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Gene: Mgst2 MGI:2448481

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Gene Summary

Name:
microsomal glutathione S-transferase 2
Synonyms:
MGST-II,  GST2

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin morphology Mgst2em1(IMPC)Mbp HOM Early adult 0.00
anophthalmia Mgst2em1(IMPC)Mbp HOM Early adult 0.00
small spleen Mgst2em1(IMPC)Mbp HOM Early adult 0.00
abnormal spleen morphology Mgst2em1(IMPC)Mbp HOM Early adult 0.00
decreased exploration in new environment Mgst2em1(IMPC)Mbp HOM Early adult 7.24×10-10
small heart Mgst2em1(IMPC)Mbp HOM Early adult 0.00
abnormal heart morphology Mgst2em1(IMPC)Mbp HOM Early adult 0.00
abnormal kidney morphology Mgst2em1(IMPC)Mbp HOM Early adult 0.00
enlarged cecum Mgst2em1(IMPC)Mbp HOM Early adult 0.00
abnormal eye morphology Mgst2em1(IMPC)Mbp HOM Early adult 0.00
small kidney Mgst2em1(IMPC)Mbp HOM Early adult 0.00
abnormal cecum morphology Mgst2em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

65 Images

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X-ray

XRay Images Whole Body Lateral Orientation

31 Images

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Human diseases caused by Mgst2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mgst2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Microphthalmia, Syndromic 12
Anophthalmia, Ventricular septal defect, Intestinal malrotation, Hypoplastic left atrium, Cleft p... OMIM:615524
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Microphthalmia, Anophthalmia ORPHA:85275
Matthew-Wood Syndrome
Anophthalmia, Renal hypoplasia, Horseshoe kidney, Aplasia/Hypoplasia of the pancreas, Duodenal st... ORPHA:2470
Meckel Syndrome, Type 8
Anophthalmia, Pericardial effusion, Cleft palate, Polycystic kidney dysplasia, Microphthalmia, En... OMIM:613885
Microphthalmia, Isolated 1
Microphthalmia, Anophthalmia OMIM:251600
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Microphthalmia, Isolated, With Coloboma 10
Microphthalmia, Anophthalmia OMIM:616428
Microphthalmia, Isolated, With Coloboma 5
Microphthalmia, Anophthalmia, Bilateral microphthalmos OMIM:611638
Microgastria-Limb Reduction Defect Syndrome
Hepatomegaly, Multicystic kidney dysplasia, Anophthalmia, Truncus arteriosus, Intestinal malrotat... ORPHA:2538
Trisomy 13
Anophthalmia, Ventricular septal defect, High, narrow palate, Abnormality of the ureter, Cleft pa... ORPHA:3378
Microphthalmia, Syndromic 9
Anophthalmia, Ventricular septal defect, Bilateral microphthalmos, Hypoplastic left atrium, Renal... OMIM:601186
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Hypoplasia of penis, Anophthalmia, Ventricular septal defect, Hypospadias, Esophageal atresia, Tr... ORPHA:77298
Fryns Microphthalmia Syndrome
Microphthalmia, Anophthalmia, Bilateral cleft lip and palate OMIM:600776
Oculocerebrocutaneous Syndrome
Microphthalmia, Anophthalmia, Cleft palate OMIM:164180
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Gastrointestinal hemorrhage, Hepatomegaly, Abnormal large intestine morphology, Esophageal neopla... ORPHA:2198
Anencephaly 2
Anophthalmia, Median cleft palate OMIM:619452
Trisomy 1Q
Multicystic kidney dysplasia, Anophthalmia, Ventricular septal defect, Cleft palate, Congenital m... ORPHA:261344
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia ORPHA:411986
Microphthalmia, Syndromic 16
Microphthalmia, Anophthalmia OMIM:611038
