Gene Summary

Name:
myosin XVIIIA
Synonyms:
MyoPDZ

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Myo18atm1b(KOMP)Wtsi HOM   Early adult 0.00
pale yolk sac Myo18atm1b(KOMP)Wtsi HOM E12.5 0.00
pale liver Myo18atm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal placenta size Myo18atm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal embryo size Myo18atm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal limb bud morphology Myo18atm1b(KOMP)Wtsi HOM E12.5 0.00
pallor Myo18atm1b(KOMP)Wtsi HOM E12.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

No Adult expression data was found for this gene.

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Axial skeleton N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
Brain N/A heterozygote 33.33% (2 of 6)
Brain N/A homozygote Ambiguous
Central nervous system ganglion N/A heterozygote 100% (2 of 2)
N/A Ambiguous
Ear N/A heterozygote 33.33% (2 of 6)
Ear N/A homozygote Ambiguous
Embryo N/A heterozygote 100% (6 of 6)
Embryo N/A homozygote 100% (3 of 3)
Eye N/A heterozygote 33.33% (2 of 6)
Eye N/A homozygote Ambiguous
Footplate N/A heterozygote 33.33% (2 of 6)
Footplate N/A homozygote Ambiguous
Forebrain N/A heterozygote 33.33% (2 of 6)
Forebrain N/A homozygote Ambiguous
Forelimb N/A heterozygote 33.33% (2 of 6)
Forelimb N/A homozygote Ambiguous
Gut N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
Handplate N/A heterozygote 33.33% (2 of 6)
Handplate N/A homozygote Ambiguous
Head N/A heterozygote 0.0% (0 of 6)
Head N/A homozygote Ambiguous
Heart N/A heterozygote 33.33% (2 of 6)
Heart N/A homozygote Ambiguous
Hindbrain N/A heterozygote 33.33% (2 of 6)
Hindbrain N/A homozygote Ambiguous
Hindlimb N/A heterozygote 33.33% (2 of 6)
Hindlimb N/A homozygote Ambiguous
Liver N/A heterozygote 0.0% (0 of 6)
Liver N/A homozygote Ambiguous
Lung N/A heterozygote 0.0% (0 of 6)
Lung N/A homozygote Ambiguous
Mandibular process N/A heterozygote 0.0% (0 of 6)
Mandibular process N/A homozygote Ambiguous
Maxillary process N/A heterozygote 0.0% (0 of 6)
Maxillary process N/A homozygote Ambiguous
Midbrain N/A heterozygote 33.33% (2 of 6)
Midbrain N/A homozygote Ambiguous
Nose N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
Oral cavity N/A heterozygote 0.0% (0 of 6)
Oral cavity N/A homozygote Ambiguous
Skeleton N/A heterozygote 100% (2 of 2)
N/A Ambiguous
Skin N/A heterozygote 33.33% (2 of 6)
Skin N/A homozygote Ambiguous
Spinal cord N/A heterozygote 100% (2 of 2)
N/A Ambiguous
Tail somite N/A heterozygote 33.33% (2 of 6)
Tail somite N/A homozygote Ambiguous
Tail N/A heterozygote 0.0% (0 of 6)
Tail N/A homozygote Ambiguous
Trachea N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
Urinary system N/A heterozygote 100% (2 of 2)
N/A Ambiguous

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
axial skeleton Ambiguous
brain 0.0%
central nervous system ganglion Ambiguous
ear 0.0%
embryo 0.0%
eye 0.0%
footplate 0.0%
forebrain 0.0%
forelimb 0.0%
gut Ambiguous
handplate 0.0%
head 0.0%
heart 0.0%
hindbrain 0.0%
hindlimb 0.0%
liver 0.0%
lung 0.0%
mandibular process 0.0%
maxillary process 0.0%
midbrain 0.0%
nose Ambiguous
oral cavity 0.0%
skeleton Ambiguous
skin 0.0%
spinal cord Ambiguous
tail 0.0%
tail somite group 0.0%
trachea Ambiguous
urinary system Ambiguous

