Genes Phenotypes

Gene: Lrrc8a

Name
leucine rich repeat containing 8A
MGI ID
MGI:2652847
Synonyms
Lrrc8 ebo
Viability
Homozygous - Lethal
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (10) Measurements chart (42) All data table (496)
Expression & images (73) Disease models (0) Order (3)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal lung morphology Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
prenatal lethality prior to heart atrial septation Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 14.5 0.00
preweaning lethality, complete penetrance Lrrc8atm1.1(KOMP)Vlcg HOM n/a 0.00
abnormal eye morphology Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
abnormal embryo size Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
anophthalmia Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
enlarged lung Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
edema Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal seminal vesicle morphology Lrrc8atm1.1(KOMP)Vlcg HET postnatal 0.00
abnormal craniofacial morphology Lrrc8atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584)  (4/4) N/A
Aorta 4 No  (4/4)  Section images
Blood 2 No N/A
Bone marrow 2 No  (1/2) N/A
Brain 4 No  (2/4)  Section images
Brainstem 4 No  (2/4) N/A
Brown adipose tissue 4 No  (4/4)  Section images
Cartilage tissue 4 No N/A
Cecum 2 No  (12/383)  (2/2) N/A
Cerebellum 4 No  (2/4) N/A
Cerebral cortex 4 No  (2/4) N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (2/2) N/A
Diaphragm 2 No  (2/2) N/A
Duodenum 2 No  (2/127)  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 4 No  (7/415)  (4/4) N/A
Eye 4 No  (4/4)  Section images
Gall bladder 2 No N/A
Gonadal fat pad 2 No  (2/2) N/A
Harderian gland 2 No  (2/2) N/A
Heart 4 No  (2/4)  Section images
Hindlimb 2 No N/A
Hippocampus 4 No N/A
Hypothalamus 4 No N/A
Ileum 2 No  (14/127)  (2/2) N/A
Jejunum 2 No  (6/127) N/A
Kidney 4 No  (18/584)  (4/4) N/A
Large intestine 4 No  (10/584)  (2/4) N/A
Liver 4 No  (1/4) N/A
Lower urinary tract 4 No  (2/4) N/A
Lung 4 No  (4/4)  Section images
Lymph node 4 No N/A
Mammary gland 4 No  (1/4) N/A
Mesenteric adipose tissue 2 No  (2/2) N/A
Mesenteric lymph node 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 4 No  (2/4) N/A
Ovary 4 No  (1/584)  (2/4) N/A
Oviduct 4 No  (2/4) N/A
Pancreas 4 No  (5/584)  (4/4) N/A
Parathyroid gland 2 No  (2/2) N/A
Parotid gland 2 No  (2/2) N/A
Penis 2 No  (1/2) N/A
Peripheral nervous system 4 No N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (2/4) N/A
Prostate gland 4 No  (12/584)  (2/4) N/A
Quadriceps 2 No  (2/2) N/A
Sciatic nerve 2 No  (1/2) N/A
Skeletal muscle 4 No  (2/4)  Section images
Skin 4 No  (4/4)  Section images
Small intestine 4 No  (9/584)  (2/4) N/A
Spinal cord 4 No  (4/4)  Section images
Spleen 4 No  (2/584)  (2/4) N/A
Stomach 4 No  (12/584)  (4/4) N/A
Stomach pyloric region 2 No N/A
Striatum 4 No N/A
Sublingual gland 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 4 No  (2/584)  (1/4) N/A
Thymus 4 No  (1/4) N/A
Thyroid gland 4 No  (15/584)  (4/4) N/A
Tongue 2 No  (5/127)  (2/2) N/A
Trachea 4 No  (4/4) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 4 No  (2/4) N/A
Vagina 2 No N/A
Vas deferens 2 No  (15/388) N/A
Vascular system 4 No  (2/4)  Section images
Vesicular gland 2 No  (1/2) N/A
White adipose tissue 4 No N/A
LacZ Wholemount Images
LacZ Section Images
adipose tissue (2)
Brown adipose tissue expression
MA:0000057
cardiovascular system (4)
Aorta expression
MA:0000062
integumental system (2)
Skin expression
MA:0000151
musculoskeletal system (2)
Skeletal Muscle expression
MA:0003148
nervous system (4)
Brain expression
MA:0000168
postnatal mouse (18)
Aorta expression
MA:0000062
respiratory system (2)
Lung expression
MA:0000415
sensory organ (2)
Eye expression
MA:0000261
set of connective tissues (2)
Brown adipose tissue expression
MA:0000057
trunk (7)
Aorta expression
MA:0000062
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Lateral Orientation
10 Images
Adult LacZ: LacZ Images Section
18 Images
Gross Morphology Embryo E14.5-E15.5
3 Images
X-ray: XRay Images Dorso Ventral
10 Images

 Disease Models

Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Lrrc8atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Lrrc8atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Lrrc8atm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter