Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased fasting circulating glucose level | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 2.11×10-05 | ||
decreased locomotor activity | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 4.66×10-07 | ||
decreased exploration in new environment | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 2.06×10-05 | ||
decreased total body fat amount | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 2.60×10-05 | ||
decreased circulating triglyceride level | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 5.07×10-05 | ||
decreased grip strength | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 8.51×10-05 | ||
enlarged lymph nodes | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 0.00 | ||
improved glucose tolerance | D630045J12Riktm1b(KOMP)Wtsi | HOM | Early adult | 2.20×10-12 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to D630045J12Rik by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Retinitis Pigmentosa | Hyperinsulinemia, Type II diabetes mellitus | ORPHA:791 | |
Retinitis Pigmentosa 86 | OMIM:618613 |
The table below shows human diseases predicted to be associated to D630045J12Rik by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for D630045J12Rik
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MGI Allele | Allele Type | Produced |
---|---|---|
D630045J12Riktm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice, Tissue |
D630045J12Riktm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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