Mmgt2 | membrane magnesium transporter 2

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Immune system Integument Hematopoietic system

14 No significant impact

5 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

impaired glucose tolerance1 supporting datasetMmgt2tm1b(EUCOMM)WtsihomozygoteEarly adult8.66x10-7 
decreased lymphocyte cell number1 supporting datasetMmgt2tm1b(EUCOMM)WtsihomozygoteEarly adult8.87x10-5 
abnormal coat/hair pigmentation1 supporting datasetMmgt2tm1b(EUCOMM)WtsihomozygoteEarly adult2.15x10-5 
increased basophil cell number1 supporting datasetMmgt2tm1b(EUCOMM)WtsihomozygoteEarly adult4.46x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Mmgt2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Mmgt2tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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