Dcaf5 | DDB1 and CUL4 associated factor 5

GeneMGI:2444785Synonyms: BCRP2, 9430020B07Rik, +2 more

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Vision/eye Respiratory system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:21Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal spleen morphology1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased spleen weight1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adult2.57x10-11 
short tibia1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adult7.01x10-10 
enlarged heart1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adultN/A * 
decreased body weight2 supporting datasetsDcaf5em1(IMPC)CcpczhomozygoteEarly adult7.25x10-6 
abnormal heart morphology1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged spleen1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adultN/A * 
small spleen1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal tooth morphology1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased red blood cell distribution width1 supporting datasetDcaf5em1(IMPC)CcpczhomozygoteEarly adult1.41x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dcaf5em1(IMPC)CcpczExon Deletionmouse
Dcaf5tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Dcaf5tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Dcaf5tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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