Gene Summary

lysine (K)-specific demethylase 4A
Jmjd2,  D4Ertd222e,  JHDM3A,  Jmjd2a

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kdm4a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kdm4a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kdm4a.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes. Nature cell biology (March 2020) Kdm4atm1a(EUCOMM)Wtsi 32231309
Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development. Development (Cambridge, England) (August 2017) Kdm4atm1a(EUCOMM)Wtsi 28827393
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. The EMBO journal (June 2016) Kdm4atm1c(EUCOMM)Wtsi Kdm4atm1a(EUCOMM)Wtsi PMC4899663
Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells. Genes & development (June 2016) Kdm4atm1c(EUCOMM)Wtsi PMC4911927

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Kdm4atm474(L1L2_Pgk_PM) Targeting vectors
Kdm4atm474(L1L2_gt0) Targeting vectors
Kdm4atm474(pL1L2_PAT_B0) Targeting vectors
Kdm4atm474(L1L2_Pgk_P) Targeting vectors
Kdm4aem2(IMPC)Marc Exdel Mice
Kdm4atm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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