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Genes Phenotypes

Gene: Lrrc8a

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Name
leucine rich repeat containing 8A VRAC subunit A
MGI ID
MGI:2652847
Synonyms
Lrrc8 ebo SWELL1
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (5) Measurements chart (71) All data table (354)
Expression & images (102) Disease models (0) Order (3)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Lrrc8atm1.1(KOMP)Vlcg HOM   Early adult 0.00
abnormal eye morphology Lrrc8atm1.1(KOMP)Vlcg HET Early adult 0.00
abnormal embryo size Lrrc8atm1.1(KOMP)Vlcg HOM E15.5 0.00
abnormal craniofacial morphology Lrrc8atm1.1(KOMP)Vlcg HOM E15.5 0.00
abnormal seminal vesicle morphology Lrrc8atm1.1(KOMP)Vlcg HET Early adult 0.00

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Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (3/590)  (4/4)  Section images
Aorta 4 No  (1/590)  (4/4)  Section images
Blood 2 No N/A
Bone marrow 2 No  (1/2)  Section images
Brain 4 No  (3/590)  (2/4)  Section images
Brainstem 4 No  (2/590)  (2/4) N/A
Brown adipose tissue 4 No  (4/4)  Section images
Cartilage tissue 4 No N/A
Cecum 2 No  (12/377)  (2/2)  Section images
Cerebellum 4 No  (3/590)  (2/4)  Section images
Cerebral cortex 4 No  (2/590)  (2/4) N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (2/2)  Section images
Diaphragm 2 No  (2/2)  Section images
Duodenum 2 No  (2/127)  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 4 No  (7/415)  (4/4)  Section images
Eye 4 No  (4/4)  Section images
Gall bladder 2 No N/A
Gonadal fat pad 2 No  (2/2)  Section images
Harderian gland 2 No  (2/2)  Section images
Heart 4 No  (1/590)  (2/4)  Section images
Hindlimb 2 No N/A
Hippocampus 4 No  (3/590) N/A
Hypothalamus 4 No  (2/590) N/A
Ileum 2 No  (14/127)  (2/2)  Section images
Jejunum 2 No  (6/127) N/A
Kidney 4 No  (20/590)  (4/4)  Section images
Large intestine 4 No  (10/590)  (2/4) N/A
Liver 4 No  (1/4)  Section images
Lower urinary tract 4 No  (1/590)  (2/4) N/A
Lung 4 No  (1/590)  (4/4)  Section images
Lymph node 4 No N/A
Mammary gland 4 No  (1/4)  Section images
Mesenteric adipose tissue 2 No  (2/2)  Section images
Mesenteric lymph node 2 No N/A
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 4 No  (2/590)  (2/4)  Section images
Ovary 4 No  (1/590)  (2/4)  Section images
Oviduct 4 No  (2/4)  Section images
Pancreas 4 No  (5/590)  (4/4)  Section images
Parathyroid gland 2 No  (2/2)  Section images
Parotid gland 2 No  (2/2)  Section images
Penis 2 No  (1/2)  Section images
Peripheral nervous system 4 No  (1/590) N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (1/590)  (2/4)  Section images
Prostate gland 4 No  (12/590)  (2/4)  Section images
Quadriceps 2 No  (2/2)  Section images
Sciatic nerve 2 No  (1/2)  Section images
Skeletal muscle 4 No  (2/4) N/A
Skin 4 No  (4/4)  Section images
Small intestine 4 No  (9/590)  (2/4) N/A
Spinal cord 4 No  (2/590)  (4/4)  Section images
Spleen 4 No  (2/590)  (2/4)  Section images
Stomach 4 No  (13/590)  (4/4)  Section images
Stomach pyloric region 2 No N/A
Striatum 4 No  (3/590) N/A
Sublingual gland 2 No  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 4 No  (5/590)  (1/4)  Section images
Thymus 4 No  (1/4)  Section images
Thyroid gland 4 No  (16/590)  (4/4)  Section images
Tongue 2 No  (5/127)  (2/2)  Section images
Trachea 4 No  (2/590)  (4/4)  Section images
Trigeminal V nerve 2 No  (2/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 4 No  (2/4)  Section images
Vagina 2 No N/A
Vas deferens 2 No  (15/388) N/A
Vascular system 4 No  (2/4)  Section images
Vesicular gland 2 No  (1/2)  Section images
White adipose tissue 4 No N/A
LacZ Wholemount Images
LacZ Section Images
Unassigned Top Level MA (19)
adipose tissue (10)
Brown adipose tissue expression
MA:0000057
cardiovascular system (7)
Aorta expression
MA:0000062
digestive system (37)
Cecum expression
MA:0000334
endocrine system (8)
Adrenal gland expression
MA:0000116
exocrine system (10)
Mammary gland expression
MA:0000145
immune system (6)
Bone Marrow expression
MA:0000134
integumental system (9)
Mammary gland expression
MA:0000145
limb (1)
Sciatic nerve expression
MA:0001172
musculoskeletal system (8)
Bone Marrow expression
MA:0000134
nervous system (21)
Brain expression
MA:0000168
postnatal mouse (155)
Adrenal gland expression
MA:0000116
reproductive system (14)
Epididymis expression
MA:0000397
respiratory system (28)
Diaphragm expression
MA:0001904
sensory organ (15)
Eye expression
MA:0000261
set of connective tissues (10)
Brown adipose tissue expression
MA:0000057
trunk (84)
Adrenal gland expression
MA:0000116
urinary system (12)
Kidney expression
MA:0000368
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 2  (6/506)  (2/2) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Ear 2  (1/506)  (2/2) N/A
Embryo 2  (1/507) Image Only N/A
Eye 2  (1/506)  (2/2) N/A
Foot 2  (1/506)  (2/2) N/A
Forebrain 2  (1/506)  (2/2) N/A
Forelimb 2  (1/506)  (2/2) N/A
Gut 2  (1/60)  (2/2) N/A
Hand 2  (1/506)  (2/2) N/A
Head 2  (5/506)  (2/2) N/A
Heart 2  (1/506)  (2/2) N/A
Hindbrain 2  (6/506)  (2/2) N/A
Hindlimb 2  (1/506)  (2/2) N/A
Liver 2  (1/504)  (2/2) N/A
Lung 2  (1/504)  (2/2) N/A
Mandibular process 2  (1/506)  (2/2) N/A
Maxillary process 2  (1/506)  (2/2) N/A
Midbrain 2  (1/506)  (2/2) N/A
Nose 2  (1/76)  (2/2) N/A
Oral cavity 2  (1/504)  (2/2) N/A
Skeleton 2  (1/76)  (2/2) N/A
Skin 2  (1/506)  (2/2) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Tail 2  (1/506)  (2/2) N/A
Tail somite 2  (1/506)  (2/2) N/A
Trachea 2  (1/60)  (2/2) N/A
Urinary system 2  (1/60)  (2/2) N/A

 Associated Images

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Adult LacZ: LacZ Images Section
174 Images
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X-ray: XRay Images Whole Body Lateral Orientation
10 Images
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Gross Morphology Embryo E14.5-E15.5
3 Images
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Embryo LacZ: LacZ images wholemount
8 Images
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X-ray: XRay Images Whole Body Dorso Ventral
10 Images

 Disease Models

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MGI Allele Allele Type Produced
Lrrc8atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Lrrc8atm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lrrc8atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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