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Embryo LacZ

LacZ images wholemount

1084 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Gross Pathology and Tissue Collection

Images

8 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

1 Images

Histopathology

Images

1 Images

Eye Morphology

Images Slit Lamp

1 Images

Human diseases caused by Myo18a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Myo18a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Exercise Intolerance, Riboflavin-Responsive
Ragged-red muscle fibers OMIM:616839
Polyglucosan Body Myopathy 2
Peroneal muscle weakness, Muscle fiber inclusion bodies, Muscle fiber polyglucosan inclusion bodi... OMIM:616199
Myopathy, Distal, 5
Muscle fiber splitting, Distal lower limb muscle weakness, Distal amyotrophy, Rimmed vacuoles, We... OMIM:617030
Nonaka Myopathy
Distal lower limb muscle weakness, Deposits immunoreactive to beta-amyloid protein, Distal amyotr... OMIM:605820
Inclusion Body Myositis
Inflammatory myopathy, Ragged-red muscle fibers, Rimmed vacuoles, Skeletal muscle atrophy, Abnorm... ORPHA:611
Myopathy, Distal, With Rimmed Vacuoles
Internally nucleated skeletal muscle fibers, Rimmed vacuoles, Facial palsy, Scapular winging, EMG... OMIM:617158
Myopathy, Distal, 6, Adult-Onset, Autosomal Dominant
Internally nucleated skeletal muscle fibers, Type 1 muscle fiber predominance, Distal amyotrophy,... OMIM:618655
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 26
Calf muscle hypertrophy, Muscle fiber necrosis, Increased variability in muscle fiber diameter, F... OMIM:618848
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor, Hepatomegaly, Splenomegaly ORPHA:46532
Muscular Dystrophy, Pseudohypertrophic, With Internalized Capillaries
Muscular dystrophy, Central core regions in muscle fibers OMIM:159050
Tubular Aggregate Myopathy
Muscle fiber tubular inclusions, EMG: myopathic abnormalities, Increased variability in muscle fi... ORPHA:2593
Dnajb6-Related Limb-Girdle Muscular Dystrophy D1
Rimmed vacuoles, Skeletal muscle fibrosis, Myofibrillar myopathy, Increased variability in muscle... ORPHA:34516
Myopathy, Sarcoplasmic Body
Sarcoplasmic bodies, Weakness of the intrinsic hand muscles, Increased variability in muscle fibe... OMIM:620286
Tibial Muscular Dystrophy, Tardive
Muscular dystrophy, Tibialis anterior muscle atrophy, Rimmed vacuoles, EMG: myopathic abnormaliti... OMIM:600334
Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 3
Muscle fiber inclusion bodies, Rimmed vacuoles, Increased variability in muscle fiber diameter, C... OMIM:615424
Oculopharyngeal Muscular Dystrophy
Ragged-red muscle fibers, Abnormal muscle fiber morphology, Rimmed vacuoles, Myopathy ORPHA:270
Spinal Muscular Atrophy, Type Iv
Calf muscle hypertrophy, Rimmed vacuoles, Spinal muscular atrophy, Muscle fiber necrosis, Increas... OMIM:271150
Anoctamin-5-Related Limb-Girdle Muscular Dystrophy R12
Lower limb amyotrophy, Calf muscle hypertrophy, Wrist flexion contracture, Upper limb amyotrophy,... ORPHA:206549
Amyotrophic Lateral Sclerosis 20
Muscular dystrophy, Rimmed vacuoles, Muscle fiber inclusion bodies OMIM:615426
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 15
Increased variability in muscle fiber diameter, Centrally nucleated skeletal muscle fibers, Myopathy OMIM:618992
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Peripheral Cone Dystrophy
Pallor OMIM:609021
X-Linked Sideroblastic Anemia
