
Autoimmune hemolytic anemia, Autoimmunity, Systemic lupus erythematosus ORPHA:90033
Dermatitis Herpetiformis
Autoimmunity, Malabsorption ORPHA:1656
Activated Pi3K-Delta Syndrome
Abnormal intestine morphology, Autoimmunity, Intestinal lymphoid nodular hyperplasia ORPHA:397596
Igg4-Related Aortitis
Antinuclear antibody positivity, Cytoplasmic antineutrophil antibody positivity, Intestinal obstr... ORPHA:449400
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Autoimmune hemolytic anemia, Autoimmunity OMIM:618495
Benign Schwannoma
Intestinal polyposis, Abnormal parotid gland morphology, Abnormal esophagus morphology ORPHA:252164
C3 Glomerulopathy
Autoimmunity, C3 nephritic factor positivity ORPHA:329918
Kikuchi-Fujimoto Disease
Antinuclear antibody positivity, Oral ulcer, Enlargement of parotid gland ORPHA:50918
Limited Cutaneous Systemic Sclerosis
Autoimmunity ORPHA:220402
Igg4-Related Ophthalmic Disease
Antinuclear antibody positivity, Orchitis, Abnormality of the anterior pituitary, Enlarged lacrim... ORPHA:449563
Bullous Pemphigoid
Autoimmunity ORPHA:703
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Autoimmune hemolytic anemia, Intestinal obstruction, Jejunal atresia, Autoimmunity, Ileal atresia... OMIM:243150
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Absence of Stensen duct, Decreased response to growth hormone stimulation test, Selective tooth a... OMIM:129900
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Anal stenosis, Absence of Stensen duct, Decreased response to growth hormone stimulation test, Se... OMIM:604292
Lymphoproliferative Syndrome 1
Stomatitis, Autoimmune hemolytic anemia, Autoimmunity, Autoimmune thrombocytopenia OMIM:613011
Spondyloenchondrodysplasia
Delayed eruption of teeth, Autoimmune hemolytic anemia, Autoimmunity, Decreased response to growt... ORPHA:1855
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Autoimmunity ORPHA:293964
Oligoarticular Juvenile Idiopathic Arthritis
Antinuclear antibody positivity, Autoimmunity, Rheumatoid arthritis ORPHA:85410
Immunodeficiency 7
Autoimmune hemolytic anemia, Autoimmunity OMIM:615387
Purine Nucleoside Phosphorylase Deficiency
Autoimmune hemolytic anemia, Autoimmunity, Systemic lupus erythematosus, Autoimmune thrombocytopenia ORPHA:760
Systemic-Onset Juvenile Idiopathic Arthritis
Juvenile rheumatoid arthritis, Autoimmunity ORPHA:85414
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency
Hypopituitarism, Inflammation of the large intestine, Autoimmunity, Conical tooth ORPHA:98813
Autoimmune Polyendocrinopathy Type 4
Atrophic gastritis, Antiphospholipid antibody positivity, Autoimmunity, Autoimmune thrombocytopen... ORPHA:227990
Autoimmune Polyendocrinopathy Type 3
Atrophic gastritis, Antiphospholipid antibody positivity, Autoimmunity, Autoimmune hypoparathyroi... ORPHA:227982
Autoimmune Polyendocrinopathy Type 1
Hypoparathyroidism, Adrenal hyperplasia, Autoimmunity ORPHA:3453
Autoimmune Hypoparathyroidism
Autoimmune antibody positivity, Autoimmunity, Autoimmune hypoparathyroidism ORPHA:36913
Igg4-Related Kidney Disease
Antinuclear antibody positivity, Sialadenitis, Abnormality of the anterior pituitary, Rheumatoid ... ORPHA:449395
Sarcoidosis, Susceptibility To, 1
Inflammation of the large intestine, Enlarged lacrimal glands, Abnormal salivary gland morphology OMIM:181000
Thymoma
Autoimmunity, Anti-acetylcholine receptor antibody positivity, Ulcerative colitis, Systemic lupus... ORPHA:99867
X-Linked Agammaglobulinemia
Glossoptosis, Autoimmunity, Malabsorption ORPHA:47
Pemphigus Foliaceus
Abnormal oral mucosa morphology, Autoimmunity, Oral ulcer ORPHA:79481
Adiposis Dolorosa
Xerostomia, Autoimmunity ORPHA:36397
Overlap Myositis
Antinuclear antibody positivity, Autoimmunity, Rheumatoid arthritis, Systemic lupus erythematosus ORPHA:206572
Cold Agglutinin Disease
Autoimmunity ORPHA:56425
Bronchiolitis Obliterans With Obstructive Pulmonary Disease
Autoimmunity ORPHA:1303