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Impaired lymphocyte transformation with phytohemagglutinin, Pericardial effusion, T lymphocytopen... OMIM:619313
Cerebrooculonasal Syndrome
Hypoplasia of penis, Anophthalmia, High palate ORPHA:66625
Lissencephaly Syndrome, Norman-Roberts Type
Atrial septal defect, Hypoplastic spleen, Patent foramen ovale, Dysphagia ORPHA:89844
Microphthalmia, Isolated 8
Microphthalmia, Anophthalmia, Optic nerve hypoplasia, True anophthalmia OMIM:615113
Meckel Syndrome
Accessory spleen, Ureteral duplication, Multicystic kidney dysplasia, Anophthalmia, Pancreatic fi... ORPHA:564
Anophthalmia Plus Syndrome
Anophthalmia, Cleft palate, Bilateral cleft lip and palate ORPHA:1104
Gracile Bone Dysplasia
Asplenia, Hypoplastic spleen, Aniridia, Microphthalmia, Micropenis, Ankyloglossia OMIM:602361
Oculotrichoanal Syndrome
Anteriorly placed anus, Microphthalmia, Anal stenosis, Anophthalmia ORPHA:2717
Hydrolethalus
Anophthalmia, Submucous cleft hard palate, Cleft palate, Microphthalmia, Bifid uvula ORPHA:2189
Microphthalmia, Syndromic 5
Anophthalmia, Optic nerve hypoplasia, Cleft palate, Microphthalmia, Micropenis OMIM:610125
Holoprosencephaly
Hypoplasia of penis, Anophthalmia, Ventricular septal defect, Proteinuria, Abnormal pulmonary val... ORPHA:2162
Walker-Warburg Syndrome
Hypoplasia of penis, Anophthalmia, Submucous cleft hard palate, Cleft palate, Microphthalmia, Bif... ORPHA:899
Microphthalmia, Syndromic 3
Optic nerve aplasia, Anophthalmia, Ventricular septal defect, Hypospadias, Optic nerve hypoplasia... OMIM:206900
Microphthalmia With Brain And Digit Anomalies
Microphthalmia, Anophthalmia, High palate ORPHA:139471
Manitoba Oculotrichoanal Syndrome
Anteriorly placed anus, Microphthalmia, Anal stenosis, Anophthalmia OMIM:248450
Microphthalmia With Limb Anomalies
Microphthalmia, Anophthalmia, High palate, Cleft palate OMIM:206920
Cockayne Syndrome Type 2
Hepatomegaly, Anophthalmia ORPHA:90322
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease
Colonic diverticula, Renal insufficiency, Mitral valve prolapse, Polycystic kidney dysplasia, Hep... OMIM:173900
Fraser Syndrome 1
Abnormal small intestine morphology, Anophthalmia, Hypospadias, Bilateral microphthalmos, Renal h... OMIM:219000
Vacterl With Hydrocephalus
Anophthalmia, Esophageal atresia, Tracheoesophageal fistula, Microphthalmia, Anal atresia ORPHA:3412
Joubert Syndrome 21
Splenomegaly, Anophthalmia, Renal cyst, Dysphagia OMIM:615636
Microphthalmia With Linear Skin Defects Syndrome
Abnormal penis morphology, Anophthalmia, Hypospadias, Epispadias, Dilated cardiomyopathy, Mitral ... ORPHA:2556
Solitary Median Maxillary Central Incisor
Microphthalmia, Anophthalmia OMIM:147250
Charge Syndrome
Anophthalmia, Secundum atrial septal defect, Atrial septal defect, Micropenis, Aplasia/Hypoplasia... OMIM:214800
Cockayne Syndrome Type 1
Hepatomegaly, Renal insufficiency, Anophthalmia, Proteinuria, Anemia ORPHA:90321
Mirage Syndrome
Hypospadias, Thrombocytopenia, Esophageal stricture, Leukopenia, Gastroesophageal reflux, Microph... OMIM:617053
Fibular Hemimelia
Anophthalmia, Thrombocytopenia, Abnormal heart morphology ORPHA:93323
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Hypoplasia of penis, Anophthalmia, Submucous cleft hard palate, Cleft palate, Microphthalmia, Bif... ORPHA:2250
Charge Syndrome
Anophthalmia, Abnormal soft palate morphology, Tracheoesophageal fistula, Horseshoe kidney, Cleft... ORPHA:138
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Aniridia, High, narrow palate, Anophthalmia, Tricuspid valve prolapse ORPHA:1101
Congenital Tufting Enteropathy
Villous atrophy, Abnormal small intestinal mucosa morphology, Elevated fecal osmolality, Malabsor... ORPHA:92050
Stormorken Syndrome
Howell-Jolly bodies, Asplenia, Thrombocytopenia, Hematuria, Hypoplastic spleen, Anemia OMIM:185070
Pearson Syndrome
Renal cyst, Abnormality of the liver, Neutropenia, Hepatic steatosis, Reticulocytosis, Hepatomega... ORPHA:699
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Microphthalmia, Anophthalmia, Hypospadias OMIM:615877
Proboscis Lateralis
Anophthalmia, Ventricular septal defect, Optic nerve hypoplasia, Unilateral renal agenesis, Urete... ORPHA:141099
Microphthalmia, Syndromic 2
Anophthalmia, Hypospadias, Ventricular septal defect, Dextrocardia, Submucous cleft hard palate, ... OMIM:300166
Fraser Syndrome
Hypoplasia of penis, Multicystic kidney dysplasia, Hypospadias, Anophthalmia, Anal stenosis, Rena... ORPHA:2052
Cerebrooculonasal Syndrome
Anophthalmia, Optic nerve hypoplasia, Cleft palate, Narrow palate, High palate OMIM:605627
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Anophthalmia, Renal hypoplasia ORPHA:264200
Holoprosencephaly 9
Anophthalmia, Optic nerve hypoplasia, Cleft palate, Bilateral cleft lip and palate, Microphthalmi... OMIM:610829
Fg Syndrome Type 1
Hypospadias, Optic nerve hypoplasia, Abnormal large intestine morphology, Malrotation of colon, P... ORPHA:93932
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Atrial septal defect, Microphthalmia, Leukemia, Anophthalmia ORPHA:2526
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Reticulocytosis, Anuria, Acute colitis, Intestinal perforation, Leukocytosis, Schistocytosis, Per... ORPHA:90038
Focal Dermal Hypoplasia
Ureteral duplication, Anophthalmia, Intestinal malrotation, Hiatus hernia, Horseshoe kidney, Clef... OMIM:305600
Systemic Sclerosis
Abnormality of the gastrointestinal tract, Abnormal small intestine morphology, Renal insufficien... ORPHA:90291
Branchiooculofacial Syndrome
Anophthalmia, Hypospadias, Malrotation of colon, Pyloric stenosis, Renal cyst, Cleft palate, Gast... OMIM:113620
Microphthalmia, Syndromic 1
Anophthalmia, Bicuspid aortic valve, Hydroureter, Hypospadias, Aganglionic megacolon, High, narro... OMIM:309800
Microphthalmia With Limb Anomalies
Cleft palate, Horseshoe kidney, High palate, Microphthalmia, True anophthalmia ORPHA:1106
Microphthalmia, Syndromic 6
Anophthalmia, Renal hypoplasia, Cleft palate, High palate, Microphthalmia, Microglossia, Bifid uvula OMIM:607932
Craniofacial Microsomia 1
Multicystic kidney dysplasia, Anophthalmia, Ventricular septal defect, Ectopic kidney, Cleft pala... OMIM:164210
Bannayan-Riley-Ruvalcaba Syndrome
Hamartomatous polyposis, Narrow palate, Abnormal large intestine morphology, Intestinal polyposis ORPHA:109

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mgst2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mgst2.

No publications found that use IMPC mice or data for Mgst2.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Mgst2tm88126(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Mgst2tm212190(L1L2_Bact_P) Reporter-tagged deletion allele (with selection cassette) Targeting vectors
Mgst2em1(IMPC)Mbp Exon Deletion Mice, Tissue

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