Pallor, Elevated circulating hepatic transaminase concentration, Splenomegaly ORPHA:75563
Breath-Holding Spells
Pallor OMIM:607578
Dermatitis, Atopic
Pallor, Facial erythema, Dry skin OMIM:603165
Anemia, Congenital Dyserythropoietic, Type Ib
Jaundice, Hepatomegaly, Splenomegaly, Syndactyly, Pallor OMIM:615631
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Pallor, Hepatomegaly, Elevated circulating hepatic transaminase concentration OMIM:613561
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Pallor ORPHA:2786
Creatine Phosphokinase, Elevated Serum
Muscular dystrophy, Inflammatory myopathy, EMG: myopathic abnormalities, Abnormal muscle fiber mo... OMIM:123320
Hemoglobin D Disease
Pallor, Splenomegaly ORPHA:90039
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Beta-Thalassemia
Skin ulcer, Hepatomegaly, Cholelithiasis, Splenomegaly, Pallor, Hepatitis ORPHA:848
Pyruvate Kinase Deficiency Of Red Cells
Jaundice, Hepatomegaly, Cholelithiasis, Splenomegaly, Intrauterine growth retardation, Pallor, Ch... OMIM:266200
Optic Atrophy 1
Pallor OMIM:165500
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
Irida Syndrome
Pallor, Intrahepatic cholestasis ORPHA:209981
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor OMIM:612989
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor, Pancreatic islet-cell hyperplasia ORPHA:276608
Myoglobinuria, Recurrent
Ragged-red muscle fibers OMIM:550500
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Focal pancreatic islet hyperplasia, Pallor, Hepatomegaly, Diffuse pancreatic islet hyperplasia ORPHA:276575
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Evans Syndrome
Petechiae, Pallor, Jaundice ORPHA:1959
Myelofibrosis
Splenomegaly, Purpura, Hepatomegaly, Pallor OMIM:254450
Hyperinsulinism Due To Ucp2 Deficiency
Pallor, Hepatomegaly, Diffuse pancreatic islet hyperplasia ORPHA:276556
Hb Bart'S Hydrops Fetalis
Pallor, Hepatomegaly, Splenomegaly ORPHA:163596
Leishmaniasis
Skin ulcer, Elevated circulating hepatic transaminase concentration, Hepatomegaly, Splenomegaly, ... ORPHA:507
Primary Myelofibrosis
Purpura, Hepatomegaly, Petechiae, Portal hypertension, Ecchymosis, Splenomegaly, Hepatosplenomega... ORPHA:824
Senior-Loken Syndrome 8
Polydactyly, Intrahepatic bile duct dilatation, Hepatic cysts, Pallor, Pancreatic cysts OMIM:616307
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Pallor, Hepatomegaly, Diffuse pancreatic islet hyperplasia ORPHA:276580
Elliptocytosis 1
Pallor, Jaundice, Splenomegaly OMIM:611804
Beta-Thalassemia Intermedia
Decreased liver function, Cirrhosis, Jaundice, Skin ulcer, Hepatomegaly, Cholelithiasis, Hepatoce... ORPHA:231222
Retinitis Pigmentosa 51
Polydactyly, Pallor OMIM:613464
Cold Agglutinin Disease
Pallor, Hepatomegaly, Splenomegaly ORPHA:56425
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Jaundice, Hepatomegaly, Cholelithiasis, Splenomegaly, Pallor, Hepatitis OMIM:194380
Anemia, Hypochromic Microcytic, With Iron Overload 2
Elevated hepatic iron concentration, Pallor, Hepatomegaly, Splenomegaly OMIM:615234
Hyperinsulinism Due To Hnf1A Deficiency
Pallor, Hepatomegaly ORPHA:324575
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor, Jaundice, Hepatomegaly OMIM:613839
Cyclic Vomiting Syndrome
Pallor OMIM:500007
Myopathic Ehlers-Danlos Syndrome
Congenital finger flexion contractures, Adducted thumb, Pallor, Tapered finger, Talipes equinovarus ORPHA:536516
Thiamine-Responsive Megaloblastic Anemia Syndrome
Pallor ORPHA:49827
Drug-Induced Autoimmune Hemolytic Anemia
