Name
SIK family kinase 3
MGI ID
MGI:2446296
Synonyms
5730525O22Rik
9030204A07Rik
Viability
Embryo viewer
N/A
Significant
Not Significant
Not tested
| Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
|---|---|---|---|---|---|---|
| decreased alpha-beta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased Ly6C-positive mature NK cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased memory-marker CD4-positive NK T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased regulatory T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased CD5-positive gamma-delta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased NK cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased CD4-negative NK T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased circulating calcium level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 5.56×10-06 | ||
| female infertility | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal ulna morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 3.82×10-17 | ||
| increased circulating sodium level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.27×10-07 | ||
| decreased early germinal center B cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| obsolete decreased CD4-positive, alpha beta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased NK cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased circulating alkaline phosphatase level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 4.18×10-25 | ||
| increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased memory-marker gamma-delta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal radius morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.05×10-16 | ||
| abnormal pelvic girdle bone morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.51×10-13 | ||
| abnormal femur morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 3.82×10-17 | ||
| increased bone mineral content | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.90×10-07 | ||
| decreased circulating potassium level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.17×10-08 | ||
| decreased memory-marker CD4-negative NK T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased KLRG1-positive NK cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal cornea morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 3.41×10-05 | ||
| decreased circulating cholesterol level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 8.60×10-06 | ||
| decreased circulating fructosamine level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 6.48×10-07 | ||
| decreased circulating glucose level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.14×10-24 | ||
| increased follicular B cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased KLRG1-positive T-helper cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal tail morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.52×10-16 | ||
| increased eosinophil cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal spine curvature | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.50×10-11 | ||
| increased effector memory T-helper cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal coat/hair pigmentation | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.05×10-11 | ||
| decreased effector memory T-helper cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased Ly6C-positive NK T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased red blood cell distribution width | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 8.69×10-07 | ||
| abnormal humerus morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.51×10-18 | ||
| abnormal vertebrae morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.21×10-10 | ||
| increased memory-marker NK cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased mean corpuscular hemoglobin | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 3.21×10-12 | ||
| increased heart weight | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 4.48×10-05 | ||
| abnormal cranium morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.11×10-12 | ||
| abnormal rib morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.55×10-07 | ||
| abnormal thoracic cage shape | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 6.18×10-15 | ||
| increased KLRG1+ CD8 alpha beta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased erythrocyte cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.93×10-09 | ||
| abnormal zygomatic bone morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.89×10-05 | ||
| decreased CD4-positive, alpha beta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal bone structure | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 7.18×10-06 | ||
| decreased circulating glycerol level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.09×10-06 | ||
| increased plasmacytoid dendritic cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal joint morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 5.46×10-16 | ||
| thrombocytopenia | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.45×10-05 | ||
| increased circulating bilirubin level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 8.33×10-06 | ||
| decreased circulating insulin level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 4.67×10-16 | ||
| decreased CD4-positive NK T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased circulating triglyceride level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 1.11×10-12 | ||
| decreased circulating free fatty acid level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 3.71×10-05 | ||
| decreased gamma-delta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased circulating HDL cholesterol level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 4.44×10-05 | ||
| increased CD8-positive, naive alpha-beta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal tibia morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 3.18×10-19 | ||
| decreased NK T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased KLRG1-positive CD4-negative NK T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased CD8-positive, alpha-beta T cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| improved glucose tolerance | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 5.34×10-25 | ||
| decreased T-helper cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased KLRG1-positive T-helper cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal retina morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 4.58×10-05 | ||
| decreased blood urea nitrogen level | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 9.89×10-08 | ||
| increased granulocyte number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased total body fat amount | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 4.48×10-26 | ||
| increased lean body mass | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 8.83×10-17 | ||
| kyphosis | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 2.71×10-10 | ||
| decreased germinal center B cell number | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| abnormal fibula morphology | Sik3tm1a(EUCOMM)Hmgu | HOM | Early adult | 3.18×10-19 |
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