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Gene: Stard8 MGI:2448556

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Gene Summary

Name:
StAR related lipid transfer domain containing 8
Synonyms:
N/A

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A hemizygote 100% (2 of 2)
Adrenal gland N/A heterozygote 100% (2 of 2)
Aorta N/A hemizygote 100% (2 of 2)
Aorta N/A heterozygote 50% (1 of 2)
Blood vessel N/A hemizygote 0.0% (0 of 2)
Blood vessel N/A heterozygote 0.0% (0 of 2)
Bone N/A hemizygote 0.0% (0 of 2)
Bone N/A heterozygote 0.0% (0 of 2)
Brain N/A hemizygote 100% (2 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A hemizygote 0.0% (0 of 2)
Brainstem N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A hemizygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A hemizygote 50% (1 of 2)
Cartilage tissue N/A heterozygote 50% (1 of 2)
Cerebellum N/A hemizygote 100% (2 of 2)
Cerebellum N/A heterozygote 50% (1 of 2)
Cerebral cortex N/A hemizygote 100% (2 of 2)
Cerebral cortex N/A heterozygote 100% (2 of 2)
Eye N/A hemizygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A hemizygote 0.0% (0 of 2)
Gall bladder N/A heterozygote 0.0% (0 of 2)
Heart N/A hemizygote 100% (2 of 2)
Heart N/A heterozygote 100% (2 of 2)
Hippocampus N/A hemizygote 100% (2 of 2)
Hippocampus N/A heterozygote 100% (2 of 2)
Hypothalamus N/A hemizygote 50% (1 of 2)
Hypothalamus N/A heterozygote 0.0% (0 of 2)
Kidney N/A hemizygote 100% (2 of 2)
Kidney N/A heterozygote 100% (2 of 2)
Large intestine N/A hemizygote 0.0% (0 of 2)
Large intestine N/A heterozygote 0.0% (0 of 2)
Liver N/A hemizygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A hemizygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote 0.0% (0 of 2)
Lung N/A hemizygote 50% (1 of 2)
Lung N/A heterozygote 50% (1 of 2)
Lymph node N/A hemizygote 0.0% (0 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A hemizygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Esophagus N/A hemizygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A hemizygote 100% (2 of 2)
Olfactory lobe N/A heterozygote 100% (2 of 2)
Ovary N/A hemizygote Not available
Ovary N/A heterozygote 50% (1 of 2)
Oviduct N/A hemizygote Not available
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A hemizygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A hemizygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A hemizygote 100% (2 of 2)
Peripheral nervous system N/A heterozygote 50% (1 of 2)
Peyer's patch N/A hemizygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A hemizygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A hemizygote 50% (1 of 2)
Prostate gland N/A heterozygote Not available
Skeletal muscle tissue N/A hemizygote 0.0% (0 of 2)
Skeletal muscle tissue N/A heterozygote 0.0% (0 of 2)
Skin N/A hemizygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A hemizygote 0.0% (0 of 2)
Small intestine N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A hemizygote 50% (1 of 2)
Spinal cord N/A heterozygote 50% (1 of 2)
Spleen N/A hemizygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A hemizygote 0.0% (0 of 2)
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A hemizygote 0.0% (0 of 2)
Striatum N/A heterozygote 50% (1 of 2)
Testis N/A hemizygote 100% (2 of 2)
Testis N/A heterozygote Not available
Thymus N/A hemizygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A hemizygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A hemizygote 50% (1 of 2)
Trachea N/A heterozygote 50% (1 of 2)
Uterus N/A hemizygote Not available
Uterus N/A heterozygote 0.0% (0 of 2)
White adipose tissue N/A hemizygote 0.0% (0 of 2)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood vessel
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
oesophagus
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyer's patch
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle tissue
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
uterus 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

23 Images

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X-ray

XRay Images Skull Lateral Orientation

23 Images

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X-ray

XRay Images Whole Body Lateral Orientation

23 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

24 Images

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Anti-nuclear antibody assay

Images

6 Images

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Eye Morphology

Images Ophthalmoscopy

3 Images

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DSS Histology

Images

8 Images

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X-ray

XRay Images Whole Body Dorso Ventral

24 Images

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Eye Morphology

Images Slit Lamp

1 Images

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Ear epidermis immunophenotyping

Images

12 Images

View images
Legacy Phenotype Associated Images
Stard8tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Stard8tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Stard8tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Stard8tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Stard8tm1a(EUCOMM)Wtsi
WT, Male, WTSI

View all 205 images

Stard8tm1a(EUCOMM)Wtsi
TS20 midbrain, HOM, Female, WTSI
Stard8tm1a(EUCOMM)Wtsi
TS20 stomach, HOM, Female, WTSI
Stard8tm1a(EUCOMM)Wtsi
TS20 brain, HET, Female, WTSI
Stard8tm1a(EUCOMM)Wtsi
TS20 chorioallantoic placenta, HOM, Female, WTSI
Stard8tm1b(EUCOMM)Wtsi
TS20 dorsal root ganglion, HET, Female, WTSI

View all 12 images

Stard8tm1a(EUCOMM)Wtsi
left eye, HOM, Female, WTSI
Stard8tm1a(EUCOMM)Wtsi
persistence of hyaloid vascular system, HOM, Female, WTSI
Stard8tm1a(EUCOMM)Wtsi
persistence of hyaloid vascular system, HOM, Female, WTSI
Stard8tm1a(EUCOMM)Wtsi
right eye, HOM, Female, WTSI
Stard8tm1a(EUCOMM)Wtsi
right eye, HOM, Female, WTSI

Human diseases caused by Stard8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Stard8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Stard8.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Stard8tm1a(EUCOMM)Wtsi Stard8tm1b(EUCOMM)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Stard8tm1b(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Stard8tm1a(EUCOMM)Wtsi Stard8tm1b(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Stard8tm1a(EUCOMM)Wtsi Stard8tm1b(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Stard8tm1a(EUCOMM)Wtsi Stard8tm1b(EUCOMM)Wtsi PMC5827107
A gene expression resource generated by genome-wide lacZ profiling in the mouse. Disease models & mechanisms (August 2015) Stard8tm1a(EUCOMM)Wtsi PMC4631787

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Stard8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Stard8tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Stard8tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Stard8tm40987(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Stard8tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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