Gene Summary

Name:
kinesin family member 26B
Synonyms:
D230039L06Rik,  N-11 kinesin

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
hyperactivity Kif26btm2b(KOMP)Wtsi HET Early adult 1.17×10-05
preweaning lethality, complete penetrance Kif26btm2b(KOMP)Wtsi HOM   Early adult 0.00
increased heart weight Kif26btm2b(KOMP)Wtsi HET Early adult 1.27×10-05
decreased circulating free fatty acids level Kif26btm2b(KOMP)Wtsi HET Early adult 1.35×10-06

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Aorta  Section images heterozygote 100% (2 of 2)
Brain  Section images heterozygote 100% (2 of 2)
Brainstem  Section images heterozygote 100% (2 of 2)
Cartilage tissue  Section images heterozygote 100% (2 of 2)
Cerebellum  Section images heterozygote 100% (2 of 2)
Cerebral cortex  Section images heterozygote 100% (2 of 2)
Epididymis  Section images heterozygote 50% (1 of 2)
Eye  Section images heterozygote 100% (2 of 2)
Heart  Section images heterozygote 100% (2 of 2)
Hippocampus  Section images heterozygote 100% (2 of 2)
Hypothalamus  Section images heterozygote 100% (2 of 2)
Kidney  Section images heterozygote 100% (2 of 2)
Large intestine  Section images heterozygote 100% (2 of 2)
Midbrain  Section images heterozygote 100% (2 of 2)
Olfactory lobe  Section images heterozygote 100% (2 of 2)
Ovary  Section images heterozygote 50% (1 of 2)
Oviduct  Section images heterozygote 50% (1 of 2)
Peripheral nervous system  Section images heterozygote 100% (2 of 2)
Skin  Section images heterozygote 50% (1 of 2)
Small intestine  Section images heterozygote 100% (2 of 2)
Spinal cord  Section images heterozygote 100% (2 of 2)
Stomach  Section images heterozygote 100% (2 of 2)
Submandibular gland  Section images heterozygote 100% (2 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Trachea  Section images heterozygote 100% (2 of 2)
Urinary bladder  Section images heterozygote 100% (2 of 2)
Uterus  Section images heterozygote 50% (1 of 2)
Vascular system  Section images heterozygote 100% (2 of 2)
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote Not available
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 0.0% (0 of 2)
Thalamus N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Vesicular gland N/A heterozygote Not available
White adipose tissue N/A heterozygote 0.0% (0 of 2)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Embryo N/A heterozygote 100% (2 of 2)
Embryo N/A homozygote 100% (1 of 1)
Brain N/A heterozygote 100% (2 of 2)
Brain N/A homozygote 100% (1 of 1)
Dorsal root ganglion N/A heterozygote Ambiguous
N/A Ambiguous
Ear N/A heterozygote 100% (2 of 2)
Ear N/A homozygote 100% (1 of 1)
Eye N/A heterozygote 100% (2 of 2)
Eye N/A homozygote 100% (1 of 1)
Footplate N/A heterozygote 100% (2 of 2)
Footplate N/A homozygote 100% (1 of 1)
Forebrain N/A heterozygote 100% (2 of 2)
Forebrain N/A homozygote 100% (1 of 1)
Forelimb N/A heterozygote 100% (2 of 2)
Forelimb N/A homozygote 100% (1 of 1)
Fronto-nasal process N/A heterozygote Ambiguous
N/A Ambiguous
Handplate N/A heterozygote 100% (2 of 2)
