IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|abnormal tail movements||Pik3c3tm1a(EUCOMM)Wtsi||HET||Early adult||7.04×10-06|
|decreased circulating triglyceride level||Pik3c3tm1a(EUCOMM)Wtsi||HET||Early adult||3.90×10-05|
|decreased grip strength||Pik3c3tm1a(EUCOMM)Wtsi||HET||Early adult||5.22×10-06|
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pik3c3.
There are 5 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.||The Journal of clinical investigation (May 2018)||Pik3c3tm1c(EUCOMM)Wtsi||PMC5983330|
|Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cells.||Proceedings of the National Academy of Sciences of the United States of America (July 2017)||Pik3c3tm1c(EUCOMM)Wtsi||PMC5547642|
|PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.||The Journal of clinical investigation (August 2016)||Pik3c3tm1c(EUCOMM)Wtsi||PMC5004942|
|Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34.||Journal of immunology (Baltimore, Md. : 1950) (April 2013)||Pik3c3tm1c(EUCOMM)Wtsi||PMC3646937|
|Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.||Proceedings of the National Academy of Sciences of the United States of America (January 2012)||Pik3c3tm1c(EUCOMM)Wtsi Pik3c3tm1a(EUCOMM)Wtsi||PMC3277541|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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|MGI Allele||Allele Type||Produced|
|Pik3c3tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Pik3c3tm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|
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