Gene: Galnt18 MGI:2446239

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Gene Summary

Name:
polypeptide N-acetylgalactosaminyltransferase 18
Synonyms:
2900011G21Rik,  Galntl4

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased red blood cell distribution width Galnt18tm1b(KOMP)Wtsi HOM Early adult 2.37×10-08
increased circulating alkaline phosphatase level Galnt18tm1b(KOMP)Wtsi HOM Early adult 3.65×10-07
decreased total body fat amount Galnt18tm1b(KOMP)Wtsi HOM Early adult 5.87×10-05
decreased circulating fructosamine level Galnt18tm1b(KOMP)Wtsi HOM Early adult 7.66×10-06
increased lean body mass Galnt18tm1b(KOMP)Wtsi HOM Early adult 2.76×10-05
increased NK cell number Galnt18tm1b(KOMP)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 100% (2 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Blood vessel N/A heterozygote 0.0% (0 of 2)
Bone N/A heterozygote 50% (1 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote 100% (2 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 100% (2 of 2)
Cerebellum N/A heterozygote 100% (2 of 2)
Cerebral cortex N/A heterozygote 100% (2 of 2)
Eye N/A heterozygote 100% (2 of 2)
Gall bladder N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 50% (1 of 2)
Hippocampus N/A heterozygote 100% (2 of 2)
Hypothalamus N/A heterozygote 100% (2 of 2)
Kidney N/A heterozygote 100% (2 of 2)
Large intestine N/A heterozygote 50% (1 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote 100% (2 of 2)
Lung N/A heterozygote 100% (2 of 2)
Lymph node N/A heterozygote 50% (1 of 2)
Mammary gland N/A heterozygote 50% (1 of 2)
Esophagus N/A heterozygote 100% (2 of 2)
Olfactory lobe N/A heterozygote 100% (2 of 2)
Ovary N/A heterozygote Not available
Oviduct N/A heterozygote 50% (1 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote 100% (2 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote 50% (1 of 2)
Skeletal muscle tissue N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 100% (2 of 2)
Small intestine N/A heterozygote 100% (2 of 2)
Spinal cord N/A heterozygote 100% (2 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 100% (2 of 2)
Striatum N/A heterozygote 100% (2 of 2)
Testis N/A heterozygote 50% (1 of 2)
Thymus N/A heterozygote 100% (2 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 100% (2 of 2)
Uterus N/A heterozygote 50% (1 of 2)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
blood vessel 0.0%
bone 0.0%
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
eye 0.0%
gall bladder 0.0%
heart 0.34% (2 of 584)
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
mammary gland 0.0%
oesophagus 0.0%
olfactory lobe 0.34% (2 of 584)
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
parathyroid gland 0.18% (1 of 562)
peripheral nervous system 0.34% (2 of 584)
peyer's patch 0.57% (1 of 176)
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
skeletal muscle tissue 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
striatum 0.51% (3 of 584)
testis 1.03% (6 of 584)
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
trachea 0.51% (3 of 584)
uterus 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

14 Images

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

X-ray

XRay Images Forepaw

14 Images

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

Legacy Phenotype Associated Images

View all 100 images

View all 6 images

Human diseases caused by Galnt18 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Galnt18 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
ORPHA:766
Iron-Refractory Iron Deficiency Anemia
OMIM:206200
Dyserythropoiesis, Congenital, With Ultrastructurally Normal Erythroblast Heterochromatin
OMIM:603529
Anemia, Congenital Dyserythropoietic, Type Ia
OMIM:224120
Thrombocytopenia With Congenital Dyserythropoietic Anemia
ORPHA:67044
Anemia, Congenital Dyserythropoietic, Type Ib
OMIM:615631
Anemia, Sideroblastic, 3, Pyridoxine-Refractory
OMIM:616860
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities
OMIM:300835
Myelodysplastic Syndrome Associated With Isolated Del(5Q) Chromosome Abnormality
ORPHA:86841
Overhydrated Hereditary Stomatocytosis
ORPHA:3203
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
OMIM:300908
Congenital Dyserythropoietic Anemia Type Iii
ORPHA:98870
Orotic Aciduria
OMIM:258900
Retinitis Pigmentosa And Erythrocytic Microcytosis
OMIM:616959
Autoinflammation With Infantile Enterocolitis
OMIM:616050
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
OMIM:618278
Dominant Beta-Thalassemia
ORPHA:231226
Aicardi-Goutieres Syndrome 2
OMIM:610181
Immunodeficiency 21
OMIM:614172
Ras-Associated Autoimmune Leukoproliferative Disorder
OMIM:614470
Immunodeficiency 68
OMIM:612260
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
ORPHA:331206
Persistent Polyclonal B-Cell Lymphocytosis
OMIM:606445
Congenital Erythropoietic Porphyria
ORPHA:79277
Immunodeficiency 57 With Autoinflammation
OMIM:618108
Lymphoproliferative Syndrome 3
OMIM:618261
Acquired Partial Lipodystrophy
ORPHA:79087
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
OMIM:619313
Immunodeficiency 20
OMIM:615707
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
ORPHA:79124
Immunodeficiency 54
OMIM:609981
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
ORPHA:169154
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
ORPHA:276
Acute Monoblastic/Monocytic Leukemia
ORPHA:514
Pgm3-Cdg
ORPHA:443811
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
OMIM:617718
Lymphoproliferative Syndrome, X-Linked, 1
OMIM:308240
X-Linked Lymphoproliferative Disease
ORPHA:2442
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
OMIM:242860
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
OMIM:600802
Wolcott-Rallison Syndrome
ORPHA:1667
Hermansky-Pudlak Syndrome 2
OMIM:608233
Combined Immunodeficiency Due To Zap70 Deficiency
ORPHA:911
Acute Panmyelosis With Myelofibrosis
ORPHA:86843
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
ORPHA:35078
Combined Immunodeficiency With Faciooculoskeletal Anomalies
ORPHA:221139
Ch├ędiak-Higashi Syndrome
ORPHA:167
Autoimmune Lymphoproliferative Syndrome
ORPHA:3261
Onychotrichodysplasia And Neutropenia
OMIM:258360

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Galnt18

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Galnt18.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Galnt18tm1b(KOMP)Wtsi PMC5827107

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MGI Allele Allele Type Produced
Galnt18tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Galnt18tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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