Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, complete penetrance | Lrrc8atm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 | ||
abnormal eye morphology | Lrrc8atm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
abnormal embryo size | Lrrc8atm1.1(KOMP)Vlcg | HOM | E15.5 | 0.00 | ||
abnormal craniofacial morphology | Lrrc8atm1.1(KOMP)Vlcg | HOM | E15.5 | 0.00 | ||
abnormal seminal vesicle morphology | Lrrc8atm1.1(KOMP)Vlcg | HET | Early adult | 0.00 |
Gene: Lrrc8a
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IMPC lacZ Expression Data
Anatomy | #HET Specimens | HOM Images? | WT Expr | Mutant Expr | Images |
---|---|---|---|---|---|
Adrenal gland | 4 | No | (3/590) | (4/4) | Section images |
Aorta | 4 | No | (1/590) | (4/4) | Section images |
Blood | 2 | No | N/A | ||
Bone marrow | 2 | No | (1/2) | Section images | |
Brain | 4 | No | (3/590) | (2/4) | Section images |
Brainstem | 4 | No | (2/590) | (2/4) | N/A |
Brown adipose tissue | 4 | No | (4/4) | Section images | |
Cartilage tissue | 4 | No | N/A | ||
Cecum | 2 | No | (12/377) | (2/2) | Section images |
Cerebellum | 4 | No | (3/590) | (2/4) | Section images |
Cerebral cortex | 4 | No | (2/590) | (2/4) | N/A |
Chest bone | 2 | No | N/A | ||
Colon | 2 | No | (12/127) | (2/2) | Section images |
Diaphragm | 2 | No | (2/2) | Section images | |
Duodenum | 2 | No | (2/127) | (2/2) | Section images |
Epididymis | 2 | No | (18/134) | (1/2) | Section images |
Esophagus | 4 | No | (7/415) | (4/4) | Section images |
Eye | 4 | No | (4/4) | Section images | |
Gall bladder | 2 | No | N/A | ||
Gonadal fat pad | 2 | No | (2/2) | Section images | |
Harderian gland | 2 | No | (2/2) | Section images | |
Heart | 4 | No | (1/590) | (2/4) | Section images |
Hindlimb | 2 | No | N/A | ||
Hippocampus | 4 | No | (3/590) | N/A | |
Hypothalamus | 4 | No | (2/590) | N/A | |
Ileum | 2 | No | (14/127) | (2/2) | Section images |
Jejunum | 2 | No | (6/127) | N/A | |
Kidney | 4 | No | (20/590) | (4/4) | Section images |
Large intestine | 4 | No | (10/590) | (2/4) | N/A |
Liver | 4 | No | (1/4) | Section images | |
Lower urinary tract | 4 | No | (1/590) | (2/4) | N/A |
Lung | 4 | No | (1/590) | (4/4) | Section images |
Lymph node | 4 | No | N/A | ||
Mammary gland | 4 | No | (1/4) | Section images | |
Mesenteric adipose tissue | 2 | No | (2/2) | Section images | |
Mesenteric lymph node | 2 | No | N/A | ||
Midbrain | 2 | No | (2/2) | Section images | |
Olfactory lobe | 4 | No | (2/590) | (2/4) | Section images |
Ovary | 4 | No | (1/590) | (2/4) | Section images |
Oviduct | 4 | No | (2/4) | Section images | |
Pancreas | 4 | No | (5/590) | (4/4) | Section images |
Parathyroid gland | 2 | No | (2/2) | Section images | |
Parotid gland | 2 | No | (2/2) | Section images | |
Penis | 2 | No | (1/2) | Section images | |
Peripheral nervous system | 4 | No | (1/590) | N/A | |
Peyer's patch | 4 | No | N/A | ||
Pituitary gland | 4 | No | (1/590) | (2/4) | Section images |