Sarcoidosis
Enlargement of parotid gland, Enlarged lacrimal glands, Parotitis ORPHA:797
Diffuse Cutaneous Systemic Sclerosis
Carious teeth, Xerostomia, Autoimmunity, Malabsorption ORPHA:220393
Lacrimoauriculodentodigital Syndrome 1
Absence of Stensen duct, Delayed eruption of primary teeth, Aplasia of the parotid gland, Carious... OMIM:149730
Glossopharyngeal Neuralgia
Tongue pain, Autoimmunity, Abnormal palate morphology ORPHA:221098
Combined Immunodeficiency Due To Crac Channel Dysfunction
Amelogenesis imperfecta, Autoimmunity, Hypocalcification of dental enamel ORPHA:169090
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Autoimmune hemolytic anemia, Gastritis, Autoimmunity, Autoimmune thrombocytopenia, Malabsorption,... ORPHA:37042
Localized Scleroderma
Autoimmunity, Abnormality of the dentition, Dental malocclusion, Abnormal upper lip morphology, E... ORPHA:90289
Macrophage Activation Syndrome
Juvenile rheumatoid arthritis, Autoimmunity, Systemic lupus erythematosus ORPHA:158061
Blau Syndrome
Abnormal salivary gland morphology, Xerostomia ORPHA:90340
Autoimmune Lymphoproliferative Syndrome
Autoimmune hemolytic anemia, Antiphospholipid antibody positivity, Rheumatoid factor positive, Au... ORPHA:3261
Immunodeficiency By Defective Expression Of Mhc Class Ii
Autoimmune hemolytic anemia, Neutropenia in presence of anti-neutropil antibodies, Autoimmunity, ... ORPHA:572
Selective Igm Deficiency
Autoimmunity, Autoimmune thrombocytopenia, Antinuclear antibody positivity, Neutropenia in presen... ORPHA:331235
Antisynthetase Syndrome
Xerostomia, Autoimmunity ORPHA:81
Spondyloenchondrodysplasia With Immune Dysregulation
Autoimmunity, Autoimmune thrombocytopenia, Antinuclear antibody positivity, Systemic lupus erythe... OMIM:607944
T-Cell Lymphoma, Subcutaneous Panniculitis-Like
Autoimmunity OMIM:618398
Livedoid Vasculopathy
Antinuclear antibody positivity, Lupus anticoagulant, Autoimmunity, Systemic lupus erythematosus ORPHA:542643
Myasthenia Gravis
Autoimmunity OMIM:254200
Combined Immunodeficiency-Enteropathy Spectrum
Autoimmune hemolytic anemia, Autoimmunity, Intestinal malrotation, Intestinal atresia, Hypoplasia... ORPHA:436252
Angioedema, Hereditary, 1
Intestinal edema, Autoimmunity OMIM:106100
Stiff-Person Syndrome
Autoimmunity OMIM:184850
Lymphoid Interstitial Pneumonia
Autoimmune antibody positivity, Autoimmunity, Rheumatoid arthritis ORPHA:79128
Nodular Non-Suppurative Panniculitis
Autoimmunity ORPHA:33577
Late-Onset Isolated Acth Deficiency
Hypoparathyroidism, Autoimmunity, Celiac disease, Pituitary adenoma, Adrenocorticotropic hormone ... ORPHA:199299
Intrahepatic Cholestasis Of Pregnancy
Abnormal pineal melatonin secretion, Autoimmunity ORPHA:69665
Primary Biliary Cholangitis
Antinuclear antibody positivity, Autoimmunity, Celiac disease ORPHA:186
Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency
Chronic gastritis, Autoimmunity, Celiac disease, Systemic lupus erythematosus, Rheumatoid arthritis ORPHA:183675
Secondary Intestinal Lymphangiectasia
Intestinal obstruction, Intestinal lymphedema, Autoimmunity, Malabsorption, Celiac disease, Intes... ORPHA:90363
Chronic Thromboembolic Pulmonary Hypertension
Lupus anticoagulant, Inflammation of the large intestine, Antiphospholipid antibody positivity, A... ORPHA:70591
Psoriasis-Related Juvenile Idiopathic Arthritis
Antinuclear antibody positivity, Autoimmunity ORPHA:85436
Familial Hypocalciuric Hypercalcemia
Peptic ulcer, Autoimmunity ORPHA:405

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Muc19

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Muc19.

No publications found that use IMPC mice or data for Muc19.

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MGI Allele Allele Type Produced
Muc19tm438171(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Muc19tm438203(L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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