Gene Summary

Name:
H2B clustered histone 21
Synonyms:
Hist2h2be

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of left fundus

17 Images

Eye Morphology

VIP of right eye

17 Images

Eye Morphology

VIP of left eye

17 Images

Eye Morphology

VIP of right fundus

17 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by H2bc21 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to H2bc21 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Leber Congenital Amaurosis 10
Hyposmia OMIM:611755
Anosmia For Isobutyric Acid
Partial anosmia OMIM:207000
Anosmia For Butyl Mercaptan
Anosmia OMIM:270350
Isovaleric Acid, Inability To Smell
Anosmia OMIM:243450
Anosmia, Isolated Congenital
Anosmia OMIM:301700
Anosmia, Isolated Congenital
Anosmia OMIM:107200
Musk, Inability To Smell
Anosmia OMIM:254150
Freesia Flowers, Inability To Smell
Specific anosmia OMIM:229250
Body Mass Index Quantitative Trait Locus 19
Hyposmia, Anosmia OMIM:617885
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Anosmia OMIM:614839
Dermoid Cysts, Familial Frontonasal
Deviated nasal septum, Nasal congestion, Anosmia, Papilledema, Wide nasal bridge OMIM:600679
Thumb Agenesis, Short Stature, And Immunodeficiency
Anosmia OMIM:274190
Aural Atresia, Congenital
Hyposmia OMIM:607842
Hypogonadotropic Hypogonadism 18 With Or Without Anosmia
Hyposmia, Anosmia OMIM:615267
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Anosmia OMIM:614842
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Anosmia OMIM:614858
Bardet-Biedl Syndrome 19
Hyposmia OMIM:615996
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia
Hyposmia, Anosmia OMIM:614897
Brachytelephalangy With Characteristic Facies And Kallmann Syndrome
Anosmia, Depressed nasal bridge OMIM:113480
Apnea, Obstructive Sleep
Anosmia OMIM:107650
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Anosmia OMIM:612370
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Aplasia/Hypoplasia involving the nose, Abnormality of the sense of smell, Choanal atresia ORPHA:1135
Chondrodysplasia Punctata 1, X-Linked Recessive
Anosmia, Short nasal septum, Short nose, Depressed nasal bridge OMIM:302950
Indifference To Pain, Congenital, Autosomal Recessive
Hyposmia, Anosmia, Abnormal autonomic nervous system physiology OMIM:243000
Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Hyposmia, Anosmia OMIM:614838
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia
Anosmia OMIM:616030
Neuropathy, Hereditary Sensory And Autonomic, Adult-Onset, With Anosmia
Hyposmia, Anosmia, Orthostatic hypotension OMIM:608720
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
Hyposmia, Anosmia OMIM:612702
Leukoencephalopathy With Dystonia And Motor Neuropathy
Hyposmia, Abnormal motor neuron morphology OMIM:613724
Peroxisome Biogenesis Disorder 9B
Anosmia OMIM:614879
Blepharophimosis-Ptosis-Esotropia-Syndactyly-Short Stature Syndrome
Abnormal cranial nerve morphology, Anosmia ORPHA:2057
Blepharophimosis With Ptosis, Syndactyly, And Short Stature
Frontalis muscle weakness, Anosmia, Wide nasal bridge OMIM:210745
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Anosmia OMIM:610628
Hyperostosis Cranialis Interna
Hyposmia, Facial palsy, Optic atrophy OMIM:144755
Ciliary Dyskinesia, Primary, 1
Bronchiectasis, Nasal polyposis, Anosmia, Pneumonia, Sinusitis, Chronic rhinitis, Chronic sinusit... OMIM:244400
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Anosmia OMIM:614837
Hypogonadotropic Hypogonadism 25 With Anosmia
Anosmia OMIM:618841
Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Anosmia OMIM:244200
Solitary Median Maxillary Central Incisor
Abnormal nasopharynx morphology, Anosmia, Pyriform aperture stenosis, Choanal atresia, Midnasal s... OMIM:147250
Gorlin Syndrome
Abnormality of the sense of smell, Wide nasal bridge ORPHA:377
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia
Anosmia, Choanal atresia OMIM:147950
Johnson Neuroectodermal Syndrome
Anosmia, Patent ductus arteriosus, Facial palsy, Choanal stenosis OMIM:147770
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Anosmia, Short nose, Abnormality of the nares ORPHA:1295
Ventricular Extrasystoles With Syncopal Episodes-Perodactyly-Robin Sequence Syndrome
Abnormality of the sense of smell ORPHA:3201
Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy
Decreased motor nerve conduction velocity, Anosmia, Optic disc pallor, Optic atrophy OMIM:601152
Johnson Neuroectodermal Syndrome
Anosmia, Choanal atresia, Bulbous nose, Facial palsy ORPHA:2316
Parkinson Disease 8, Autosomal Dominant
Hyposmia OMIM:607060
Huntington Disease
Abnormality of the sense of smell ORPHA:399
Hydrolethalus
Abnormality of the sense of smell, Tracheal atresia, Laryngomalacia ORPHA:2189
Refsum Disease, Classic
Anosmia OMIM:266500
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Anosmia OMIM:614841
Kufor-Rakeb Syndrome
Anosmia, Hyposmia OMIM:606693
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Anosmia, Hyposmia OMIM:308700
Campomelic Dysplasia
Tracheomalacia, Laryngomalacia, Tracheobronchomalacia, Abnormality of the sense of smell, Depress... ORPHA:140
Congenital Hypothyroidism
Anosmia, Sinusitis, Optic atrophy, Tracheoesophageal fistula, Depressed nasal ridge ORPHA:442
8Q21.11 Microdeletion Syndrome
Abnormality of the sense of smell, Underdeveloped nasal alae, Wide nose ORPHA:284160
Refsum Disease
Anosmia ORPHA:773
Acro-Renal-Mandibular Syndrome
Abnormality of the sense of smell, Tracheoesophageal fistula, Pulmonary hypoplasia, Abnormal lung... ORPHA:958
Ichthyosis And Male Hypogonadism
Anosmia OMIM:308200
Kallmann Syndrome With Spastic Paraplegia
Anosmia OMIM:308750
Septo-Optic Dysplasia Spectrum
Septo-optic dysplasia, Anosmia, Optic nerve hypoplasia, Tracheoesophageal fistula ORPHA:3157
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Anosmia, Single naris, Hyposmia, Absent nares ORPHA:2250
8P11.2 Deletion Syndrome
Anosmia, Patent ductus arteriosus, Depressed nasal bridge ORPHA:251066
Holoprosencephaly
Depressed nasal tip, Anosmia, Choanal atresia, Abnormality of neuronal migration, Hyposmia, Aplas... ORPHA:2162
Young-Onset Parkinson Disease
Hyposmia, Abnormal autonomic nervous system physiology ORPHA:2828
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Anosmia, Abnormal autonomic nervous system physiology, Long-segment aganglionic megacolon, Absent... OMIM:609136
Kallmann Syndrome-Heart Disease Syndrome
Total anosmia, Partial anosmia, Pulmonary artery hypoplasia ORPHA:2326
Kallmann Syndrome
Anosmia, Hyposmia ORPHA:478
Superficial Siderosis
Anosmia, Dysgyria, Abnormality of the vestibulocochlear nerve, Abnormality of the brachial nerve ... ORPHA:247245
Waardenburg Syndrome, Type 4C
Anosmia, Aganglionic megacolon OMIM:613266
Moebius Syndrome
Abnormality of the sense of smell, Facial palsy ORPHA:570
Hereditary Late-Onset Parkinson Disease
Hyposmia, Orthostatic hypotension due to autonomic dysfunction ORPHA:411602
Amoebiasis Due To Free-Living Amoebae
Respiratory tract infection, Pneumonia, Hyposmia, Facial palsy, Sinusitis, Myocardial necrosis ORPHA:68
Bosma Arhinia Microphthalmia Syndrome
Aplasia of the nose, Anosmia, Choanal atresia, Paranasal sinus hypoplasia OMIM:603457
Waardenburg Syndrome, Type 2E
Anosmia OMIM:611584
Meningioma
Abnormality of the sense of smell, Papilledema, Facial palsy ORPHA:2495
Charge Syndrome
Abnormal cranial nerve morphology, Anosmia, Choanal atresia, Patent ductus arteriosus, Laryngomal... ORPHA:138
Leopard Syndrome 1
Hyposmia, Depressed nasal ridge OMIM:151100
Occipital Horn Syndrome
Abnormality of the sense of smell ORPHA:198
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Hyposmia OMIM:618653
Lacrimoauriculodentodigital Syndrome
Choanal atresia, Anosmia, Patent ductus arteriosus, Hypoplasia of the epiglottis ORPHA:2363
Charge Syndrome
Anosmia, Choanal atresia, Patent ductus arteriosus, Facial palsy, Posterior choanal atresia, Trac... OMIM:214800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for H2bc21

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to H2bc21.

No publications found that use IMPC mice or data for H2bc21.

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MGI Allele Allele Type Produced
H2bc21em1(IMPC)Bay Whole-gene deletion Mice

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