Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
retrotransposon Gaglike 1
Synonyms:
Mor1,  Mar,  Mart1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rtl1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Rtl1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Postnatal growth retardation, Large placenta, Umbilical hernia, Polyhydramnios ORPHA:254534
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Intrauterine growth retardation, Polyhydramnios, Postnatal growth retardation, Large placenta, Um... ORPHA:254528
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Intrauterine growth retardation, Growth delay, Short stature, Premature birth, Spontaneous aborti... ORPHA:96334
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Premature birth, Postnatal growth retardation, Intrauterine growth retardation, Short stature ORPHA:96184
Temple Syndrome Due To Paternal 14Q32.2 Microdeletion
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254525
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254531

The table below shows human diseases predicted to be associated to Rtl1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Postnatal growth retardation, Large placenta, Umbilical hernia, Polyhydramnios ORPHA:254534
Placental Insufficiency
Eclampsia, Preeclampsia, Intrauterine growth retardation, Maternal hypertension, Spontaneous abor... ORPHA:439167
Lethal Congenital Contracture Syndrome 3
Neonatal death OMIM:611369
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Intrauterine growth retardation, Polyhydramnios, Postnatal growth retardation, Large placenta, Um... ORPHA:254528
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Severe intrauterine growth retardation, Intrauterine growth retardation, Severe postnatal growth ... ORPHA:73272
Kagami-Ogata Syndrome
Premature birth, Postnatal growth retardation, Large placenta, Polyhydramnios ORPHA:254519
Mosaic Trisomy 16
Maternal diabetes, Preeclampsia, Intrauterine growth retardation, Premature birth, Single umbilic... ORPHA:1708
Trichohepatoenteric Syndrome 1
Intrauterine growth retardation, Short stature, Polyhydramnios, Abnormalities of placenta or umbi... OMIM:222470
Silver-Russell Syndrome Due To A Point Mutation
Intrauterine growth retardation, Oligohydramnios, Postnatal growth retardation, Small placenta ORPHA:397590
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Restrictive Dermopathy 1
Short umbilical cord, Premature rupture of membranes, Intrauterine growth retardation, Premature ... OMIM:275210
Mitochondrial Complex I Deficiency, Nuclear Type 30
Premature birth, Neonatal death, Intrauterine growth retardation OMIM:301021
Meckel Syndrome, Type 1
Intrauterine growth retardation, Breech presentation, Single umbilical artery, Oligohydramnios, L... OMIM:249000
Restrictive Dermopathy
Short umbilical cord, Premature delivery because of cervical insufficiency or membrane fragility,... ORPHA:1662
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death OMIM:273680
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Intrauterine growth retardation, Growth delay, Short stature, Premature birth, Spontaneous aborti... ORPHA:96334
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Premature birth, Polyhydramnios, Large placenta, Umbilical hernia ORPHA:116
Fetal Akinesia Deformation Sequence 1
Short umbilical cord, Intrauterine growth retardation, Fetal akinesia sequence, Premature birth, ... OMIM:208150
Neu-Laxova Syndrome 1
Short umbilical cord, Intrauterine growth retardation, Decreased fetal movement, Stillbirth, Poly... OMIM:256520
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death OMIM:276822
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Premature birth, Postnatal growth retardation, Intrauterine growth retardation, Short stature ORPHA:96184
Temple Syndrome Due To Paternal 14Q32.2 Microdeletion
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254525
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254531

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rtl1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rtl1.

No publications found that use IMPC mice or data for Rtl1.

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