Disc1 | disrupted in schizophrenia 1
GeneMGI:2447658
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
12 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| hyperactivity | 5 supporting datasets | Disc1em1(IMPC)Mbp | homozygote | Early adult | 5.87x10-8 | ||
| enlarged heart | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased prepulse inhibition | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | 7.06x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small kidney | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| eye hemorrhage | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | 9.32x10-5 | ||
| abnormal heart morphology | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| cataract | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | 6.35x10-5 | ||
| abnormal spleen morphology | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal vitreous body morphology | 1 supporting dataset | Disc1em1(IMPC)Mbp | homozygote | Early adult | 5.99x10-5 |
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Human diseases caused by Disc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Disc1.
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| Disc1em1(IMPC)Mbp | Exon Deletion | | mouse |