Gene Summary

Name:
mitogen-activated protein kinase kinase kinase 13
Synonyms:
C130026N12Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

33 Images

X-ray

XRay Images Whole Body Lateral Orientation

11 Images

Human diseases caused by Map3k13 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Map3k13

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Map3k13.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. eLife (January 2021) Map3k13tm1a(KOMP)Wtsi PMC7870138
Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Scientific reports (August 2016) Map3k13tm1a(KOMP)Wtsi PMC4980599

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Map3k13tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Map3k13tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Map3k13em1(IMPC)Mbp Exon Deletion Mice, Tissue

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