banner
Genes Phenotypes Help, News, Blog

Gene: Nyx MGI:2448607

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
nyctalopin
Synonyms:
CLNP,  nob,  CSNB4,  CSNB1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nyx mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Nyx by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Congenital Stationary Night Blindness
Myopia, Nyctalopia, Reduced visual acuity, Congenital stationary night blindness with normal fund... ORPHA:215
Night Blindness, Congenital Stationary, Type 1A
Hemeralopia, Congenital stationary night blindness, High myopia OMIM:310500

The table below shows human diseases predicted to be associated to Nyx by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Optic Atrophy 5
Constriction of peripheral visual field, Central scotoma, Abnormality of pattern visual evoked po... OMIM:610708
Tritanopia
Tritanomaly, Dyschromatopsia, Abnormal light-adapted electroretinogram, Color vision defect OMIM:190900
Optic Atrophy 1
Central scotoma, Red-green dyschromatopsia, Reduced visual acuity, Abnormal amplitude of pattern ... OMIM:165500
Optic Atrophy 8
Visual loss, Central scotoma, Abnormality of pattern visual evoked potentials, Visual impairment OMIM:616648
Occult Macular Dystrophy
Abnormal multifocal electroretinogram, Slow decrease in visual acuity OMIM:613587
Stargardt Disease
Central scotoma, Nyctalopia, Reduced visual acuity, Abnormality of visual evoked potentials, Colo... ORPHA:827
Cortical Blindness-Intellectual Disability-Polydactyly Syndrome
Abnormality of visual evoked potentials, Cerebral visual impairment ORPHA:1389
Usher Syndrome, Type I
Visual loss, Abnormal electroretinogram, Undetectable electroretinogram OMIM:276900
Macular Dystrophy, Vitelliform, 2
Abnormal electroretinogram, Reduced visual acuity, Visual impairment OMIM:153700
Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy
Central scotoma, Red-green dyschromatopsia, Reduced visual acuity, Abnormal amplitude of pattern ... OMIM:125250
Primary Non-Essential Cutis Verticis Gyrata
Abnormality of pattern visual evoked potentials, Reduced visual acuity ORPHA:357225
Canavan Disease
Abnormality of visual evoked potentials, Blindness, Visual impairment ORPHA:141
Optic Atrophy 13 With Retinal And Foveal Abnormalities
Abnormal electroretinogram, Reduced visual acuity OMIM:165510
Choroideremia
Myopia, Nyctalopia, Abnormal electroretinogram, Abnormality of vision, Progressive visual loss, V... ORPHA:180
Leber Congenital Amaurosis 5
Visual loss, Hypermetropia, High hypermetropia, Visual impairment, Undetectable electroretinogram OMIM:604537
X-Linked Retinoschisis
Abnormality of vision, Abnormal electroretinogram ORPHA:792
Intellectual Developmental Disorder And Retinitis Pigmentosa
Abnormal flash visual evoked potentials, Nyctalopia, Reduced visual acuity OMIM:618195
Progressive Cone Dystrophy
Photophobia, Abnormal electroretinogram, Visual impairment, Color vision defect ORPHA:1871
Retinitis Pigmentosa 39
Abnormal electroretinogram, Visual impairment, Visual field defect OMIM:613809
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic Aciduria
Abnormality of visual evoked potentials, Abnormal electroretinogram, Visual impairment ORPHA:1933
Oculocutaneous Albinism Type 1
Photophobia, Abnormality of visual evoked potentials, Reduced visual acuity, Amblyopia ORPHA:352731
Developmental And Epileptic Encephalopathy 3
Abnormality of visual evoked potentials OMIM:609304
Peroxisomal Acyl-Coa Oxidase Deficiency
Abnormality of visual evoked potentials, Myopia, Abnormal electroretinogram ORPHA:2971
Autosomal Dominant Optic Atrophy Plus Syndrome
Abnormality of visual evoked potentials, Constriction of peripheral visual field, Progressive vis... ORPHA:1215
Blue Cone Monochromatism
Blue cone monochromacy, Photophobia, Abnormal electroretinogram, Visual impairment ORPHA:16
Autosomal Recessive Spastic Paraplegia Type 44
Abnormality of visual evoked potentials ORPHA:320401
Sorsby Fundus Dystrophy
Blindness, Abnormal electroretinogram OMIM:136900
Retinitis Pigmentosa 31
Abnormal electroretinogram, Visual field defect OMIM:609923
Ataxia With Vitamin E Deficiency
Abnormality of visual evoked potentials, Nyctalopia, Visual impairment ORPHA:96
Retinal Cone Dystrophy 1
Photophobia, Abnormal electroretinogram, Progressive visual loss, Color vision defect OMIM:180020
Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type
Undetectable electroretinogram, Abnormality of pattern visual evoked potentials, Progressive visu... ORPHA:1947
Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy
Abnormality of visual evoked potentials, Central scotoma, Color vision defect, Slow decrease in v... OMIM:601152
Retinitis Pigmentosa-Juvenile Cataract-Short Stature-Intellectual Disability Syndrome
Undetectable visual evoked potentials, Progressive night blindness, Constriction of peripheral vi... ORPHA:436245
Mohr-Tranebjaerg Syndrome
Cerebral visual impairment, Visual loss, Central scotoma, Photophobia, Abnormality of visual evok... ORPHA:52368
Åland Islands Eye Disease
Myopia, Abnormal electroretinogram, Difficulty adjusting from light to dark, Reduced visual acuit... ORPHA:178333
Cone-Rod Dystrophy 12
Central scotoma, Nyctalopia, Reduced visual acuity, Abnormal light- and dark-adapted electroretin... OMIM:612657
Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy, And Sensorineural Hearing Loss
Blindness, Visual loss, Undetectable visual evoked potentials, Progressive visual loss, Visual im... OMIM:601338
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1
Abnormality of visual evoked potentials, Visual loss, Abnormal electroretinogram OMIM:125310
Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations
Abnormality of visual evoked potentials, Amblyopia OMIM:617523
Ichthyosis, Spastic Quadriplegia, And Impaired Intellectual Development
Photophobia, Abnormality of visual evoked potentials, High myopia OMIM:614457
Cerebellar Atrophy, Visual Impairment, And Psychomotor Retardation
Myopia, Cerebral visual impairment, Abnormal electroretinogram, Hypermetropia, Abnormality of vis... OMIM:616875
Congenital Stationary Night Blindness
Myopia, Nyctalopia, Reduced visual acuity, Congenital stationary night blindness with normal fund... ORPHA:215
Retinal Degeneration-Nanophthalmos-Glaucoma Syndrome
Myopia, Abnormal electroretinogram, Visual impairment ORPHA:1574
Oligocone Trichromacy
Photophobia, Abnormal electroretinogram ORPHA:75378
Neurodegeneration With Brain Iron Accumulation 2A
Abnormality of visual evoked potentials, Visual loss OMIM:256600
Night Blindness, Congenital Stationary, Type 1C
Congenital stationary night blindness, Myopia, Abnormal electroretinogram, Reduced visual acuity OMIM:613216
Charcot-Marie-Tooth Disease, Type 4D
Abnormality of visual evoked potentials, Myopia OMIM:601455
Friedreich Ataxia
Abnormality of visual evoked potentials, Reduced visual acuity, Visual impairment, Visual field d... OMIM:229300
Oculocutaneous Albinism Type 1A
Photophobia, Visual impairment, Abnormality of visual evoked potentials ORPHA:79431
Mitochondrial Complex Iv Deficiency, Nuclear Type 7
Undetectable visual evoked potentials, Visual loss, Cerebral visual impairment OMIM:619051
Mepan Syndrome
Abnormality of visual evoked potentials, Reduced visual acuity ORPHA:508093
Krabbe Disease
Abnormal flash visual evoked potentials, Blindness OMIM:245200
Late Infantile Neuronal Ceroid Lipofuscinosis
Myopia, Blindness, Visual loss, Abnormal amplitude of flash visual evoked potentials, Reduced vis... ORPHA:168491
Retinitis Pigmentosa 93
Constriction of peripheral visual field, Reduced visual acuity, Undetectable electroretinogram OMIM:619845
Late-Infantile/Juvenile Krabbe Disease
Abnormality of visual evoked potentials, Visual loss, Blindness, Visual impairment ORPHA:206443
Retinitis Pigmentosa 54
Nyctalopia, Abnormal electroretinogram, Visual impairment OMIM:613428
Cln5 Disease
Abnormality of visual evoked potentials, Visual impairment ORPHA:228360
Pelizaeus-Merzbacher Disease
Abnormality of visual evoked potentials, Visual impairment ORPHA:702
Bothnia Retinal Dystrophy
Nyctalopia, Abnormal electroretinogram OMIM:607475
Retinitis Pigmentosa 19
Constriction of peripheral visual field, Nyctalopia, Abnormal electroretinogram, Reduced visual a... OMIM:601718
Global Developmental Delay-Visual Anomalies-Progressive Cerebellar Atrophy-Truncal Hypotonia Syndrome
Abnormality of visual evoked potentials, Myopia, Cerebral visual impairment ORPHA:480898
Retinitis Pigmentosa 7
Nyctalopia, Constriction of peripheral visual field, Abnormal electroretinogram, Adult-onset nigh... OMIM:608133
Mff-Related Encephalopathy Due To Mitochondrial And Peroxisomal Fission Defect
Abnormality of visual evoked potentials, Visual impairment ORPHA:485421
Retinitis Pigmentosa 69
Nyctalopia, Constriction of peripheral visual field, Reduced visual acuity, Undetectable electror... OMIM:615780
Retinitis Pigmentosa 4
Blindness, Nyctalopia, Abnormal electroretinogram, Reduced visual acuity, Visual field defect OMIM:613731
Reticular Dystrophy Of Retinal Pigment Epithelium
Nyctalopia, Abnormal electrooculogram OMIM:179840
Cone-Rod Dystrophy 2
