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Gene: Rtl1 MGI:2656842

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
retrotransposon Gaglike 1
Synonyms:
Mor1,  Mar,  Mart1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rtl1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Rtl1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Polyhydramnios, Postnatal growth retardation, Large placenta, Umbilical hernia ORPHA:254534
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Umbilical hernia, Postnatal growth retardation, Intrauterine growth retardation, Large placenta, ... ORPHA:254528
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Spinal dysraphism, Growth delay, Postnatal growth retardation, Intrauterine growth retardation, L... ORPHA:96334
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Short stature, Postnatal growth retardation, Intrauterine growth retardation, Premature birth ORPHA:96184
Temple Syndrome Due To Paternal 14Q32.2 Microdeletion
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254525
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254531

The table below shows human diseases predicted to be associated to Rtl1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Placental Insufficiency
Abnormal umbilical cord blood vessel morphology, Small placenta, Intrauterine growth retardation,... ORPHA:439167
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Polyhydramnios, Postnatal growth retardation, Large placenta, Umbilical hernia ORPHA:254534
Lethal Congenital Contracture Syndrome 3
Neonatal death OMIM:611369
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Diaphragmatic Hernia 5, X-Linked
Neonatal death OMIM:306950
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Umbilical hernia, Postnatal growth retardation, Intrauterine growth retardation, Large placenta, ... ORPHA:254528
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small placenta, Postnatal growth retardation, Intrauterine growth retardation, Severe postnatal g... ORPHA:73272
Congenital Syphilis
Intrauterine growth retardation, Large placenta, Hydrops fetalis, Premature birth ORPHA:499009
Kagami-Ogata Syndrome
Polyhydramnios, Postnatal growth retardation, Large placenta, Premature birth ORPHA:254519
Greenberg Dysplasia
Rhizomelia, Disproportionate short-limb short stature, Large placenta, Increased nuchal transluce... OMIM:215140
Mosaic Trisomy 16
Intrauterine growth retardation, Large placenta, Single umbilical artery, Premature birth ORPHA:1708
Trichohepatoenteric Syndrome 1
Intrauterine growth retardation, Large placenta, Abnormalities of placenta or umbilical cord, Pol... OMIM:222470
Silver-Russell Syndrome Due To A Point Mutation
Small placenta, Postnatal growth retardation, Intrauterine growth retardation, Oligohydramnios ORPHA:397590
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Mitochondrial Complex I Deficiency, Nuclear Type 30
Neonatal death, Intrauterine growth retardation, Premature birth OMIM:301021
Restrictive Dermopathy 1
Premature rupture of membranes, Spontaneous chorioamniotic separation, Intrauterine growth retard... OMIM:275210
Restrictive Dermopathy
Small placenta, Intrauterine growth retardation, Large placenta, Short umbilical cord, Decreased ... ORPHA:1662
Meckel Syndrome, Type 1
Occipital encephalocele, Intrauterine growth retardation, Oligohydramnios, Large placenta, Breech... OMIM:249000
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death OMIM:273680
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Spinal dysraphism, Growth delay, Postnatal growth retardation, Intrauterine growth retardation, L... ORPHA:96334
Fetal Akinesia Deformation Sequence 1
Small placenta, Intrauterine growth retardation, Increased nuchal translucency, Short umbilical c... OMIM:208150
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Umbilical hernia, Large placenta, Polyhydramnios, Premature birth ORPHA:116
Neu-Laxova Syndrome 1
Hydranencephaly, Small placenta, Intrauterine growth retardation, Short umbilical cord, Decreased... OMIM:256520
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death OMIM:276822
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Short stature, Postnatal growth retardation, Intrauterine growth retardation, Premature birth ORPHA:96184
Temple Syndrome Due To Paternal 14Q32.2 Microdeletion
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254525
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Postnatal growth retardation, Intrauterine growth retardation ORPHA:254531

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rtl1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rtl1.

No publications found that use IMPC mice or data for Rtl1.

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