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Gene: Kif20b MGI:2444576

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
kinesin family member 20B
Synonyms:
33cex,  Kif20b,  N-6 kinesin,  Mphosph1,  magoo,  C330014J10Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kif20b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Kif20b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Anophthalmia, Microphthalmia ORPHA:85275
Orofacial Cleft 11
Cleft lip, Cleft palate OMIM:600625
Syngnathia
Cleft palate OMIM:119550
Anencephaly 2
Median cleft upper lip, Cleft maxillary alveolar ridge, Median cleft palate, Anophthalmia OMIM:619452
Microphthalmia/Coloboma 5
Orofacial cleft, Anophthalmia, Bilateral microphthalmos, Microphthalmia OMIM:611638
Fryns Microphthalmia Syndrome
Tessier cleft, Anophthalmia, Bilateral cleft palate, Bilateral cleft lip, Microphthalmia OMIM:600776
Microphthalmia, Isolated 1
Anophthalmia, Microphthalmia OMIM:251600
Megaepiphyseal Dwarfism
Severe short stature, Short stature, Cleft palate OMIM:249230
Orofacial Cleft 10
Unilateral cleft palate, Unilateral cleft lip OMIM:613705
Microphthalmia/Coloboma 10
Anophthalmia, Microphthalmia OMIM:616428
Palatopharyngeal Incompetence
Velopharyngeal insufficiency, Cleft palate OMIM:167500
Orofacial Cleft 5
Cleft palate, Cleft upper lip OMIM:608874
Orofacial Cleft 6, Susceptibility To
Cleft palate, Cleft upper lip OMIM:608864
Orofacial Cleft 1
Cleft palate, Cleft upper lip OMIM:119530
2q33.1 deletion syndrome
Short stature, High palate, Cleft palate DECIPHER:51
Ankyloblepharon Filiforme Adnatum-Imperforate Anus Syndrome
Non-midline cleft of the upper lip, Cleft palate, Tooth agenesis ORPHA:1074
Congenital Laryngomalacia
Non-midline cleft of the upper lip, Cleft palate ORPHA:2373
Facial Clefting, Oblique, 1
Tessier number 4 facial cleft, Cleft palate, Cleft upper lip, Microphthalmia OMIM:600251
Microphthalmia, Syndromic 12
Intestinal malrotation, Anophthalmia, Cleft palate, Microphthalmia OMIM:615524
Microphthalmia, Syndromic 16
Anophthalmia, Microphthalmia OMIM:611038
Ankyloblepharon Filiforme Adnatum And Cleft Palate
Cleft palate, Cleft upper lip OMIM:106250
Maternal Hyperthermia-Induced Birth Defects
Short stature, Intrauterine growth retardation, Aplasia/Hypoplasia affecting the eye, Cleft palate ORPHA:2216
Pierre Robin Syndrome
Glossoptosis, Cleft palate, Pierre-Robin sequence OMIM:261800
Pierre Robin Syndrome And Oligodactyly
Cleft palate, Pierre-Robin sequence OMIM:172880
Anophthalmia Plus Syndrome
Tessier cleft, Anophthalmia, Bilateral cleft palate, Non-midline cleft of the upper lip, Cleft pa... ORPHA:1104
Isolated Pierre Robin Syndrome
Glossoptosis, Cleft palate ORPHA:718
Cleft Palate, Isolated
Gingival overgrowth, Cleft palate, Anterior open-bite malocclusion, Increased overbite OMIM:119540
Cleft Palate-Lateral Synechia Syndrome
Cleft palate, Narrow mouth, Everted lower lip vermilion, Oral synechia ORPHA:2016
Oculocerebrocutaneous Syndrome
Anophthalmia, Cleft palate, Microphthalmia OMIM:164180
Cerebrooculonasal Syndrome
Tessier cleft, Long philtrum, Widely spaced teeth, Anophthalmia, Microdontia, Solitary median max... ORPHA:66625
Van Der Woude Syndrome 1
Bifid uvula, Cleft upper lip, Lower lip pit, Hypodontia, Cleft palate OMIM:119300
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Meckel Syndrome, Type 8
Cleft upper lip, Anophthalmia, Cleft palate, Microphthalmia OMIM:613885
Microphthalmia, Isolated 8
True anophthalmia, Optic nerve hypoplasia, Anophthalmia, Microphthalmia OMIM:615113
Cerebrooculofacioskeletal Syndrome 3
Intrauterine growth retardation, Cleft palate, Microphthalmia OMIM:616570
Solitary Median Maxillary Central Incisor
Cleft upper lip, Anophthalmia, Prominent median palatal raphe, Solitary median maxillary central ... OMIM:147250
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Impaired Intellectual Development
Cleft palate, Cleft upper lip, Microphthalmia OMIM:120433
Hydrolethalus
Bifid uvula, Gingival cleft, Unilateral cleft lip, Anophthalmia, Submucous cleft hard palate, Mic... ORPHA:2189
Microphthalmia, Syndromic 5
Anophthalmia, Microphthalmia, Short stature, Cleft palate, Optic nerve hypoplasia OMIM:610125
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia, Everted lower lip vermilion, Abnormal spaced incisors, Thick vermilion border, Shor... ORPHA:411986
Trisomy 13
High, narrow palate, Abnormality of the dentition, Long philtrum, Intrauterine growth retardation... ORPHA:3378
Diffuse Gastric And Lobular Breast Cancer Syndrome
Atrophic gastritis, Stomach cancer, Cleft palate, Cleft upper lip OMIM:137215
Microphthalmia, Syndromic 11
Cleft palate, Cleft upper lip, Microphthalmia OMIM:614402
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies
Aplasia/Hypoplasia of the pyramidal tract, Abnormal cortical gyration, Polymicrogyria, Neonatal d... OMIM:619602
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Chromosome 22Q11.2 Deletion Syndrome, Distal
Intrauterine growth retardation, Thin upper lip vermilion, Smooth philtrum, Short stature, Cleft ... OMIM:611867
Cleft Palate With Or Without Ankyloglossia, X-Linked
Bifid uvula, Ankyloglossia, Cleft palate OMIM:303400
Lowry-Maclean Syndrome
Intrauterine growth retardation, Delayed eruption of teeth, Cleft palate OMIM:600252
Van Der Woude Syndrome 2
Lip pit, Dental malocclusion, Cleft upper lip, Anodontia, Hypodontia, Cleft palate OMIM:606713
Weaver-Williams Syndrome
Narrow mouth, Cleft palate ORPHA:3448
Microphthalmia With Limb Anomalies
Cleft upper lip, Postnatal growth retardation, Anophthalmia, Deep philtrum, Microphthalmia, High ... OMIM:206920
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Microphthalmia, Syndromic 8
Cleft upper lip, Orofacial cleft, Microphthalmia, Widely-spaced maxillary central incisors, Cleft... OMIM:601349
Van Der Woude Syndrome
Lip pit, Cleft upper lip, Lower lip pit, Hypodontia, Abnormal salivary gland morphology, Cleft pa... ORPHA:888
Cockayne Syndrome Type 2
Widely spaced primary teeth, Intrauterine growth retardation, Hypoplasia of the primary teeth, An... ORPHA:90322
Oculotrichoanal Syndrome
Anal stenosis, Anophthalmia, Anteriorly placed anus, Microphthalmia ORPHA:2717
Matthew-Wood Syndrome
Microphthalmia, Intrauterine growth retardation, Anophthalmia, Duodenal stenosis ORPHA:2470
Congenital Arthrogryposis With Anterior Horn Cell Disease
Abnormal anterior horn cell morphology, Cerebral atrophy, Neonatal death, Microcephaly, Paucity o... OMIM:611890
Holzgreve Syndrome
Cleft palate, Cleft upper lip OMIM:236110
Cleft Lip/Palate
Dental malocclusion, Velopharyngeal insufficiency, Palate fistula, Peg-shaped maxillary lateral i... ORPHA:199306
Trochlea Of The Humerus, Aplasia Of
Cleft palate OMIM:191000
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Microphthalmia, High palate, Cleft palate, Tooth agenesis ORPHA:1135
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Anophthalmia, Tracheoesophageal fistula, Esophageal atresia, Microphthalmia, Growth delay ORPHA:77298
Omphalocele-Cleft Palate Syndrome, Lethal
Bifid uvula, Cleft palate OMIM:258320
Microphthalmia With Brain And Digit Anomalies
High palate, Anophthalmia, Microphthalmia ORPHA:139471
Radius, Aplasia Of, With Cleft Lip/Palate
Cleft palate, Cleft upper lip OMIM:179400
Lissencephaly 7 With Cerebellar Hypoplasia
Death in infancy, Agenesis of corpus callosum, Cerebellar hypoplasia, Microcephaly, Neonatal deat... OMIM:616342
Joubert Syndrome 15
Exencephaly OMIM:614464
Cerebrooculonasal Syndrome
Narrow palate, Downturned corners of mouth, Long philtrum, Postnatal growth retardation, Anophtha... OMIM:605627
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Bifid uvula, Tooth malposition, Failure of eruption of permanent teeth, Anophthalmia, Submucous c... ORPHA:2250
Hartsfield Syndrome
Intrauterine growth retardation, Non-midline cleft of the upper lip, Cleft palate, Microphthalmia ORPHA:2117
Peroxisome Biogenesis Disorder 6A (Zellweger)
Pachygyria, Colpocephaly, Neonatal death OMIM:614870
Oculopalatocerebral Syndrome
Short stature, Cleft palate, Microphthalmia OMIM:257910
Walker-Warburg Syndrome