Prostate gland | 4 | No | (12/590) | (2/4) | Section images |
Quadriceps | 2 | No | (2/2) | Section images | |
Sciatic nerve | 2 | No | (1/2) | Section images | |
Skeletal muscle | 4 | No | (2/4) | N/A | |
Skin | 4 | No | (4/4) | Section images | |
Small intestine | 4 | No | (9/590) | (2/4) | N/A |
Spinal cord | 4 | No | (2/590) | (4/4) | Section images |
Spleen | 4 | No | (2/590) | (2/4) | Section images |
Stomach | 4 | No | (13/590) | (4/4) | Section images |
Stomach pyloric region | 2 | No | N/A | ||
Striatum | 4 | No | (3/590) | N/A | |
Sublingual gland | 2 | No | (2/2) | Section images | |
Submandibular gland | 2 | No | (2/132) | (2/2) | Section images |
Testis | 4 | No | (5/590) | (1/4) | Section images |
Thymus | 4 | No | (1/4) | Section images | |
Thyroid gland | 4 | No | (16/590) | (4/4) | Section images |
Tongue | 2 | No | (5/127) | (2/2) | Section images |
Trachea | 4 | No | (2/590) | (4/4) | Section images |
Trigeminal V nerve | 2 | No | (2/2) | Section images | |
Urinary bladder | 2 | No | (2/2) | Section images | |
Uterus | 4 | No | (2/4) | Section images | |
Vagina | 2 | No | N/A | ||
Vas deferens | 2 | No | (15/388) | N/A | |
Vascular system | 4 | No | (2/4) | Section images | |
Vesicular gland | 2 | No | (1/2) | Section images | |
White adipose tissue | 4 | No | N/A |
LacZ Wholemount Images
LacZ Section Images
Anatomy | #HET Specimens | WT Expr | Mutant Expr | Images |
---|---|---|---|---|
Axial skeleton | 2 | (1/65) | (2/2) | N/A |
Brain | 2 | (6/506) | (2/2) | N/A |
Central nervous system ganglion | 2 | (1/74) | (2/2) | N/A |
Ear | 2 | (1/506) | (2/2) | N/A |
Embryo | 2 | (1/507) | Image Only | N/A |
Eye | 2 | (1/506) | (2/2) | N/A |
Foot | 2 | (1/506) | (2/2) | N/A |
Forebrain | 2 | (1/506) | (2/2) | N/A |
Forelimb | 2 | (1/506) | (2/2) | N/A |
Gut | 2 | (1/60) | (2/2) | N/A |
Hand | 2 | (1/506) | (2/2) | N/A |
Head | 2 | (5/506) | (2/2) | N/A |
Heart | 2 | (1/506) | (2/2) | N/A |
Hindbrain | 2 | (6/506) | (2/2) | N/A |
Hindlimb | 2 | (1/506) | (2/2) | N/A |
Liver | 2 | (1/504) | (2/2) | N/A |
Lung | 2 | (1/504) | (2/2) | N/A |
Mandibular process | 2 | (1/506) | (2/2) | N/A |
Maxillary process | 2 | (1/506) | (2/2) | N/A |
Midbrain | 2 | (1/506) | (2/2) | N/A |
Nose | 2 | (1/76) | (2/2) | N/A |
Oral cavity | 2 | (1/504) | (2/2) | N/A |
Skeleton | 2 | (1/76) | (2/2) | N/A |
Skin | 2 | (1/506) | (2/2) | N/A |
Spinal cord | 2 | (1/73) | (2/2) | N/A |
Tail | 2 | (1/506) | (2/2) | N/A |
Tail somite | 2 | (1/506) | (2/2) | N/A |
Trachea | 2 | (1/60) | (2/2) | N/A |
Urinary system | 2 | (1/60) | (2/2) | N/A |
Associated Images
Disease Models
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MGI Allele | Allele Type | Produced |
---|---|---|
Lrrc8atm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Lrrc8atm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Lrrc8atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, Targeting vectors, ES Cells |
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