The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kdm4a.
There are 4 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes.||Nature cell biology (March 2020)||Kdm4atm1a(EUCOMM)Wtsi||32231309|
|Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development.||Development (Cambridge, England) (August 2017)||Kdm4atm1a(EUCOMM)Wtsi||28827393|
|Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.||The EMBO journal (June 2016)||Kdm4atm1c(EUCOMM)Wtsi Kdm4atm1a(EUCOMM)Wtsi||PMC4899663|
|Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.||Genes & development (June 2016)||Kdm4atm1c(EUCOMM)Wtsi||PMC4911927|
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|MGI Allele||Allele Type||Produced|
|Kdm4atm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|