Gene Summary

Name:
phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms:
Vps34,  5330434F23Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Pik3c3tm1a(EUCOMM)Wtsi HET   Early adult 5.22×10-06
decreased circulating triglyceride level Pik3c3tm1a(EUCOMM)Wtsi HET Early adult 3.90×10-05
abnormal tail movements Pik3c3tm1a(EUCOMM)Wtsi HET   Early adult 7.04×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Pik3c3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pik3c3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pik3c3.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. The Journal of clinical investigation (May 2018) Pik3c3tm1c(EUCOMM)Wtsi PMC5983330
Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cells. Proceedings of the National Academy of Sciences of the United States of America (July 2017) Pik3c3tm1c(EUCOMM)Wtsi PMC5547642
PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models. The Journal of clinical investigation (August 2016) Pik3c3tm1c(EUCOMM)Wtsi PMC5004942
Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Journal of immunology (Baltimore, Md. : 1950) (April 2013) Pik3c3tm1c(EUCOMM)Wtsi PMC3646937
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proceedings of the National Academy of Sciences of the United States of America (January 2012) Pik3c3tm1c(EUCOMM)Wtsi Pik3c3tm1a(EUCOMM)Wtsi PMC3277541

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MGI Allele Allele Type Produced
Pik3c3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Pik3c3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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