Sik3 - SIK family kinase 3 | International Mouse Phenotyping Consortium

Genes Phenotypes

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Gene: Sik3

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Name

SIK family kinase 3

MGI ID

MGI:2446296

Synonyms

5730525O22Rik 9030204A07Rik

Viability

N/A

Embryo viewer

N/A

Other links

MGI Ensembl

Significant phenotypes (69) Measurements chart (378) All data table (919)

Expression & images (0) Disease models (0) Order (1)

Significant

Not Significant

Not tested

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Phenotype	Allele	Zyg	Life Stage	P Value
decreased early germinal center B cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
abnormal ulna morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	4.06×10^-17
increased circulating sodium level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	7.11×10^-07
decreased circulating fructosamine level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.71×10^-06
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased circulating calcium level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.20×10^-07
decreased caudal vertebrae number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.31×10^-05
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased blood urea nitrogen level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	7.01×10^-11
decreased alpha-beta T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
abnormal pelvic girdle bone morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.18×10^-13
increased lean body mass	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.12×10^-08
decreased T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased total body fat amount	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.27×10^-11
increased memory-marker gamma-delta T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased germinal center B cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
increased KLRG1-positive T-helper cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased circulating glucose level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.28×10^-15
abnormal thoracic cage shape	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	6.58×10^-15
abnormal tibia morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	3.38×10^-19
long tail	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.59×10^-16
decreased KLRG1-positive NK cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased T-helper cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
increased KLRG1-positive CD4-negative NK T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased circulating potassium level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.49×10^-05
decreased Ly6C low monocyte number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.20×10^-06
increased KLRG1+ CD8 alpha beta T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
abnormal femur morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	4.06×10^-17
decreased body length	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	4.21×10^-05
increased NK cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased NK cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
abnormal rib morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.62×10^-07
abnormal cornea morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	3.83×10^-05
abnormal vertebrae morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.94×10^-10
abnormal cranium morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.28×10^-12
increased memory-marker NK cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
increased CD8-positive, alpha-beta T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
improved glucose tolerance	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	6.27×10^-05
abnormal zygomatic bone morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.94×10^-05
increased Ly6C high monocyte number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.19×10^-05
increased effector memory T-helper cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
increased CD8-positive, naive alpha-beta T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
increased bone mineral content	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	3.24×10^-07
abnormal spine curvature	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.68×10^-11
increased mean corpuscular hemoglobin	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.47×10^-13
increased circulating bilirubin level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.07×10^-05
abnormal coat/hair pigmentation	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.13×10^-11
decreased circulating insulin level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.64×10^-07
increased red blood cell distribution width	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.90×10^-12
increased neutrophil cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	9.00×10^-07
abnormal fibula morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	3.38×10^-19
increased granulocyte number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
abnormal bone structure	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	3.29×10^-09
kyphosis	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.87×10^-10
decreased lean body mass	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.67×10^-05
decreased circulating triglyceride level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.61×10^-06
abnormal radius morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.12×10^-16
female infertility	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
increased plasmacytoid dendritic cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
abnormal joint morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	5.80×10^-16
increased eosinophil cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
curly tail	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	9.74×10^-16
decreased circulating free fatty acid level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.64×10^-05
abnormal humerus morphology	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.72×10^-18
decreased CD4-positive, alpha beta T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
increased circulating alkaline phosphatase level	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	1.62×10^-08
decreased gamma-delta T cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	0.00
decreased erythrocyte cell number	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.63×10^-09
thrombocytopenia	Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	2.51×10^-05