Gene: Acvr1c

Name
activin A receptor, type IC
MGI ID
MGI:2661081
Synonyms
Alk-7 ALK7
Viability
Homozygous - Viable
Other links
Significant phenotypes (0) All measurements (67) Expression & images (73) Disease models (0) Order (2)
View data by physiological system
Significant
Not Significant
Not tested

Filtered by: all phenotypes

Mouseover the data points for more information. Click and drag to zoom the chart. Click on the legends to disable/enable data.

Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / PQ HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.290 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / RR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.114 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Percent time in light HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.291 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / Click +50dB waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Side changes HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0642 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / rMSSD HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.570 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / PR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0455 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / Click-evoked ABR threshold HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / N1-N3 Interval (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 24kHz-evoked ABR Threshold HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 24kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 24kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Light side time spent HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00407 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00556 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / HR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0556 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 6kHz-evoked ABR Threshold HOM 0f:2m 0.0634 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 6kHz-evoked ABR Threshold HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 6kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / Click +20dB waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / Click-evoked ABR waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Time mobile light side HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.796 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / P1-N1 amplitude (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb grip strength measurement mean HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.841 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.733 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / CV HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.528 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / Preyer Reflex HOM 1f:0m - 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Dark side time spent HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00407 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb and hindlimb grip strength measurement mean HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.716 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / P3-N3 amplitude (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 12kHz-evoked ABR Threshold HOM 0f:2m 0.0789 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 12kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 12kHz-evoked ABR Threshold HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / QTc HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00387 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb grip strength normalised against body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.105 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 12kHz-evoked ABR waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / P1 Latency (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Time mobile dark side HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.000669 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Fecal boli HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.388 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / P3 Latency (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Fertility of Homozygous Knock-out Mice / Gross Findings Female HOM f:m Supplied as data Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 6kHz-evoked ABR waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb and hindlimb grip strength normalised against body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0278 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.576 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / N1 Latency (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / HRV HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.446 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1 HOM 8f:8m Mixed Model framework, generalized least squares, equation withoutWeight 0.717 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / QRS HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.246 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.773 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / N3 Latency (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 30kHz-evoked ABR Threshold HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 30kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 30kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / P1-P3 Interval (at each stimulus level) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.735 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 24kHz-evoked ABR waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.276 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Latency to first transition into dark HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.327 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Viability Primary Screen / Outcome HOM 59f:51m Supplied as data Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 18kHz-evoked ABR waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / QTc Dispersion HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.757 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Fertility of Homozygous Knock-out Mice / Gross Findings Male HOM f:m Supplied as data Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 30kHz-evoked ABR waveforms (numerical format) HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / ST HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0326 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 18kHz-evoked ABR Threshold HOM 2f:0m 0.171 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 18kHz-evoked ABR Threshold HOM 1f:0m Not processed 1.00 FAILED - Not enough mutant or control data
Acvr1ctm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 18kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Acvr1ctm1b(EUCOMM)Hmgu JAX Light-Dark Test / Percent time in dark HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.291 Success

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 2  (1/48) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 2  (1/51) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Dorso Ventral
8 Images
X-ray: XRay Images Skull Lateral Orientation
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
X-ray: XRay Images Forepaw
8 Images
X-ray: XRay Images Lateral Orientation
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Acvr1ctm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Acvr1ctm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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