Gene: Lrrc8a

Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal lung morphology Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
prenatal lethality prior to heart atrial septation Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 14.5 0.00
preweaning lethality, complete penetrance Lrrc8atm1.1(KOMP)Vlcg HOM n/a 0.00
abnormal eye morphology Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
abnormal embryo size Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
anophthalmia Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
enlarged lung Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
edema Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal seminal vesicle morphology Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
abnormal craniofacial morphology Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584)  (4/4) N/A
Aorta 4 No  (4/4)  Section images
Blood 2 No N/A
Bone marrow 2 No  (1/2) N/A
Brain 4 No  (2/4)  Section images
Brainstem 4 No  (2/4) N/A
Brown adipose tissue 4 No  (4/4)  Section images
Cartilage tissue 4 No N/A
Cecum 2 No  (12/383)  (2/2) N/A
Cerebellum 4 No  (2/4) N/A
Cerebral cortex 4 No  (2/4) N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (2/2) N/A
Diaphragm 2 No  (2/2) N/A
Duodenum 2 No  (2/127)  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 4 No  (7/415)  (4/4) N/A
Eye 4 No  (4/4)  Section images
Gall bladder 2 No N/A
Gonadal fat pad 2 No  (2/2) N/A
Harderian gland 2 No  (2/2) N/A
Heart 4 No  (2/4)  Section images
Hindlimb 2 No N/A
Hippocampus 4 No N/A
Hypothalamus 4 No N/A
Ileum 2 No  (14/127)  (2/2) N/A
Jejunum 2 No  (6/127) N/A
Kidney 4 No  (18/584)  (4/4) N/A
Large intestine 4 No  (10/584)  (2/4) N/A
Liver 4 No  (1/4) N/A
Lower urinary tract 4 No  (2/4) N/A
Lung 4 No  (4/4)  Section images
Lymph node 4 No N/A
Mammary gland 4 No  (1/4) N/A
Mesenteric adipose tissue 2 No  (2/2) N/A
Mesenteric lymph node 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 4 No  (2/4) N/A
Ovary 4 No  (1/584)  (2/4) N/A
Oviduct 4 No  (2/4) N/A
Pancreas 4 No  (5/584)  (4/4) N/A
Parathyroid gland 2 No  (2/2) N/A
Parotid gland 2 No  (2/2) N/A
Penis 2 No  (1/2) N/A
Peripheral nervous system 4 No N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (2/4) N/A
Prostate gland 4 No  (12/584)  (2/4) N/A
Quadriceps 2 No  (2/2) N/A
Sciatic nerve 2 No  (1/2) N/A
Skeletal muscle 4 No  (2/4)  Section images
Skin 4 No  (4/4)  Section images
Small intestine 4 No  (9/584)  (2/4) N/A
Spinal cord 4 No  (4/4)  Section images
Spleen 4 No  (2/584)  (2/4) N/A
Stomach 4 No  (12/584)  (4/4) N/A
Stomach pyloric region 2 No N/A
Striatum 4 No N/A
Sublingual gland 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 4 No  (2/584)  (1/4) N/A
Thymus 4 No  (1/4) N/A
Thyroid gland 4 No  (15/584)  (4/4) N/A
Tongue 2 No  (5/127)  (2/2) N/A
Trachea 4 No  (4/4) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 4 No  (2/4) N/A
Vagina 2 No N/A
Vas deferens 2 No  (15/388) N/A
Vascular system 4 No  (2/4)  Section images
Vesicular gland 2 No  (1/2) N/A
White adipose tissue 4 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Lateral Orientation
10 Images
Adult LacZ: LacZ Images Section
18 Images
Gross Morphology Embryo E14.5-E15.5
3 Images
X-ray: XRay Images Dorso Ventral
10 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Lrrc8atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Lrrc8atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Lrrc8atm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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