Blindness, Metamorphopsia, Constriction of peripheral visual field, Central scotoma, Nyctalopia, ... OMIM:120970
Ruvalcaba Syndrome
Abnormality of visual evoked potentials, Abnormal electroretinogram ORPHA:3121
X-Linked Cerebral-Cerebellar-Coloboma Syndrome
Undetectable visual evoked potentials ORPHA:163961
Usher Syndrome Type 3
Scotoma, Visual loss, Nyctalopia, Abnormal electroretinogram, Hemianopia, High hypermetropia ORPHA:231183
Peho Syndrome
Undetectable visual evoked potentials OMIM:260565
Infantile Neuroaxonal Dystrophy
Abnormality of visual evoked potentials, Blindness ORPHA:35069
Xq12-Q13.3 Duplication Syndrome
Abnormality of visual evoked potentials ORPHA:314389
Metachromatic Leukodystrophy, Late Infantile Form
Abnormality of visual evoked potentials, Reduced visual acuity ORPHA:309256
Mohr-Tranebjaerg Syndrome
Myopia, Constriction of peripheral visual field, Cerebral visual impairment, Abnormal electroreti... OMIM:304700
Metachromatic Leukodystrophy, Juvenile Form
Abnormality of visual evoked potentials, Reduced visual acuity ORPHA:309263
Usher Syndrome Type 1
Scotoma, Visual loss, Nyctalopia, Abnormal electroretinogram, Hemianopia, High hypermetropia ORPHA:231169
Retinitis Pigmentosa 50
Nyctalopia, Abnormal electroretinogram, Reduced visual acuity OMIM:613194
Spinocerebellar Ataxia Type 1
Abnormal flash visual evoked potentials ORPHA:98755
Brachydactyly-Short Stature-Retinitis Pigmentosa Syndrome
Nyctalopia, Abnormality of pattern visual evoked potentials, Abnormal electroretinogram, Visual f... ORPHA:166035
Infantile Krabbe Disease
Photophobia, Visual loss, Blindness, Abnormality of visual evoked potentials ORPHA:206436
Micro Syndrome
Abnormality of visual evoked potentials, Cerebral visual impairment ORPHA:2510
White-Sutton Syndrome
Myopia, Mild myopia, Abnormal electroretinogram, Hypermetropia, Abnormality of visual evoked pote... OMIM:616364
Achalasia-Addisonianism-Alacrima Syndrome
Abnormality of visual evoked potentials OMIM:231550
Mpdu1-Cdg
Undetectable visual evoked potentials ORPHA:79323
Hermansky-Pudlak Syndrome
Myopia, Amblyopia, Photophobia, Abnormality of visual evoked potentials, Visual impairment ORPHA:79430
Metachromatic Leukodystrophy, Adult Form
Abnormality of visual evoked potentials, Reduced visual acuity ORPHA:309271
X-Linked Intellectual Disability-Limb Spasticity-Retinal Dystrophy-Diabetes Insipidus Syndrome
Undetectable visual evoked potentials ORPHA:423479
Acute Zonal Occult Outer Retinopathy
Myopia, Constriction of peripheral visual field, Blind-spot enlargment, Scotoma, Photopsia, Visua... ORPHA:284454
Metachromatic Leukodystrophy
Abnormality of visual evoked potentials, Visual impairment ORPHA:512
Warburg Micro Syndrome 2
Undetectable visual evoked potentials OMIM:614225
Retinitis Pigmentosa 45
Nyctalopia, Abnormal electroretinogram, Peripheral visual field loss OMIM:613767
Mogs-Cdg
Abnormality of visual evoked potentials ORPHA:79330
Autosomal Recessive Spastic Paraplegia Type 11
Abnormality of pattern visual evoked potentials, Visual impairment ORPHA:2822
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Abnormality of visual evoked potentials, Visual loss, Cerebral visual impairment OMIM:203700
Osteopetrosis, Autosomal Recessive 5
Undetectable visual evoked potentials, Severely reduced visual acuity, Visual impairment OMIM:259720
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Abnormality of visual evoked potentials ORPHA:258
Retinitis Pigmentosa 43
Nyctalopia, Abnormal electroretinogram, Peripheral visual field loss, Visual impairment OMIM:613810
Autosomal Recessive Malignant Osteopetrosis
Abnormality of visual evoked potentials, Visual impairment ORPHA:667
Cerebrotendinous Xanthomatosis
Abnormality of visual evoked potentials, Visual impairment ORPHA:909
Cockayne Syndrome B
Abnormality of visual evoked potentials, Hypermetropia OMIM:133540
Cockayne Syndrome A
Abnormality of visual evoked potentials, Hypermetropia OMIM:216400
Mitochondrial Complex I Deficiency, Nuclear Type 1
Undetectable visual evoked potentials, Blindness OMIM:252010
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Myopia, Enlarged flash visual evoked potentials, Decreased light- and dark-adapted electroretinog... OMIM:253280
Night Blindness, Congenital Stationary, Type 1A
Hemeralopia, Congenital stationary night blindness, High myopia OMIM:310500

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nyx

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nyx.

No publications found that use IMPC mice or data for Nyx.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nyxtm373502(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter