The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Map3k13.
There are 2 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.||eLife (January 2021)||Map3k13tm1a(KOMP)Wtsi||PMC7870138|
|Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.||Scientific reports (August 2016)||Map3k13tm1a(KOMP)Wtsi||PMC4980599|
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|MGI Allele||Allele Type||Produced|
|Map3k13tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Map3k13tm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Map3k13em1(IMPC)Mbp||Exon Deletion||Mice, Tissue|