Handplate N/A homozygote 100% (1 of 1)
Head N/A heterozygote 100% (2 of 2)
Head N/A homozygote 100% (1 of 1)
Heart N/A heterozygote 100% (2 of 2)
Heart N/A homozygote 100% (1 of 1)
Hindbrain N/A heterozygote 100% (2 of 2)
Hindbrain N/A homozygote 100% (1 of 1)
Hindlimb N/A heterozygote 100% (2 of 2)
Hindlimb N/A homozygote 100% (1 of 1)
Liver N/A heterozygote 0.0% (0 of 2)
Liver N/A homozygote Ambiguous
Lung N/A heterozygote Ambiguous
Lung N/A homozygote 100% (1 of 1)
Mandibular process N/A heterozygote 100% (2 of 2)
Mandibular process N/A homozygote 100% (1 of 1)
Maxillary process N/A heterozygote 100% (2 of 2)
Maxillary process N/A homozygote 100% (1 of 1)
Midbrain N/A heterozygote 100% (2 of 2)
Midbrain N/A homozygote 100% (1 of 1)
Nose N/A heterozygote 100% (1 of 1)
N/A Ambiguous
Oral cavity N/A heterozygote 50% (1 of 2)
Oral cavity N/A homozygote 100% (1 of 1)
Skin N/A heterozygote 100% (2 of 2)
Skin N/A homozygote 0.0% (0 of 1)
Spinal cord N/A heterozygote 100% (1 of 1)
N/A Ambiguous
Tail somite N/A heterozygote 0.0% (0 of 2)
Tail somite N/A homozygote 100% (1 of 1)
Tail N/A heterozygote 100% (2 of 2)
Tail N/A homozygote 100% (1 of 1)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.67% (4 of 598)
aorta 0.17% (1 of 598)
brain 0.84% (5 of 598)
brainstem 0.33% (2 of 598)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 598)
cerebellum 0.5% (3 of 598)
cerebral cortex 0.33% (2 of 598)
epididymis 14.29% (21 of 147)
esophagus 1.66% (7 of 422)
eye 0.0%
heart 0.33% (2 of 598)
hippocampus 0.5% (3 of 598)
hypothalamus 0.33% (2 of 598)
kidney 4.52% (27 of 598)
large intestine 5.35% (32 of 598)
liver 0.0%
lower urinary tract 0.17% (1 of 598)
lung 0.33% (2 of 598)
lymph node 0.17% (1 of 598)
mammary gland 0.0%
midbrain 0.0%
olfactory lobe 0.33% (2 of 598)
ovary 0.17% (1 of 598)
oviduct 0.0%
pancreas 0.84% (5 of 598)
peripheral nervous system 0.33% (2 of 598)
peyers patch 0.0%
pituitary gland 0.17% (1 of 598)
prostate gland 2.17% (13 of 598)
skeletal muscle 0.0%
skin 0.17% (1 of 598)
small intestine 5.35% (32 of 598)
spinal cord 0.5% (3 of 598)
spleen 0.5% (3 of 598)
stomach 3.68% (22 of 598)
striatum 0.5% (3 of 598)
submandibular gland 1.38% (2 of 145)
testis 1% (6 of 598)
thalamus 0.0%
thymus 0.17% (1 of 598)
thyroid gland 3.01% (18 of 598)
trachea 0.5% (3 of 598)
urinary bladder 0.0%
uterus 0.33% (2 of 598)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.36% (6 of 440)
dorsal root ganglion 1.75% (1 of 57)
ear 0.0%
embryo 0.22% (1 of 458)
eye 0.22% (1 of 457)
footplate 0.21% (1 of 466)
forebrain 0.22% (1 of 455)
forelimb 0.22% (1 of 452)
fronto-nasal process 1.82% (1 of 55)
handplate 0.22% (1 of 460)
head 0.87% (4 of 461)
heart 0.22% (1 of 455)
hindbrain 1.08% (5 of 463)
hindlimb 0.0%
liver 0.22% (1 of 454)
lung 0.22% (1 of 453)
mandibular process 0.0%
maxillary process 0.22% (1 of 445)
midbrain 0.22% (1 of 458)
nose 1.45% (1 of 69)
oral cavity 0.22% (1 of 451)
skin 0.22% (1 of 458)
spinal cord 1.59% (1 of 63)
tail 0.22% (1 of 465)
tail somite group 0.22% (1 of 455)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

