Gene: Sik3

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Name
SIK family kinase 3
MGI ID
MGI:2446296
Synonyms
9030204A07Rik 5730525O22Rik
Viability
N/A
Embryo Screen
N/A
Other links
Expression & images (0) Disease models (0) Order (1)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal humerus morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.89×10-18
abnormal rib morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.72×10-07
abnormal joint morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 6.30×10-16
increased mean corpuscular hemoglobin Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.22×10-13
abnormal coat/hair pigmentation Sik3tm1a(EUCOMM)Hmgu HOM postnatal 6.54×10-12
decreased erythrocyte cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 6.57×10-09
decreased body length Sik3tm1a(EUCOMM)Hmgu HOM postnatal 4.45×10-05
abnormal tail morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 5.34×10-16
increased eosinophil cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased circulating glucose level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 4.04×10-15
increased KLRG1+ CD8 alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
abnormal bone structure Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.53×10-09
increased memory-marker NK cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased red blood cell distribution width Sik3tm1a(EUCOMM)Hmgu HOM postnatal 4.32×10-12
decreased T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
abnormal zygomatic bone morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.97×10-05
increased effector memory T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
abnormal radius morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.21×10-16
increased memory-marker gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
improved glucose tolerance Sik3tm1a(EUCOMM)Hmgu HOM postnatal 5.57×10-05
decreased effector memory T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased CD8-positive, naive alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased CD4-positive, alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased total body fat amount Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.28×10-11
increased neutrophil cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.00×10-06
decreased NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased plasmacytoid dendritic cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased circulating bilirubin level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.13×10-05
decreased gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
thrombocytopenia Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.85×10-05
decreased germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased circulating alkaline phosphatase level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.61×10-08
decreased circulating free fatty acid level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.65×10-05
decreased caudal vertebrae number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.04×10-05
increased granulocyte number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
abnormal fibula morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.67×10-19
decreased blood urea nitrogen level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 8.36×10-11
abnormal retina morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 5.13×10-05
decreased alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased lean body mass Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.64×10-05
abnormal spine curvature Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.89×10-11
increased CD8-positive, alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased Ly6C high monocyte number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.26×10-05
decreased CD4-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased circulating triglyceride level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.67×10-06
decreased T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased lean body mass Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.03×10-08
decreased Ly6C-positive mature NK cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased memory-marker CD4-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
female infertility Sik3tm1a(EUCOMM)Hmgu HOM postpartum stage 0.00
kyphosis Sik3tm1a(EUCOMM)Hmgu HOM postnatal 4.88×10-10
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased circulating fructosamine level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.21×10-06
abnormal tibia morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.67×10-19
increased KLRG1-positive T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased circulating sodium level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 6.68×10-07
decreased circulating calcium level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.74×10-07
decreased CD5-positive gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased circulating insulin level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.40×10-07
abnormal ulna morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 4.40×10-17
increased KLRG1-positive CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased Ly6C low monocyte number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.00×10-06
decreased memory-marker CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased bone mineral content Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.82×10-07
abnormal pelvic girdle bone morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 2.38×10-13
abnormal cornea morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.53×10-05
decreased KLRG1-positive T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased early germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
decreased KLRG1-positive NK cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
abnormal cranium morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.02×10-12
abnormal vertebrae morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.56×10-10
increased Ly6C-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
abnormal thoracic cage shape Sik3tm1a(EUCOMM)Hmgu HOM postnatal 1.17×10-14
increased follicular B cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
increased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM postnatal 0.00
abnormal femur morphology Sik3tm1a(EUCOMM)Hmgu HOM postnatal 4.40×10-17
decreased circulating potassium level Sik3tm1a(EUCOMM)Hmgu HOM postnatal 3.51×10-05

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 Expression

Expression data not available

 Associated Images

Spleen Immunophenotyping: Images associated with FACS analysis
168 Images
Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
180 Images
Anti-nuclear antibody assay
6 Images
DSS Histology
8 Images
X-ray: XRay Images Dorso Ventral
43 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Lateral Orientation
28 Images
X-ray: XRay Images Forepaw
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
15 Images
Eye Morphology: Images Slit Lamp
8 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Sik3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells