Gene: Flnb

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Flnbtm1b(KOMP)Wtsi HET Early adult 2.92×10-05
preweaning lethality, complete penetrance Flnbtm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased bone mineral content Flnbtm1b(KOMP)Wtsi HET Early adult 1.09×10-05
decreased lean body mass Flnbtm1b(KOMP)Wtsi HET Early adult 1.55×10-05
decreased red blood cell distribution width Flnbtm1b(KOMP)Wtsi HET Early adult 1.01×10-07
decreased neutrophil cell number Flnbtm1b(KOMP)Wtsi HET Early adult 1.02×10-06

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Bone 2 No N/A
Brain 2 No  (3/590) N/A
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (1/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590)  (1/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590) N/A
Lymph node 2 No  (1/2) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/590) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/590)  (1/2)  Wholemount images
Oviduct 2 No N/A
Pancreas 2 No  (5/590) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590) N/A
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Striatum 2 No  (3/590) N/A
Testis 2 No  (5/590)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/506)  (2/2) N/A
Ear 1  (1/506) N/A
Embryo 1  (1/507)  (2/2) N/A
Eye 1  (1/506)  (2/2) N/A
Foot 1  (1/506)  (2/2) N/A
Forebrain 1  (1/506)  (2/2) N/A
Forelimb 1  (1/506)  (2/2) N/A
Hand 1  (1/506)  (2/2) N/A
Head 1  (5/506)  (2/2) N/A
Heart 1  (1/506) N/A
Hindbrain 1  (6/506)  (2/2) N/A
Hindlimb 1  (1/506)  (2/2) N/A
Liver 1  (1/504) N/A
Lung 1  (1/504) N/A
Mandibular process 1  (1/506) N/A
Maxillary process 1  (1/506) N/A
Midbrain 1  (1/506)  (2/2) N/A
Oral cavity 1  (1/504) N/A
Skin 1  (1/506) N/A
Tail 1  (1/506)  (2/2) N/A
Tail somite 1  (1/506)  (1/2) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
6 Images
X-ray: XRay Images Whole Body Lateral Orientation
7 Images
X-ray: XRay Images Whole Body Dorso Ventral
8 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
7 Images
Immunophenotyping: Panel A FCS file(s)
8 Images
Immunophenotyping: Panel B FCS file(s)
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Flnbtm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Flnbtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells