Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
doublecortin domain containing 2a
Synonyms:
RU2,  Dcdc2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dcdc2a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dcdc2a by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Senior-Boichis Syndrome
Suicidal ideation, Aggressive behavior ORPHA:84081
Deafness, Autosomal Recessive 66
OMIM:610212
Nephronophthisis 19
OMIM:616217
Sclerosing Cholangitis, Neonatal
OMIM:617394

The table below shows human diseases predicted to be associated to Dcdc2a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
Schizophrenia 19
Cognitive impairment OMIM:617629
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Familial Alzheimer-Like Prion Disease
Deficit in phonologic short-term memory, Cognitive impairment, Emotional lability, Anxiety, Depre... ORPHA:280397
Microangiopathy And Leukoencephalopathy, Pontine, Autosomal Dominant
Dementia, Cognitive impairment OMIM:618564
Semantic Dementia
Abulia, Dementia ORPHA:100069
Severe Primary Trimethylaminuria
Low self esteem, Aggressive behavior, Emotional lability, Negative affectivity, Anxiety, Depression ORPHA:468726
Epilepsy, Nocturnal Frontal Lobe, 5
Aggressive behavior, Cognitive impairment, Depression, Personality disorder OMIM:615005
Obsessive-Compulsive Disorder
Skin-picking, Anxiety, Depression OMIM:164230
Creutzfeldt-Jakob Disease
Dementia, Apathy, Irritability, Anxiety, Depression, Memory impairment OMIM:123400
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Dementia, Inappropriate behavior, Apathy, Frontotemporal dementia, Motor deterioration, Anxiety, ... ORPHA:412066
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Inappropriate behavior, Cognitive impairment, Anxiety, Depression, Memory impairment ORPHA:401901
Childhood Disintegrative Disorder
Dementia, Social and occupational deterioration, Mental deterioration, Motor deterioration, Anxie... ORPHA:168782
Basal Ganglia Calcification, Idiopathic, 5
Dementia, Cognitive impairment, Apathy, Anxiety, Depression OMIM:615483
Huntington Disease-Like 2
Dementia, Apathy, Irritability, Anxiety, Depression OMIM:606438
Epilepsy, Progressive Myoclonic, 12
Mental deterioration, Anxiety, Depression OMIM:619191
Huntington Disease-Like 1
Aggressive behavior, Anxiety, Dementia, Depression OMIM:603218
Parkinson Disease 6, Autosomal Recessive Early-Onset
Anxiety, Dementia, Depression OMIM:605909
Pandas
Abnormal fear/anxiety-related behavior, Agoraphobia, Claustrophobia, Irritability, Emotional labi... ORPHA:66624
Early-Onset Schizophrenia
Unhappy demeanor, Low self esteem, Suicidal ideation, Cognitive impairment, Irritability, Anhedon... ORPHA:96369
Gm2 Gangliosidosis, Ab Variant
Anxiety, Cognitive impairment, Abnormal fear/anxiety-related behavior, Inappropriate behavior ORPHA:309246
Senior-Boichis Syndrome
Suicidal ideation, Aggressive behavior ORPHA:84081
Deafness, Autosomal Recessive 66
OMIM:610212
Nephronophthisis 19
OMIM:616217
Sclerosing Cholangitis, Neonatal
OMIM:617394

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dcdc2a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dcdc2a.

No publications found that use IMPC mice or data for Dcdc2a.

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MGI Allele Allele Type Produced
Dcdc2atm30(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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