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Gene: Kif20b MGI:2444576

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
kinesin family member 20B
Synonyms:
33cex,  Kif20b,  N-6 kinesin,  Mphosph1,  C330014J10Rik,  magoo

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kif20b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Kif20b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Orofacial Cleft 11
Cleft lip, Cleft palate OMIM:600625
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Microphthalmia, Anophthalmia ORPHA:85275
Syngnathia
Cleft palate OMIM:119550
Anencephaly 2
Anophthalmia, Median cleft palate, Median cleft lip, Cleft maxillary alveolar ridge OMIM:619452
Microphthalmia, Isolated, With Coloboma 5
Microphthalmia, Anophthalmia, Bilateral microphthalmos, Orofacial cleft OMIM:611638
Microphthalmia, Isolated 1
Microphthalmia, Anophthalmia OMIM:251600
Megaepiphyseal Dwarfism
Severe short stature, Short stature, Cleft palate OMIM:249230
Fryns Microphthalmia Syndrome
Microphthalmia, Anophthalmia, Bilateral cleft lip and palate OMIM:600776
Microphthalmia, Isolated, With Coloboma 10
Microphthalmia, Anophthalmia OMIM:616428
Palatopharyngeal Incompetence
Velopharyngeal insufficiency, Cleft palate OMIM:167500
Orofacial Cleft 5
Cleft palate, Cleft upper lip OMIM:608874
Orofacial Cleft 6, Susceptibility To
Cleft palate, Cleft upper lip OMIM:608864
Orofacial Cleft 1
Cleft palate, Cleft upper lip OMIM:119530
Orofacial Cleft 10
Unilateral cleft palate, Unilateral cleft lip OMIM:613705
2q33.1 deletion syndrome
Short stature, High palate, Cleft palate DECIPHER:51
Microphthalmia, Syndromic 12
Microphthalmia, Anophthalmia, Intestinal malrotation, Cleft palate OMIM:615524
Microphthalmia, Syndromic 16
Microphthalmia, Anophthalmia OMIM:611038
Ankyloblepharon Filiforme Adnatum And Cleft Palate
Cleft palate, Cleft upper lip OMIM:106250
Pierre Robin Syndrome And Oligodactyly
Pierre-Robin sequence, Cleft palate OMIM:172880
Ankyloblepharon Filiforme Adnatum-Imperforate Anus Syndrome
Tooth agenesis, Non-midline cleft lip, Cleft palate ORPHA:1074
Congenital Laryngomalacia
Non-midline cleft lip, Cleft palate ORPHA:2373
Facial Clefting, Oblique, 1
Microphthalmia, Cleft palate, Cleft upper lip OMIM:600251
Cleft Palate, Isolated
Anterior open-bite malocclusion, Increased overbite, Gingival overgrowth, Cleft palate OMIM:119540
Cleft Palate-Lateral Synechia Syndrome
Oral synechia, Everted lower lip vermilion, Cleft palate, Narrow mouth ORPHA:2016
Oculocerebrocutaneous Syndrome
Microphthalmia, Anophthalmia, Cleft palate OMIM:164180
Van Der Woude Syndrome 1
Cleft upper lip, Lower lip pit, Cleft palate, Hypodontia, Bifid uvula OMIM:119300
Maternal Hyperthermia-Induced Birth Defects
Intrauterine growth retardation, Aplasia/Hypoplasia affecting the eye, Short stature, Cleft palate ORPHA:2216
Meckel Syndrome, Type 8
Microphthalmia, Anophthalmia, Cleft palate, Cleft upper lip OMIM:613885
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Microphthalmia, Isolated 8
Microphthalmia, Anophthalmia, Optic nerve hypoplasia, True anophthalmia OMIM:615113
Anophthalmia Plus Syndrome
Non-midline cleft lip, Anophthalmia, Cleft palate, Bilateral cleft lip and palate ORPHA:1104
Solitary Median Maxillary Central Incisor
Anophthalmia, Short stature, Cleft upper lip, Prominent median palatal raphe, Torus palatinus, So... OMIM:147250
Cerebrooculofacioskeletal Syndrome 3
Microphthalmia, Cleft palate, Intrauterine growth retardation OMIM:616570
Cerebrooculonasal Syndrome
Anophthalmia, High palate, Widely spaced teeth, Solitary median maxillary central incisor, Long p... ORPHA:66625
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Impaired Intellectual Development
Microphthalmia, Cleft palate, Cleft upper lip OMIM:120433
Hydrolethalus
Anophthalmia, Submucous cleft hard palate, Gingival cleft, Cleft palate, Unilateral cleft lip, Mi... ORPHA:2189
Microphthalmia, Syndromic 5
Anophthalmia, Short stature, Optic nerve hypoplasia, Cleft palate, Microphthalmia OMIM:610125
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia, Abnormal spaced incisors, Everted lower lip vermilion, Thick vermilion border, Shor... ORPHA:411986
Diffuse Gastric And Lobular Breast Cancer Syndrome
Stomach cancer, Atrophic gastritis, Cleft palate, Cleft upper lip OMIM:137215
Trisomy 13
Anophthalmia, Median cleft lip, Abnormality of the dentition, High, narrow palate, Cleft palate, ... ORPHA:3378
Microphthalmia, Syndromic 11
Microphthalmia, Cleft palate, Cleft upper lip OMIM:614402
Chromosome 22Q11.2 Deletion Syndrome, Distal
Thin upper lip vermilion, Short stature, Cleft palate, Intrauterine growth retardation, Smooth ph... OMIM:611867
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Cleft Palate With Or Without Ankyloglossia, X-Linked
Ankyloglossia, Bifid uvula, Cleft palate OMIM:303400
Lowry-Maclean Syndrome
Delayed eruption of teeth, Intrauterine growth retardation, Cleft palate OMIM:600252
Van Der Woude Syndrome 2
Lip pit, Cleft upper lip, Dental malocclusion, Cleft palate, Hypodontia, Anodontia OMIM:606713
Weaver-Williams Syndrome
Cleft palate, Narrow mouth ORPHA:3448
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies
Abnormal cortical gyration, Microcephaly, Aplasia/Hypoplasia of the pyramidal tract, Neonatal dea... OMIM:619602
Microphthalmia With Limb Anomalies
Anophthalmia, Cleft upper lip, Postnatal growth retardation, Deep philtrum, Cleft palate, Growth ... OMIM:206920
Van Der Woude Syndrome
Lip pit, Cleft upper lip, Lower lip pit, Cleft palate, Hypodontia, Abnormal salivary gland morpho... ORPHA:888
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Microphthalmia, Syndromic 8
Cleft upper lip, Cleft palate, Orofacial cleft, Widely-spaced maxillary central incisors, Microph... OMIM:601349
Congenital Arthrogryposis With Anterior Horn Cell Disease
Abnormal anterior horn cell morphology, Microcephaly, Paucity of anterior horn motor neurons, Cry... OMIM:611890
Cockayne Syndrome Type 2
Anophthalmia, Delayed eruption of primary teeth, Intrauterine growth retardation, Widely spaced p... ORPHA:90322
Oculotrichoanal Syndrome
Anteriorly placed anus, Microphthalmia, Anal stenosis, Anophthalmia ORPHA:2717
Matthew-Wood Syndrome
Microphthalmia, Intrauterine growth retardation, Anophthalmia, Duodenal stenosis ORPHA:2470
Holzgreve Syndrome
Cleft palate, Cleft upper lip OMIM:236110
Cleft Lip/Palate
Agenesis of lateral incisor, Bilateral cleft palate, Velopharyngeal insufficiency, Abnormality of... ORPHA:199306
Trochlea Of The Humerus, Aplasia Of
Cleft palate OMIM:191000
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Anophthalmia, Esophageal atresia, Tracheoesophageal fistula, Growth delay, Microphthalmia ORPHA:77298
Microphthalmia With Brain And Digit Anomalies
Microphthalmia, Anophthalmia, High palate ORPHA:139471
Omphalocele-Cleft Palate Syndrome, Lethal
Bifid uvula, Cleft palate OMIM:258320
Radius, Aplasia Of, With Cleft Lip/Palate
Cleft palate, Cleft upper lip OMIM:179400
Cerebrooculonasal Syndrome
Anophthalmia, Optic nerve hypoplasia, Postnatal growth retardation, Narrow palate, Cleft palate, ... OMIM:605627
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Anophthalmia, Failure of eruption of permanent teeth, Submucous cleft hard palate, Cleft palate, ... ORPHA:2250
Joubert Syndrome 15
Exencephaly OMIM:614464
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Tooth agenesis, Microphthalmia, High palate, Cleft palate ORPHA:1135
Lissencephaly 7 With Cerebellar Hypoplasia
Death in infancy, Microcephaly, Lissencephaly, Cerebellar hypoplasia, Neonatal death, Agenesis of... OMIM:616342
Hartsfield Syndrome
Microphthalmia, Non-midline cleft lip, Cleft palate, Intrauterine growth retardation ORPHA:2117
Oculopalatocerebral Syndrome
Microphthalmia, Short stature, Cleft palate OMIM:257910
Peroxisome Biogenesis Disorder 6A (Zellweger)
Neonatal death, Colpocephaly, Pachygyria OMIM:614870
Walker-Warburg Syndrome
Anophthalmia, Submucous cleft hard palate, Cleft palate, Microphthalmia, Bifid uvula ORPHA:899
Holoprosencephaly 9
Anophthalmia, Short stature, Optic nerve hypoplasia, Cleft upper lip, Agenesis of incisor, Dental... OMIM:610829
Braddock-Carey Syndrome 2
Wide mouth, Microphthalmia, Pierre-Robin sequence, Cleft palate OMIM:619981
Manitoba Oculotrichoanal Syndrome
Anteriorly placed anus, Microphthalmia, Anal stenosis, Anophthalmia OMIM:248450
Ankyloblepharon Filiforme Adnatum-Cleft Palate Syndrome
Cleft palate, Non-midline cleft lip, Lip pit ORPHA:1072
Tetraploidy
Intrauterine growth retardation, Aplasia/Hypoplasia affecting the eye, Short philtrum, Cleft palate ORPHA:3305
Trisomy 1Q
Anal atresia, Anophthalmia, Cleft palate, Narrow mouth ORPHA:261344
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Hypoplasia of the brainstem, Stillbirth, Cerebellar hypoplasia, Neonatal death, Multinucleated ne... OMIM:236500
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Cleft lip, Cleft palate OMIM:612370
Cockayne Syndrome Type 1
Anophthalmia, Delayed eruption of primary teeth, Abnormality of the dentition, Postnatal growth r... ORPHA:90321
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Microphthalmia, Anophthalmia, Rhizomelia, Long philtrum OMIM:615877
Vacterl With Hydrocephalus
Anophthalmia, Esophageal atresia, Tracheoesophageal fistula, Microphthalmia, Anal atresia, Intrau... ORPHA:3412
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Neonatal death, Macrocephaly OMIM:612138
Lethal Congenital Contracture Syndrome 1
Paucity of anterior horn motor neurons, Neonatal death OMIM:253310
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death, Eosinophilia OMIM:257100
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Microcephaly-Cleft Palate-Abnormal Retinal Pigmentation Syndrome
Submucous cleft hard palate, Bifid uvula, Cleft palate ORPHA:2521
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts
Death in infancy, Cryptorchidism, Secondary microcephaly, Cerebellar hypoplasia, Neonatal death OMIM:613730
Meckel Syndrome, Type 5
Microphthalmia, Cleft palate, Cleft upper lip OMIM:611561
Microphthalmia, Syndromic 9
Severe short stature, Anophthalmia, Short stature, Bilateral microphthalmos, Intrauterine growth ... OMIM:601186
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4B
Neonatal death, Cerebellar hypoplasia OMIM:615228
Meckel Syndrome, Type 2
Microphthalmia, Intestinal malrotation, Cleft palate, Intrauterine growth retardation OMIM:603194
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Microphthalmia, Syndromic 3
Optic nerve aplasia, Anophthalmia, Short stature, Optic nerve hypoplasia, Postnatal growth retard... OMIM:206900
Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Postnatal growth retardation, Cleft palate, Hypoplasia of teeth, Widely spaced teeth, Microdontia... ORPHA:2728
Microgastria-Limb Reduction Defect Syndrome
Anophthalmia, Intestinal malrotation, Hiatus hernia, Esophageal atresia, Rectal atresia, Tracheoe... ORPHA:2538
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Aniridia, High, narrow palate, Anophthalmia, Long philtrum ORPHA:1101
Holoprosencephaly
Anophthalmia, Median cleft lip, Bilateral cleft lip, Median cleft lip and palate, Deep philtrum, ... ORPHA:2162
Combined Oxidative Phosphorylation Deficiency 21
Neonatal death, Hypoplasia of the corpus callosum, Cerebral atrophy OMIM:615918
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Stuve-Wiedemann Syndrome 2
Neonatal death, Stillbirth, Death in adolescence OMIM:619751
Bresek Syndrome
Optic nerve hypoplasia, Microcephaly, Cryptorchidism, Hydrocephalus, Neonatal death, Decreased te... ORPHA:85284
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uvula, Unilateral cleft lip, Cleft soft palate, Cleft palate ORPHA:2736
Microphthalmia With Limb Anomalies
Macrodontia, Short stature, Cleft upper lip, Cleft palate, Thin vermilion border, High palate, Lo... ORPHA:1106
Charge Syndrome
Delayed eruption of teeth, Anophthalmia, Short stature, Cleft upper lip, Abnormal soft palate mor... ORPHA:138
14Q22Q23 Microdeletion Syndrome
Downturned corners of mouth, Optic nerve aplasia, Anophthalmia, Short stature ORPHA:264200
Meckel Syndrome
Anophthalmia, Aplasia/Hypoplasia of the tongue, Cleft palate, Furrowed tongue, Aplasia/Hypoplasia... ORPHA:564
Microphthalmia, Syndromic 2
Delayed eruption of teeth, Anophthalmia, Short stature, Persistence of primary teeth, Supernumera... OMIM:300166
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Severe short stature, Anophthalmia, Thick vermilion border, Long philtrum, Microphthalmia ORPHA:2526
Fraser Syndrome 1
Abnormal small intestine morphology, Anophthalmia, Dental crowding, Cleft upper lip, Bilateral mi... OMIM:219000
Proboscis Lateralis
Anophthalmia, Optic nerve hypoplasia, Agenesis of canine, Orofacial cleft, High palate, Long phil... ORPHA:141099
Fraser Syndrome
Anal stenosis, Anophthalmia, Dental crowding, Cleft upper lip, Dental malocclusion, Orofacial cle... ORPHA:2052
Focal Dermal Hypoplasia
Delayed eruption of teeth, Anophthalmia, Short stature, Intestinal malrotation, Cleft upper lip, ... OMIM:305600
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities
Frontal polymicrogyria, Cerebellar vermis hypoplasia, Cerebral calcification, Microcephaly, Crypt... OMIM:620024
Fibular Hemimelia
Anophthalmia ORPHA:93323
Combined Oxidative Phosphorylation Deficiency 11
Death in infancy, Stillbirth, Hypoplasia of the corpus callosum, Death in childhood, Neonatal dea... OMIM:614922
Thanatophoric Dysplasia, Type I
Hydrocephalus, Temporal lobe dysplasia, Gray matter heterotopia, Macrocephaly, Neonatal death OMIM:187600
Microphthalmia With Linear Skin Defects Syndrome
Anophthalmia, Severe short stature, Abnormal dental enamel morphology, Growth delay, Abnormal rec... ORPHA:2556
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Encephalocele, Exencephaly ORPHA:2211
Fanconi Anemia, Complementation Group O
Neonatal death, Cryptorchidism, Miscarriage, Death in infancy OMIM:613390
Branchiooculofacial Syndrome
Anophthalmia, Cleft upper lip, Malrotation of colon, Abnormality of the dentition, Lower lip pit,... OMIM:113620
Dyssegmental Dysplasia, Silverman-Handmaker Type
Neonatal death, Cryptorchidism, Occipital encephalocele, Microcephaly OMIM:224410
Microcephaly-Micromelia Syndrome
Microcephaly, Aqueductal stenosis, Simplified gyral pattern, Aplasia/Hypoplasia of the corpus cal... OMIM:251230
Microphthalmia, Syndromic 1
Anophthalmia, Dental crowding, Aganglionic megacolon, Cleft upper lip, High, narrow palate, Recta... OMIM:309800
Charge Syndrome
Anal stenosis, Anophthalmia, Cleft upper lip, Postnatal growth retardation, Esophageal atresia, T... OMIM:214800
Microphthalmia, Syndromic 6
Anophthalmia, Cleft palate, High palate, Microphthalmia, Microglossia, Bifid uvula OMIM:607932
Arthrogryposis Multiplex Congenita 6
Neonatal death, Death in infancy, Death in childhood OMIM:619334
Joubert Syndrome 21
Anophthalmia OMIM:615636
Molybdenum Cofactor Deficiency, Complementation Group C
Hypoplasia of the pons, Polymicrogyria, Cerebellar hypoplasia, Neonatal death OMIM:615501
Fanconi Anemia, Complementation Group D2
Patent ductus arteriosus, Hydrocephalus, Agenesis of corpus callosum, Prolonged G2 phase of cell ... OMIM:227646
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Absent septum pellucidum, Microcephaly, Lobar holoprosencephaly, Hypoplasia of the corpus callosu... OMIM:618500
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract OMIM:600145
Afibrinogenemia, Congenital
Neonatal death, Death in infancy, Death in adolescence, Death in childhood OMIM:202400
Craniofacial Microsomia 1
Anophthalmia, Cleft upper lip, Cleft palate, Wide mouth, Transverse facial cleft, Microphthalmia OMIM:164210
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle OMIM:600901
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle OMIM:227650
Fanconi Anemia, Complementation Group C
Prolonged G2 phase of cell cycle OMIM:227645
Neu-Laxova Syndrome 1
Spina bifida, Cryptorchidism, Stillbirth, Lissencephaly, Cerebellar hypoplasia, Neonatal death, P... OMIM:256520
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kif20b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kif20b.

No publications found that use IMPC mice or data for Kif20b.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Kif20btm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Kif20btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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