The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|dilated heart left ventricle||Atg4dem1(IMPC)Marc||HOM||Early adult||1.51×10-05|
|abnormal retina morphology||Atg4dem1(IMPC)Marc||HOM||Early adult||2.47×10-06|
|increased anxiety-related response||Atg4dem1(IMPC)Marc||HOM||Early adult||4.40×10-05|
|abnormal behavior||Atg4dem1(IMPC)Marc||HOM||Early adult||8.36×10-05|
|increased thigmotaxis||Atg4dem1(IMPC)Marc||HOM||Early adult||8.36×10-05|
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Atg4d by phenotypic similarity.
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|MGI Allele||Allele Type||Produced|
|Atg4dtm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|