Gene: Sik3

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Name
SIK family kinase 3
MGI ID
MGI:2446296
Synonyms
5730525O22Rik 9030204A07Rik
Viability
N/A
Embryo viewer
N/A
Other links
Expression & images (0) Disease models (0) Order (1)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal fibula morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.38×10-19
decreased circulating glucose level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.28×10-15
abnormal thoracic cage shape Sik3tm1a(EUCOMM)Hmgu HOM Early adult 6.58×10-15
decreased T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased KLRG1-positive NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
abnormal bone structure Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.29×10-09
long tail Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.59×10-16
increased KLRG1+ CD8 alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased erythrocyte cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.63×10-09
abnormal humerus morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.72×10-18
abnormal rib morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.62×10-07
abnormal spine curvature Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.68×10-11
increased mean corpuscular hemoglobin Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.47×10-13
decreased total body fat amount Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.27×10-11
abnormal pelvic girdle bone morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.18×10-13
decreased germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
abnormal coat/hair pigmentation Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.13×10-11
abnormal ulna morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.06×10-17
decreased caudal vertebrae number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.31×10-05
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased circulating fructosamine level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.71×10-06
decreased blood urea nitrogen level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 7.01×10-11
increased Ly6C high monocyte number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.19×10-05
increased CD8-positive, alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased plasmacytoid dendritic cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased memory-marker gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
curly tail Sik3tm1a(EUCOMM)Hmgu HOM Early adult 9.74×10-16
decreased circulating free fatty acid level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.64×10-05
decreased gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased eosinophil cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
thrombocytopenia Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.51×10-05
decreased CD4-positive, alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased circulating alkaline phosphatase level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.62×10-08
abnormal radius morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.12×10-16
abnormal joint morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 5.80×10-16
increased KLRG1-positive T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
female infertility Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased Ly6C low monocyte number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.20×10-06
decreased circulating potassium level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.49×10-05
decreased lean body mass Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.67×10-05
increased KLRG1-positive CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased circulating insulin level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.64×10-07
abnormal tibia morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.38×10-19
increased circulating bilirubin level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.07×10-05
abnormal femur morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.06×10-17
increased lean body mass Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.12×10-08
decreased alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased neutrophil cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 9.00×10-07
decreased circulating triglyceride level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.61×10-06
increased bone mineral content Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.24×10-07
kyphosis Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.87×10-10
increased granulocyte number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased early germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased memory-marker NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
abnormal vertebrae morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.94×10-10
increased circulating sodium level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 7.11×10-07
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased red blood cell distribution width Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.90×10-12
improved glucose tolerance Sik3tm1a(EUCOMM)Hmgu HOM Early adult 6.27×10-05
increased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
abnormal cranium morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.28×10-12
abnormal cornea morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.83×10-05
decreased body length Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.21×10-05
decreased T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased effector memory T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased CD8-positive, naive alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
abnormal zygomatic bone morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.94×10-05
decreased circulating calcium level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.20×10-07

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 Expression

Expression data not available

 Associated Images

DSS Histology
8 Images
Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
180 Images
Spleen Immunophenotyping: Images associated with FACS analysis
168 Images
Eye Morphology: Images Slit Lamp
8 Images
Eye Morphology: Images Ophthalmoscopy
7 Images
X-ray: XRay Images Whole Body Dorso Ventral
43 Images
X-ray: XRay Images Whole Body Lateral Orientation
28 Images
X-ray: XRay Images Forepaw
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
15 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
Legacy Phenotype Associated Images

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 Disease Models

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MGI Allele Allele Type Produced
Sik3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells