Gene: Sik3

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Name
SIK family kinase 3
MGI ID
MGI:2446296
Synonyms
5730525O22Rik 9030204A07Rik
Embryo viewer
N/A
Other links
Expression & images (0) Disease models (0) Order (1)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased Ly6C-positive mature NK cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased memory-marker CD4-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased CD5-positive gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased circulating calcium level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 5.56×10-06
female infertility Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
abnormal ulna morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.82×10-17
increased circulating sodium level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.27×10-07
decreased early germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
obsolete decreased CD4-positive, alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
decreased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 0.00
increased circulating alkaline phosphatase level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.18×10-25
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased memory-marker gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal radius morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.05×10-16
abnormal pelvic girdle bone morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.51×10-13
abnormal femur morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.82×10-17
increased bone mineral content Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.90×10-07
decreased circulating potassium level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.17×10-08
decreased memory-marker CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased KLRG1-positive NK cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal cornea morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.41×10-05
decreased circulating cholesterol level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 8.60×10-06
decreased circulating fructosamine level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 6.48×10-07
decreased circulating glucose level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.14×10-24
increased follicular B cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased KLRG1-positive T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal tail morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.52×10-16
increased eosinophil cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal spine curvature Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.50×10-11
increased effector memory T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal coat/hair pigmentation Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.05×10-11
decreased effector memory T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased Ly6C-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased red blood cell distribution width Sik3tm1a(EUCOMM)Hmgu HOM Early adult 8.69×10-07
abnormal humerus morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.51×10-18
abnormal vertebrae morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.21×10-10
increased memory-marker NK cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased mean corpuscular hemoglobin Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.21×10-12
increased heart weight Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.48×10-05
abnormal cranium morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.11×10-12
abnormal rib morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.55×10-07
abnormal thoracic cage shape Sik3tm1a(EUCOMM)Hmgu HOM Early adult 6.18×10-15
increased KLRG1+ CD8 alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased erythrocyte cell number Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.93×10-09
abnormal zygomatic bone morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.89×10-05
decreased CD4-positive, alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal bone structure Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 7.18×10-06
decreased circulating glycerol level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.09×10-06
increased plasmacytoid dendritic cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal joint morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 5.46×10-16
thrombocytopenia Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.45×10-05
increased circulating bilirubin level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 8.33×10-06
decreased circulating insulin level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.67×10-16
decreased CD4-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased circulating triglyceride level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 1.11×10-12
decreased circulating free fatty acid level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.71×10-05
decreased gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased circulating HDL cholesterol level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.44×10-05
increased CD8-positive, naive alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal tibia morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.18×10-19
decreased NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased KLRG1-positive CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased CD8-positive, alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
improved glucose tolerance Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 5.34×10-25
decreased T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
increased KLRG1-positive T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal retina morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.58×10-05
decreased blood urea nitrogen level Sik3tm1a(EUCOMM)Hmgu HOM Early adult 9.89×10-08
increased granulocyte number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
decreased total body fat amount Sik3tm1a(EUCOMM)Hmgu HOM Early adult 4.48×10-26
increased lean body mass Sik3tm1a(EUCOMM)Hmgu HOM Early adult 8.83×10-17
kyphosis Sik3tm1a(EUCOMM)Hmgu HOM Early adult 2.71×10-10
decreased germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal fibula morphology Sik3tm1a(EUCOMM)Hmgu HOM Early adult 3.18×10-19

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 Expression

Expression data not available

 Associated Images

Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
180 Images
Spleen Immunophenotyping: Images associated with FACS analysis
168 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
15 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Forepaw
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
14 Images
DSS Histology
8 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
Anti-nuclear antibody assay
6 Images
Ear epidermis immunophenotyping
12 Images
Legacy Phenotype Associated Images

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 Disease Models

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MGI Allele Allele Type Produced
Sik3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells