Gene: Dock5 MGI:2652871

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
dedicator of cytokinesis 5
Synonyms:
lr2,  1110060D06Rik,  rlc

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dock5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dock5 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hereditary Hyperferritinemia-Cataract Syndrome
ORPHA:163
Cataract 36
OMIM:613887
Cataract 18
OMIM:610019
Cataract 20, Multiple Types
OMIM:116100
Cataract 29
OMIM:115800
Cataract 35
OMIM:609376
Cataract 45
OMIM:616851
Cataract 4, Multiple Types
OMIM:115700
Cataract 38
OMIM:614691
Cataract 39, Multiple Types
OMIM:615188
Cataract 13 With Adult I Phenotype
OMIM:116700
Cataract 37
OMIM:614422
Cataract And Congenital Ichthyosis
OMIM:212400
Cochleosaccular Degeneration With Progressive Cataracts
OMIM:120040
Cataract 44
OMIM:616509
Hypertrophic Neuropathy And Cataract
OMIM:239900
Cataract 12, Multiple Types
OMIM:611597
Aniridia 3
OMIM:617142
Trichomegaly
OMIM:190330
Corneal Dystrophy, Groenouw Type I
OMIM:121900
Pupillary Membrane, Persistence Of
OMIM:178900
Corneal Dystrophy, Fuchs Endothelial, 8
OMIM:615523
Corneal Dystrophy, Lisch Epithelial
OMIM:300778
Corneal Degeneration, Band-Shaped Spheroid
OMIM:217520
Cataract 14, Multiple Types
OMIM:601885
Aldh18A1-Related De Barsy Syndrome
ORPHA:35664
Cataract 7
OMIM:115660
Cataract 41
OMIM:116400
Hydrocephaly-Cerebellar Agenesis Syndrome
ORPHA:1397
Aniridia, Microcornea, And Spontaneously Reabsorbed Cataract
OMIM:106230
Cataract 46, Juvenile-Onset, With Or Without Arrhythmic Cardiomyopathy
OMIM:212500
Cataract 10, Multiple Types
OMIM:600881
Galactosemia Iv
OMIM:618881
Aniridia 2
OMIM:617141
Microphthalmia, Isolated, With Coloboma 3
OMIM:610092
Cataract 43
OMIM:616279
Spinal Muscular Atrophy-Dandy-Walker Malformation-Cataracts Syndrome
ORPHA:73245
Cataract 1, Multiple Types
OMIM:116200
Uncombable Hair Syndrome 2
OMIM:617251
Cataract-Microcornea Syndrome
ORPHA:1377
Nathalie Syndrome
ORPHA:2663
Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay
OMIM:613076
Cataract 47
OMIM:612018
Cataract 15, Multiple Types
OMIM:615274
Chorea, Remitting, With Nystagmus And Cataract
OMIM:601372
Deafness, Cataract, Retinitis Pigmentosa, And Sperm Abnormalities
OMIM:300719
Cataract-Nephropathy-Encephalopathy Syndrome
ORPHA:1380
Corneal Dystrophy, Posterior Polymorphous, 2
OMIM:609140
Foveal Hypoplasia 1
OMIM:136520
Cataract 8, Multiple Types
OMIM:115665
Cataract 3, Multiple Types
OMIM:601547
Muscular Dystrophy, Congenital, With Infantile Cataract And Hypogonadism
OMIM:254000
Alpha-N-Acetylgalactosaminidase Deficiency Type 3
ORPHA:79281
Cataract 42
OMIM:115900
Cataract, Age-Related Nuclear
OMIM:601371
Cataract 22, Multiple Types
OMIM:609741
Proximal Myotonic Myopathy
ORPHA:606
Iris Pigment Layer, Cleavage Of
OMIM:147610
Thumb, Hypoplastic, With Choroid Coloboma, Poorly Developed Antihelix, And Deafness
OMIM:274205
Galactosemia Ii
OMIM:230200
Foveal Hypoplasia-Presenile Cataract Syndrome
ORPHA:2253
Dermoids Of Cornea
OMIM:304730
X-Linked Retinoschisis
ORPHA:792
Kyrle Disease
OMIM:149500
Microphthalmia, Isolated, With Cataract 1
OMIM:156850
Genetic Hyperferritinemia Without Iron Overload
ORPHA:254704
Alg2-Cdg
ORPHA:79326
Hyperferritinemia With Or Without Cataract
OMIM:600886
Cataract 9, Multiple Types
OMIM:604219
Cataract 30, Multiple Types
OMIM:116300
Hemolytic Anemia Due To Glutathione Reductase Deficiency
OMIM:618660
Cataract 5, Multiple Types
OMIM:116800
Spastic Paraparesis And Deafness
OMIM:312910
Cataract 32, Multiple Types
OMIM:115650
Anterior Segment Dysgenesis 8
OMIM:617319
Megalocornea
OMIM:309300
Ectopia Lentis 2, Isolated, Autosomal Recessive
OMIM:225100
Ectopia Lentis 1, Isolated, Autosomal Dominant
OMIM:129600
Aniridia-Intellectual Disability Syndrome
ORPHA:1068
Cataract 16, Multiple Types
OMIM:613763
Spinocerebellar Ataxia, Autosomal Recessive 24
OMIM:617133
Cataract 31, Multiple Types
OMIM:605387
Ectopia Lentis Et Pupillae
OMIM:225200
Mental Retardation, Truncal Obesity, Retinal Dystrophy, And Micropenis Syndrome
OMIM:610156
Cataract 21, Multiple Types
OMIM:610202
Leber Congenital Amaurosis 7