9 Images

X-ray

XRay Images Skull Lateral Orientation

9 Images

X-ray

XRay Images Whole Body Lateral Orientation

9 Images

Adult LacZ

LacZ Images Section

28 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

9 Images

Embryo LacZ

LacZ images wholemount

12 Images

Eye Morphology

Images Slit Lamp

1 Images

X-ray

XRay Images Whole Body Dorso Ventral

9 Images

MicroCT E18.5

Embryo reconstruction

2 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

Human diseases caused by Kif26b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Kif26b by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Schizophrenia 15
Hyperactivity OMIM:613950
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Congenital Anomalies Of Kidney And Urinary Tract 1
Stage 5 chronic kidney disease, Ureteropelvic junction obstruction, Unilateral renal agenesis, Ve... OMIM:610805
Hirschsprung Disease With Polydactyly, Renal Agenesis, And Deafness
Unilateral renal agenesis OMIM:235740
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 3
Bilateral renal agenesis, Ureteral atresia, Unilateral renal agenesis, Death in infancy OMIM:618845
Lethal Congenital Contracture Syndrome 3
Neonatal death OMIM:611369
Pyknoachondrogenesis
Stillbirth OMIM:265880
Renal Hypoplasia
Recurrent urinary tract infections, Hydronephrosis, Proteinuria, Abnormal renal morphology, Vesic... ORPHA:93101
Ethanolaminosis
Cardiomegaly OMIM:227150
Autosomal Recessive Primary Microcephaly
Vesicoureteral reflux, Unilateral renal agenesis ORPHA:2512
Renal Hypodysplasia/Aplasia 3
Hydronephrosis, Horseshoe kidney, Renal dysplasia, Vesicoureteral reflux, Multicystic kidney dysp... OMIM:617805
Focal Segmental Glomerulosclerosis 7
Proteinuria, Stage 5 chronic kidney disease, Nephrotic syndrome, Focal segmental glomeruloscleros... OMIM:616002
Radial-Renal Syndrome
Ectopic kidney, Unilateral renal agenesis OMIM:179280
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2
Renal hypoplasia, Unilateral renal agenesis, Chronic kidney disease OMIM:617661
Aniridia, Partial, With Unilateral Renal Agenesis And Psychomotor Retardation
Unilateral renal agenesis OMIM:206750
8p23.1 deletion syndrome
Atrioventricular canal defect, Hyperactivity, Abnormal heart morphology, Atrial septal defect DECIPHER:39
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Unilateral renal agenesis OMIM:601355
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Sacral Agenesis With Vertebral Anomalies
Unilateral renal agenesis, Persistent cloaca, Neonatal death OMIM:615709
Holzgreve Syndrome
Renal agenesis, Renal hypoplasia OMIM:236110
Congenital Anomalies Of Kidney And Urinary Tract 3
Hydronephrosis, Ectopic kidney, Vesicoureteral reflux, Multicystic kidney dysplasia, Renal hypopl... OMIM:618270
Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies
Ectopic kidney, Unilateral renal agenesis, Renal agenesis OMIM:601076
Vesicoureteral Reflux 2
Vesicoureteral reflux, Renal hypoplasia OMIM:610878
Bladder Exstrophy And Epispadias Complex
Horseshoe kidney, Epispadias, Hydroureter, Unilateral renal agenesis, Bladder exstrophy OMIM:600057
Syndromic Recessive X-Linked Ichthyosis
Renal insufficiency, Unilateral renal agenesis ORPHA:281090
Intellectual Developmental Disorder, Autosomal Recessive 71
Unilateral renal agenesis, Micropenis OMIM:618504
Oligomeganephronia
Proteinuria, Renal tubular atrophy, Stage 5 chronic kidney disease, Decreased glomerular filtrati... ORPHA:2260
Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Unilateral renal agenesis, Micropenis OMIM:244200
Thymic-Renal-Anal-Lung Dysplasia
Ureteral agenesis, Ureteral dysgenesis, Renal agenesis OMIM:274265
Renal Agenesis
Proteinuria, Renal insufficiency, Unilateral renal agenesis, Renal agenesis, Bilateral renal agen... ORPHA:411709
Congenital Anomalies Of Kidney And Urinary Tract 2
Hydronephrosis, Hydroureter, Ureteropelvic junction obstruction, Congenital megaureter, Renal ins... OMIM:143400
Microcephaly, Facial Dysmorphism, Renal Agenesis, And Ambiguous Genitalia Syndrome
Unilateral renal agenesis, Crossed fused renal ectopia, Micropenis OMIM:618142
Burn-Mckeown Syndrome
Unilateral renal agenesis, Renal hypoplasia OMIM:608572
Mayer-Rokitansky-Küster-Hauser Syndrome
Horseshoe kidney, Abnormality of the kidney, Unilateral renal agenesis, Ectopic kidney ORPHA:3109
Beaulieu-Boycott-Innes Syndrome
Horseshoe kidney, Recurrent urinary tract infections, Unilateral renal agenesis OMIM:613680
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity, Impulsivity OMIM:301008
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Tubulointerstitial Kidney Disease, Autosomal Dominant, 4
Proteinuria, Renal tubular atrophy, Chronic kidney disease, Focal segmental glomerulosclerosis, T... OMIM:613092
Chopra-Amiel-Gordon Syndrome
Unilateral renal agenesis OMIM:619504
Peroxisome Biogenesis Disorder 6A (Zellweger)
Neonatal death, Renal cyst OMIM:614870
Bardet-Biedl Syndrome 16
Stage 5 chronic kidney disease, Renal cyst, Renal insufficiency, Renal dysplasia, Renal agenesis OMIM:615993
Renal Tubular Acidosis, Distal, With Nephrocalcinosis, Short Stature, Impaired Intellectual Development, And Distinctive Facies
Proteinuria, Beta 2-microglobulinuria, Reduced renal corticomedullary differentiation, Renal cort... OMIM:611555
Immunoneurologic Disorder, X-Linked
Functional abnormality of the bladder, Neonatal death OMIM:300076
Williams-Beuren Region Duplication Syndrome
Hydronephrosis, Unilateral renal agenesis OMIM:609757
Braddock Syndrome
Unilateral renal agenesis ORPHA:52047
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Inverted Duplicated Chromosome 15 Syndrome
Unilateral renal agenesis ORPHA:3306
Congenital Hypotonia, Epilepsy, Developmental Delay, And Digital Anomalies
Hydronephrosis, Unilateral renal agenesis, Renal hypoplasia OMIM:618494
Kallmann Syndrome With Spastic Paraplegia
Unilateral renal agenesis, Micropenis OMIM:308750
Intellectual Developmental Disorder, Autosomal Dominant 36
Unilateral renal agenesis OMIM:616362
Klippel-Feil Syndrome 1, Autosomal Dominant
Abnormality of the kidney, Unilateral renal agenesis OMIM:118100
Congenital Disorder Of Glycosylation, Type Iil
Hyperechogenic kidneys, Unilateral renal agenesis, Proximal tubulopathy, Death in infancy OMIM:614576
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death OMIM:273680
Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay
Absence of renal corticomedullary differentiation, Decreased numbers of nephrons, Bifid ureter, M... OMIM:617641
Coach Syndrome 1
Stage 5 chronic kidney disease, Renal cyst, Unilateral renal agenesis, Nephronophthisis, Multiple... OMIM:216360
Ehlers-Danlos Syndrome, Classic-Like
Vesicoureteral reflux, Unilateral renal agenesis OMIM:606408
Smith-Magenis syndrome
Hyperactivity DECIPHER:8
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts
Ectopic kidney, Death in infancy, Cystic renal dysplasia, Neonatal death OMIM:613730
Aniridia-Renal Agenesis-Psychomotor Retardation Syndrome
Unilateral renal agenesis ORPHA:1064
Diamond-Blackfan Anemia 11
Unilateral renal agenesis OMIM:614900
Mitochondrial Dna Depletion Syndrome 12A (Cardiomyopathic Type), Autosomal Dominant
Death in infancy, Organic aciduria, Neonatal death OMIM:617184
Mitochondrial Complex I Deficiency, Nuclear Type 30
Neonatal death OMIM:301021
Thoc6-Related Developmental Delay-Microcephaly-Facial Dysmorphism Syndrome
Recurrent urinary tract infections, Abnormality of the kidney, Micropenis, Horseshoe kidney, Unil... ORPHA:363444
Branchiootorenal Syndrome 1
Polycystic kidney dysplasia, Abnormal renal collecting system morphology, Unilateral renal agenes... OMIM:113650
Cardiomyopathy, Dilated, 1I
Cardiomegaly, Dilated cardiomyopathy OMIM:604765
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4B
3-Methylglutaconic aciduria, Neonatal death OMIM:615228
Fanconi Anemia, Complementation Group O
Hydronephrosis, Miscarriage, Stage 5 chronic kidney disease, Renal cyst, Death in infancy, Neonat... OMIM:613390
Encephalopathy, Progressive, With Or Without Lipodystrophy
Hypertriglyceridemia, Hepatomegaly, Hyperactivity OMIM:615924
Renal Cysts And Diabetes Syndrome
Abnormal renal morphology, Proteinuria, Abnormality of the kidney, Multiple glomerular cysts, Sta... OMIM:137920
Developmental And Epileptic Encephalopathy 43
Attention deficit hyperactivity disorder, Hyperactivity, Impulsivity OMIM:617113
Nephronophthisis 13
Global glomerulosclerosis, Renal interstitial fibrosis, Proteinuria, Stage 5 chronic kidney disea... OMIM:614377
Fraser Syndrome 2
Unilateral renal agenesis, Bilateral renal agenesis, Ureteral agenesis, Renal agenesis, Renal hyp... OMIM:617666
Emanuel Syndrome
Recurrent urinary tract infections, Unilateral renal agenesis, Micropenis, Renal hypoplasia OMIM:609029
Hartnup Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:234500
Mullerian Aplasia And Hyperandrogenism
Unilateral renal agenesis OMIM:158330
Schizophrenia 1
Ectopic kidney, Partially duplicated kidney, Renal agenesis OMIM:181510
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Unilateral renal agenesis, Micropenis OMIM:308700
Bifid Nose With Or Without Anorectal And Renal Anomalies
Unilateral renal agenesis, Renal agenesis OMIM:608980
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Attention deficit hyperactivity disorder, Hyperactivity, Patent foramen ovale OMIM:617182
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Unilateral renal agenesis, Renal agenesis OMIM:619227
Nager Syndrome
Unilateral renal agenesis ORPHA:245
Tessadori-Bicknell-Van Haaften Neurodevelopmental Syndrome 4
Vesicoureteral reflux, Unilateral renal agenesis, Micropenis OMIM:619951
Shashi-Pena Syndrome
Unilateral renal agenesis OMIM:617190
Emanuel Syndrome
Unilateral renal agenesis, Micropenis, Renal hypoplasia ORPHA:96170
Cutis Laxa, Autosomal Dominant 3
Unilateral renal agenesis OMIM:616603
Lethal Congenital Contracture Syndrome 8
Death in infancy, Neonatal death OMIM:616287
Short Stature, Microcephaly, And Endocrine Dysfunction
Ectopic kidney, Unilateral renal agenesis, Micropenis, Renal hypoplasia OMIM:616541
Mayer-Rokitansky-Küster-Hauser Syndrome Type 2
Ectopic kidney, Renal dysplasia, Renal agenesis ORPHA:2578
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Renal cyst, Neonatal death, Renal dysplasia, Stillbirth, Ureteral agenesis, Renal hypoplasia OMIM:236500
Methylmalonic Acidemia With Homocystinuria Type Cblf
Unilateral renal agenesis, Methylmalonic aciduria ORPHA:79284
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Polycystic kidney dysplasia, Hydronephrosis, Renal insufficiency, Unilateral renal agenesis, Rena... ORPHA:2237
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies
Neonatal death OMIM:619602
Combined Oxidative Phosphorylation Deficiency 11
Death in childhood, Renal cyst, Renal insufficiency, Death in infancy, Neonatal death, Renal dysp... OMIM:614922
Chromosome 17Q12 Deletion Syndrome
Recurrent urinary tract infections, Hydronephrosis, Stage 5 chronic kidney disease, Hypoplasia of... OMIM:614527
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities
Unilateral renal agenesis, Neonatal death OMIM:620024