Bifid uvula, Anophthalmia, Submucous cleft hard palate, Microphthalmia, Cleft palate ORPHA:899
Ankyloblepharon Filiforme Adnatum-Cleft Palate Syndrome
Lip pit, Non-midline cleft of the upper lip, Cleft palate ORPHA:1072
Braddock-Carey Syndrome 2
Microphthalmia, Wide mouth, Cleft palate, Pierre-Robin sequence OMIM:619981
Tetraploidy
Intrauterine growth retardation, Short philtrum, Aplasia/Hypoplasia affecting the eye, Cleft palate ORPHA:3305
Trisomy 1Q
Anal atresia, Narrow mouth, Anophthalmia, Cleft palate ORPHA:261344
Manitoba Oculotrichoanal Syndrome
Anal stenosis, Anophthalmia, Anteriorly placed anus, Microphthalmia OMIM:248450
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Hydranencephaly, Hypoplasia of the brainstem, Neonatal death, Cerebellar hypoplasia, Stillbirth, ... OMIM:236500
Cockayne Syndrome Type 1
Abnormality of the dentition, Widely spaced primary teeth, Postnatal growth retardation, Hypoplas... ORPHA:90321
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Rhizomelia, Anophthalmia, Long philtrum, Microphthalmia OMIM:615877
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Neonatal death, Macrocephaly OMIM:612138
Vacterl With Hydrocephalus
Intrauterine growth retardation, Anophthalmia, Tracheoesophageal fistula, Esophageal atresia, Mic... ORPHA:3412
Holoprosencephaly 9
Dental malocclusion, Downturned corners of mouth, Cleft upper lip, Thick lower lip vermilion, Ano... OMIM:610829
Lethal Congenital Contracture Syndrome 1
Paucity of anterior horn motor neurons, Neonatal death OMIM:253310
Frontonasal Dysplasia 3
Tessier cleft, Cleft palate, Microphthalmia OMIM:613456
Neutropenia, Lethal Congenital, With Eosinophilia
Eosinophilia, Neonatal death OMIM:257100
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Microcephaly-Cleft Palate-Abnormal Retinal Pigmentation Syndrome
Bifid uvula, Cleft palate, Submucous cleft hard palate ORPHA:2521
Microgastria-Limb Reduction Defect Syndrome
Microgastria, Intestinal malrotation, Esophagitis, Anophthalmia, Perineal fistula, Hiatus hernia,... ORPHA:2538
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4B
Cerebellar hypoplasia, Neonatal death OMIM:615228
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
High, narrow palate, Aniridia, Anophthalmia, Long philtrum ORPHA:1101
Microphthalmia, Syndromic 9
Severe short stature, Bilateral microphthalmos, Intrauterine growth retardation, Anophthalmia, Sh... OMIM:601186
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Meckel Syndrome, Type 2
Intestinal malrotation, Intrauterine growth retardation, Cleft palate, Microphthalmia OMIM:603194
Meckel Syndrome, Type 5
Cleft palate, Cleft upper lip, Microphthalmia OMIM:611561
Microphthalmia, Syndromic 3
Optic nerve aplasia, Postnatal growth retardation, Anophthalmia, Esophageal atresia, Microphthalm... OMIM:206900
Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Widely spaced teeth, Postnatal growth retardation, Intrauterine growth retardation, Microdontia, ... ORPHA:2728
Holoprosencephaly
Tooth agenesis, Median cleft palate, Anophthalmia, Median cleft upper lip, Bilateral cleft lip, S... ORPHA:2162
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts
Secondary microcephaly, Death in infancy, Cerebellar hypoplasia, Neonatal death OMIM:613730
Combined Oxidative Phosphorylation Deficiency 21
Hypoplasia of the corpus callosum, Cerebral atrophy, Neonatal death OMIM:615918
Diaphragmatic Hernia 5, X-Linked
Neonatal death OMIM:306950
Stuve-Wiedemann Syndrome 2
Neonatal death, Death in adolescence, Stillbirth OMIM:619751
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uvula, Cleft soft palate, Unilateral cleft lip, Cleft palate ORPHA:2736
Microphthalmia, Syndromic 2
Bifid uvula, Dental malocclusion, Delayed eruption of teeth, Long philtrum, Persistence of primar... OMIM:300166
Microphthalmia With Limb Anomalies
Long philtrum, Cleft upper lip, Macrodontia, True anophthalmia, Microphthalmia, Thin vermilion bo... ORPHA:1106
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Short stature, Downturned corners of mouth, Anophthalmia ORPHA:264200