OMIM:613829
Exfoliation Syndrome
OMIM:177650
Nathalie Syndrome
OMIM:255990
Cataract 33, Multiple Types
OMIM:611391
Cataract 17, Multiple Types
OMIM:611544
Edict Syndrome
OMIM:614303
Myopia 17, Autosomal Dominant
OMIM:608367
Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 1
OMIM:619082
Encephalopathy, Axonal, With Necrotizing Myopathy, Cardiomyopathy, And Cataracts
OMIM:225740
Optic Atrophy 3, Autosomal Dominant
OMIM:165300
Anterior Segment Dysgenesis 1
OMIM:107250
Anterior Segment Dysgenesis 7
OMIM:269400
Cataract 11, Multiple Types
OMIM:610623
Bardet-Biedl Syndrome 18
OMIM:615995
Peters Anomaly
ORPHA:708
Retinitis Pigmentosa 84
OMIM:618220
Aniridia And Absent Patella
OMIM:106220
Cataract 23, Multiple Types
OMIM:610425
Coats Disease
ORPHA:190
Cornea Guttata With Anterior Polar Cataracts
OMIM:121390
Alg8-Cdg
ORPHA:79325
Cataract 40
OMIM:302200
Myopia, High, With Cataract And Vitreoretinal Degeneration
OMIM:614292
Congenital Disorder Of Glycosylation, Type Ii
OMIM:607906
Thanatophoric Dysplasia, Glasgow Variant
OMIM:273680
Aniridia-Ptosis-Intellectual Disability-Familial Obesity Syndrome
ORPHA:1067
Cataract 24
OMIM:601202
Amoebic Keratitis
ORPHA:67043
Isolated Aniridia
ORPHA:250923
Leber Congenital Amaurosis 6
OMIM:613826
Retinitis Pigmentosa 23
OMIM:300424
Cataract 6, Multiple Types
OMIM:116600
Pellagra-Like Syndrome
OMIM:260650
Cataract, Microcephaly, Failure To Thrive, Kyphoscoliosis Syndrome
OMIM:212540
Leber Congenital Amaurosis 8
OMIM:613835
Autosomal Dominant Keratitis
ORPHA:2334
Anterior Segment Dysgenesis 2
OMIM:610256
Stickler Syndrome Type 2
ORPHA:90654
X-Linked Endothelial Corneal Dystrophy
ORPHA:293621
Oculoauricular Syndrome
OMIM:612109
Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation
OMIM:604278
Cochleosaccular Degeneration-Cataract Syndrome
ORPHA:3233
Ichthyosis-Intellectual Disability-Dwarfism-Renal Impairment Syndrome
ORPHA:2278
Kahrizi Syndrome
OMIM:612713
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome
ORPHA:1369
Congenital Varicella Syndrome
ORPHA:291
Leber Congenital Amaurosis 2
OMIM:204100
Intellectual Developmental Disorder And Retinitis Pigmentosa
OMIM:618195
Intellectual Disability-Cataracts-Kyphosis Syndrome
ORPHA:171860
Hypogonadism-Cataract Syndrome
OMIM:240950
Exudative Vitreoretinopathy 6
OMIM:616468
Retinitis Pigmentosa 4
OMIM:613731
Vitreoretinal Degeneration, Snowflake Type
OMIM:193230
Mitochondrial Dna Depletion Syndrome 12B (Cardiomyopathic Type), Autosomal Recessive
OMIM:615418
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Mental Retardation
OMIM:120433
Split-Hand With Congenital Nystagmus, Fundal Changes, And Cataracts
OMIM:183800
Leber Congenital Amaurosis 16
OMIM:614186
Uveal Coloboma-Cleft Lip And Palate-Intellectual Disability
ORPHA:1473
Retinitis Pigmentosa 2
OMIM:312600
Congenital Cataracts, Hearing Loss, And Neurodegeneration
OMIM:614482
Cahmr Syndrome
OMIM:211770
Retinal Dystrophy And Iris Coloboma With Or Without Congenital Cataract
OMIM:616722
Optic Disc Anomalies With Retinal And/Or Macular Dystrophy
OMIM:212550
Coloboma, Ocular, Autosomal Recessive
OMIM:216820
Retinitis Pigmentosa 9
OMIM:180104
Cataract-Intellectual Disability-Anal Atresia-Urinary Defects Syndrome
ORPHA:1381
Blindness-Scoliosis-Arachnodactyly Syndrome
ORPHA:171844
Norrie Disease
OMIM:310600
Achromatopsia 3
OMIM:262300
Polycystic Kidney, Cataract, And Congenital Blindness
OMIM:263100
Isolated Ectopia Lentis
ORPHA:1885
Aniridia-Absent Patella Syndrome
ORPHA:1069
Hypoparathyroidism, Familial Isolated, 1
OMIM:146200
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
OMIM:221900
Autoinflammation, Antibody Deficiency, And Immune Dysregulation
OMIM:614878
Aniridia 1
OMIM:106210
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
OMIM:615877
Alport Syndrome 2, Autosomal Recessive
OMIM:203780
Morning Glory Disc Anomaly
ORPHA:35737
Ifap Syndrome 2
OMIM:619016

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dock5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dock5.

No publications found that use IMPC mice or data for Dock5.

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