Pallor, Splenomegaly ORPHA:90037
Congenital Heart Block
Intrauterine growth retardation, Pallor ORPHA:60041
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Pallor, Hepatosplenomegaly OMIM:611590
Deafness-Lymphedema-Leukemia Syndrome
Pallor, Hepatomegaly, Splenomegaly ORPHA:3226
Dominant Beta-Thalassemia
Cirrhosis, Jaundice, Skin ulcer, Genu valgum, Hepatocellular carcinoma, Hepatic fibrosis, Bowing ... ORPHA:231226
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Increased hepatic glycogen... ORPHA:263455
Acquired Idiopathic Sideroblastic Anemia
Pallor, Hepatomegaly, Splenomegaly ORPHA:75564
Dravet Syndrome
Pallor, Tibial torsion ORPHA:33069
Idiopathic Pulmonary Hemosiderosis
Pallor, Hepatomegaly, Hepatosplenomegaly ORPHA:99931
American Trypanosomiasis
Pallor, Hepatomegaly, Splenomegaly ORPHA:3386
Autoimmune Hemolytic Anemia, Warm Type
Pallor, Jaundice, Splenomegaly ORPHA:90033
Beta-Thalassemia Major
Cirrhosis, Jaundice, Skin ulcer, Hepatomegaly, Genu valgum, Hepatocellular carcinoma, Hepatic fib... ORPHA:231214
Hereditary Spherocytosis
Jaundice, Skin ulcer, Hepatomegaly, Cholelithiasis, Splenomegaly, Pallor ORPHA:822
Fanconi Anemia, Complementation Group I
Hypoplasia of the radius, Absent thumb, Short thumb, Intrauterine growth retardation, Short 1st m... OMIM:609053
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema ORPHA:439218
Letterer-Siwe Disease
Pallor, Jaundice, Hepatosplenomegaly OMIM:246400
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Retinitis Pigmentosa 75
Pallor OMIM:617023
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Prolonged neonatal jaundice, Pallor, Jaundice, Splenomegaly OMIM:300908
Fructose-1,6-Bisphosphatase Deficiency
Hepatic steatosis, Pallor, Hepatomegaly, Elevated circulating hepatic transaminase concentration ORPHA:348
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Elevated hepatic iron concentration, Pallor, Elevated circulating hepatic transaminase concentrat... ORPHA:300298
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Sepsis In Premature Infants
Decreased liver function, Purpura, Jaundice, Hepatomegaly, Petechiae, Splenomegaly, Pallor ORPHA:90051
Congenital Dyserythropoietic Anemia Type Iii
Pallor, Elevated circulating hepatic transaminase concentration ORPHA:98870
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Pallor OMIM:600462
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor, Hepatomegaly, Elevated circulating hepatic transaminase concentration, Hepatosplenomegaly ORPHA:331206
Cone-Rod Dystrophy 8
Pallor OMIM:605549
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Tay-Sachs Disease
Pallor OMIM:272800
Rheumatic Fever
Pallor, Erythema ORPHA:3099
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor, Hepatomegaly, Elevated circulating alanine aminotransferase concentration, Elevated circu... OMIM:246450
3-Hydroxy-3-Methylglutaric Aciduria
Jaundice, Elevated circulating hepatic transaminase concentration, Hepatomegaly, Acute pancreatit... ORPHA:20
Pearson Marrow-Pancreas Syndrome
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Macronodular cirrhosis, Ex... OMIM:557000
Waldenström Macroglobulinemia
Splenomegaly, Purpura, Hepatomegaly, Pallor ORPHA:33226
Beta-Ketothiolase Deficiency
Pallor, Hepatomegaly ORPHA:134
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Anemia, Sideroblastic, And Spinocerebellar Ataxia
Intrauterine growth retardation, Pallor OMIM:301310
Hereditary Folate Malabsorption
Pallor ORPHA:90045
Myopathy, Mitochondrial, And Ataxia
Pallor OMIM:617675
Fumarase Deficiency
Pallor, Intrahepatic cholestasis, Hepatic failure OMIM:606812
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor, Hepatomegaly, Splenomegaly ORPHA:98849
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Idiopathic Hypereosinophilic Syndrome
Portal fibrosis, Cholangitis, Elevated circulating hepatic transaminase concentration, Pancreatit... ORPHA:3260
Imerslund-Gräsbeck Syndrome
Pallor ORPHA:35858
Aregenerative Anemia
Pallor ORPHA:101096
Adenohypophysitis
Pallor ORPHA:95512
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Pallor, Hepatomegaly OMIM:277400
Panhypophysitis
Pallor ORPHA:95513
Sheehan Syndrome
Pallor, Dry skin ORPHA:91355
Pituitary Apoplexy
Pallor ORPHA:95613
Hereditary Pheochromocytoma-Paraganglioma
Pallor ORPHA:29072
Refractory Anemia With Excess Blasts
Anemic pallor ORPHA:86839
Degcags Syndrome
Polydactyly, Hepatomegaly, Genu valgum, Talipes equinovarus, Cholestasis, Abnormal spleen morphol... OMIM:619488
Prolactinoma
Pallor ORPHA:2965
Diamond-Blackfan Anemia 1
Hypoplasia of the radius, Triphalangeal thumb, Spina bifida occulta, Partial duplication of thumb... OMIM:105650
Fanconi Anemia, Complementation Group C
Absent radius, Anemic pallor, Complete duplication of thumb phalanx, Absent thumb, Short thumb, I... OMIM:227645
Incontinentia Pigmenti
Pallor, Erythema OMIM:308300
Alternating Hemiplegia Of Childhood
Pallor ORPHA:2131
Fanconi Anemia, Complementation Group E
Anemic pallor, Complete duplication of thumb phalanx, Absent thumb, Short thumb, Absent radius OMIM:600901
Autosomal Recessive Malignant Osteopetrosis
Abnormal metaphysis morphology, Hepatomegaly, Bowing of the long bones, Splenomegaly, Pallor ORPHA:667
Histiocytoid Cardiomyopathy
Pallor, Hepatomegaly ORPHA:137675
Fanconi Anemia, Complementation Group D2
Annular pancreas, Anemic pallor, Aplasia of the 1st metacarpal, Complete duplication of thumb pha... OMIM:227646
Fanconi Anemia, Complementation Group A
Anemic pallor, Complete duplication of thumb phalanx, Absent thumb, Short thumb, Absent radius OMIM:227650
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Anemic pallor ORPHA:329971
Esophageal Atresia
Pallor, Clinodactyly ORPHA:1199
Von Hippel-Lindau Disease
Pallor, Neoplasm of the pancreas, Pancreatic cysts, Pancreatic islet cell adenoma ORPHA:892
Neuroblastoma
Anemic pallor ORPHA:635
Multiple Endocrine Neoplasia Type 2
Pallor, Neoplasm of the liver ORPHA:653
Infection-Related Hemolytic Uremic Syndrome
Pallor, Pancreatitis ORPHA:544482
Diamond-Blackfan Anemia
Triphalangeal thumb, Partial duplication of thumb phalanx, Absent thumb, Short thumb, Pallor ORPHA:124
Tsh-Secreting Pituitary Adenoma
Pallor ORPHA:91347
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor OMIM:233450
Congenital Total Pulmonary Venous Return Anomaly
Pallor, Hepatomegaly ORPHA:99125

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Myo18a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myo18a.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart. The Journal of Biological Chemistry (February 2019) Myo18atm1a(KOMP)Wtsi PMC6509511

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Myo18atm119203(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Myo18atm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Myo18atm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice, Tissue
Myo18atm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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