Gene: Slc25a21

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solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Other links
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal cranium morphology Slc25a21tm1a(KOMP)Wtsi HOM postnatal 1.72×10-10
decreased circulating alanine transaminase level Slc25a21tm1a(KOMP)Wtsi HOM postnatal 1.73×10-08
decreased effector memory CD8-positive, alpha-beta T cell number Slc25a21tm1a(KOMP)Wtsi HOM postnatal 8.29×10-05
abnormal mandible morphology Slc25a21tm1a(KOMP)Wtsi HOM postnatal 2.57×10-06
decreased NK T cell number Slc25a21tm1d(KOMP)Wtsi HOM postnatal 6.82×10-06
vertebral fusion Slc25a21tm1a(KOMP)Wtsi HOM postnatal 9.23×10-06
abnormal tooth morphology Slc25a21tm1a(KOMP)Wtsi HOM postnatal 2.04×10-07
abnormal snout morphology Slc25a21tm1a(KOMP)Wtsi HOM postnatal 6.07×10-11
decreased bone mineral content Slc25a21tm1a(KOMP)Wtsi HOM postnatal 5.03×10-07
decreased circulating aspartate transaminase level Slc25a21tm1a(KOMP)Wtsi HOM postnatal 4.99×10-08
absent pinna reflex Slc25a21tm1a(KOMP)Wtsi HOM postnatal 6.03×10-10
preweaning lethality, incomplete penetrance Slc25a21tm1a(KOMP)Wtsi HOM n/a 0.00
abnormal joint morphology Slc25a21tm1a(KOMP)Wtsi HOM postnatal 7.22×10-12
decreased lean body mass Slc25a21tm1a(KOMP)Wtsi HOM postnatal 3.23×10-05
decreased total body fat amount Slc25a21tm1a(KOMP)Wtsi HOM postnatal 3.09×10-10
decreased mean corpuscular volume Slc25a21tm1d(KOMP)Wtsi HOM postnatal 8.77×10-08
decreased mean corpuscular hemoglobin Slc25a21tm1d(KOMP)Wtsi HOM postnatal 1.09×10-05
decreased bone mineral content Slc25a21tm1d(KOMP)Wtsi HOM postnatal 3.05×10-05
decreased body weight Slc25a21tm1a(KOMP)Wtsi HOM postnatal 3.03×10-24
decreased bone mineral density Slc25a21tm1a(KOMP)Wtsi HOM postnatal 2.15×10-09
decreased body length Slc25a21tm1a(KOMP)Wtsi HOM postnatal 5.04×10-05
abnormal incisor morphology Slc25a21tm1a(KOMP)Wtsi HOM postnatal 5.32×10-05
increased total body fat amount Slc25a21tm1d(KOMP)Wtsi HOM postnatal 3.40×10-05

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Select physiological systems to view:
Viewing: all phenotypes


IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 6 No  (2/584) N/A
Aorta 6 No N/A
Blood vessel 6 No N/A
Bone 6 No N/A
Brain 6 No  (2/10) N/A
Brainstem 6 No N/A
Brown adipose tissue 6 No N/A
Cartilage tissue 6 No N/A
Cerebellum 6 No N/A
Cerebral cortex 6 No N/A
Eye 6 No N/A
Gall bladder 6 No N/A
Heart 6 No N/A
Hippocampus 6 No N/A
Hypothalamus 6 No N/A
Kidney 6 No  (18/584) N/A
Large intestine 6 No  (10/584) N/A
Liver 6 No N/A
Lower urinary tract 6 No N/A
Lung 6 No N/A
Lymph node 6 No N/A
Mammary gland 6 No N/A
Esophagus 6 No N/A
Olfactory lobe 6 No N/A
Ovary 6 No  (1/584) N/A
Oviduct 6 No N/A
Pancreas 6 No  (5/584) N/A
Parathyroid gland 6 No  (2/10) N/A
Peripheral nervous system 6 No N/A
Peyer's patch 6 No N/A
Pituitary gland 6 No N/A
Prostate gland 6 No  (12/584) N/A
Skeletal muscle tissue 6 No N/A
Skin 6 No N/A
Small intestine 6 No  (9/584) N/A
Spinal cord 6 No N/A
Spleen 6 No  (2/584) N/A
Stomach 6 No  (12/584) N/A
Striatum 6 No N/A
Testis 6 No  (2/584)  (2/10) N/A
Thymus 6 No N/A
Thyroid gland 6 No  (15/584) N/A
Trachea 6 No N/A
Uterus 6 No N/A
White adipose tissue 6 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
X-ray: XRay Images Dorso Ventral
40 Images
X-ray: XRay Images Lateral Orientation
24 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Forepaw
13 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Slc25a21tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Slc25a21tm41920(L1L2_Pgk_PM) Targeting vectors
Slc25a21tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Slc25a21tm1d(KOMP)Wtsi Deletion allele (post-Flp and Cre with no reporter) Mice
Slc25a21tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Slc25a21tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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