Arthrogryposis Multiplex Congenita 6
Death in childhood, Death in infancy, Neonatal death, Hypospadias OMIM:619334
Takenouchi-Kosaki Syndrome
Hydronephrosis, Unilateral renal agenesis, Hypospadias OMIM:616737
Stuve-Wiedemann Syndrome 2
Stillbirth, Death in adolescence, Neonatal death OMIM:619751
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity OMIM:301076
Hyperparathyroidism, Transient Neonatal
Unilateral renal agenesis, Enlarged kidney OMIM:618188
Mitochondrial Complex I Deficiency, Nuclear Type 35
Elevated urinary 4-hydroxybutyric acid, Lacticaciduria, Neonatal death OMIM:619003
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Neonatal death OMIM:612138
Combined Oxidative Phosphorylation Deficiency 8
Death in childhood, Death in infancy, Neonatal death OMIM:614096
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Hydronephrosis, Megacystis, Hydroureter, Neonatal death, Fetal megacystis OMIM:619362
Bresek Syndrome
Hypoplasia of the bladder, Neonatal death, Renal dysplasia, Vesicoureteral reflux, Renal hypoplasia ORPHA:85284
Ichthyosis, Congenital, Autosomal Recessive 4B
Death in infancy, Neonatal death OMIM:242500
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Stillbirth, Hydronephrosis, Unilateral renal agenesis OMIM:308050
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation
Hydronephrosis, Micropenis, Renal cyst, Unilateral renal agenesis, Pelvic kidney, Hypospadias ORPHA:464311
Fanconi Anemia, Complementation Group L
Unilateral renal agenesis, Micropenis, Renal hypoplasia OMIM:614083
Ventriculomegaly With Defects Of The Radius And Kidney
Horseshoe kidney, Ureteral duplication, Renal agenesis, Ectopic kidney OMIM:602200
Acrodysostosis 1 With Or Without Hormone Resistance
Unilateral renal agenesis OMIM:101800
Combined Immunodeficiency With Facio-Oculo-Skeletal Anomalies
Recurrent urinary tract infections, Unilateral renal agenesis ORPHA:221139
Neurofaciodigitorenal Syndrome
Unilateral renal agenesis ORPHA:2673
Dyrk1A-Related Intellectual Disability Syndrome
Hydronephrosis, Micropenis, Renal cyst, Unilateral renal agenesis, Pelvic kidney, Hypospadias ORPHA:464306
Lung Agenesis, Congenital Heart Defects, And Thumb Anomalies Syndrome
Neonatal death OMIM:601612
Penoscrotal Transposition
Penoscrotal transposition, Abnormality of the ureter, Renal dysplasia, Abnormality of the urethra... ORPHA:2842
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Renal tubular atrophy, Tubular basement membrane disintegration, Decreased glomerular filtration ... OMIM:174000
7Q11.23 Microduplication Syndrome
Enuresis, Hydronephrosis, Unilateral renal agenesis, Hypospadias ORPHA:96121
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Absence of renal corticomedullary differentiation, Polycystic kidney dysplasia, Enlarged kidney, ... OMIM:263200
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Abnormal renal collecting system morphology, Microphallus, Unilateral renal agenesis, Pelvic kidn... ORPHA:468631
Cockayne Syndrome Type 3
Hydronephrosis, Urinary retention, Neurogenic bladder, Hydroureter, Renal insufficiency, Unilater... ORPHA:90324
Cardiomyopathy, Dilated, 2H
Neonatal death OMIM:620203
Medium Chain 3-Ketoacyl-Coa Thiolase Deficiency
Myoglobinuria, Neonatal death OMIM:602199
Neurofacioskeletal Syndrome With Or Without Renal Agenesis
Bilateral renal agenesis, Hydroureter, Unilateral renal agenesis OMIM:619194
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency
Dilatation of the renal pelvis, Micropenis, Unilateral renal agenesis, Stillbirth, Vesicoureteral... ORPHA:95699
Smith-Lemli-Opitz Syndrome
Hydronephrosis, Penoscrotal hypospadias, Micropenis, Renal cyst, Ureteropelvic junction obstructi... OMIM:270400
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death OMIM:276822
Myoectodermal Gonadal Dysgenesis Syndrome
Unilateral renal agenesis OMIM:618419
Scalp-Ear-Nipple Syndrome
Renal insufficiency, Unilateral renal agenesis, Renal hypoplasia, Pyelonephritis OMIM:181270
Craniofacial Dysmorphism, Skeletal Anomalies, And Impaired Intellectual Development Syndrome 1
Unilateral renal agenesis OMIM:213980
Macrothrombocytopenia-Lymphedema-Developmental Delay-Facial Dysmorphism-Camptodactyly Syndrome
Hydronephrosis, Unilateral renal agenesis, Hypospadias ORPHA:487796
Cardiomyopathy, Familial Hypertrophic, 27
Cardiomyocyte hypertrophy, Concentric hypertrophic cardiomyopathy, Right ventricular hypertrophy,... OMIM:618052
Myotubular Myopathy With Abnormal Genital Development
Micropenis, Death in infancy, Neonatal death, Glandular hypospadias, Penile hypospadias, Hypospadias OMIM:300219
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Unilateral renal agenesis ORPHA:457284
Combined Oxidative Phosphorylation Deficiency 21
Neonatal death OMIM:615918
Leopard Syndrome 1
Unilateral renal agenesis, Micropenis, Hypospadias OMIM:151100
Mucopolysaccharidosis, Type Iiib
Asymmetric septal hypertrophy, Hyperactivity, Hepatomegaly, Cardiomegaly, Splenomegaly OMIM:252920
Serkal Syndrome
Abnormal penis morphology, Renal agenesis, Hypoplasia of the bladder, Hypospadias ORPHA:139466
Cockayne Syndrome
Proteinuria, Abnormal renal physiology, Neurogenic bladder, Urinary incontinence, Renal insuffici... ORPHA:191
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Death in childhood, Death in infancy, Methylmalonic aciduria, Neonatal death, Lacticaciduria OMIM:245400
Larsen-Like Syndrome, Lethal Type
Neonatal death OMIM:245650
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
Recurrent urinary tract infections, Dilatation of the renal pelvis, Micropenis, Unilateral renal ... ORPHA:268261
Multiple Acyl-Coa Dehydrogenase Deficiency
Polycystic kidney dysplasia, Renal cortical cysts, Glycosuria, Glutaric aciduria, Neonatal death,... OMIM:231680
Zttk Syndrome
Horseshoe kidney, Polyuria, Unilateral renal agenesis OMIM:617140
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Death in childhood, Unilateral renal agenesis, Death in infancy, Neonatal death, Renal dysplasia,... OMIM:308205
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Hydronephrosis, Urethral atresia, Enlarged kidney, Neonatal death OMIM:314390
Distal 22Q11.2 Microduplication Syndrome
Unilateral renal agenesis ORPHA:261337
Acrofacial Dysostosis 1, Nager Type
Unilateral renal agenesis OMIM:154400
Denys-Drash Syndrome
Stage 5 chronic kidney disease, Diffuse mesangial sclerosis, Enlarged kidney, Nephropathy, Nephro... OMIM:194080
Autosomal Dominant Cutis Laxa
Unilateral renal agenesis, Bladder diverticulum, Pyelonephritis ORPHA:90348
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Neonatal death OMIM:619817
Proboscis Lateralis
Ureteral agenesis, Unilateral renal agenesis, Duplication of renal pelvis ORPHA:141099
Multiple Mitochondrial Dysfunctions Syndrome 1
Alpha-aminoadipic aciduria, Death in infancy, Neonatal death, Increased urine alpha-ketoglutarate... OMIM:605711
8Q24.3 Microdeletion Syndrome
Abnormality of the kidney, Pelvic kidney, Unilateral renal agenesis, Bilateral renal hypoplasia, ... ORPHA:508488
Afibrinogenemia, Congenital
Death in childhood, Death in infancy, Death in adolescence, Neonatal death OMIM:202400
Boomerang Dysplasia
Neonatal death OMIM:112310
Fetal Gaucher Disease
Stillbirth, Death in infancy, Neonatal death ORPHA:85212
Mitochondrial Complex I Deficiency, Nuclear Type 9
Neonatal death OMIM:618232
Congenital Tricuspid Valve Dysplasia
Abnormal tricuspid valve leaflet morphology, Tricuspid valve prolapse, Hepatomegaly, Right ventri... ORPHA:555874
Lymphatic Malformation 12
Death in adolescence, Neonatal death OMIM:620014
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Horseshoe kidney, Unilateral renal agenesis, Bilateral renal dysplasia ORPHA:500150
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal
Micropenis, Neonatal death OMIM:618810
Pallister-Hall Syndrome
Micropenis, Ectopic kidney, Unilateral renal agenesis, Renal dysplasia, Bilateral renal agenesis,... ORPHA:672
Digeorge Syndrome
Renal dysplasia, Hydronephrosis, Renal insufficiency, Unilateral renal agenesis OMIM:188400
Microphthalmia, Syndromic 9
Hydronephrosis, Horseshoe kidney, Neonatal death, Renal malrotation, Pelvic kidney, Renal hypoplasia OMIM:601186
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Pelvic kidney, Urinary urgency, Micropenis, Unilateral renal agenesis OMIM:619503
Lethal Congenital Contracture Syndrome 1
Neonatal death OMIM:253310
Renal-Hepatic-Pancreatic Dysplasia 1
Polycystic kidney dysplasia, Stage 5 chronic kidney disease, Enlarged kidney, Ureteral atresia, R... OMIM:208540
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Acute kidney injury, Glomerulopathy, Renal cell carcinoma, Horseshoe kidney, Renal Fanconi syndro... ORPHA:93111
Molybdenum Cofactor Deficiency, Complementation Group B
Increased urinary sulfite, Increased urinary hypoxanthine, Neonatal death, Decreased urinary urat... OMIM:252160
Abcd Syndrome
Neonatal death OMIM:600501
Meacham Syndrome
Death in childhood, Enlarged kidney, Horseshoe kidney, Death in infancy, Neonatal death, Stillbirth OMIM:608978
Phosphoribosylaminoimidazole Carboxylase Deficiency
Coronal hypospadias, Neonatal death OMIM:619859
Mitochondrial Complex Ii Deficiency, Nuclear Type 3
Ketonuria, Lacticaciduria, Neonatal death OMIM:619167
Histidinemia
Hyperactivity ORPHA:2157
Molybdenum Cofactor Deficiency, Complementation Group C
Increased urinary taurine, Neonatal death OMIM:615501
Pallister-Hall Syndrome
Hydronephrosis, Micropenis, Renal cyst, Ectopic kidney, Hydroureter, Neonatal death, Renal dyspla... OMIM:146510
Lumbar Syndrome
Renal duplication, Micropenis, Bladder exstrophy, Vesicoureteral reflux, Renal agenesis, Hypospadias ORPHA:83628
Combined Oxidative Phosphorylation Deficiency 40
Death in infancy, Neonatal death OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Death in infancy, Neonatal death OMIM:618839
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Death in childhood, Death in adolescence, Death in infancy, Neonatal death, Aminoaciduria OMIM:619055
Metaphyseal Chondromatosis With D-2-Hydroxyglutaric Aciduria
Unilateral renal agenesis, D-2-hydroxyglutaric aciduria ORPHA:99646
Mednik Syndrome
Death in childhood, Death in infancy, Neonatal death OMIM:609313
Surfactant Metabolism Dysfunction, Pulmonary, 1
Death in infancy, Neonatal death OMIM:265120
3-Methylglutaconic Aciduria, Type Viii
3-Methylglutaconic aciduria, 3-Methylglutaric aciduria, Death in infancy, Neonatal death OMIM:617248

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kif26b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kif26b.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PloS one (July 2017) Kif26btm2b(KOMP)Wtsi PMC5503261

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Kif26btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Kif26btm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Kif26btm2b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Kif26btm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Kif26btm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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