Meckel Syndrome
Aplasia/Hypoplasia of the tongue, Furrowed tongue, Anophthalmia, Aplasia/Hypoplasia of the iris, ... ORPHA:564
Charge Syndrome
Delayed eruption of teeth, Cleft upper lip, Postnatal growth retardation, Intrauterine growth ret... ORPHA:138
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
Bresek Syndrome
Neonatal death, Microcephaly, Hydrocephalus, Optic nerve hypoplasia ORPHA:85284
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Severe short stature, Long philtrum, Thick vermilion border, Anophthalmia, Microphthalmia ORPHA:2526
Fraser Syndrome 1
Tessier cleft, Dental crowding, Dental malocclusion, Cleft upper lip, Bilateral microphthalmos, A... OMIM:219000
Proboscis Lateralis
Long philtrum, Anophthalmia, Orofacial cleft, Agenesis of canine, Microphthalmia, High palate, Op... ORPHA:141099
Focal Dermal Hypoplasia
Dental malocclusion, Delayed eruption of teeth, Cleft upper lip, Anteriorly placed anus, Intestin... OMIM:305600
Fibular Hemimelia
Anophthalmia ORPHA:93323
Microphthalmia With Linear Skin Defects Syndrome
Severe short stature, Abnormal dental enamel morphology, Abnormal rectum morphology, Anophthalmia... ORPHA:2556
Thanatophoric Dysplasia, Type I
Neonatal death, Temporal lobe dysplasia, Hydrocephalus, Macrocephaly, Gray matter heterotopia OMIM:187600
Combined Oxidative Phosphorylation Deficiency 11
Cerebral cortical atrophy, Death in childhood, Hypoplasia of the corpus callosum, Neonatal death,... OMIM:614922
Fraser Syndrome
Anal stenosis, Dental malocclusion, Dental crowding, Cleft upper lip, Anophthalmia, Orofacial cle... ORPHA:2052
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities
Leukoencephalopathy, Cerebellar vermis hypoplasia, Cerebral cortical atrophy, Cerebral calcificat... OMIM:620024
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Encephalocele, Exencephaly ORPHA:2211
Branchiooculofacial Syndrome
Abnormality of the dentition, Cleft upper lip, Postnatal growth retardation, Intrauterine growth ... OMIM:113620
Microcephaly-Micromelia Syndrome
Aplasia/Hypoplasia of the corpus callosum, Neonatal death, Microcephaly, Aqueductal stenosis, Sim... OMIM:251230
Microphthalmia, Syndromic 1
High, narrow palate, Tooth malposition, Dental crowding, Cleft upper lip, Anophthalmia, Aganglion... OMIM:309800
Microphthalmia, Syndromic 6
Bifid uvula, Microglossia, Anophthalmia, Microphthalmia, High palate, Cleft palate OMIM:607932
Arthrogryposis Multiplex Congenita 6
Death in childhood, Death in infancy, Neonatal death OMIM:619334
Charge Syndrome
Anal stenosis, Cleft upper lip, Postnatal growth retardation, Unilateral microphthalmos, Anophtha... OMIM:214800
Dyssegmental Dysplasia, Silverman-Handmaker Type
Microcephaly, Occipital encephalocele, Neonatal death OMIM:224410
Joubert Syndrome 21
Anophthalmia OMIM:615636
Molybdenum Cofactor Deficiency, Type C
Cerebellar hypoplasia, Neonatal death, Hypoplasia of the pons, Polymicrogyria OMIM:615501
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Semilobar holoprosencephaly, Absent septum pellucidum, Hypoplasia of the corpus callosum, Neonata... OMIM:618500
Afibrinogenemia, Congenital
Death in adolescence, Death in childhood, Death in infancy, Neonatal death OMIM:202400
Sacral Defect With Anterior Meningocele
Myelomeningocele, Myeloschisis, Hydrocephalus, Meningocele, Dermal sinus tract OMIM:600145
Craniofacial Microsomia 1
Cleft upper lip, Anophthalmia, Microphthalmia, Wide mouth, Cleft palate, Transverse facial cleft OMIM:164210
Neu-Laxova Syndrome 1
Hydranencephaly, Agenesis of corpus callosum, Cerebellar hypoplasia, Neonatal death, Primary micr... OMIM:256520
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kif20b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kif20b.

No publications found that use IMPC mice or data for Kif20b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Kif20btm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Kif20btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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