Gene Summary

Name:
serine active site containing 1
Synonyms:
4930511N22Rik,  D17Ertd141e

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged lymph nodes Serac1em1(IMPC)Tcp HOM Early adult 0.00
decreased exploration in new environment Serac1em1(IMPC)Tcp HOM Early adult 6.29×10-10
decreased locomotor activity Serac1em1(IMPC)Tcp HOM   Early adult 5.21×10-06
decreased lean body mass Serac1em1(IMPC)Tcp HOM Early adult 8.26×10-05
enhanced contextual conditioning behavior Serac1em1(IMPC)Tcp HOM Early adult 1.63×10-05
abnormal freezing behavior Serac1em1(IMPC)Tcp HOM   Early adult 5.06×10-05
abnormal ovary morphology Serac1em1(IMPC)Tcp HOM Early adult 0.00
increased freezing behavior Serac1em1(IMPC)Tcp HOM Early adult 1.69×10-06
decreased vertical activity Serac1em1(IMPC)Tcp HOM   Early adult 2.00×10-06
increased total body fat amount Serac1em1(IMPC)Tcp HOM Early adult 9.80×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Gross Pathology and Tissue Collection

Images

9 Images

Eye Morphology

Images Ophthalmoscopy

84 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Serac1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Serac1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
3-Methylglutaconic Aciduria With Deafness, Encephalopathy, And Leigh-Like Syndrome
Failure to thrive, Inability to walk OMIM:614739

The table below shows human diseases predicted to be associated to Serac1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Severe Primary Trimethylaminuria
Anxiety, Negative affectivity, Aggressive behavior, Emotional lability, Low self esteem, Depression ORPHA:468726
Familial Alzheimer-Like Prion Disease
Cognitive impairment, Deficit in phonologic short-term memory, Anxiety, Emotional lability, Depre... ORPHA:280397
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Short stepped shuffling gait, Memory impairment, Shuffling gait, Inertia, Anxiety, Dementia, Moto... ORPHA:412066
Creutzfeldt-Jakob Disease
Memory impairment, Anxiety, Dementia, Apathy, Gait ataxia, Irritability, Depression OMIM:123400
Panic Disorder 1
Anxiety OMIM:167870
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Huntington Disease-Like 2
Anxiety, Dementia, Bradykinesia, Apathy, Irritability, Depression, Weight loss OMIM:606438
Leukoencephalopathy, Progressive, With Ovarian Failure
Premature ovarian insufficiency, Dementia, Depression, Ataxia OMIM:615889
Obsessive-Compulsive Disorder
Anxiety, Depression, Skin-picking OMIM:164230
Epilepsy, Progressive Myoclonic, 12
Dysmetria, Anxiety, Mental deterioration, Ataxia, Depression, Difficulty walking OMIM:619191
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Cognitive impairment, Memory impairment, Anxiety, Inappropriate behavior, Ataxia, Depression ORPHA:401901
Huntington Disease-Like 1
Dysmetria, Anxiety, Dementia, Aggressive behavior, Unsteady gait, Depression OMIM:603218
Chorea, Benign Hereditary
Anxiety, Gait disturbance OMIM:118700
Parkinson Disease 6, Autosomal Recessive Early-Onset
Anxiety, Dementia, Bradykinesia, Depression OMIM:605909
Mitochondrial Dna Depletion Syndrome 16B (Neuroophthalmic Type)
Anxiety, Ataxia, Premature ovarian insufficiency, Depression, Difficulty walking OMIM:619425
Dystonia 12
Anxiety, Bradykinesia, Unsteady gait, Emotional lability, Depression OMIM:128235
Spinocerebellar Ataxia 12
Dysmetria, Anxiety, Dementia, Progressive cerebellar ataxia, Dysdiadochokinesis, Depression OMIM:604326
Basal Ganglia Calcification, Idiopathic, 5
Cognitive impairment, Anxiety, Dementia, Athetosis, Apathy, Depression OMIM:615483
Leukoencephalopathy, Motor Delay, Spasticity, And Dysarthria Syndrome
Anxiety, Bradykinesia OMIM:618878
Congenital Muscular Dystrophy-Infantile Cataract-Hypogonadism Syndrome
Abnormality of the ovary, Decreased testicular size, Hypogonadism, Gait disturbance ORPHA:1875
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Shuffling gait, Abnormal aggressive, impulsive or violent behavior, Obesity, Aggressive behavior,... ORPHA:3077
Spinocerebellar Ataxia 48
Dysmetria, Anxiety, Mental deterioration, Ataxia, Gait ataxia, Irritability, Cachexia, Depression OMIM:618093
Pandas
Emotional lability, Irritability, Separation insecurity, Claustrophobia, Depression, Impulsivity,... ORPHA:66624
Huntington Disease
Suicidal ideation, Memory impairment, Disinhibition, Anxiety, Bradykinesia, Mental deterioration,... ORPHA:399
Rapid-Onset Dystonia-Parkinsonism
Anxiety, Bradykinesia, Emotional lability, Gait ataxia, Depression ORPHA:71517
Parkinsonism With Polyneuropathy
Anxiety, Depression, Bradykinesia OMIM:619279
Perry Syndrome
Suicidal ideation, Short stepped shuffling gait, Disinhibition, Anxiety, Bradykinesia, Inappropri... OMIM:168605
Leukoencephalopathy With Vanishing White Matter
Memory impairment, Lethargy, Emotional lability, Unsteady gait, Gait disturbance, Premature ovari... OMIM:603896
Fragile X Tremor/Ataxia Syndrome
Dysmetria, Memory impairment, Disinhibition, Anxiety, Dementia, Bradykinesia, Mental deterioratio... OMIM:300623
Childhood Disintegrative Disorder
Progressive language deterioration, Anxiety, Dementia, Motor deterioration, Mental deterioration,... ORPHA:168782
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Cognitive impairment, Dysmetria, Anxiety, Bradykinesia, Ataxia, Aggressive behavior, Dysdiadochok... OMIM:615157
Posterior Cortical Atrophy
Inertia, Anxiety, Memory impairment, Ataxia ORPHA:54247
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Suicidal ideation, Abnormal fear/anxiety-related behavior, Aggressive behavior ORPHA:208441
Gonadoblastoma
Abnormality of the ovary, Ovarian gonadoblastoma, Gonadal calcification, Ambiguous genitalia, Fem... ORPHA:206484
Non-Syndromic Posterior Hypospadias
Ventral shortening of foreskin, Urethral diverticulum, Small for gestational age, Cryptorchidism,... ORPHA:95706
Early-Onset Schizophrenia
Suicidal ideation, Cognitive impairment, Unhappy demeanor, Anxiety, Anhedonia, Impairment in pers... ORPHA:96369
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Failure to thrive, Genital ulcers, Aplasia of the thymus, Lymph node hypoplasia OMIM:602450
Young-Onset Parkinson Disease
Cognitive impairment, Anxiety, Dementia, Bradykinesia, Panic attack, Impulsivity, Apathy, Frontal... ORPHA:2828
Burkitt Lymphoma
Abnormality of the lymph nodes, Abnormality of the spleen, Abnormality of the ovary ORPHA:543
Perrault Syndrome 4
Cognitive impairment, Obesity, Bicornuate uterus, Gait ataxia, Premature ovarian insufficiency, I... OMIM:615300
Stiff Person Spectrum Disorder
Anxiety, Agoraphobia, Emotional lability, Falls, Difficulty walking ORPHA:3198
Parkinson Disease 7, Autosomal Recessive Early-Onset
Anxiety, Bradykinesia OMIM:606324
Porphyria Due To Ala Dehydratase Deficiency
Anxiety, Ankle flexion contracture, Apathy, Depression, Difficulty walking, Abnormal fear/anxiety... ORPHA:100924
Tetragametic Chimerism
Perineal hypospadias, Ovotestis, Cryptorchidism, Abnormality of the ovary, Micropenis, True herma... ORPHA:199310
Gm2 Gangliosidosis, Ab Variant
Inappropriate behavior, Anxiety, Cognitive impairment, Abnormal fear/anxiety-related behavior ORPHA:309246
Fragile X-Associated Tremor/Ataxia Syndrome
Dysmetria, Memory impairment, Inertia, Anxiety, Dementia, Bradykinesia, Ataxia, Gait ataxia, Gait... ORPHA:93256
Diethylstilbestrol Syndrome
Epididymal cyst, Small for gestational age, Micropenis, Cryptorchidism, Abnormality of the uterus... ORPHA:1916
Ovarian Fibroma
Abnormality of the ovary, Ovarian fibroma, Gonadal calcification ORPHA:314473
Ovarian Fibrothecoma
Abnormality of the endometrium, Ovarian fibroma, Gonadal calcification, Abnormality of the ovary ORPHA:314478
Meige Disease
Absence of lymph node germinal center, Cellulitis, Lymph node hypoplasia, Atypical scarring of skin ORPHA:90186
Purine Nucleoside Phosphorylase Deficiency
Failure to thrive, Lymph node hypoplasia, Splenomegaly, Ataxia OMIM:613179
Müllerian Aplasia And Hyperandrogenism
Abnormality of the ovary, Abnormal vagina morphology, Obesity, Hypoplasia of the uterus ORPHA:247768
Satoyoshi Syndrome
Abnormality of the ovary, Hypoplasia of the ovary, Hypoplasia of the uterus, Abnormality of the u... ORPHA:3130
Bardet-Biedl Syndrome 1
Micropenis, Abnormality of the ovary, Obesity, Vaginal atresia, Ataxia, Truncal obesity, Abdomina... OMIM:209900
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia, Failure to thrive ORPHA:276
Fowler Urethral Sphincter Dysfunction Syndrome
Abnormality of the ovary, Abnormality of the urethra, Polycystic ovaries ORPHA:2795
Pituitary Adenoma 4, Acth-Secreting
Obesity, Emotional lability, Pituitary adenoma, Abdominal obesity, Abnormal fear/anxiety-related ... OMIM:219090
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency
Abnormal ovarian morphology, Flexion contracture, Polycystic ovaries, Cryptorchidism, Micropenis,... ORPHA:95699
Agammaglobulinemia, X-Linked
Epididymitis, Lymph node hypoplasia, Prostatitis OMIM:300755
Turner Syndrome
Atypical scarring of skin, Failure to thrive in infancy, Abnormality of the ovary, Anxiety, Obesi... ORPHA:881
Monosomy X
Atypical scarring of skin, Failure to thrive in infancy, Abnormality of the ovary, Anxiety, Obesi... ORPHA:99226
Turner Syndrome Due To Structural X Chromosome Anomalies
Atypical scarring of skin, Failure to thrive in infancy, Abnormality of the ovary, Anxiety, Obesi... ORPHA:99413
Mosaic Monosomy X
Atypical scarring of skin, Failure to thrive in infancy, Abnormality of the ovary, Anxiety, Obesi... ORPHA:99228
Hypoplasminogenemia
Abnormality of the ovary, Cervicitis, Abnormal fallopian tube morphology ORPHA:722
3-Methylglutaconic Aciduria With Deafness, Encephalopathy, And Leigh-Like Syndrome
Failure to thrive, Inability to walk OMIM:614739

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Serac1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Serac1.

No publications found that use IMPC mice or data for Serac1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Serac1tm42544(L1L2_Pgk_PM) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Serac1em1(IMPC)Tcp Exon Deletion Mice
Serac1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Serac1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Serac1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter